Nicorandil: Difference between revisions
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==Overview== | ==Overview== | ||
'''Nicorandil''' is a [[drug]] used to treat [[Angina pectoris|angina]]. It is marketed under the trade names '''Ikorel''' (in the United Kingdom, Australia and most of Europe), '''Zynicor''' (in India) and '''Sigmart''' (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States. | '''Nicorandil''' is a [[drug]] used to treat [[Angina pectoris|angina]]. It is marketed under the trade names '''Ikorel''' (in the United Kingdom, Australia and most of Europe), '''Zynicor''' (in India) and '''Sigmart''' (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States. | ||
== Mechanism of | == Mechanism of Action == | ||
Nicorandil acts by relaxing the [[smooth muscle]] of the blood vessels, especially those of the [[Systemic venous system|venous system]]. It does this through two methods. Firstly, by activating [[potassium channel]]s, and secondly by donating [[nitric oxide]] to activate the [[enzyme]] [[guanylate cyclase]]. Guanylate cyclase causes activation of [[GMP]] leading to both arterial and venous vasodilatation. As it is selective for vascular potassium channels, it has no significant action on cardiac contractility and conduction. | Nicorandil acts by relaxing the [[smooth muscle]] of the blood vessels, especially those of the [[Systemic venous system|venous system]]. It does this through two methods. Firstly, by activating [[potassium channel]]s, and secondly by donating [[nitric oxide]] to activate the [[enzyme]] [[guanylate cyclase]]. Guanylate cyclase causes activation of [[GMP]] leading to both arterial and venous vasodilatation. As it is selective for vascular potassium channels, it has no significant action on cardiac contractility and conduction. | ||
Although it can dilate the [[coronary circulation|coronary vessels]] of a healthy individual, its effects on the coronary vessels of someone with ischaemic heart disease will be little as they will already be completely dilated. Instead, it dilates the venous system, reducing [[Frank-Starling law of the heart|preload]] and the work of the heart. | Although it can dilate the [[coronary circulation|coronary vessels]] of a healthy individual, its effects on the coronary vessels of someone with ischaemic heart disease will be little as they will already be completely dilated. Instead, it dilates the venous system, reducing [[Frank-Starling law of the heart|preload]] and the work of the heart. | ||
== Side | == Side Effects == | ||
Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a recognised side effect. | Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a recognised side effect. | ||
== References == | == References == | ||
{{reflist|2}} | |||
{{Vasodilators used in cardiac diseases}} | {{Vasodilators used in cardiac diseases}} | ||
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[[Category:Antianginals]] | [[Category:Antianginals]] | ||
[[Category:Vasodilators]] | [[Category:Vasodilators]] | ||
[[Category:Drugs]] | [[Category:Cardiovascular Drugs]] | ||
[[Category: | [[Category:Drug]] | ||
Latest revision as of 21:37, 24 July 2014
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| Clinical data | |
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| Pregnancy category |
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| Routes of administration | Oral |
| ATC code | |
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| Pharmacokinetic data | |
| Bioavailability | 75 to 80% |
| Protein binding | 25% |
| Metabolism | Hepatic |
| Elimination half-life | 1 hour |
| Excretion | Renal (21%) |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C8H9N3O4 |
| Molar mass | 211.175 g/mol |
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WikiDoc Resources for Nicorandil |
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Most recent articles on Nicorandil |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on Nicorandil at Clinical Trials.gov Clinical Trials on Nicorandil at Google
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Guidelines / Policies / Govt |
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US National Guidelines Clearinghouse on Nicorandil
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News |
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Commentary |
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Definitions |
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Patient Resources / Community |
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Patient resources on Nicorandil Discussion groups on Nicorandil Patient Handouts on Nicorandil Directions to Hospitals Treating Nicorandil Risk calculators and risk factors for Nicorandil
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Healthcare Provider Resources |
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Causes & Risk Factors for Nicorandil |
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Continuing Medical Education (CME) |
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International |
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Business |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Nicorandil is a drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Zynicor (in India) and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.
Mechanism of Action
Nicorandil acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of GMP leading to both arterial and venous vasodilatation. As it is selective for vascular potassium channels, it has no significant action on cardiac contractility and conduction.
Although it can dilate the coronary vessels of a healthy individual, its effects on the coronary vessels of someone with ischaemic heart disease will be little as they will already be completely dilated. Instead, it dilates the venous system, reducing preload and the work of the heart.
Side Effects
Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a recognised side effect.
References
- Pages with script errors
- Pages using duplicate arguments in template calls
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
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- Antianginals
- Vasodilators
- Cardiovascular Drugs
- Drug