X-linked dominant: Difference between revisions
No edit summary |
m (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +)) |
||
| Line 1: | Line 1: | ||
{{SI}} | {{SI}} | ||
==Overview== | ==Overview== | ||
'''X-linked dominant''' is mode of [[mendelian inheritance|inheritance]] in which a [[gene]] on the [[X chromosome]] is [[dominant]].<ref>[http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/xdomin.html X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital]</ref> Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women. | '''X-linked dominant''' is mode of [[mendelian inheritance|inheritance]] in which a [[gene]] on the [[X chromosome]] is [[dominant]].<ref>[http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/xdomin.html X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital]</ref> Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women. | ||
| Line 25: | Line 25: | ||
{{X-linked disorders}} | {{X-linked disorders}} | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Latest revision as of 17:32, 20 August 2012
|
WikiDoc Resources for X-linked dominant |
|
Articles |
|---|
|
Most recent articles on X-linked dominant Most cited articles on X-linked dominant |
|
Media |
|
Powerpoint slides on X-linked dominant |
|
Evidence Based Medicine |
|
Cochrane Collaboration on X-linked dominant |
|
Clinical Trials |
|
Ongoing Trials on X-linked dominant at Clinical Trials.gov Trial results on X-linked dominant Clinical Trials on X-linked dominant at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on X-linked dominant NICE Guidance on X-linked dominant
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on X-linked dominant Discussion groups on X-linked dominant Patient Handouts on X-linked dominant Directions to Hospitals Treating X-linked dominant Risk calculators and risk factors for X-linked dominant
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for X-linked dominant |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Overview
X-linked dominant is mode of inheritance in which a gene on the X chromosome is dominant.[1] Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women.
As a disease inheritance pattern, it is less common than X-linked recessive.
Inheritance
Females usually have two X chromosomes, while most males have one X and one Y chromosome. If a child has inherited the mutation from the X chromosome of one of their parents they will have the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each pregnancy. The sons of a man with an X-linked dominant disorder will not be affected (since they inherit their only X chromosome from their mother), but his daughters will all inherit the condition.
-
A woman with an X-linked dominant disorder has a 50% chance of having an affected child.
-
The daughters of a man with an X-linked dominant disorder will all inherit the condition.
Some X-linked dominant conditions such as Aicardi Syndrome are fatal to boys, therefore only girls with these conditions survive. Similarly, individuals with Klinefelter's Syndrome are referred to as "47,XXY Males".