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__NOTOC__
{{Gigantism}}
{{CMG}}; {{AE}}
'''For patient information, click [[Gigantism (patient information)|here]]'''
{{SK}} Giantism
{{Infobox_Disease
{{Infobox_Disease
  | Name          = Gigantism  
  | Name          = Gigantism  
  | Image          = Anna Swan with her parents.jpg
  | Image          = Anna Swan with her parents.jpg
  | Caption        = [[Anna Haining Bates]] with her parents
  | Caption        = Anna Haining Bates with her parents
  | DiseasesDB    = 30730
  | DiseasesDB    = 30730
  | ICD10          = {{ICD10|E|22|0|e|20}}, {{ICD10|E|34|4|e|20}}
  | ICD10          = {{ICD10|E|22|0|e|20}}, {{ICD10|E|34|4|e|20}}
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  | OMIM          =  
  | OMIM          =  
  | MedlinePlus    = 001174
  | MedlinePlus    = 001174
| eMedicineSubj  =
| eMedicineTopic =
  | MeshID        = D005877
  | MeshID        = D005877
}}
}}
{{SI}}
{{EH}}


==Overview==
==[[Gigantism overview|Overview]]==
'''Gigantism''',  also known as '''giantism''' (from [[Greek language|Greek]] ''gigas'', ''gigantas'' "[[wiktionary:giant|giant]]"), is a condition characterized by excessive growth and height significantly above [[average height|average]].<ref>{{DorlandsDict|four/000044375|Gigantism}}</ref>
 
==[[Gigantism historical perspective|Historical Perspective]]==
 
==[[Gigantism classification|Classification]]==
 
==[[Gigantism pathophysiology|Pathophysiology]]==
 
==[[Gigantism causes|Causes]]==
 
==[[Gigantism differential diagnosis|Differentiating Gigantism from other Diseases]]==
 
==[[Gigantism epidemiology and demographics|Epidemiology and Demographics]]==


==Types==
==[[Gigantism risk factors|Risk Factors]]==
As a medical term, gigantism can refer to:
* "Pituitary gigantism",these are people who their hormones over produce  which is due to prepubertal [[growth hormone]] excess. This is sometimes equated with [[acromegaly]], but more precisely, an excess of growth hormone leads to "pituitary gigantism" (vertical growth) if the [[epiphyseal plate]]s have not yet closed,<ref>{{DorlandsDict|four/000044382|pituitary gigantism}}</ref> but it leads to "acromegaly" (lateral growth) if they have closed.


* "Cerebral gigantism", also known as [[Sotos syndrome]],<ref>{{DorlandsDict|nine/000632774|Sotos syndrome}}</ref> which is due to a mutation in [[NSD1]].
==[[Gigantism screening|Screening]]==


==Terminology==
==[[Gigantism natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


The term is typically applied to those whose height is not just in the upper 1% of the population but several [[standard deviation]]s above mean for persons of the same sex, age, and ethnic ancestry. The term is seldom applied to those who are simply "tall" or "above average" whose heights appear to be the healthy result of normal [[genetics]] and nutrition.
==Diagnosis==
[[Gigantism history and symptoms|History and Symptoms]] | [[Gigantism physical examination|Physical Examination]] | [[Gigantism laboratory findings|Laboratory Findings]] | [[Gigantism electrocardiogram|Electrocardiogram]] | [[Gigantism x ray|X Ray]] | [[Gigantism CT|CT]] | [[Gigantism MRI|MRI]] | [[Gigantism echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Gigantism other imaging findings|Other Imaging Findings]] | [[Gigantism other diagnostic studies|Other Diagnostic Studies]]


Other names somewhat obsolete for this pathology are hypersomia (Greek: ''hyper'' over the normal level; ''soma'' body) and somatomegaly (Greek; ''soma'' body, object pronoun ''somatos''  of the body; ''megas'', ''megalos'' great).
==Treatment==
[[Gigantism medical therapy|Medical Therapy]] | [[Gigantism surgery|Surgery]] | [[Gigantism primary prevention|Primary Prevention]] | [[Gigantism secondary prevention|Secondary Prevention]] | [[Gigantism cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gigantism future or investigational therapies|Future or Investigational Therapies]]


Many of those who have been identified with gigantism have suffered from multiple health problems involving their [[circulatory system|circulatory]] or [[skeletal system]].
==Case Studies==
[[Gigantism case study one|Case #1]]


==See also==
==Related Chapters==
*[[Acromegaly]]
*[[Acromegaly]]
*[[Growth hormone]]
*[[Growth hormone]]
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==References==
==References==
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== External links ==
* [http://www.medstudents.com.br/endoc/endoc8.htm Acromegaly and Gigantism article]
* {{PDFlink|[http://www.gghjournal.com/pdf/volume_10/10-1/feature_1_10_1.pdf Brief overview of overgrowth syndromes in childhood]|2.95&nbsp;[[Mebibyte|MiB]]<!-- application/pdf, 3099033 bytes -->}}


{{Endocrine pathology}}
{{Endocrine pathology}}


[[Category:Growth disorders]]
[[Category:Human height]]
[[Category:Growth hormones]]
[[Category:Neuroendocrinology]]
[[Category:People with gigantism]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
{{SIB}}
 
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Latest revision as of 15:40, 22 July 2016

Gigantism Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gigantism from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Gigantism On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Gigantism

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Gigantism

CDC on Gigantism

Gigantism in the news

Blogs on Gigantism

Directions to Hospitals Treating Gigantism

Risk calculators and risk factors for Gigantism

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

For patient information, click here

Synonyms and keywords: Giantism

Gigantism
Anna Haining Bates with her parents
ICD-10 E22.0, E34.4
ICD-9 253.0
DiseasesDB 30730
MedlinePlus 001174
MeSH D005877

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gigantism from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

References

de:Riesenwuchs et:Gigantism el:Γιγαντισμός eu:Erraldoitasun id:Gigantisme it:Gigantismo he:ענקיות sr:Gigantizam fi:Jättikasvu sv:Gigantism

Template:WH Template:WS

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