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'''For the WikiDoc page for this topic, click [[Head and neck cancer|here]]''' | e'''For the WikiDoc page for this topic, click [[Head and neck cancer|here]]''' | ||
{{ | {{Infobox_Disease | | ||
Name = {{PAGENAME}} | | |||
Image = | | |||
Caption = | they have no neck | |||
DiseasesDB = | | |||
ICD10 = {{ICD10|C|07||c|00}}-{{ICD10|C|14||c|00}}<BR>{{ICD10|C|32||c|30}}-{{ICD10|C|33||c|30}} | | |||
ICD9 = | | |||
ICDO = | | |||
OMIM = | | |||
MedlinePlus = | | |||
MeshID = D006258 | | |||
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{{Head and neck cancer (patient information)}} | |||
'''Editor-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; '''Associate Editor-In-Chief:''' Alexandra M. Palmer | |||
== | ==Overview== | ||
Head and neck cancer includes [[cancers]] of the [[mouth]], [[nose]], [[sinuses]], [[salivary glands]], [[throat]] and [[lymph nodes]] in the [[neck]]. Most begin in the moist tissues that line the [[mouth]], [[nose]] and [[throat]]. | Head and neck cancer includes [[cancers]] of the [[mouth]], [[nose]], [[sinuses]], [[salivary glands]], [[throat]] and [[lymph nodes]] in the [[neck]]. Most begin in the moist tissues that line the [[mouth]], [[nose]] and [[throat]].<ref>[http://www.cancer.gov/cancertopics/factsheet/Sites-Types/head-and-neck NCI factsheet on head and neck cancer]</ref> | ||
Head and neck cancers account for approximately 3 to 5 percent of all [[cancers]] in the United States. These [[cancers]] are more common in men and in people over age 50. | Head and neck cancers account for approximately 3 to 5 percent of all [[cancers]] in the United States. These [[cancers]] are more common in men and in people over age 50. | ||
==What are the symptoms of Head and neck cancer?== | ==What are the symptoms of Head and neck cancer?== | ||
Symptoms include | [[Symptoms]] include: | ||
*A lump or sore that does not heal | *A [[lump]] or sore that does not heal | ||
*A sore throat that does not go away | *A [[sore throat]] that does not go away | ||
*Trouble swallowing | *Trouble [[swallowing]] | ||
*A change or hoarseness in the voice | *A change or hoarseness in the voice | ||
Other symptoms may include the following: | Other [[symptoms]] may include the following: | ||
*'''Oral cavity.''' A white or red patch on the gums, tongue, or lining of the mouth; a swelling of the jaw that causes dentures to fit poorly or become uncomfortable; and unusual bleeding or pain in the mouth. | *'''[[Oral cavity]].''' A white or red patch on the [[gums]], [[tongue]], or lining of the [[mouth]]; a swelling of the [[jaw]] that causes [[dentures]] to fit poorly or become uncomfortable; and unusual [[bleeding]] or [[pain]] in the [[mouth]]. | ||
*'''Nasal cavity and sinuses.''' Sinuses that are blocked and do not clear, chronic sinus infections that do not respond to treatment with antibiotics, bleeding through the nose, frequent headaches, swelling or other trouble with the eyes, pain in the upper teeth, or problems with dentures. | *'''[[Nasal cavity]] and [[sinuses]].''' [[Sinuses]] that are blocked and do not clear, chronic sinus infections that do not respond to treatment with [[antibiotics]], [[bleeding]] through the [[nose]], frequent [[headaches]], swelling or other trouble with the [[eyes]], pain in the upper [[teeth]], or problems with [[dentures]]. | ||
*'''Salivary glands.''' Swelling under the chin or around the jawbone; numbness or paralysis of the muscles in the face; or pain that does not go away in the face, chin, or neck. | *'''[[Salivary glands]].''' Swelling under the [[chin]] or around the [[jawbone]]; [[numbness]] or [[paralysis]] of the [[muscles]] in the [[face]]; or pain that does not go away in the [[face]], [[chin]], or [[neck]]. | ||
*'''Oropharynx and hypopharynx.''' Ear pain. | *'''[[Oropharynx]] and [[hypopharynx]].''' Ear pain. | ||
*'''Nasopharynx.''' Trouble breathing or speaking, frequent headaches, pain or ringing in the ears, or trouble hearing. | *'''[[Nasopharynx]].''' Trouble breathing or speaking, frequent [[headaches]], pain or ringing in the ears, or trouble hearing. | ||
*'''Larynx.''' Pain when swallowing, or ear pain. | *'''[[Larynx]].''' Pain when swallowing, or ear pain. | ||
*'''Metastatic squamous neck cancer.''' Pain in the neck or throat that does not go away. | *'''Metastatic squamous neck cancer.''' Pain in the [[neck]] or [[throat]] that does not go away. | ||
These symptoms may be caused by cancer or by other, less serious conditions. It is important to check with a doctor or dentist about any of these symptoms | These [[symptoms]] may be caused by [[cancer]] or by other, less serious conditions. It is important to check with a doctor or [[dentist]] about any of these [[symptoms]]. | ||
==Who is at highest risk?== | |||
Tobacco (including smokeless tobacco, sometimes called “chewing tobacco” or “snuff”) and alcohol use are the most important risk factors for [[head and neck cancers]], particularly those of the [[oral cavity]], [[oropharynx]], [[hypopharynx]], and [[larynx]]. Eighty-five percent of [[head and neck cancers]] are linked to tobacco use. People who use both tobacco and alcohol are at greater risk for developing these [[cancers]] than people who use either tobacco or alcohol alone. | |||
Other risk factors for cancers of the head and neck include the following: | Other risk factors for cancers of the head and neck include the following: | ||
*'''Oral cavity.''' Sun exposure (lip); possibly human papillomavirus (HPV) infection. | *'''[[Oral cavity]].''' Sun exposure (lip); possibly [[human papillomavirus]] (HPV) infection. | ||
*'''Salivary glands.''' Radiation to the head and neck. This exposure can come from diagnostic x-rays or from radiation therapy for noncancerous conditions or cancer. | *'''[[Salivary glands]].''' [[Radiation]] to the head and neck. This exposure can come from [[diagnostic]] [[x-rays]] or from [[radiation therapy]] for noncancerous conditions or [[cancer]]. | ||
*'''Paranasal sinuses and nasal cavity.''' Certain industrial exposures, such as wood or nickel dust inhalation. Tobacco and alcohol use may play less of a role in this type of cancer. | *'''[[Paranasal sinuses]] and [[nasal cavity]].''' Certain industrial exposures, such as wood or nickel dust inhalation. Tobacco and alcohol use may play less of a role in this type of [[cancer]]. | ||
*'''Nasopharynx.''' Asian, particularly Chinese, ancestry; Epstein-Barr virus infection; occupational exposure to wood dust; and consumption of certain preservatives or salted foods. | *'''[[Nasopharynx]].''' Asian, particularly Chinese, ancestry; [[Epstein-Barr virus]] infection; occupational exposure to wood dust; and consumption of certain preservatives or salted foods. | ||
*'''Oropharynx.''' Poor oral hygiene; HPV infection and the use of mouthwash that has a high alcohol content are possible, but not proven, risk factors. | *'''[[Oropharynx]].''' Poor oral hygiene; [[HPV]] infection and the use of mouthwash that has a high alcohol content are possible, but not proven, risk factors. | ||
*'''Hypopharynx.''' Plummer-Vinson (also called Paterson-Kelly) syndrome, a rare disorder that results from iron and other nutritional deficiencies. This syndrome is characterized by severe anemia and leads to difficulty swallowing due to webs of tissue that grow across the upper part of the esophagus. | *'''[[Hypopharynx]].''' [[Plummer-Vinson syndrome|Plummer-Vinson]] (also called [[Paterson-Kelly syndrome|Paterson-Kelly]]) syndrome, a rare disorder that results from [[iron]] and other nutritional deficiencies. This syndrome is characterized by severe [[anemia]] and leads to difficulty swallowing due to webs of tissue that grow across the upper part of the [[esophagus]]. | ||
*'''Larynx.''' Exposure to airborne particles of asbestos, especially in the workplace. | *'''[[Larynx]].''' Exposure to airborne particles of [[asbestos]], especially in the workplace. | ||
Immigrants from Southeast Asia who use paan (betel quid) in the mouth should be aware that this habit has been strongly associated with an increased risk for oral cancer. Also, consumption of mate, a tea-like beverage habitually consumed by South Americans, has been associated with an increased risk of cancers of the mouth, throat, esophagus, and larynx. | Immigrants from Southeast Asia who use paan (betel quid) in the [[mouth]] should be aware that this habit has been strongly associated with an increased risk for [[oral cancer]]. Also, consumption of mate, a tea-like beverage habitually consumed by South Americans, has been associated with an increased risk of [[cancers]] of the [[mouth]], [[throat]], [[esophagus]], and [[larynx]]. | ||
People who are at risk for head and neck cancers should talk with their doctor about ways they can reduce their risk. They should also discuss how often to have checkups. | People who are at risk for [[head and neck cancers]] should talk with their doctor about ways they can reduce their risk. They should also discuss how often to have checkups. | ||
== | ==Diagnosis== | ||
To find the cause of symptoms, a doctor evaluates a person's medical history, performs a physical examination, and orders diagnostic tests. The exams and tests conducted may vary depending on the symptoms. Examination of a sample of tissue under the microscope is always necessary to confirm a diagnosis of cancer. | To find the cause of [[symptoms]], a doctor evaluates a person's [[medical history]], performs a [[physical examination]], and orders [[diagnostic]] tests. The exams and tests conducted may vary depending on the [[symptoms]]. Examination of a sample of tissue under the [[microscope]] is always necessary to confirm a [[diagnosis]] of [[cancer]]. | ||
Some exams and tests that may be useful are described below: | Some exams and tests that may be useful are described below: | ||
*Physical examination may include visual inspection of the oral and nasal cavities, neck, throat, and tongue using a small mirror and/or lights. The doctor may also feel for lumps on the neck, lips, gums, and cheeks. | *'''[[Physical examination]]''' may include visual inspection of the oral and nasal cavities, [[neck]], [[throat]], and [[tongue]] using a small mirror and/or lights. The doctor may also feel for lumps on the [[neck]], [[lips]], [[gums]], and [[cheeks]]. | ||
*Endoscopy is the use of a thin, lighted tube called an endoscope to examine areas inside the body. The type of endoscope the doctor uses depends on the area being examined. For example, a laryngoscope is inserted through the mouth to view the larynx; an esophagoscope is inserted through the mouth to examine the esophagus; and a nasopharyngoscope is inserted through the nose so the doctor can see the nasal cavity and nasopharynx. | *'''[[Endoscopy]]''' is the use of a thin, lighted tube called an [[endoscope]] to examine areas inside the body. The type of [[endoscope]] the doctor uses depends on the area being examined. For example, a [[laryngoscope]] is inserted through the [[mouth]] to view the [[larynx]]; an esophagoscope is inserted through the mouth to examine the [[esophagus]]; and a nasopharyngoscope is inserted through the [[nose]] so the doctor can see the [[nasal cavity]] and [[nasopharynx]]. | ||
*Laboratory tests examine samples of blood, urine, or other substances from the body. | *'''Laboratory tests''' examine samples of [[blood]], [[urine]], or other substances from the body. | ||
*X-rays create images of areas inside the head and neck on film. | *'''[[X-rays]]''' create images of areas inside the [[head]] and [[neck]] on film. | ||
*CT (or CAT) scan is a series of detailed pictures of areas inside the head and neck created by a computer linked to an x-ray machine. | *'''[[CT]] (or CAT) scan''' is a series of detailed pictures of areas inside the [[head]] and [[neck]] created by a computer linked to an [[x-ray machine]]. | ||
*Magnetic resonance imaging (or MRI) uses a powerful magnet linked to a computer to create detailed pictures of areas inside the head and neck. | *'''[[Magnetic resonance imaging]]''' (or MRI) uses a powerful magnet linked to a computer to create detailed pictures of areas inside the [[head]] and [[neck]]. | ||
*PET scan uses sugar that is modified in a specific way so it is absorbed by cancer cells and appears as dark areas on the scan. | *'''[[PET scan]]''' uses sugar that is modified in a specific way so it is absorbed by [[cancer cells]] and appears as dark areas on the scan. | ||
*Biopsy is the removal of tissue. A pathologist studies the tissue under a microscope to make a diagnosis. A biopsy is the only sure way to tell whether a person has cancer. | *'''[[Biopsy]]''' is the removal of tissue. A [[pathologist]] studies the tissue under a [[microscope]] to make a [[diagnosis]]. A [[biopsy]] is the only sure way to tell whether a person has [[cancer]]. | ||
If the diagnosis is cancer, the doctor will want to learn the stage (or extent) of disease. Staging is a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Staging may involve an examination under anesthesia (in the operating room), x-rays and other imaging procedures, and laboratory tests. Knowing the stage of the disease helps the doctor plan treatment. | If the [[diagnosis]] is [[cancer]], the doctor will want to learn the stage (or extent) of disease. Staging is a careful attempt to find out whether the [[cancer]] has spread and, if so, to which parts of the body. Staging may involve an examination under [[anesthesia]] (in the operating room), [[x-rays]] and other imaging procedures, and laboratory tests. Knowing the stage of the disease helps the doctor plan treatment. | ||
==When to seek urgent medical care== | ==When to seek urgent medical care?== | ||
Since cancers are capable of spreading to other parts of the body, it is crucial to see a doctor right away if any of the aforementioned symptoms arise. | Since [[cancers]] are capable of spreading to other parts of the body, it is crucial to see a doctor right away if any of the aforementioned [[Head and neck cancer (patient information)#What are the symptoms of Head and neck cancer?|symptoms]] arise. | ||
==Treatment options== | ==Treatment options== | ||
If found early, these cancers are often curable. Treatments may include surgery, radiation therapy, chemotherapy or a combination. Treatments can affect eating, speaking or even breathing, so patients may need rehabilitation. | If found early, these [[cancers]] are often curable. Treatments may include [[surgery]], [[radiation therapy]], [[chemotherapy]] or a combination. Treatments can affect eating, speaking or even breathing, so patients may need rehabilitation. | ||
The treatment plan for an individual patient depends on a number of factors, including the exact location of the tumor, the stage of the cancer, and the person's age and general health. The patient and the doctor should consider treatment options carefully. They should discuss each type of treatment and how it might change the way the patient looks, talks, eats, or breathes. | The treatment plan for an individual patient depends on a number of factors, including the exact location of the [[tumor]], the stage of the [[cancer]], and the person's age and general health. The patient and the doctor should consider treatment options carefully. They should discuss each type of treatment and how it might change the way the patient looks, talks, eats, or breathes. | ||
*'''Surgery.''' The surgeon may remove the cancer and some of the healthy tissue around it. Lymph nodes in the neck may also be removed (lymph node dissection), if the doctor suspects that the cancer has spread. Surgery may be followed by radiation treatment. Head and neck surgery often changes the patient's ability to chew, swallow, or talk. The patient may look different after surgery, and the face and neck may be swollen. The swelling usually goes away within a few weeks. However, lymph node dissection can slow the flow of lymph, which may collect in the tissues; this swelling may last for a long time. After a laryngectomy (surgery to remove the larynx), parts of the neck and throat may feel numb because nerves have been cut. If lymph nodes in the neck were removed, the shoulder and neck may be weak and stiff. Patients should report any side effects to their doctor or nurse, and discuss what approach to take | *'''[[Surgery]].''' The [[surgeon]] may remove the [[cancer]] and some of the healthy tissue around it. [[Lymph nodes]] in the [[neck]] may also be removed (lymph node dissection), if the doctor suspects that the [[cancer]] has spread. [[Surgery]] may be followed by [[radiation]] treatment. Head and neck surgery often changes the patient's ability to chew, swallow, or talk. The patient may look different after [[surgery]], and the [[face]] and [[neck]] may be swollen. The swelling usually goes away within a few weeks. However, lymph node dissection can slow the flow of [[lymph]], which may collect in the tissues; this swelling may last for a long time. After a [[laryngectomy]] ([[surgery]] to remove the [[larynx]]), parts of the [[neck]] and [[throat]] may feel numb because nerves have been cut. If [[lymph nodes]] in the [[neck]] were removed, the [[shoulder]] and [[neck]] may be weak and stiff. Patients should report any [[side effects]] to their doctor or nurse, and discuss what approach to take. | ||
*'''Radiation therapy''', also called radiotherapy. This treatment involves the use of high-energy x-rays to kill cancer cells. Radiation may come from a machine outside the body (external radiation therapy). It can also come from radioactive materials placed directly into or near the area where the cancer cells are found (internal radiation therapy or radiation implant). In addition to its desired effect on cancer cells, radiation therapy often causes unwanted effects. Patients who receive radiation to the head and neck may experience redness, irritation, and sores in the mouth; a dry mouth or thickened saliva; difficulty in swallowing; changes in taste; or nausea. Other problems that may occur during treatment are loss of taste, which may decrease appetite and affect nutrition, and earaches (caused by hardening of the ear wax). Patients may also notice some swelling or drooping of the skin under the chin and changes in the texture of the skin. The jaw may feel stiff and patients may not be able to open their mouth as wide as before treatment. Patients should report any side effects to their doctor or nurse and ask how to manage these effects. | *'''[[Radiation therapy]]''', also called [[radiotherapy]]. This treatment involves the use of high-energy [[x-rays]] to kill [[cancer cells]]. [[Radiation]] may come from a machine outside the body (external radiation therapy). It can also come from radioactive materials placed directly into or near the area where the [[cancer cells]] are found (internal radiation therapy or radiation implant). In addition to its desired effect on [[cancer cells]], [[radiation therapy]] often causes unwanted effects. Patients who receive [[radiation]] to the [[head]] and [[neck]] may experience redness, [[irritation]], and sores in the [[mouth]]; a [[dry mouth]] or thickened [[saliva]]; difficulty in swallowing; changes in taste; or [[nausea]]. Other problems that may occur during treatment are loss of taste, which may decrease [[appetite]] and affect [[nutrition]], and [[earaches]] (caused by hardening of the ear wax). Patients may also notice some swelling or drooping of the skin under the chin and changes in the texture of the [[skin]]. The [[jaw]] may feel stiff and patients may not be able to open their [[mouth]] as wide as before treatment. Patients should report any [[side effects]] to their doctor or nurse and ask how to manage these effects. | ||
*'''Chemotherapy''', also called anticancer drugs. This treatment is used to kill cancer cells throughout the body. The side effects of chemotherapy depend on the drugs that are given. In general, anticancer drugs affect rapidly growing cells, including blood cells that fight infection, cells that line the mouth and the digestive tract, and cells in hair follicles. As a result, patients may have side effects such as lower resistance to infection, sores in the mouth and on the lips, loss of appetite, nausea, vomiting, diarrhea, and hair loss. They may also feel unusually tired and experience skin rash and itching, joint pain, loss of balance, and swelling of the feet or lower legs. Patients should talk with their doctor or nurse about the side effects they are experiencing, and how to handle them. | *'''[[Chemotherapy]]''', also called anticancer drugs. This treatment is used to kill [[cancer cells]] throughout the body. The side effects of [[chemotherapy]] depend on the drugs that are given. In general, anticancer drugs affect rapidly growing cells, including [[blood cells]] that fight [[infection]], cells that line the [[mouth]] and the [[digestive tract]], and cells in [[hair follicles]]. As a result, patients may have [[side effects]] such as lower resistance to [[infection]], sores in the [[mouth]] and on the [[lips]], [[loss of appetite]], [[nausea]], [[vomiting]], [[diarrhea]], and [[hair loss]]. They may also feel unusually tired and experience [[skin rash]] and [[itching]], [[joint pain]], loss of balance, and swelling of the [[feet]] or lower legs. Patients should talk with their doctor or nurse about the [[side effects]] they are experiencing, and how to handle them. | ||
==Diseases with similar symptoms== | ==Diseases with similar symptoms== | ||
| Line 86: | Line 96: | ||
*[[skin cancer]]s - may involve the head and neck | *[[skin cancer]]s - may involve the head and neck | ||
==Where to find medical care for Head and neck cancer== | ==Where to find medical care for Head and neck cancer?== | ||
[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|Head and neck cancer}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating Head and neck cancer] | [http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|Head and neck cancer}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating Head and neck cancer] | ||
==Prevention of Head and neck cancer== | ==Prevention of Head and neck cancer== | ||
Avoidance of | Avoidance of recognized risk factors (as described above)is the single most effective form of prevention. Regular dental examinations may identify pre-cancerous lesions in the [[oral cavity]]. | ||
People who have been treated for head and neck cancer have an increased chance of developing a new cancer, usually in the head and neck, esophagus, or lungs. The chance of a second primary cancer varies depending on the original diagnosis, but is higher for people who smoke and drink alcohol. Patients who do not smoke should never start. Those who smoke should do their best to quit. Studies have shown that continuing to smoke or drink (or both) increases the chance of a second primary cancer for up to 20 years after the original diagnosis. | People who have been treated for [[head and neck cancer]] have an increased chance of developing a new [[cancer]], usually in the [[head]] and [[neck]], [[esophagus]], or [[lungs]]. The chance of a second primary cancer varies depending on the original [[diagnosis]], but is higher for people who smoke and drink alcohol. Patients who do not smoke should never start. Those who smoke should do their best to quit. Studies have shown that continuing to smoke or drink (or both) increases the chance of a second primary cancer for up to 20 years after the original [[diagnosis]]. | ||
Some research has shown that isotretinoin (13-cis-retinoic acid), a substance related to vitamin A, may reduce the risk of the tumor recurring (coming back) in patients who have been successfully treated for cancers of the oral cavity, oropharynx, and larynx. However, treatment with isotretinoin has not yet been shown to improve survival or to prevent future cancers. | Some research has shown that [[isotretinoin]] (13-cis-retinoic acid), a substance related to [[vitamin A]], may reduce the risk of the [[tumor]] recurring (coming back) in patients who have been successfully treated for [[cancers]] of the [[oral cavity]], [[oropharynx]], and [[larynx]]. However, treatment with [[isotretinoin]] has not yet been shown to improve survival or to prevent future [[cancers]]. | ||
==What to expect (Outlook/Prognosis)?== | |||
Although early-stage head and neck cancers (especially [[laryngeal]] and [[oral cavity]]) have high cure rates, up to 50% of head and neck cancer patients present with advanced disease.<ref>{{cite journal |author=Gourin C, Podolsky R |title=Racial disparities in patients with head and neck squamous cell carcinoma |journal=Laryngoscope |volume=116 |issue=7 |pages=1093-106 |year=2006 |pmid=16826042}}</ref> | |||
Cure rates decrease in locally advanced cases, whose probability of cure is inversely related to [[tumor]] size and even more so to the extent of regional node involvement. | |||
Consensus panels in America (American Joint Committee on Cancer AJCC and Europe) have established staging systems for head and neck squamous cancers. These staging systems attempt to standardize clinical trial criteria for research studies, and attempt to define [[prognostic]] categories of disease. Squamous cell cancers of the head and neck are staged according to the [[TNM]] classification system, where T is the size and configuration of the tumor, N is the presence or absence of [[lymph node metastases]], and M is the presence or absence of distant metastases. The T, N, and M characteristics are combined to produce a “stage” of the cancer, from I to IVB.<ref>{{cite journal |author=Iro H, Waldfahrer F |title=Evaluation of the newly updated TNM classification of head and neck carcinoma with data from 3247 patients |journal=Cancer |volume=83 |issue=10 |pages=2201-7 |year=1998 |pmid=9827726}}</ref> | |||
===Residual deficits=== | ===Residual deficits=== | ||
Even after successful definitive therapy, head and neck cancer patients face tremendous impacts on quality of life. Despite marked advances in reconstructive surgery and rehabilitation, intensity-modulated radiotherapy (IMRT) and conservation approaches to certain malignancies, some patients continue to have significant functional deficits. | Even after successful definitive therapy, head and neck cancer patients face tremendous impacts on [[quality of life]]. Despite marked advances in [[reconstructive surgery]] and rehabilitation, intensity-modulated radiotherapy (IMRT) and conservation approaches to certain [[malignancies]], some patients continue to have significant functional deficits. | ||
===Problem of second primaries=== | ===Problem of second primaries=== | ||
Survival advantages provided by new treatment modalities have been undermined by the significant percentage of patients cured of head and neck squamous cell carcinoma (HNSCC) who subsequently develop second primary tumors. The incidence of second primary tumors ranges in studies from 9.1%<ref>{{cite journal |author=Jones A, Morar P, Phillips D, Field J, Husband D, Helliwell T |title=Second primary tumors in patients with head and neck squamous cell carcinoma |journal=Cancer |volume=75 |issue=6 |pages=1343-53 |year=1995 |pmid=7882285}}</ref> | Survival advantages provided by new treatment modalities have been undermined by the significant percentage of patients cured of head and neck squamous cell carcinoma (HNSCC) who subsequently develop second primary tumors. The incidence of second primary tumors ranges in studies from 9.1%<ref>{{cite journal |author=Jones A, Morar P, Phillips D, Field J, Husband D, Helliwell T |title=Second primary tumors in patients with head and neck squamous cell carcinoma |journal=Cancer |volume=75 |issue=6 |pages=1343-53 |year=1995 |pmid=7882285}}</ref> | ||
to 23%<ref>{{cite journal |author=Cooper J, Pajak T, Rubin P, Tupchong L, Brady L, Leibel S, Laramore G, Marcial V, Davis L, Cox J |title=Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience |journal=Int J Radiat Oncol Biol Phys |volume=17 |issue=3 |pages=449-56 |year=1989 |pmid=2674073}}</ref> | to 23%<ref>{{cite journal |author=Cooper J, Pajak T, Rubin P, Tupchong L, Brady L, Leibel S, Laramore G, Marcial V, Davis L, Cox J |title=Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience |journal=Int J Radiat Oncol Biol Phys |volume=17 |issue=3 |pages=449-56 |year=1989 |pmid=2674073}}</ref> | ||
at 20 years. Second primary tumors are the major threat to long-term survival after successful therapy of early-stage HNSCC. Their high incidence results from the same carcinogenic exposure responsible for the initial primary process, called field cancerization. | at 20 years. Second primary tumors are the major threat to long-term survival after successful therapy of early-stage HNSCC. Their high incidence results from the same [[carcinogenic]] exposure responsible for the initial primary process, called field cancerization. | ||
Throat cancer has numerous negative effects on the body systems. | Throat cancer has numerous negative effects on the body systems. | ||
===Digestive system=== | ===Digestive system=== | ||
As it can impair a person’s ability to swallow and eat, throat cancer affects the [[digestive system]]. The difficulty in swallowing can lead to a person to [[choking|choke]] on their food in the early stages of digestion and interfere with the food’s smooth travels down into the [[esophagus]] and beyond. | As it can impair a person’s ability to swallow and eat, throat cancer affects the [[digestive system]]. The difficulty in swallowing can lead to a person to [[choking|choke]] on their food in the early stages of [[digestion]] and interfere with the food’s smooth travels down into the [[esophagus]] and beyond. | ||
The treatments for throat cancer can also be harmful to the digestive system as well as other body systems. Radiation therapy can lead to [[nausea]] and [[vomiting]], which can deprive a body of vital fluids (although these may be obtained through intravenous fluids if necessary). Frequent vomiting can lead to an electrolyte imbalance which has serious consequences for the proper functioning of the heart. Frequent vomiting can also upset the balance of stomach acids which has a negative impact on the digestive system, especially the lining of the stomach and esophagus. | The treatments for throat cancer can also be harmful to the [[digestive system]] as well as other body systems. [[Radiation therapy]] can lead to [[nausea]] and [[vomiting]], which can deprive a body of vital fluids (although these may be obtained through [[intravenous]] fluids if necessary). Frequent [[vomiting]] can lead to an [[electrolyte]] imbalance which has serious consequences for the proper functioning of the [[heart]]. Frequent [[vomiting]] can also upset the balance of stomach acids which has a negative impact on the [[digestive system]], especially the lining of the [[stomach]] and [[esophagus]]. | ||
===Respiratory system=== | ===Respiratory system=== | ||
In the cases of some throat cancers, the air passages in the [[mouth]] and behind the [[nose]] may become blocked from lumps or the swelling from the open sores. If the throat cancer is near the bottom of the throat it has a high likelihood of spreading to the [[lung]]s and interfering with the person’s ability to [[breath]]e; this is even more likely if the patient is a smoker, because they are highly susceptible to [[lung cancer]]. If the respiratory system is unable to bring oxygen into the body, the oxygen deprivation will cause the body's cells to wither and die, causing one to become weaker and sicker. | In the cases of some throat cancers, the air passages in the [[mouth]] and behind the [[nose]] may become blocked from lumps or the swelling from the open sores. If the throat cancer is near the bottom of the [[throat]] it has a high likelihood of spreading to the [[lung]]s and interfering with the person’s ability to [[breath]]e; this is even more likely if the patient is a smoker, because they are highly susceptible to [[lung cancer]]. If the [[respiratory system]] is unable to bring [[oxygen]] into the body, the oxygen deprivation will cause the body's cells to wither and die, causing one to become weaker and sicker. | ||
===Others=== | ===Others=== | ||
Like any [[cancer]], [[metastasize|metastasization]] affects many areas of the body, as the cancer spreads from cell to cell and [[organ (biology)|organ]] to organ. For example, if it spreads to the [[bone marrow]], it will prevent the body from producing enough [[red blood cell]]s and affects the proper functioning of the [[white blood cell]]s and the body's [[immune system]]; spreading to the [[circulatory system]] will prevent oxygen from being transported to all the cells of the body; and throat cancer can throw the [[nervous system]] into chaos, making it unable to properly regulate and control the body. | Like any [[cancer]], [[metastasize|metastasization]] affects many areas of the body, as the [[cancer]] spreads from cell to cell and [[organ (biology)|organ]] to organ. For example, if it spreads to the [[bone marrow]], it will prevent the body from producing enough [[red blood cell]]s and affects the proper functioning of the [[white blood cell]]s and the body's [[immune system]]; spreading to the [[circulatory system]] will prevent [[oxygen]] from being transported to all the cells of the body; and throat cancer can throw the [[nervous system]] into chaos, making it unable to properly regulate and control the body. | ||
== | ==Resources== | ||
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[[Category:Oral and maxillofacial surgery]] | |||
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[[Category:Otolaryngology patient information]] | |||
[[Category:Oncology patient information]] | |||
[[Category:Mature chapter]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
Latest revision as of 01:53, 27 November 2017
eFor the WikiDoc page for this topic, click here
| Head and neck cancer (patient information) | |
| ICD-10 | C07-C14 C32-C33 |
|---|---|
| MeSH | D006258 |
|
Head and neck cancer |
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Head and neck cancer On the Web |
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Editor-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Associate Editor-In-Chief: Alexandra M. Palmer
Overview
Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat and lymph nodes in the neck. Most begin in the moist tissues that line the mouth, nose and throat.[1]
Head and neck cancers account for approximately 3 to 5 percent of all cancers in the United States. These cancers are more common in men and in people over age 50.
What are the symptoms of Head and neck cancer?
Symptoms include:
- A lump or sore that does not heal
- A sore throat that does not go away
- Trouble swallowing
- A change or hoarseness in the voice
Other symptoms may include the following:
- Oral cavity. A white or red patch on the gums, tongue, or lining of the mouth; a swelling of the jaw that causes dentures to fit poorly or become uncomfortable; and unusual bleeding or pain in the mouth.
- Nasal cavity and sinuses. Sinuses that are blocked and do not clear, chronic sinus infections that do not respond to treatment with antibiotics, bleeding through the nose, frequent headaches, swelling or other trouble with the eyes, pain in the upper teeth, or problems with dentures.
- Salivary glands. Swelling under the chin or around the jawbone; numbness or paralysis of the muscles in the face; or pain that does not go away in the face, chin, or neck.
- Oropharynx and hypopharynx. Ear pain.
- Nasopharynx. Trouble breathing or speaking, frequent headaches, pain or ringing in the ears, or trouble hearing.
- Larynx. Pain when swallowing, or ear pain.
- Metastatic squamous neck cancer. Pain in the neck or throat that does not go away.
These symptoms may be caused by cancer or by other, less serious conditions. It is important to check with a doctor or dentist about any of these symptoms.
Who is at highest risk?
Tobacco (including smokeless tobacco, sometimes called “chewing tobacco” or “snuff”) and alcohol use are the most important risk factors for head and neck cancers, particularly those of the oral cavity, oropharynx, hypopharynx, and larynx. Eighty-five percent of head and neck cancers are linked to tobacco use. People who use both tobacco and alcohol are at greater risk for developing these cancers than people who use either tobacco or alcohol alone.
Other risk factors for cancers of the head and neck include the following:
- Oral cavity. Sun exposure (lip); possibly human papillomavirus (HPV) infection.
- Salivary glands. Radiation to the head and neck. This exposure can come from diagnostic x-rays or from radiation therapy for noncancerous conditions or cancer.
- Paranasal sinuses and nasal cavity. Certain industrial exposures, such as wood or nickel dust inhalation. Tobacco and alcohol use may play less of a role in this type of cancer.
- Nasopharynx. Asian, particularly Chinese, ancestry; Epstein-Barr virus infection; occupational exposure to wood dust; and consumption of certain preservatives or salted foods.
- Oropharynx. Poor oral hygiene; HPV infection and the use of mouthwash that has a high alcohol content are possible, but not proven, risk factors.
- Hypopharynx. Plummer-Vinson (also called Paterson-Kelly) syndrome, a rare disorder that results from iron and other nutritional deficiencies. This syndrome is characterized by severe anemia and leads to difficulty swallowing due to webs of tissue that grow across the upper part of the esophagus.
- Larynx. Exposure to airborne particles of asbestos, especially in the workplace.
Immigrants from Southeast Asia who use paan (betel quid) in the mouth should be aware that this habit has been strongly associated with an increased risk for oral cancer. Also, consumption of mate, a tea-like beverage habitually consumed by South Americans, has been associated with an increased risk of cancers of the mouth, throat, esophagus, and larynx.
People who are at risk for head and neck cancers should talk with their doctor about ways they can reduce their risk. They should also discuss how often to have checkups.
Diagnosis
To find the cause of symptoms, a doctor evaluates a person's medical history, performs a physical examination, and orders diagnostic tests. The exams and tests conducted may vary depending on the symptoms. Examination of a sample of tissue under the microscope is always necessary to confirm a diagnosis of cancer.
Some exams and tests that may be useful are described below:
- Physical examination may include visual inspection of the oral and nasal cavities, neck, throat, and tongue using a small mirror and/or lights. The doctor may also feel for lumps on the neck, lips, gums, and cheeks.
- Endoscopy is the use of a thin, lighted tube called an endoscope to examine areas inside the body. The type of endoscope the doctor uses depends on the area being examined. For example, a laryngoscope is inserted through the mouth to view the larynx; an esophagoscope is inserted through the mouth to examine the esophagus; and a nasopharyngoscope is inserted through the nose so the doctor can see the nasal cavity and nasopharynx.
- Laboratory tests examine samples of blood, urine, or other substances from the body.
- X-rays create images of areas inside the head and neck on film.
- CT (or CAT) scan is a series of detailed pictures of areas inside the head and neck created by a computer linked to an x-ray machine.
- Magnetic resonance imaging (or MRI) uses a powerful magnet linked to a computer to create detailed pictures of areas inside the head and neck.
- PET scan uses sugar that is modified in a specific way so it is absorbed by cancer cells and appears as dark areas on the scan.
- Biopsy is the removal of tissue. A pathologist studies the tissue under a microscope to make a diagnosis. A biopsy is the only sure way to tell whether a person has cancer.
If the diagnosis is cancer, the doctor will want to learn the stage (or extent) of disease. Staging is a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Staging may involve an examination under anesthesia (in the operating room), x-rays and other imaging procedures, and laboratory tests. Knowing the stage of the disease helps the doctor plan treatment.
When to seek urgent medical care?
Since cancers are capable of spreading to other parts of the body, it is crucial to see a doctor right away if any of the aforementioned symptoms arise.
Treatment options
If found early, these cancers are often curable. Treatments may include surgery, radiation therapy, chemotherapy or a combination. Treatments can affect eating, speaking or even breathing, so patients may need rehabilitation.
The treatment plan for an individual patient depends on a number of factors, including the exact location of the tumor, the stage of the cancer, and the person's age and general health. The patient and the doctor should consider treatment options carefully. They should discuss each type of treatment and how it might change the way the patient looks, talks, eats, or breathes.
- Surgery. The surgeon may remove the cancer and some of the healthy tissue around it. Lymph nodes in the neck may also be removed (lymph node dissection), if the doctor suspects that the cancer has spread. Surgery may be followed by radiation treatment. Head and neck surgery often changes the patient's ability to chew, swallow, or talk. The patient may look different after surgery, and the face and neck may be swollen. The swelling usually goes away within a few weeks. However, lymph node dissection can slow the flow of lymph, which may collect in the tissues; this swelling may last for a long time. After a laryngectomy (surgery to remove the larynx), parts of the neck and throat may feel numb because nerves have been cut. If lymph nodes in the neck were removed, the shoulder and neck may be weak and stiff. Patients should report any side effects to their doctor or nurse, and discuss what approach to take.
- Radiation therapy, also called radiotherapy. This treatment involves the use of high-energy x-rays to kill cancer cells. Radiation may come from a machine outside the body (external radiation therapy). It can also come from radioactive materials placed directly into or near the area where the cancer cells are found (internal radiation therapy or radiation implant). In addition to its desired effect on cancer cells, radiation therapy often causes unwanted effects. Patients who receive radiation to the head and neck may experience redness, irritation, and sores in the mouth; a dry mouth or thickened saliva; difficulty in swallowing; changes in taste; or nausea. Other problems that may occur during treatment are loss of taste, which may decrease appetite and affect nutrition, and earaches (caused by hardening of the ear wax). Patients may also notice some swelling or drooping of the skin under the chin and changes in the texture of the skin. The jaw may feel stiff and patients may not be able to open their mouth as wide as before treatment. Patients should report any side effects to their doctor or nurse and ask how to manage these effects.
- Chemotherapy, also called anticancer drugs. This treatment is used to kill cancer cells throughout the body. The side effects of chemotherapy depend on the drugs that are given. In general, anticancer drugs affect rapidly growing cells, including blood cells that fight infection, cells that line the mouth and the digestive tract, and cells in hair follicles. As a result, patients may have side effects such as lower resistance to infection, sores in the mouth and on the lips, loss of appetite, nausea, vomiting, diarrhea, and hair loss. They may also feel unusually tired and experience skin rash and itching, joint pain, loss of balance, and swelling of the feet or lower legs. Patients should talk with their doctor or nurse about the side effects they are experiencing, and how to handle them.
Diseases with similar symptoms
- oral cancer
- cancer of the larynx
- thyroid cancer
- adenoid cystic carcinoma - a type of salivary gland cancer
- Burkitt's lymphoma - a type of lymphoma that affects the head and neck
- Dermatofibrosarcoma protuberans - a type of sarcoma that may involve the head and neck
- Hodgkin's disease - a lymphoma that often involves the lymph nodes in the neck
- paraganglioma - usually found in the head and neck region
- skin cancers - may involve the head and neck
Where to find medical care for Head and neck cancer?
Directions to Hospitals Treating Head and neck cancer
Prevention of Head and neck cancer
Avoidance of recognized risk factors (as described above)is the single most effective form of prevention. Regular dental examinations may identify pre-cancerous lesions in the oral cavity.
People who have been treated for head and neck cancer have an increased chance of developing a new cancer, usually in the head and neck, esophagus, or lungs. The chance of a second primary cancer varies depending on the original diagnosis, but is higher for people who smoke and drink alcohol. Patients who do not smoke should never start. Those who smoke should do their best to quit. Studies have shown that continuing to smoke or drink (or both) increases the chance of a second primary cancer for up to 20 years after the original diagnosis.
Some research has shown that isotretinoin (13-cis-retinoic acid), a substance related to vitamin A, may reduce the risk of the tumor recurring (coming back) in patients who have been successfully treated for cancers of the oral cavity, oropharynx, and larynx. However, treatment with isotretinoin has not yet been shown to improve survival or to prevent future cancers.
What to expect (Outlook/Prognosis)?
Although early-stage head and neck cancers (especially laryngeal and oral cavity) have high cure rates, up to 50% of head and neck cancer patients present with advanced disease.[2] Cure rates decrease in locally advanced cases, whose probability of cure is inversely related to tumor size and even more so to the extent of regional node involvement.
Consensus panels in America (American Joint Committee on Cancer AJCC and Europe) have established staging systems for head and neck squamous cancers. These staging systems attempt to standardize clinical trial criteria for research studies, and attempt to define prognostic categories of disease. Squamous cell cancers of the head and neck are staged according to the TNM classification system, where T is the size and configuration of the tumor, N is the presence or absence of lymph node metastases, and M is the presence or absence of distant metastases. The T, N, and M characteristics are combined to produce a “stage” of the cancer, from I to IVB.[3]
Residual deficits
Even after successful definitive therapy, head and neck cancer patients face tremendous impacts on quality of life. Despite marked advances in reconstructive surgery and rehabilitation, intensity-modulated radiotherapy (IMRT) and conservation approaches to certain malignancies, some patients continue to have significant functional deficits.
Problem of second primaries
Survival advantages provided by new treatment modalities have been undermined by the significant percentage of patients cured of head and neck squamous cell carcinoma (HNSCC) who subsequently develop second primary tumors. The incidence of second primary tumors ranges in studies from 9.1%[4] to 23%[5] at 20 years. Second primary tumors are the major threat to long-term survival after successful therapy of early-stage HNSCC. Their high incidence results from the same carcinogenic exposure responsible for the initial primary process, called field cancerization.
Throat cancer has numerous negative effects on the body systems.
Digestive system
As it can impair a person’s ability to swallow and eat, throat cancer affects the digestive system. The difficulty in swallowing can lead to a person to choke on their food in the early stages of digestion and interfere with the food’s smooth travels down into the esophagus and beyond.
The treatments for throat cancer can also be harmful to the digestive system as well as other body systems. Radiation therapy can lead to nausea and vomiting, which can deprive a body of vital fluids (although these may be obtained through intravenous fluids if necessary). Frequent vomiting can lead to an electrolyte imbalance which has serious consequences for the proper functioning of the heart. Frequent vomiting can also upset the balance of stomach acids which has a negative impact on the digestive system, especially the lining of the stomach and esophagus.
Respiratory system
In the cases of some throat cancers, the air passages in the mouth and behind the nose may become blocked from lumps or the swelling from the open sores. If the throat cancer is near the bottom of the throat it has a high likelihood of spreading to the lungs and interfering with the person’s ability to breathe; this is even more likely if the patient is a smoker, because they are highly susceptible to lung cancer. If the respiratory system is unable to bring oxygen into the body, the oxygen deprivation will cause the body's cells to wither and die, causing one to become weaker and sicker.
Others
Like any cancer, metastasization affects many areas of the body, as the cancer spreads from cell to cell and organ to organ. For example, if it spreads to the bone marrow, it will prevent the body from producing enough red blood cells and affects the proper functioning of the white blood cells and the body's immune system; spreading to the circulatory system will prevent oxygen from being transported to all the cells of the body; and throat cancer can throw the nervous system into chaos, making it unable to properly regulate and control the body.
Resources
- ↑ NCI factsheet on head and neck cancer
- ↑ Gourin C, Podolsky R (2006). "Racial disparities in patients with head and neck squamous cell carcinoma". Laryngoscope. 116 (7): 1093–106. PMID 16826042.
- ↑ Iro H, Waldfahrer F (1998). "Evaluation of the newly updated TNM classification of head and neck carcinoma with data from 3247 patients". Cancer. 83 (10): 2201–7. PMID 9827726.
- ↑ Jones A, Morar P, Phillips D, Field J, Husband D, Helliwell T (1995). "Second primary tumors in patients with head and neck squamous cell carcinoma". Cancer. 75 (6): 1343–53. PMID 7882285.
- ↑ Cooper J, Pajak T, Rubin P, Tupchong L, Brady L, Leibel S, Laramore G, Marcial V, Davis L, Cox J (1989). "Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience". Int J Radiat Oncol Biol Phys. 17 (3): 449–56. PMID 2674073.