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__NOTOC__
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{EH}}
{{CMG}}; {{AE}} {{MJM}}; {{Ammu}}


==Overview==
{{SK}} Adenolymphoma; Albrecht-Arzt-Warthin tumor; papillary cystadenoma lymphomatosum; Warthin tumour
{{DiseaseDisorder infobox |
{{Warthin's tumor}}
  Name          = Warthin's tumor |
  ICD10          = {{ICD10|D|11||d|10}} |
  ICD9          = {{ICD9|210.2}} |
  ICDO          = 8561/0 |
  Image          = Warthin's tumor.jpg |
  Caption        = This Warthin's tumor presented as a parotid mass in a middle-aged male, who underwent superficial parotidectomy. The tumor, at the right of the image, is well-demarcated from the adjacent parotid tissue and tends to shell out from it. |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = plastic |
  eMedicineTopic = 371 |
  DiseasesDB    = 31941 |
}}
{{SI}}
'''Warthin's tumor''' is a type of [[benign]] [[tumor]] of the [[salivary glands]].  It is also known as '''benign [[papillary]] [[cystadenoma]] lymphomatosum'''.  Its [[etiology]] is unknown, but there is a strong association with cigarette [[Tobacco smoking|smoking]].  Smokers are at 8 times greater risk of developing Warthin's tumor than the general population.


==Locations==
==[[Warthin's tumor overview|Overview]]==
==[[Warthin's tumor historical perspective|Historical Perspective]]==
==[[Warthin's tumor pathophysiology|Pathophysiology]]==
==[[Warthin's tumor causes|Causes]]==


The gland most likely affected is the [[parotid gland]].  Though much less likely to occur than [[pleomorphic adenoma]], Warthin's tumor is the second most common benign parotid tumor.
==[[Warthin's tumor differential diagnosis|Differentiating Warthin's tumor from other Diseases]]==


==Characteristic==
==[[Warthin's tumor epidemiology and demographics|Epidemiology and Demographics]]==
==[[Warthin's tumor risk factors|Risk Factors]]==
==[[Warthin's tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


Warthin's tumor is more likely to occur in older adults between 60 -70 years of age.  There is a slight female predilection according to recent studies, but historically it has been associated with a strong male predilection.  This change is possibly due to the tumor's association with cigarette smoking and the growing use of cigarettes in women.  The tumor is slow growing, painless, and usually appears in the tail of the parotid gland near the angle of the [[mandible]].  In 5 - 14% of cases, Warthin's tumor is bilateral, but the two masses usually are at different times.
==Diagnosis==
 
[[Warthin's tumor history and symptoms|History and Symptoms]] | [[Warthin's tumor physical examination|Physical Examination]] | [[Warthin's tumor laboratory findings|Laboratory Findings]] | [[Warthin's tumor echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Warthin's tumor CT|CT]] | [[Warthin's tumor MRI|MRI]] | [[Warthin's tumor other imaging findings|Other Imaging Findings]] | [[Warthin's tumor biopsy|Biopsy]]
==Histology==
 
The appearance of this tumor under the microscope is unique.  There are cystic spaces surrounded by two uniform rows of [[cell (biology)|cells]] with centrally placed pyknotic [[cell nucleus|nuclei]].  The cystic spaces have epithelium referred to as papillary infoldings that protude into them.  Additionally, the epithelium has lymphoid stroma with germinal center formation.


==Treatment==
==Treatment==
 
[[Warthin's tumor surgery|Surgery]] | [[Warthin's tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]]
Most of these tumors are treated with surgical removal.  Recurrence is rare, occurring in 6 - 12% of cases.  Warthin's tumor is highly unlikely to become [[malignant]].
==Case Studies==
 
:[[Warthin's tumor case study one|Case #1]]
==Additional images==
 
[[Image:Warthin tumor (1).jpg|thumb|200px|left|Histopathology of Warthin tumor in the parotid gland. H&E stain.]]
[[Image:Warthin tumor (2).jpg||thumb|200px|left|Histopathology of Warthin tumor in the parotid gland. Another view of a file "Warthin tumor (1).jpg". H&E stain.]]
[[Image:Warthin tumor (3).jpg||thumb|200px|left|Histopathology of Warthin tumor in the parotid gland. Higher magnification of a file "Warthin tumor (1).jpg". H&E stain.]]
 
==References==
*Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
 
==See also==
==See also==
* [[Pleomorphic adenoma]]
* [[Pleomorphic adenoma]]


==External links==
* [http://www.thedoctorsdoctor.com/diseases/warthinstumor.htm Doctor's Doctor]
* [http://www.ghorayeb.com/WarthinsTumor.html Picture]
* [http://web2.iadfw.net/uthman/specimens/images/warthin.html Photo]
* [http://www.bizbozos.com/nci_Warthin_s_Tumor Overview]


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Latest revision as of 17:43, 27 November 2017

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Michael Maddaleni, B.S.; Ammu Susheela, M.D. [2]

Synonyms and keywords: Adenolymphoma; Albrecht-Arzt-Warthin tumor; papillary cystadenoma lymphomatosum; Warthin tumour

Warthin's tumor Microchapters

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Overview

Historical Perspective

Pathophysiology

Causes

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Risk Factors

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Diagnosis

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Physical Examination

Laboratory Findings

CT

MRI

Echocardiography or Ultrasound

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Biopsy

Treatment

Surgery

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Case Studies

Case #1

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Overview

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Pathophysiology

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Epidemiology and Demographics

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History and Symptoms | Physical Examination | Laboratory Findings | Echocardiography or Ultrasound | CT | MRI | Other Imaging Findings | Biopsy

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Case #1

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