Pericarditis pathophysiology: Difference between revisions

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{{Pericarditis}}
{{Pericarditis}}


{{CMG}}
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Varun Kumar, M.B.B.S.]], {{CZ}}, [[User:Rim Halaby|Rim Halaby]]{{Homa}}


==Classification==
==Overview==
Pericarditis can be classified according to the composition of the inflammatory [[exudate]] or the composition of the fluid that accumulates around the heart.
Pericarditis is [[inflammation]] of the [[pericardium]], which is the double-walled sac that contains the [[heart]] and the roots of the [[great vessels]]. There can be an accompanying accumulation of [[fluid]] that can be either [[serous]] (free flowing [[fluid]]) or [[fibrinous]] (an [[exudate]], which is a thick [[fluid]] composed of [[proteins]], [[fibrin]] strands, [[inflammatory cells]], [[cell]] breakdown products, and sometimes [[bacteria]]). [[Vascular congestion]] of the [[pericardium]] is also present. The underlying [[myocardium]] may or may not be [[inflamed]] as well. If the [[myocardium]] is involved in the [[inflammatory process]], it is called [[myopericarditis]], and [[CK]] and [[troponin]] levels may be elevated. [[Cardio|Cardiotropic]] [[viruses]] usually spread to the [[myocardium]] and [[pericardium]] [[Hematogen|hematogenously]] and cause [[acute]] [[inflammation]] with [[Infiltration (medical)|infiltration]] of [[Polymorphonuclear cells|polymorphonuclear]] ([[PMN]]) [[leukocytes]] and [[pericardial]] vascularization. Most [[patients]] with [[viral]] pericarditis recover completely with few developing recurrences. Some [[patients]] develop [[constrictive pericarditis]] which could be disabling. [[Bacterial]] pericarditis results from [[contiguous]] spread of [[infection]] within the [[chest]], either [[de novo]] or after [[surgery]] or [[trauma]], spread from [[infective endocarditis]], [[Hematogen|hematogenous]], or direct [[inoculation]] as a result of [[Penetrating trauma|penetrating injury]] or [[cardiothoracic surgery]].


Types include:
==Pathophysiology==
* [[Serous]]
===Anatomy and Physiology of Pericardium===
* [[Purulent]]
* [[Uremic pericarditis|fibrinous]]
* [[Caseous]]
* [[Hemopericardium|Hemorrhagic]]
* [[Dressler's Syndrome|Post infarction or Dressler's Syndrome]]


===Acute Versus Chronic Pericarditis===
====Layers of the Pericardium====
Depending on the timing of presentation and duration, pericarditis is divided into "acute" and "chronic" forms. Clinically, acute pericarditis presents within 6 weeks of the disease onset; subacute pericarditis presents within 6 weeks to 6 months of the disease onset; and chronic pericarditis manifests after 6 months of the disease onset.[[Acute pericarditis]] is more common than chronic pericarditis, and often occurs as a complication of viral infections, immunologic conditions, or as a result of a [[heart attack]] ([[myocardial infarction]]). Chronic pericarditis is less common, which may manifest as scarring of the pericardium a condition known as [[constrictive pericarditis]].
*The [[pericardium]] is made up of two layers:<ref =="" “kishore”="">Kishore, K. (2003). The Heart of Structural Development: The Functional Basis of the Location and Morphology of the Human Vascular Pump. J Postgrad Med, 49:282-4.</ref><ref =="" "moore"="">Moore, K. L., Agur, A. M., & Dalley, A. F. (2011). Essential Clinical Anatomy - Fourth Edition. Lippincott Williams & Wilkins.</ref><ref =="" "tank"="">Tank, P. W. (2009). Grant's Dissector - Fourteenth Edition. Lippincott Williams & Wilkins.</ref>
**[[Fibrous]] [[pericardium]]:
***Hard protective external layer
***Attached to [[sternum]] anteriorly by [[Sternum|sterno]]-[[pericardial]] [[ligaments]] and fused with the [[central tendon]] of the [[diaphragm]] and [[great vessels]] to allow [[mobility]] of the [[pericardial sac]] against sudden [[cardiac]] overfilling
**[[Serous pericardium]]:
***Smooth [[internal]] layer made up of 2 components:
****[[Parietal]]: reflects onto [[fibrous pericardium]]
****[[Visceral]]: reflects onto [[heart]] and [[great vessels]] and forms the [[epicardium]], the external layer of the [[heart]] wall
*[[Pericardial cavity]]: Potential space between [[parietal]] and [[visceral]] layers. It contains a [[serous fluid]] film that occupies the [[cavity]] and functions as [[lubricant]] against [[friction]] by all [[chest]] movements.


==Gross Pathology Images==
====Pericardial Sinuses====


[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]  
*There are two small chambers or [[Sinuse|sinuses]] located where the [[visceral]] and [[parietal]] [[pericardium]] are [[continuous]] with one another within the [[pericardial cavity]].<ref =="" “kishore”="">Kishore, K. (2003). The Heart of Structural Development: The Functional Basis of the Location and Morphology of the Human Vascular Pump. J Postgrad Med, 49:282-4.</ref><ref =="" "moore"="">Moore, K. L., Agur, A. M., & Dalley, A. F. (2011). Essential Clinical Anatomy - Fourth Edition. Lippincott Williams & Wilkins.</ref><ref =="" "tank"="">Tank, P. W. (2009). Grant's Dissector - Fourteenth Edition. Lippincott Williams & Wilkins.</ref>
*[[Transverse sinus]]:
**Located [[posterior]] to the [[pulmonary trunk]] and [[ascending aorta]] at the level between the [[superior vena cava]] and [[aortic arch]]
**Formed after [[dorsal]] [[myocardium]] ruptured [[Embryonic|embryonically]]
**Functional role is to allow the unhindered expansion of [[great arteries]] [[Posterior|posteriorly]] during [[cardiac]] [[systole]]
**Utilized [[Surgery|surgically]] to pass surgical [[Clamp connection|clamps]] or place [[Ligature|ligatures]] around [[great arteries]].
*[[Oblique sinus]]:
**A blind recess (cul-de-sac) [[posterior]] to the [[left atrium]] between [[superior vena cava]], right and left [[pulmonary vein]]s inferior to the [[Transverse sinuses|transverse sinus]]
**Formed [[Embryonic|embryonically]] by the incorporation of the [[pulmonary vein]] [[tributaries]] into the [[left atrium]]
**Functional role believed to be the expansion of the [[left atrium]] upon normal [[collapse]] of the [[thorax]]


<div align="left">
<div align="center"><gallery heights="125" widths="125">
<gallery heights="175" widths="175">
Image:Pericardium.JPG
Image:Pericarditis 0001.jpg|Fibrinous pericarditis: Gross, natural color, an excellent example of bread and butter appearance. Uremia, chronic glomerulonephritis and sepsis.
Image:Pericardial sinuses.JPG
Image:Pericarditis 0002.jpg|Fibrinous pericarditis: Gross, a good example (bread and butter appearance).
Image:Pericarditis 0003.jpg|Fibrinous pericarditis: Gross, an excellent example.
</gallery>
</gallery>
</div>
</div>




<div align="left">
 
<gallery heights="175" widths="175">
 
Image:Pericarditis 0004.jpg|Fibrinous pericarditis: Gross, an excellent example, close-up view of fibrin.
 
Image:Pericarditis 0005.jpg|Fibrinous pericarditis: Gross, an excellent example, close-up view.
 
Image:Pericarditis 0006.jpg|Fibrinous pericarditis: Gross, an excellent example.
 
<br />
====Diseases of the Pericardium====
 
* [[Pericarditis]] is an [[inflammatory]] condition of the [[pericardium]].
* [[Pericardial effusion]] is [[fluid]] accumulation in the [[pericardial sac]].
* [[Constrictive pericarditis]] occurs when there is a [[scar]] encasing, the [[heart]] that [[Chronic (medicine)|chronically]] constricts the filling of the [[heart]].
* [[Cardiac tamponade]] is a [[medical emergency]] in which [[fluid]] in the [[pericardial sac]] [[Acute (medicine)|acutely]] restricts the filling of the [[heart]]. This requires [[Surgery|surgical]] drainage or [[pericardiocentesis]].
 
<br />
 
==== Additional Images ====
 
 
 
<br /><gallery>
Image:Gray806.png|The phrenic nerve and its relations with the vagus nerve.
Image:Gray846.png|Thoracic portion of the sympathetic trunk.
Image:Gray1088.png|Liver with the septum transversum. Human embryo 3 mm long.
Image:Gray1178.png|The thymus of a full-time fetus, exposed in situ.
</gallery>
</gallery>
</div>




<div align="left">
<gallery heights="175" widths="175">
Image:Pericarditis 0007.jpg|Fibrinous pericarditis: Gross, external view of localized pericarditis over an acute infarction 
Image:Pericarditis 0008.jpg|Fibrinous pericarditis: Gross, intact heart, good example 
Image:Pericarditis 0009.jpg|Fibrinous pericarditis: Gross, good example, mild, with small amount of fibrin 
</gallery>
</div>




<div align="left">
<gallery heights="175" widths="175">
Image:Pericarditis 0010.jpg|Fibrinous pericarditis: Gross, close-up, an excellent example of color and detail
Image:Pericarditis 0011.jpg|Fibrinous pericarditis: Gross, a good example 
Image:Pericarditis 0012.jpg|Fibrinous pericarditis: Gross, a good example, very mild case
</gallery>
</div>


===Pathogenesis===
*Cardiotropic [[viruses]] usually spread to the [[myocardium]] and [[pericardium]] [[Hematogen|hematogenously]] and cause [[acute]] [[inflammation]] with [[Infiltration (medical)|infiltration]] of [[Polymorphonuclear cells|polymorphonuclear]] ([[PMN]]) [[leukocytes]] and [[pericardial]] vascularization. This may cause [[pericardial effusion]] and [[fibrinous]] change of the [[pericardium]]. The [[pericardium]] may also develop a [[serous]] or [[hemorrhagic]] effusion. Most [[patients]] with [[viral]] pericarditis recover completely with few developing recurrences. Some [[patients]] develop [[constrictive pericarditis]] which could be disabling.<ref name="pmid5489188">{{cite journal| author=Matthews JD, Cameron SJ, George M| title=Constrictive pericarditis following Coxsackie virus infection. | journal=Thorax | year= 1970 | volume= 25 | issue= 5 | pages= 624-6 | pmid=5489188 | doi= | pmc=PMC472200 | url= }} </ref><ref name="pmid1920818">{{cite journal| author=Ilan Y, Oren R, Ben-Chetrit E| title=Acute pericarditis: etiology, treatment and prognosis. A study of 115 patients. | journal=Jpn Heart J | year= 1991 | volume= 32 | issue= 3 | pages= 315-21 | pmid=1920818 | doi= | pmc= | url= }} </ref><ref name="pmid2249218">{{cite journal| author=Shabetai R| title=Acute pericarditis. | journal=Cardiol Clin | year= 1990 | volume= 8 | issue= 4 | pages= 639-44 | pmid=2249218 | doi= | pmc= | url= }} </ref>
*[[Bacterial]] pericarditis results from:<ref name="pmid930941">{{cite journal| author=Klacsmann PG, Bulkley BH, Hutchins GM| title=The changed spectrum of purulent pericarditis: an 86 year autopsy experience in 200 patients. | journal=Am J Med | year= 1977 | volume= 63 | issue= 5 | pages= 666-73 | pmid=930941 | doi= | pmc= | url= }} </ref><ref name="pmid4200204">{{cite journal| author=Kauffman CA, Watanakunakorn C, Phair JP| title=Purulent pneumococcal pericarditis. A continuing problem in the antibiotic era. | journal=Am J Med | year= 1973 | volume= 54 | issue= 6 | pages= 743-50 | pmid=4200204 | doi= | pmc= | url= }} </ref><ref name="pmid1138554">{{cite journal| author=Rubin RH, Moellering RC| title=Clinical, microbiologic and therapeutic aspects of purulent pericarditis. | journal=Am J Med | year= 1975 | volume= 59 | issue= 1 | pages= 68-78 | pmid=1138554 | doi= | pmc= | url= }} </ref><ref name="pmid4076207">{{cite journal| author=Ribeiro P, Shapiro L, Nihoyannopoulos P, Gonzalez A, Oakley CM| title=Pericarditis in infective endocarditis. | journal=Eur Heart J | year= 1985 | volume= 6 | issue= 11 | pages= 975-8 | pmid=4076207 | doi= | pmc= | url= }} </ref><ref name="pmid4402567">{{cite journal| author=Roberts WC, Buchbinder NA| title=Right-sided valvular infective endocarditis. A clinicopathologic study of twelve necropsy patients. | journal=Am J Med | year= 1972 | volume= 53 | issue= 1 | pages= 7-19 | pmid=4402567 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4402567  }} </ref>
#[[Contiguous]] spread of [[infection]] within the [[chest]], either [[de novo]] or after [[surgery]] or [[trauma]].
#Spread from [[infective endocarditis]]
#[[Hematogen|Hematogenous]] spread of [[infection]]
#Direct [[inoculation]] as a result of [[Penetrating trauma|penetrating injury]] or [[cardiothoracic surgery]]
*[[Tuberculous]] pericarditis develops from [[lymphatic]] spread of peritracheal, peribronchial or [[mediastinal]] [[lymph nodes]] or by [[contiguous]] spread from a focus of [[infection]] in the [[lung]] or [[pleura]]. There are four pathologic stages observed:<ref name="pmid18610109">{{cite journal| author=Peel AA| title=TUBERCULOUS PERICARDITIS. | journal=Br Heart J | year= 1948 | volume= 10 | issue= 3 | pages= 195-207 | pmid=18610109 | doi= | pmc=PMC481044 | url= }} </ref><ref name="pmid4050698">{{cite journal| author=Permanyer-Miralda G, Sagristá-Sauleda J, Soler-Soler J| title=Primary acute pericardial disease: a prospective series of 231 consecutive patients. | journal=Am J Cardiol | year= 1985 | volume= 56 | issue= 10 | pages= 623-30 | pmid=4050698 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4050698  }} </ref><ref name="pmid16330703">{{cite journal| author=Mayosi BM, Burgess LJ, Doubell AF| title=Tuberculous pericarditis. | journal=Circulation | year= 2005 | volume= 112 | issue= 23 | pages= 3608-16 | pmid=16330703 | doi=10.1161/CIRCULATIONAHA.105.543066 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16330703  }} </ref>
:*Stage 1: Presence of [[diffuse]] [[fibrin]] [[Deposition (chemistry)|deposition]], [[granuloma]]s and abundant [[mycobacterium]].
:*Stage 2: Development of [[serous]] or [[Serosanguineous discharge|serosanguineous]] [[pericardial effusion]] with a predominantly [[lymphocytic]] [[exudate]] with [[monocyte]]s and [[foam cells]].
:*Stage 3: [[Absorption]] of effusion with the organization of [[granulomatous]] caseation and thickening of [[pericardium]] [[secondary]] to [[Deposition (chemistry)|deposition]] of [[fibrin]] and [[collagen]].
:*Stage 4: [[Development]] of [[constrictive pericarditis]]. The [[pericardial space]] is obliterated by [[dense]] [[adhesions]] with marked thickening of the parietal layer and replacement of [[granuloma]]s by [[fibrous]] [[tissue]].
:These types of [[granulomatous]] pericarditis also occur with [[fungal infection]]s, [[rheumatoid arthritis]] ([[RA]]), and [[sarcoidosis]].


<div align="left">
*Pericarditis in [[renal failure]] is thought to result from [[inflammation]] of the [[visceral]] and [[parietal]] layers of the [[pericardium]] by [[metabolic]] [[toxins]] such as [[urea]], [[creatinine]], [[uric acid]], methylguanidine, [[guanidinoacetate]], [[parathyroid hormone]], [[Beta-2 microglobulin|beta2-microglobulin]], and others. It may be associated with [[hemorrhagic]] or [[serous]] effusion.
<gallery heights="175" widths="175">
Image:Pericarditis 0013.jpg|Fibrinous pericarditis: Gross, an excellent example.
Image:Pericarditis 0014.jpg|Fibrinous pericarditis: Gross, a close-up view, an excellent illustration of fibrinous exudate.
Image:Pericarditis 0015.jpg|Pericarditis in [[uremia]]
</gallery>
</div>


==Gross Pathology Images==
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]


<div align="left">
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<gallery heights="175" widths="175">
<gallery heights="175" widths="175">
Image:Pericarditis 0016.jpg|Fibrinous pericarditis: Gross, fixed tissue (note to color changes), a close-up view of fibrin on epicardial surface of heart. A typical example.
Image:Pericarditis 0001.jpg|Fibrinous pericarditis: Gross, natural color, an excellent example of bread and butter appearance. Uremia, chronic glomerulonephritis and sepsis.
Image:Pericarditis 0017.jpg|Fibrinous pericarditis: Gross, natural color, large right atrial thrombus and fibrinous pericarditis. Normal [[tricuspid valve]] with some aging changes (good example)
Image:Pericarditis 0002.jpg|Fibrinous pericarditis: Gross, a good example (bread and butter appearance).
Image:Pericarditis 0018.jpg|Fibrinous pericarditis: Gross, natural color
Image:Pericarditis 0003.jpg|Fibrinous pericarditis: Gross, an excellent example.
</gallery>
</gallery>
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<gallery heights="175" widths="175">
<gallery heights="175" widths="175">
Image:Pericarditis 0019.jpg|Fibrinous pericarditis: Gross, natural color, an excellent example  
Image:Pericarditis 0004.jpg|Fibrinous pericarditis: Gross, an excellent example, close-up view of fibrin.
Image:Pericarditis 0020.jpg|Fibrinous pericarditis: Gross, natural color, very close-up photo showing fibrinous exudate simulating frost (an excellent example)
Image:Pericarditis 0005.jpg|Fibrinous pericarditis: Gross, an excellent example, close-up view.
Image:Pericarditis 0021.jpg|Rheumatoid fibrinous pericarditis: Gross, natural color, a typical lesion in 22 years old white female due to juvenile rheumatoid arthritis.
Image:Pericarditis 0006.jpg|Fibrinous pericarditis: Gross, an excellent example.
</gallery>
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<gallery heights="175" widths="175">
<gallery heights="175" widths="175">
Image:Pericarditis 0022.jpg|Fibrinous pericarditis: Gross, natural color, close-up view of minimal fibrinous exudate on epicardial surface due to terminal renal failure
Image:Pericarditis 0007.jpg|Fibrinous pericarditis: Gross, external view of localized pericarditis over an acute infarction.
Image:Pericarditis 0023.jpg|Fibrinous pericarditis: Gross, natural color, anterior view of heart with mild fibrinous exudate over epicardium due to terminal renal failure
Image:Pericarditis 0008.jpg|Fibrinous pericarditis: Gross, intact heart, good example.
Image:Pericarditis 0024.jpg|Tuberculous pericarditis: Gross, natural color, shaggy hemorrhagic exudate. This case is much more hemorrhagic than the typical tuberculous pericarditis.
Image:Pericarditis 0009.jpg|Fibrinous pericarditis: Gross, good example, mild, with small amount of fibrin.
</gallery>
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<gallery heights="175" widths="175">
<gallery heights="175" widths="175">
Image:Pericarditis 0025.jpg|Heart transplant: Gross, natural color, external view of heart. Two months after transplantation with fibrinous pericarditis
Image:Pericarditis 0010.jpg|Fibrinous pericarditis: Gross, close-up, an excellent example of color and detail.
Image:Pericarditis 0026.jpg|Neoplastic pericarditis: Gross, natural color, shaggy pericarditis. Primer is adenocarcinoma of the lung.
Image:Pericarditis 0011.jpg|Fibrinous pericarditis: Gross, a good example.
Image:Pericarditis 0027.jpg|Heart: Septic pericarditis
Image:Pericarditis 0012.jpg|Fibrinous pericarditis: Gross, a good example, very mild case.
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<gallery heights="175" widths="175">
<gallery heights="175" widths="175">
Image:Hemopericardium 001.jpg|Hemopericardium: Gross, an excellent in situ view 
Image:Pericarditis 0013.jpg|Fibrinous pericarditis: Gross, an excellent example.
Image:Hemopericardium 002.jpg|Hemopericardium: Gross, in situ, unopened pericardium (a very good  example)
Image:Pericarditis 0014.jpg|Fibrinous pericarditis: Gross, a close-up view, an excellent illustration of fibrinous exudate.
Image:Hemopericardium 003.jpg|Hemopericardium: Gross, natural color, heart in situ with opened pericardium and filled with red blood clot (quite good example) dissecting aneurysm 
Image:Pericarditis 0015.jpg|Pericarditis in [[uremia]].
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<gallery heights="175" widths="175">
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Image:Hemopericardium 004.jpg|Hemopericardium due to Needle Puncture: Gross, natural color, external view of heart covered by blood 
Image:Pericarditis 0016.jpg|Fibrinous pericarditis: Gross, fixed tissue (note to color changes), a close-up view of fibrin on epicardial surface of heart, a typical example.
Image:Hemopericardium 005.jpg|Needle Puncture Mark in Epicardium: Gross, natural color, close-up of needle puncture marks tap resulted in hemopericardium 
Image:Pericarditis 0017.jpg|Fibrinous pericarditis: Gross, natural color, large right atrial thrombus and fibrinous pericarditis. Normal [[tricuspid valve]] with some aging changes (good example).
Image:Hemopericardium 006.jpg|Hemopericardium: Hemopericardium caused by pericardiocentesis: Gross, natural color, close-up view of apex of the heart. Needle apparently entered the distal posterior descending artery.  
Image:Pericarditis 0018.jpg|Fibrinous pericarditis: Gross, natural color.
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Image:Hemopericardium 007.jpg|Hemopericardium: Hemopericardium caused by pericardiocentesis: Gross, natural color, view of apex of the heart. Needle apparently entered the distal posterior descending artery
Image:Pericarditis 0019.jpg|Fibrinous pericarditis: Gross, natural color, an  excellent example.
Image:Hemopericardium 008.jpg|Hemopericardium: Hemopericardium due to pericardiocentesis: Gross, fixed tissue, close-up view of slice through distal posterior descending artery showing periarterial hemorrhage
Image:Pericarditis 0020.jpg|Fibrinous pericarditis: Gross, natural color, very close-up photo showing fibrinous exudate simulating frost (an excellent example).
Image:Hemopericardium 009.jpg|Hemopericardium: Liver:  Gross, natural color, typical shock liver case of death due to hemopericardium secondary to pericardiocentesis 
Image:Pericarditis 0021.jpg|Rheumatoid fibrinous pericarditis: Gross, natural color, a typical lesion in 22 years old white female due to juvenile rheumatoid arthritis.
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Image:Hemopericardium 010.jpg|Hemopericardium in newborn: Gross, natural color, opened body with large collection blood in pericardial sac. Cause uncertain. A 26 week premature with hyaline membrane disease and DIC 
Image:Pericarditis 0022.jpg|Fibrinous pericarditis: Gross, natural color, close-up view of minimal fibrinous exudate on epicardial surface due to terminal renal failure.
Image:Hemopericardium 011.jpg|Hemopericardium: Myocardial Infarction and Ventricular Rupture
Image:Pericarditis 0023.jpg|Fibrinous pericarditis: Gross, natural color, anterior view of heart with mild fibrinous exudate over epicardium due to terminal renal failure.
Image:Pericarditis 0024.jpg|Tuberculous pericarditis: Gross, natural color, shaggy hemorrhagic exudate. This case is much more hemorrhagic than the typical tuberculous pericarditis.
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Image:Hemopericardium 012.jpg|Hemopericardium: Infarct rupture after 7 days of chest pain onset.  
Image:Pericarditis 0025.jpg|Heart transplant: Gross, natural color, external view of heart. Two months after transplantation with fibrinous pericarditis.
Image:Hemopericardium 013.jpg|Hemopericardium in dissecting aneurysm: Gross, heart with root of aorta to show hemorrhage into pericardium (very good example) 
Image:Pericarditis 0026.jpg|Neoplastic pericarditis: Gross, natural color, shaggy pericarditis. Primer is adenocarcinoma of the lung.
Image:Pericarditis 0027.jpg|Heart: Septic pericarditis.
</gallery>
</gallery>
</div>
</div>


==Microscopic Pathology Images==
==Microscopic Pathology Images==
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]  
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]  


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==Videos==
{|
|-
!{{#ev:youtube|AKS7kSl4x5k}}
!Acute Fibrinous Pericarditis
{{#ev:youtube|5fz_W1YxbC8}}
|}


* <Youtube v=AKS7kSl4x5k/>
==References==
 
 
* Acute fibrinous pericarditis
 
<Youtube v=5fz_W1YxbC8/>
 
{{Reflist|2}}
{{Reflist|2}}
{{WH}}
{{WS}}


[[Category:Medicine]]
[[Category:Cardiology]]
[[Category:Cardiology]]
 
[[Category:Up-To-Date]]
{{WH}}
[[Category:Emergency medicine]]
{{WS}}
[[Category:Intensive care medicine]]

Latest revision as of 23:39, 29 July 2020

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Risk calculators and risk factors for Pericarditis pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S., Cafer Zorkun, M.D., Ph.D. [2], Rim Halaby Homa Najafi, M.D.[3]

Overview

Pericarditis is inflammation of the pericardium, which is the double-walled sac that contains the heart and the roots of the great vessels. There can be an accompanying accumulation of fluid that can be either serous (free flowing fluid) or fibrinous (an exudate, which is a thick fluid composed of proteins, fibrin strands, inflammatory cells, cell breakdown products, and sometimes bacteria). Vascular congestion of the pericardium is also present. The underlying myocardium may or may not be inflamed as well. If the myocardium is involved in the inflammatory process, it is called myopericarditis, and CK and troponin levels may be elevated. Cardiotropic viruses usually spread to the myocardium and pericardium hematogenously and cause acute inflammation with infiltration of polymorphonuclear (PMN) leukocytes and pericardial vascularization. Most patients with viral pericarditis recover completely with few developing recurrences. Some patients develop constrictive pericarditis which could be disabling. Bacterial pericarditis results from contiguous spread of infection within the chest, either de novo or after surgery or trauma, spread from infective endocarditis, hematogenous, or direct inoculation as a result of penetrating injury or cardiothoracic surgery.

Pathophysiology

Anatomy and Physiology of Pericardium

Layers of the Pericardium

Pericardial Sinuses





Diseases of the Pericardium


Additional Images


  • The phrenic nerve and its relations with the vagus nerve.

    The phrenic nerve and its relations with the vagus nerve.

  • Thoracic portion of the sympathetic trunk.

    Thoracic portion of the sympathetic trunk.

  • Liver with the septum transversum. Human embryo 3 mm long.

    Liver with the septum transversum. Human embryo 3 mm long.

  • The thymus of a full-time fetus, exposed in situ.

    The thymus of a full-time fetus, exposed in situ.



Pathogenesis

  1. Contiguous spread of infection within the chest, either de novo or after surgery or trauma.
  2. Spread from infective endocarditis
  3. Hematogenous spread of infection
  4. Direct inoculation as a result of penetrating injury or cardiothoracic surgery
These types of granulomatous pericarditis also occur with fungal infections, rheumatoid arthritis (RA), and sarcoidosis.

Gross Pathology Images

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

  • Fibrinous pericarditis: Gross, natural color, an excellent example of bread and butter appearance. Uremia, chronic glomerulonephritis and sepsis.

    Fibrinous pericarditis: Gross, natural color, an excellent example of bread and butter appearance. Uremia, chronic glomerulonephritis and sepsis.

  • Fibrinous pericarditis: Gross, a good example (bread and butter appearance).

    Fibrinous pericarditis: Gross, a good example (bread and butter appearance).

  • Fibrinous pericarditis: Gross, an excellent example.

    Fibrinous pericarditis: Gross, an excellent example.


  • Fibrinous pericarditis: Gross, an excellent example, close-up view of fibrin.

    Fibrinous pericarditis: Gross, an excellent example, close-up view of fibrin.

  • Fibrinous pericarditis: Gross, an excellent example, close-up view.

    Fibrinous pericarditis: Gross, an excellent example, close-up view.

  • Fibrinous pericarditis: Gross, an excellent example.

    Fibrinous pericarditis: Gross, an excellent example.


  • Fibrinous pericarditis: Gross, external view of localized pericarditis over an acute infarction.

    Fibrinous pericarditis: Gross, external view of localized pericarditis over an acute infarction.

  • Fibrinous pericarditis: Gross, intact heart, good example.

    Fibrinous pericarditis: Gross, intact heart, good example.

  • Fibrinous pericarditis: Gross, good example, mild, with small amount of fibrin.

    Fibrinous pericarditis: Gross, good example, mild, with small amount of fibrin.


  • Fibrinous pericarditis: Gross, close-up, an excellent example of color and detail.

    Fibrinous pericarditis: Gross, close-up, an excellent example of color and detail.

  • Fibrinous pericarditis: Gross, a good example.

    Fibrinous pericarditis: Gross, a good example.

  • Fibrinous pericarditis: Gross, a good example, very mild case.

    Fibrinous pericarditis: Gross, a good example, very mild case.


  • Fibrinous pericarditis: Gross, an excellent example.

    Fibrinous pericarditis: Gross, an excellent example.

  • Fibrinous pericarditis: Gross, a close-up view, an excellent illustration of fibrinous exudate.

    Fibrinous pericarditis: Gross, a close-up view, an excellent illustration of fibrinous exudate.

  • Pericarditis in uremia.

    Pericarditis in uremia.


  • Fibrinous pericarditis: Gross, fixed tissue (note to color changes), a close-up view of fibrin on epicardial surface of heart, a typical example.

    Fibrinous pericarditis: Gross, fixed tissue (note to color changes), a close-up view of fibrin on epicardial surface of heart, a typical example.

  • Fibrinous pericarditis: Gross, natural color, large right atrial thrombus and fibrinous pericarditis. Normal tricuspid valve with some aging changes (good example).

    Fibrinous pericarditis: Gross, natural color, large right atrial thrombus and fibrinous pericarditis. Normal tricuspid valve with some aging changes (good example).

  • Fibrinous pericarditis: Gross, natural color.

    Fibrinous pericarditis: Gross, natural color.


  • Fibrinous pericarditis: Gross, natural color, an excellent example.

    Fibrinous pericarditis: Gross, natural color, an excellent example.

  • Fibrinous pericarditis: Gross, natural color, very close-up photo showing fibrinous exudate simulating frost (an excellent example).

    Fibrinous pericarditis: Gross, natural color, very close-up photo showing fibrinous exudate simulating frost (an excellent example).

  • Rheumatoid fibrinous pericarditis: Gross, natural color, a typical lesion in 22 years old white female due to juvenile rheumatoid arthritis.

    Rheumatoid fibrinous pericarditis: Gross, natural color, a typical lesion in 22 years old white female due to juvenile rheumatoid arthritis.


  • Fibrinous pericarditis: Gross, natural color, close-up view of minimal fibrinous exudate on epicardial surface due to terminal renal failure.

    Fibrinous pericarditis: Gross, natural color, close-up view of minimal fibrinous exudate on epicardial surface due to terminal renal failure.

  • Fibrinous pericarditis: Gross, natural color, anterior view of heart with mild fibrinous exudate over epicardium due to terminal renal failure.

    Fibrinous pericarditis: Gross, natural color, anterior view of heart with mild fibrinous exudate over epicardium due to terminal renal failure.

  • Tuberculous pericarditis: Gross, natural color, shaggy hemorrhagic exudate. This case is much more hemorrhagic than the typical tuberculous pericarditis.

    Tuberculous pericarditis: Gross, natural color, shaggy hemorrhagic exudate. This case is much more hemorrhagic than the typical tuberculous pericarditis.


  • Heart transplant: Gross, natural color, external view of heart. Two months after transplantation with fibrinous pericarditis.

    Heart transplant: Gross, natural color, external view of heart. Two months after transplantation with fibrinous pericarditis.

  • Neoplastic pericarditis: Gross, natural color, shaggy pericarditis. Primer is adenocarcinoma of the lung.

    Neoplastic pericarditis: Gross, natural color, shaggy pericarditis. Primer is adenocarcinoma of the lung.

  • Heart: Septic pericarditis.

    Heart: Septic pericarditis.

Microscopic Pathology Images

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

  • Tuberculous pericarditis.

    Tuberculous pericarditis.

  • Tuberculous pericarditis.

    Tuberculous pericarditis.

  • Tuberculous pericarditis: Micro oil acid fast stain. The organism easily seen.

    Tuberculous pericarditis: Micro oil acid fast stain. The organism easily seen.


  • Tuberculous pericarditis: Micro oil acid fast stain. The organism easily seen.

    Tuberculous pericarditis: Micro oil acid fast stain. The organism easily seen.

  • Uremic pericarditis: Micro med mag, H&E. A good example

    Uremic pericarditis: Micro med mag, H&E. A good example

  • Tuberculous pericarditis: Micro med mag, H&E, a typical lesion

    Tuberculous pericarditis: Micro med mag, H&E, a typical lesion


  • Fibrinous pericarditis.

    Fibrinous pericarditis.

  • Pericarditis fibrinosa (Fibrinous pericarditis).

    Pericarditis fibrinosa (Fibrinous pericarditis).

  • Malignant Mesothelioma, Biphasic Type: Pericardium: This tumor has epithelioid cells (lower half) surrounded by spindled cells. The patient was a 46-year-old woman with constrictive pericarditis; the pericardium was studded with coalescing tumor nodules.

    Malignant Mesothelioma, Biphasic Type: Pericardium: This tumor has epithelioid cells (lower half) surrounded by spindled cells. The patient was a 46-year-old woman with constrictive pericarditis; the pericardium was studded with coalescing tumor nodules.

Videos

AKS7kSl4x5k}} Acute Fibrinous Pericarditis

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References

  1. ↑ Kishore, K. (2003). The Heart of Structural Development: The Functional Basis of the Location and Morphology of the Human Vascular Pump. J Postgrad Med, 49:282-4.
  2. ↑ Moore, K. L., Agur, A. M., & Dalley, A. F. (2011). Essential Clinical Anatomy - Fourth Edition. Lippincott Williams & Wilkins.
  3. ↑ Tank, P. W. (2009). Grant's Dissector - Fourteenth Edition. Lippincott Williams & Wilkins.
  4. ↑ Kishore, K. (2003). The Heart of Structural Development: The Functional Basis of the Location and Morphology of the Human Vascular Pump. J Postgrad Med, 49:282-4.
  5. ↑ Moore, K. L., Agur, A. M., & Dalley, A. F. (2011). Essential Clinical Anatomy - Fourth Edition. Lippincott Williams & Wilkins.
  6. ↑ Tank, P. W. (2009). Grant's Dissector - Fourteenth Edition. Lippincott Williams & Wilkins.
  7. ↑ Matthews JD, Cameron SJ, George M (1970). "Constrictive pericarditis following Coxsackie virus infection". Thorax. 25 (5): 624–6. PMC 472200. PMID 5489188.
  8. ↑ Ilan Y, Oren R, Ben-Chetrit E (1991). "Acute pericarditis: etiology, treatment and prognosis. A study of 115 patients". Jpn Heart J. 32 (3): 315–21. PMID 1920818.
  9. ↑ Shabetai R (1990). "Acute pericarditis". Cardiol Clin. 8 (4): 639–44. PMID 2249218.
  10. ↑ Klacsmann PG, Bulkley BH, Hutchins GM (1977). "The changed spectrum of purulent pericarditis: an 86 year autopsy experience in 200 patients". Am J Med. 63 (5): 666–73. PMID 930941.
  11. ↑ Kauffman CA, Watanakunakorn C, Phair JP (1973). "Purulent pneumococcal pericarditis. A continuing problem in the antibiotic era". Am J Med. 54 (6): 743–50. PMID 4200204.
  12. ↑ Rubin RH, Moellering RC (1975). "Clinical, microbiologic and therapeutic aspects of purulent pericarditis". Am J Med. 59 (1): 68–78. PMID 1138554.
  13. ↑ Ribeiro P, Shapiro L, Nihoyannopoulos P, Gonzalez A, Oakley CM (1985). "Pericarditis in infective endocarditis". Eur Heart J. 6 (11): 975–8. PMID 4076207.
  14. ↑ Roberts WC, Buchbinder NA (1972). "Right-sided valvular infective endocarditis. A clinicopathologic study of twelve necropsy patients". Am J Med. 53 (1): 7–19. PMID 4402567.
  15. ↑ Peel AA (1948). "TUBERCULOUS PERICARDITIS". Br Heart J. 10 (3): 195–207. PMC 481044. PMID 18610109.
  16. ↑ Permanyer-Miralda G, Sagristá-Sauleda J, Soler-Soler J (1985). "Primary acute pericardial disease: a prospective series of 231 consecutive patients". Am J Cardiol. 56 (10): 623–30. PMID 4050698.
  17. ↑ Mayosi BM, Burgess LJ, Doubell AF (2005). "Tuberculous pericarditis". Circulation. 112 (23): 3608–16. doi:10.1161/CIRCULATIONAHA.105.543066. PMID 16330703.

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