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| {{Infobox_Disease | | | __NOTOC__ |
| Name = Pulmonary embolism |
| | {| class="infobox" style="float:right;" |
| Image = Pe on pulmonary angiography.jpg|
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| Caption = |
| | | [[File:Siren.gif|30px|link=Pulmonary embolism resident survival guide]]|| <br> || <br> |
| DiseasesDB = 10956 |
| | | [[Pulmonary embolism resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] |
| ICD10 = {{ICD10|I|26||i|26}} |
| | |} |
| ICD9 = {{ICD9|415.1}} |
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| ICDO = |
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| OMIM = |
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| MedlinePlus = 000132 |
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| }}
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| {{Pulmonary embolism}} | | {{Pulmonary embolism}} |
| {{CMG}}
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| '''Associate Editor-In-Chief:''' {{CZ}} | | '''For patient information, click [[{{PAGENAME}} (patient information)|here]]''' |
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| ==Overview==
| | '''For economy class syndrome, click [[economy class syndrome|here]]''' |
| '''Synonyms and Associated Terms:''' PE | |
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| '''Pulmonary embolism''' (PE) is a common illness that can cause death and significant disability. PE occurs when there is an acute obstruction of the [[pulmonary artery]] (or one of its branches). Most often this is due to a [[vein|venous]] [[thrombus]] (blood clot from a vein), which has been dislodged from its site of formation and [[embolism|embolizes]] to the [[pulmonary artery|arterial]] blood supply of one of the lungs. This process is termed ''[[thromboembolism]]''.
| | {{CMG}} {{ATI}}; {{AE}} {{CZ}}; {{Rim}} |
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| Patients present with a wide array of symptoms and signs. These may include [[dyspnea|difficulty breathing]], [[Pain and nociception|pain]] [[chest pain|in the chest]] during breathing, and in more severe cases [[Collapse (medical)|collapse]], [[Shock (medical)|circulatory instability]] and [[cardiac arrest|sudden death]]. PE treatment requires rapid and accurate risk stratification before haemodynamic decompensation and the development of cardiogenic shock. Therapeutic application most often consists of an [[anticoagulant]] medication, such as [[heparin]] and [[warfarin]], and rarely (in severe cases) with [[thrombolysis]] or surgery. In other, rarer forms of pulmonary embolism, material other than a blood clot is responsible; this may include [[Lipid|fat]] or [[bone]] (usually in association with significant trauma), air (often when diving), clumped [[tumor cell]]s, and [[amniotic fluid]] (affecting mothers during [[childbirth]]).
| | {{SK}} PE; lung blood clot; blood clot-lung; embolism-pulmonary |
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| ==[[Pulmonary embolism epidemiology and demographics|Epidemiology and Demographics]]== | | ==[[Pulmonary embolism overview|Overview]]== |
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| | ==[[Pulmonary embolism historical perspective|Historical Perspective]]== |
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| ==[[Pulmonary embolism risk factors|Risk factors]]== | | ==[[Pulmonary embolism classification|Classification]]== |
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| ==[[Pulmonary embolism pathophysiology|Pathophysiology]]== | | ==[[Pulmonary embolism pathophysiology|Pathophysiology]]== |
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| ==[[Pulmonary embolism natural history|Natural History, Complications & Prognosis]]== | | ==[[Pulmonary embolism causes|Causes]]== |
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| ==Diagnosis== | | ==[[Pulmonary embolism differential diagnosis|Differentiating Pulmonary Embolism from other Diseases]]== |
| The diagnosis of PE is based primarily on the clinical evaluation combined with diagnostic modalities such as spiral CT, V/Q scan, use of the D-dimer and lower extremity ultrasound.
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| === Pretest Probability === | | ==[[Pulmonary embolism epidemiology and demographics|Epidemiology and Demographics]]== |
| In spite of all of nonspecific clinical and lab findings, it has been shown that clinicians are actually fairly good at assigning meaningful clinical probabilities for PE.
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| *In PIOPED, 67% of the patients labeled as having a high clinical probability (>80% likelihood) had PE, as compared with only 9% of those give a low clinical probability (<20% likelihood).
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| *Unfortunately, the majority of patients (64%) were assigned an intermediate clinical probability (20 – 80% likelihood), reinforcing the fact that a clinical diagnosis can be difficult.
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| ====High Pretest Probability==== | | ==[[Pulmonary embolism risk factors|Risk Factors]]== |
| Many authors, reserve the term high pretest probability for those patients with a clinical presentation consistent with PE, in whom an alternative diagnosis is not apparent (e.g. pneumonia) and who have known risk factors for venous thromboembolism (VTE).
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| ====Low Pretest Probability==== | | ==[[Pulmonary embolism triggers|Triggers]]== |
| Low pretest probability patients include those patients with an alternative diagnosis to explain the clinical findings or those without risk factors.
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| ====Intermediate Pretest Probability==== | | ==[[Pulmonary embolism natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
| Intermediate probability patients include those patients not fitting either high or low pretest probability definitions.
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| ===Predicting the Risk of Pulmonary Embolism=== | | ==Diagnosis== |
| The decision to do medical imaging is usually based on clinical grounds, i.e. the [[medical history]], symptoms and findings on [[physical examination]].
| | [[Pulmonary embolism diagnostic approach|Diagnostic Approach]] | [[Pulmonary embolism assessment of clinical probability and risk scores|Assessment of Clinical Probability and Risk Scores]] | [[Pulmonary embolism assessment of probability of subsequent VTE and risk scores|Assessment of Probability of Subsequent VTE and Risk Scores]] | [[Pulmonary embolism history & symptoms|History and Symptoms]] | [[Pulmonary embolism physical examination|Physical Examination]] | [[Pulmonary embolism laboratory findings|Laboratory Findings]] | [[Pulmonary embolism arterial blood gas analysis|Arterial Blood Gas Analysis]] | [[Pulmonary embolism D-dimer|D-dimer]] | [[Pulmonary embolism biomarkers|Biomarkers]] | [[Pulmonary embolism electrocardiogram|Electrocardiogram]] | [[Pulmonary embolism chest x ray|Chest X Ray]] | [[Pulmonary embolism ventilation/perfusion scan|Ventilation/Perfusion Scan]] | [[Pulmonary embolism echocardiography|Echocardiography]] | [[Pulmonary embolism compression ultrasonography|Compression Ultrasonography]] | [[Pulmonary embolism CT|CT]] | [[Pulmonary embolism MRI|MRI]] |
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| ;Development of the Wells score
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| The most commonly used method to predict clinical probability, the Wells score, is [[clinical prediction rule]], whose use is complicated by multiple versions being available. In 1995, Wells ''et al'' initially developed a prediction rule (based on a literature search) to predict the likelihood of PE, based on clinical criteria.<ref name="pmid7752753">{{cite journal |author=Wells PS, Hirsh J, Anderson DR, Lensing AW, Foster G, Kearon C, Weitz J, D'Ovidio R, Cogo A, Prandoni P |title=Accuracy of clinical assessment of deep-vein thrombosis |journal=Lancet |volume=345 |issue=8961 |pages=1326-30 |year=1995 |pmid=7752753 |doi=doi:10.1016/S0140-6736(95)92535-X}}</ref> The prediction rule was revised in 1998<ref name="pmid9867786">{{cite journal |author=Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J |title=Use of a clinical model for safe management of patients with suspected pulmonary embolism |journal=Ann Intern Med |volume=129 |issue=12 |pages=997-1005 |year=1998 |pmid=9867786}}</ref> This prediction rule was further revised when simplified during a validation by Wells ''et al'' in 2000.<ref name="pmid10744147">{{cite journal | author = Wells P, Anderson D, Rodger M, Ginsberg J, Kearon C, Gent M, Turpie A, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J | title = Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. | journal = Thromb Haemost | volume = 83 | issue = 3 | pages = 416-20 | year = 2000 | id = PMID 10744147}}</ref> In the 2000 publication, Wells proposed two different scoring systems using cutoffs or 2 or 4 with the same prediction rule.<ref name="pmid10744147"/> In 2001, Wells published results using the more conservative cutoff of 2 to create three categories.<ref name="pmid11453709">{{cite journal |author=Wells PS, Anderson DR, Rodger M, Stiell I, Dreyer JF, Barnes D, Forgie M, Kovacs G, Ward J, Kovacs MJ |title=Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer |journal=Ann Intern Med |volume=135 |issue=2 |pages=98-107 |year=2001 |pmid=11453709 | url=http://www.annals.org/cgi/content/full/135/2/98}}</ref> An additional version, the "modified extended version", using the more recent cutoff of 2 but including findings from Wells's initial studies<ref name="pmid7752753"/><ref name="pmid9867786"/> were proposed.<ref name="pmid10739372">{{cite journal |author=Sanson BJ, Lijmer JG, Mac Gillavry MR, Turkstra F, Prins MH, Büller HR |title=Comparison of a clinical probability estimate and two clinical models in patients with suspected pulmonary embolism. ANTELOPE-Study Group |journal=Thromb. Haemost. |volume=83 |issue=2 |pages=199-203 |year=2000 |pmid=10739372}}</ref> Most recently, a further study reverted to Wells's earlier use of a cutoff of 4 points<ref name="pmid10744147"/> to create only two categories.<ref name="pmid16403929">{{cite journal |author=van Belle A, Büller H, Huisman M, Huisman P, Kaasjager K, Kamphuisen P, Kramer M, Kruip M, Kwakkel-van Erp J, Leebeek F, Nijkeuter M, Prins M, Sohne M, Tick L |title=Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography |journal=JAMA |volume=295 |issue=2 |pages=172-9 |year=2006 |pmid=16403929 | url=http://jama.ama-assn.org/cgi/content/full/295/2/172 | doi=10.1001/jama.295.2.172}}</ref>
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| There are additional prediction rules for PE, such as the Geneva rule. More importantly, the use of ''any'' rule is associated with reduction in recurrent thromboembolism.<ref name="pmid16461959">{{cite journal |author=Roy PM, Meyer G, Vielle B, Le Gall C, Verschuren F, Carpentier F, Leveau P, Furber A |title=Appropriateness of diagnostic management and outcomes of suspected pulmonary embolism |journal=Ann. Intern. Med. |volume=144 |issue=3 |pages=157-64 |year=2006 |pmid=16461959}}</ref>
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| ;Wells score
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| ''The Wells score'':<ref name="pmid12952389">{{cite journal |author=Neff MJ |title=ACEP releases clinical policy on evaluation and management of pulmonary embolism |journal=American family physician |volume=68 |issue=4 |pages=759-60 |year=2003 |pmid=12952389 |doi=|url=http://www.aafp.org/afp/20030815/practice.html}}</ref>
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| *clinically suspected [[DVT]] - 3.0 points
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| *alternative diagnosis is less likely than PE - 3.0 points
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| *tachycardia - 1.5 points
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| *immobilization/surgery in previous four weeks - 1.5 points
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| *history of DVT or PE - 1.5 points
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| *hemoptysis - 1.0 points
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| *malignancy (treatment for within 6 months, palliative) - 1.0 points
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| ;Interpretation of the Wells score
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| Traditional interpretation<ref name="pmid10744147"/><ref name="pmid11453709"/>
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| * Score >6.0 - High (probability 59% based on pooled data<ref name="pmid17185658">{{cite journal |author=Stein PD, Woodard PK, Weg JG, Wakefield TW, Tapson VF, Sostman HD, Sos TA, Quinn DA, Leeper KV, Hull RD, Hales CA, Gottschalk A, Goodman LR, Fowler SE, Buckley JD |title=Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II Investigators |journal=Radiology |volume=242 |issue=1 |pages=15-21 |year=2007 |doi=10.1148/radiol.2421060971 | pmid=17185658}}</ref>)
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| * Score 2.0 to 6.0 - Moderate (probability 29% based on pooled data<ref name="pmid17185658"/>)
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| * Score <2.0 - Low (probability 15% based on pooled data<ref name="pmid17185658"/>)
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| Alternate interpretation<ref name="pmid10744147"/><ref name="pmid16403929"/>
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| * Score > 4 - PE likely. Consider diagnostic imaging.
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| * Score 4 or less - PE unlikely. Consider [[D-dimer]] to rule out PE.
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| ==[[Pulmonary embolism differential diagnosis|Differential Diagnosis]]==
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| ==[[Pulmonary embolism history & symptoms|History & Symptoms]]==
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| ==[[Pulmonary embolism physical examination|Physical Examination]]==
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| ==[[Pulmonary embolism laboratory findings|Laboratory Findings]]==
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| ==[[Pulmonary embolism electrocardiogram|Electrocardiogram]]==
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| ==[[Pulmonary embolism pulmonary angiography|Pulmonary Angiography]]==
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| ==[[Pulmonary embolism computed tomography|Computed Tomography]]==
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| ==[[Pulmonary embolism ventilation/perfusion scan|Ventilation/Perfusion scan]]==
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| ==[[Pulmonary embolism echocardiography or ultrasound|Echocardiography or Ultrasound]]==
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| ==[[Pulmonary embolism chest xray|Chest Xray]]==
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| ==[[Pulmonary embolism magnetic resonance imaging|Magnetic Resonance Imaging]]==
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| ===Low Probablitity Diagnostic Tests and non-Diagnostic Tests===
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| Tests that are frequently done that are not [[sensitivity (tests)|sensitive]] for PE, but can be diagnostic.
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| *''[[medical ultrasound|Ultrasonography]] of the legs'', also known as ''leg doppler'', in search of [[deep venous thrombosis]] (DVT). The presence of [[deep venous thrombosis|DVT]], as shown on [[ultrasonography]] of the legs, is in itself enough to warrant anticoagulation, without requiring the V/Q or spiral CT scans (because of the strong association between DVT and PE). This may be valid approach in [[pregnancy]], in which the other modalities would increase the risk of birth defects in the unborn child. However, a negative scan does not rule out PE, and low-radiation dose scanning may be required if the mother is deemed at high risk of having pulmonary embolism.
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| ===Combining tests into algorithms===
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| Recent recommendations for a diagnostic algorithm have been published by the PIOPED investigators; however, these recommendations do not reflect research using 64 slice MDCT.<ref name="pmid17185658"/> These investigators recommended:
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| * Low clinical probability. If negative D-dimer, PE is excluded. If positive D-dimer, obtain MDCT and based treatment on results.
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| * Moderate clinical probability. If negative D-dimer, PE is excluded. ''However'', the authors were not concerned that a negative MDCT with negative D-dimer in this setting has an 5% probability of being false. Presumably, the 5% error rate will fall as 64 slice MDCT is more commonly used. If positive D-dimer, obtain MDCT and based treatment on results.
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| * High clinical probability. Proceed to MDCT. If positive, treat, if negative, addition tests are needed to exclude PE.
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| ==[[Pulmonary embolism medical therapy|Medical Therapy]]==
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| ==[[Pulmonary embolism surgery|Surgery]]==
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| ==Prognosis==
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| Mortality from untreated PE is said to be 26%. This figure comes from a trial published in 1960 by Barrit and Jordan<ref name="Barritt">{{cite journal | Barritt DW, Jorden SC | title=Anticoagulant drugs in the treatment of pulmonary embolism: a controlled trial. | journal=[[The Lancet|Lancet]] | year=1960 | volume=1 | pages=1309–1312 | id=PMID 13797091 }}</ref> which compared anticoagulation against placebo for the management of PE. Barritt and Jordan performed their study in the [[Bristol Royal Infirmary]] in 1957. This study is the only placebo controlled trial ever to examine the place of anticoagulants in the treatment of PE, the results of which were so convincing that the trial has never been repeated as to do so would be considered unethical. That said, the reported mortality rate of 26% in the placebo group is probably an overstatement, given that the technology of the day may have detected only severe PEs.
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| Prognosis depends on the amount of lung that is affected and on the co-existence of other medical conditions; chronic embolisation to the lung can lead to [[pulmonary hypertension]]. There is controversy over whether or not small subsegmental PEs need to be treated at all<ref>{{cite journal |author=Le Gal G, Righini M, Parent F, van Strijen M, Couturaud F |title=Diagnosis and management of subsegmental pulmonary embolism |journal=J Thromb Haemost |volume=4 |issue=4 |pages=724-31 |year=2006 |pmid=16634736}}</ref> and some evidence exists that patients with subsegmental PEs may do well without treatment.<ref name="pmid16738276">{{cite journal |author=Perrier A, Bounameaux H |title=Accuracy or outcome in suspected pulmonary embolism |journal=N Engl J Med |volume=354 |issue=22 |pages=2383-5 |year=2006 |pmid=16738276|url=http://content.nejm.org/cgi/content/full/354/22/2383}}</ref><ref name="pmid16738268">{{cite journal |author=Stein P, Fowler S, Goodman L, Gottschalk A, Hales C, Hull R, Leeper K, Popovich J, Quinn D, Sos T, Sostman H, Tapson V, Wakefield T, Weg J, Woodard P |title=Multidetector computed tomography for acute pulmonary embolism |journal=N Engl J Med |volume=354 |issue=22 |pages=2317-27 |year=2006 |pmid=16738268}}</ref>
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| ===Predicting mortality===
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| The PESI and Geneva prediction rules can estimate mortality and so may guide selection of patients who can be considered for outpatient therapy.<ref name="pmid17625081">{{cite journal |author=Jiménez D, Yusen RD, Otero R, ''et al'' |title=Prognostic models for selecting patients with acute pulmonary embolism for initial outpatient therapy |journal=Chest |volume=132 |issue=1 |pages=24-30 |year=2007 |pmid=17625081 |doi=10.1378/chest.06-2921}}</ref>
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| Right ventricular dysfunction on echocardiography and higher than normal concentrations of troponin identify high risk patients who might need escalation of therapy with thrombolysis or embolectomy even if the blood pressure is normal on presentation.
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| ===Evaluation for underlying causes for recurrence===
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| After a first PE, the search for secondary causes is usually brief. Only when a second PE occurs, and especially when this happens while still under [[anticoagulant]] therapy, a further search for underlying conditions is undertaken. This will include testing ("thrombophilia screen") for Factor V Leiden mutation, antiphospholipid antibodies, protein C and S and antithrombin levels, and later prothrombin mutation, MTHFR mutation, Factor VIII concentration and rarer inherited [[coagulation]] abnormalities.
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| For prevention of recurrences, when patients are admitted to medical wards or when patients undergo surgery, their physicians should prescribe prophylactic measures to prevent PE. After hospital discharge, prophylaxis should continue for about a month for patients at high risk of thromboembolism.
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| ==References== | | ==Treatment== |
| {{Reflist|2}}
| | [[Pulmonary embolism treatment approach|Treatment Approach]] | [[Pulmonary embolism medical therapy|Medical Therapy]] | [[Pulmonary embolism IVC filter|IVC Filter]] | [[Pulmonary thrombectomy|Pulmonary Thrombectomy]] | [[Pulmonary thromboendarterectomy|Pulmonary Thromboendarterectomy]] | [[Pulmonary embolism discharge care and long term treatment|Discharge Care and Long Term Treatment]] | [[Pulmonary embolism prevention|Prevention]] | [[Pulmonary embolism cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Pulmonary embolism future or investigational therapies|Future or Investigational Therapies]] |
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| ==Sources== | | === Follow-Up === |
| #Bertucci, V., Asch, M.R., Balter, M., Prognosis in a patient with an initial normal pulmonary angiogram, Chest 1994; 105: 1257-1258.
| | [[Pulmonary embolism support group|Support group]] |
| #Cvitanic, O, Marino, P.L., Improved use of arterial blood gas analysis in suspected pulmonary embolism, Chest 1989; 95: 48-51.
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| #Drucker, E.A., et.al., Acute pulmonary embolism: assessment of helical CT for diagnosis, Radiology 1998; 209: 235-241.
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| #Ferrari, E., et.al., The ECG in pulmonary embolism: predictive value of negative T waves in precordial leads – 80 case reports, Chest 1997; 111: 537-543.
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| #Goldhaber, S.Z., et.al., Quantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism, JAMA 1993; 270: 2819-2822.
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| #Goldhaber, S.Z., Pulmonary embolism, NEJM 1998; 339: 93-104.
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| #Mayo, J.R., et.al., Pulmonary embolism: prospective comparison of spiral CT with ventilation-perfusion scintigraphy, Radiology 1997; 205: 447-452.
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| #Meaney, J.F.M., et.al., Diagnosis of pulmonary embolism with magnetic resonance angiography, NEJM 1997; 336: 1422-1427.
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| #The PIOPED investigators, Value of the ventilation / perfusion scan in acute pulmonary embolism: results of the prospective investigation of pulmonary embolism diagnosis (PIOPED), JAMA 1990; 263: 2753-2759.
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| #Remy-Jardin, M., et.al., Diagnosis of pulmonary embolism with spiral CT: comparison with pulmonary angiography and scintigraphy, Radiology 1996; 200: 6999-706.
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| #Stein, P.D., et.al., Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease, Chest 1991; 100: 598-603.
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| #Stein, P.D., et.al., Arterial blood gas analysis in the assessment of suspected pulmonary embolism, Chest 1996; 109: 78-81.
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| #Thompson, B.T., Hales, C.A., Diagnostic strategies for acute pulmonary embolism, in UpToDate, September 10, 1998.
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| #Van Erkel, A.R., et.al., Spiral CT angiography for suspected pulmonary embolism: a cost-effective analysis, Radiology 1996; 201: 29-36.
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| == Acknowledgements == | | === Special Scenarios === |
| The content on this page was first contributed by: {{CMG}} and David Feller-Kopman, M.D.
| | [[Pulmonary embolism special scenario pregnancy|Pregnancy]] | [[Pulmonary embolism special scenario cancer|Cancer]] |
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| List of contributors:
| | == Trials == |
| | [[Pulmonary embolism landmark trials|Landmark Trials]] |
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| == For Patients == | | == Case Studies == |
| | [[Pulmonary embolism case studies|Case #1]] |
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| [http://www.nhlbi.nih.gov/new/press/06-05-31.htm NIH information page]
| | ==Related Chapters== |
| | | *[[Venous thromboembolism]] |
| <youtube v=gGrDAGN5pC0/>
| | *[[Deep venous thrombosis]] |
| | | {{WH}} |
| ==External links== | | {{WS}} |
| * [http://www.vdf.org/ Vascular Disease Foundation] | |
| * [http://www.venousdiseasefoundation.org/ Venous Disease Coalition]
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| * [http://goldminer.arrs.org/search.php?query=pulmonary%20embolism Goldminer, Pulmonary embolism] | |
| * [http://rad.usuhs.edu/medpix/medpix.html?mode=image_finder&action=search&srchstr=pulmonary%20embolism&srch_type=all#top Images of Pulmonary Embolism]
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| * [http://www.natfonline.org/ North American Thrombosis Forum]
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| [[Category:Hematology]] | | [[Category:Hematology]] |
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| [[Category:Cardiology]] | | [[Category:Cardiology]] |
| [[Category:Emergency medicine]] | | [[Category:Emergency medicine]] |
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| [[es:Tromboembolismo pulmonar]] | |
| [[eo:Pulma embolio]]
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| [[fr:Embolie pulmonaire]]
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| [[ko:폐색전증]]
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| [[nl:Longembolie]]
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| [[no:Lungeemboli]]
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| [[pl:Zatorowość płucna]]
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| [[pt:Embolia pulmonar]]
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| [[sr:Плућна емболија]]
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| [[tr:Pulmoner emboli]]
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