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__NOTOC__
{{Ventricular septal defect}}
{{Ventricular septal defect}}
{{CMG}}; '''Associate Editor-In-Chief:''' [[Priyamvada Singh]], [[MBBS]]; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; Leida Perez, M.D.


{{CMG}}  '''Associate Editor-In-Chief:''' [[Priyamvada Singh]], [[MBBS]]; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; Leida Perez, M.D.
==Overview==
 
The physical examination findings of a ventricular septal defect depend upon the size of the defect, the location of the defect, the magnitude and directionality of the intracardiac shunt, and the age of the patient (the duration of the VSD).
==Children==
==Physical Examination==
===Small VSD===
===Heart===
* The patient may be asymptomatic and without signs of a VSD.
====Children====
* A systolic [[thrill]] may be palpable along the left sternal border.
=====Small VSD=====
* The patient may be without signs or symptoms of a VSD.
* A systolic [[thrill]] may be palpable along the [[left sternal border]].
* A loud [[holosystolic murmur]] (harsher quality than that of [[mitral regurgitation]]) may be localized to the left lower sternal border.
* A loud [[holosystolic murmur]] (harsher quality than that of [[mitral regurgitation]]) may be localized to the left lower sternal border.
* In patients with small muscular defects, the [[murmur]] may end in mid [[systole]] because of systolic contraction of the [[septal]] musculature.
* In patients with small muscular defects, the [[murmur]] may end in mid [[systole]] because of systolic contraction of the [[septal]] musculature.


===Medium-Sized VSD===
=====Medium-Sized VSD=====
* A forceful left ventricular impulse or [[heave]] may be present.
* A forceful [[left ventricular impulse]] or [[heave]] may be present.
* A systolic [[thrill]] along left sternal border may be present.
* A systolic [[thrill]] along [[left sternal border]] may be present.
* A split and accentuated pulmonic component of the heart sound may be present
* A split and accentuated [[pulmonic component]] of the second [[heart sound]] may be present.
* A [[third heart sound]] ([[S3]])(suggests increased flow across the [[mitral valve]])
* A [[third heart sound]] ([[S3]]) (suggesting increased flow across the [[mitral valve]]) may be present.
* Harsh holosystolic murmur at 3rd to 4th intercostal space to left side of sternum (characteristic of a VSD murmur)
* Harsh [[holosystolic murmur]] at the 3rd to 4th intercostal space to left side of sternum is characteristic of a VSD [[murmur]].
* A rumbling mid-diastolic murmur at cardiac apex suggests increased flow across the [[mitral valve]].
* A rumbling mid-diastolic [[murmur]] at [[cardiac apex]] suggests increased flow across the [[mitral valve]].
* A midsystolic ejection murmur may be present due to increased flow across the [[pulmonary valve]].  
* A midsystolic [[ejection murmur]] may be present due to increased flow across the [[pulmonary valve]].
 
=====Large-Sized VSD with Pulmonary Obstructive Disease=====
* The features are similar to those seen in a medium-sized VSD.
* In the first 2 years of life, the patient may have signs of left sided volume overload. After the age of 2 years, the patient have exhibit signs and symptoms of progressive pulmonary vascular obstructive disease ([[pulmonary hypertension]]). As a consequence, poor growth may be present and the left anterior thorax may bulge outward.
* The [[JVP]] may be elevated due to [[right ventricular failure]].
* In the first two years of life there may be a prominent [[LV impulse]] or [[heave]], but with the development of [[pulmonary hypertension]], this LV prominence is diminished and [[cyanosis]] may be present which worsens with effort and with time.
 
====Adults====
=====Small VSD=====
*The patient may be asymptomatic with no signs or symptoms.
*A [[Holosystolic murmur]] may be present which is best heard at [[left sternal border]] in the 3rd and 4th intercostal space.


===Large-Sized VSD with Pulmonary Obstructive Disease===
=====Moderate VSD=====
* Features similar to seen in medium sized VSD.
* A displaced [[cardiac apex]] may be present.
* In the first 2 years of age the patients have signs of left sided volume overload. After age 2 old, the patients have signs and symptoms of progressive pulmonary vascular obstructive disease. As a consequence, poor growth and left anterior thorax may bulge outward early.  
* A harsh [[holosystolic murmur]] at 3rd to 4th intercostal space along the left sternal border may be present.
* JVD may be elevated due to RV failure.
* The presence of a rumbling mid-diastolic murmur at [[cardiac apex]] suggests an increase flow across the [[mitral valve]].
* In the first two years there is a prominent LV impulse, but with the development of pulmonary hypertension, this LV prominence is diminished and cyanosis is present, worsens with effort and with time.
* A midsystolic ejection [[murmur]] due to increased flow across the [[pulmonary valve]] may be present.  


==Adults==
=====Large VSD=====
===Small VSD===
A large VSD may progress to [[Eisenmenger's syndrome]]. Physical examination may reveal the following:
*May be asymptomatic with no signs or symptoms
*[[Holosystolic murmur]] heard best at left sternal border in the 3rd and 4th intercostal space


===Moderate VSD===
* [[Central cyanosis]] and [[clubbing]] may be present suggesting [[hypoxemia]].
* Displaced cardiac apex
* The [[JVP]] may be elevated or normal. A prominent [[v wave]] may be seen if [[tricuspid regurgitation]] is present.
* Harsh holosystolic murmur at 3rd to 4th  intercostal space to left side of sternum
* [[Arrythmias]] such as [[atrial fibrillation]], [[atrial flutter]], and/or [[ventricular tachycardia]] may be present.
* Rumbling mid-diastolic murmur at cardiac apex suggesting increase flow across the mitral valve.
* [[Peripheral edema]] may be observed in the presence of [[right sided heart failure]].
* Midsystolic ejection murmur due to increased flow across pulmonary valve.
* [[Pulmonary hypertension]] may be present signified by the presence of a [[right ventricular]] [[heave]], a palpable, loud [[P2]], and a right sided [[S4]].
* [[Pulmonary regurgitation]]may be present as evidenced by a high pitched decresendo [[diastolic murmur]] (Graham Steelle murmur)


===Large VSD===
===Video Examples of Physical Examination Findings===
Large VSD may progress to [[Eisenmenger syndrome]]. Physical examination may reveal-
In first video one can appreciate the normal heart sound. On careful listening one can appreciate the S1 and S2 (lub-dub):
{{#ev:youtube|xS3jX1FYG-M}}


* [[Central cyanosis]], [[Clubbing]] (suggesting hypoxemia)
* JVP may be elevated or normal. A prominent 'v' wave may be seen in case a [[tricuspid regurgitation]] is present.
* Rhythm disturbances - [[Atrial fibrillation]], [[atrial flutter]], [[ventricular tachycardia]]
* Peripheral edema in case of right sided heart failure.
* [[Pulmonary hypertension]]-
**right ventricular heave
**palpable, loud P2
** right sided S4
* [[Pulmonary regurgitation]]- high pitched decresendo diastolic murmur ([[Graham Steelle murmur]])


==Video Examples of Physical Examination Findings==
In first video one can appreciate '''the normal heart sound'''. On careful listening one can appreciate the '''S1 and S2 (lub-dub)'''
<youtube v=xS3jX1FYG-M/>


In the second video one can appreciate that the '''first and second heart sounds are not audible and a murmur that covers the whole systole is there'''. This is characteristic '''holosystolic murmur''' of '''ventricular septal defect'''
In the second video one can appreciate that the first and second heart sounds are not audible and a murmur that covers the whole systole is there. This is characteristic holosystolic murmur of ventricular septal defect:
<youtube v=7oKz6J0Ay_I/>
{{#ev:youtube|7oKz6J0Ay_I}}


==References==
==References==
{{reflist|2}}
{{reflist|2}}
 
[[Category:Cardiology]]
[[Category: Cardiology]]
[[Category:Congenital heart disease]]
[[Category:Pediatrics]]
[[Category:Pediatrics]]
[[Category:Mature chapter]]
[[Category:Disease]]


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{{WH}}
{{WS}}
{{WS}}

Latest revision as of 17:29, 8 January 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, MBBS; Keri Shafer, M.D. [2]; Leida Perez, M.D.

Overview

The physical examination findings of a ventricular septal defect depend upon the size of the defect, the location of the defect, the magnitude and directionality of the intracardiac shunt, and the age of the patient (the duration of the VSD).

Physical Examination

Heart

Children

Small VSD
Medium-Sized VSD
Large-Sized VSD with Pulmonary Obstructive Disease
  • The features are similar to those seen in a medium-sized VSD.
  • In the first 2 years of life, the patient may have signs of left sided volume overload. After the age of 2 years, the patient have exhibit signs and symptoms of progressive pulmonary vascular obstructive disease (pulmonary hypertension). As a consequence, poor growth may be present and the left anterior thorax may bulge outward.
  • The JVP may be elevated due to right ventricular failure.
  • In the first two years of life there may be a prominent LV impulse or heave, but with the development of pulmonary hypertension, this LV prominence is diminished and cyanosis may be present which worsens with effort and with time.

Adults

Small VSD
Moderate VSD
Large VSD

A large VSD may progress to Eisenmenger's syndrome. Physical examination may reveal the following:

Video Examples of Physical Examination Findings

In first video one can appreciate the normal heart sound. On careful listening one can appreciate the S1 and S2 (lub-dub): {{#ev:youtube|xS3jX1FYG-M}}


In the second video one can appreciate that the first and second heart sounds are not audible and a murmur that covers the whole systole is there. This is characteristic holosystolic murmur of ventricular septal defect: {{#ev:youtube|7oKz6J0Ay_I}}

References

Template:WH Template:WS