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'''For the WikiDoc page for this topic, click [[Squamous cell carcinoma|here]]'''
'''For the WikiDoc page for this topic, click [[Squamous cell carcinoma of the skin|here]]'''
{{Squamous cell carcinoma (patient information)}}


{{DiseaseDisorder infobox |
'''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:charlesmichaelgibson@gmail.com]  Phone:617-632-7753; '''Associate Editor(s)-In-Chief:''' Jinhui Wu, M.D.
  Name        = Squamous cell carcinoma, NOS |
  Image      = Squamous Cell Carcinoma.jpg |
  Caption    = Tends to arise from pre-malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here). |
  ICD10      = C44 |
  ICD9        = {{ICD9|173}} |
  ICDO        = {{ICDO|8070|3}} |
  eMedicineSubj  = derm |
  eMedicineTopic = 401 |
  MedlinePlus    = 000829 |
}}
 
{{SI}}
 
{{CMG}};  Jinhui Wu, MD


==Overview==
==Overview==
The skin, as the largest organ in the body, covers and protects the organs inside the body, protecting the body against germs and preventing the loss of fluids. Squamous cell carcinoma origins the upper part of the epidermis. Usual signs involve rough and flat reddish patches, scars or skin ulcers, or other skin lesions. Skin [[biopsy]] can confirm whether the lesion is carcinoma or not. Treatments includes surgery and chemotherapy.
The skin is the largest organ in the body, and covers and protects the body against germs, and prevents the loss of fluids. Squamous cell carcinoma is cancer that originates in the upper part of the skin called the epidermis. Signs of squamous cell carcinoma include rough and flat red patches, scars, skin ulcers, or other lesions of the skin. Skin [[biopsy]] can confirm whether the lesion is malignant or not. Treatments include surgery and chemotherapy.


==What are the symptoms of squamous cell carcinoma?==
==What are the symptoms of Squamous cell carcinoma?==
Usual signs are rough, flat reddish patches. Buy you need to pay more attention to the following signs:  
General appearance is a rough, flat reddish patch, but special attention needs to be given to the following:  


:*A new growth
:*Any new growth


:*A spot or bump that's getting larger
:*A mark or bump that is increasing in size


:*A sore that doesn't heal within three months
:*A sore or ulcer that doesn't heal within three months


Other skin problems may also cause lesions. Only a dermatologist can tell for sure. A person with any suspicious skin markings and any changes should go to see the dermatologist so that the problems can be diagnosed and treated as early as possible. Conditions with similar symptoms are:
Many skin problems can cause lesions that are similar in appearance to squamous cell carcinoma. A dermatologist will need to assess the lesion to confirm the exact nature of it. Any person with suspicious skin markings and changes should seek help from a dermatologist immediately to ensure that it is diagnosed and treated as early as possible. Conditions with symptoms similar to sqaumous cell carcinoma are:
:*[[Eczema]]
:*[[Eczema]]


:*[[Condyloma acuminata]]
:*[[Condyloma acuminata]] or genital warts


:*Skin [[ulcer]]
:*Skin [[ulcer]]
Line 39: Line 26:


==Who is at the highest risk?==
==Who is at the highest risk?==
Clinical data has suggested that the development of squamous cell carcinoma is related to several factors.
Clinical data suggests that the development of squamous cell carcinoma is related to several factors.


:*Sunlight(solar UV radiation): Too much exposure to sunlight(solar UV radiation) is thought to be the biggest risk factor for most skin cancer.  
:*Sunlight(solar UV radiation): Excessive exposure to sunlight is thought to be the largest risk factor for developing [[squamous cell carcinoma]].  


:*Fair skin: Data show the Whites has much higher risk of skin cancer than that of dark-skinned African Americans.
:*Fair skin: Data show that caucasian persons and persons with fair skin are at higher risk for skin cancer than darker skinned persons.


:*Genetic factors: Doctors have found that certain people have more possibilities to get skin cancer after sun exposure than others.
:*Genetic factors: Some persons are genetically more at risk to develop skin cancer, and may have a history of skin cancer in their family.


:*Immunosuppressive factors: Clinical surveys suggest patients treated with immunosuppressive medicines such as transplant patients, have an increased risk of developing squamous cell carcinoma.  
:*Immunosuppressive factors: Persons who have been treated with immunosuppressive medications such as transplant patients, have an increased risk of developing squamous cell carcinoma.  


:*Xeroderma pigmentosum (XP): Patients with XP are at higher risk of squamous cell carcinoma because thay can not repair damage caused by sunlight.  
:*[[Xeroderma pigmentosum]] (XP): Patients with XP are at higher risk of squamous cell carcinoma because thay cannot repair the damage caused by sunlight.  


:*Chemicals exposure: Work exposure large amounts of arsenic, tar, coal or paraffin increases the risk of squamous cell carcinoma.
:*Chemical exposure: Work exposure to large amounts of arsenic, tar, coal, or paraffin increases the risk of squamous cell carcinoma.


:*Radiation exposure
:*[[Radiation exposure]]


:*Age: Epidemiological data suggest that squamous cell carcinoma can be found in old people more than in younger people.  
:*Age: Epidemiological data suggests that the risk of squamous cell carcinoma increases with age.  


:*Gender: Men have a higher chance of developing squamous cell carcinoma than women.
:*Gender: Men are at greater risk of developing squamous cell carcinoma than women.


==When to seek urgent medical care?==
==When to seek urgent medical care?==
Go to see your dermatologist if symptoms of squamous cell carcinoma develops.
See your dermatologist if you get any new or rapidly growing lesions on the skin.


==Treatment options==
==Treatment options==
Regular self-examinations are key to early detection of squamous cell carcinoma. Any time skin cancer is suspected, go to see a dermatologist. He may suggest you several tests such as:
Regular self-examinations are key to the early detection of squamous cell carcinoma. A dermatologist will need to evaluate any skin lesions. He may suggest you several tests such as:


:*[[Biopsy]]: At first the dermatologist check skin cancer through a visual examination of the skin and mucous membranes. Then, if malignancy is suspected, a biopsy will be performed. It is the most important measure for the diagnosis of squamous cell carcinoma.
:*[[Biopsy]]: A visual examination of the skin and mucous membranes may prompt the dermatologist to perform a biopsy if malignancy is suspected. This is the most important step in the diagnosis of skin cancer.


Patients with squamous cell carcinoma have many treatment options. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. [[Side effect]] may not be the same for each person, and they may change from one treatment session to the next.
Patients with squamous cell carcinoma have several treatment options, for which the selection of treatment depends on the stage of the tumor. The options include surgery, radiation therapy, chemotherapy, or a combination of these. Before treatment starts, ask your health care team about possible side effects of treatment and how treatment may impact your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. [[Side effects]] vary from person and person, and may change from one treatment session to the next.


:*[[Surgery]]: Surgery depends on the size of the tumor, whether it has spread to distant organs.
:*[[Surgery]]: Surgery as an option will depend on the size of the tumor, and the extent of spread to other organs.


:*[[Radiation therapy]]: If the tumor is very large, or if it is in an area hard to do surgery, radiation may be used as the main treatment. This treatment is to kill cancer cells or keep them from growing by using high-energy x-rays or other types of radiation.  
:*[[Radiation therapy]]: If the tumor is very large, or if it is in an area that is difficult to access through surgery, radiation may be used as the main treatment. This treatment is to kill cancer cells or keep them from growing by using high-energy x-rays or other types of rays.  


:*[[Chemotherapy]]: The treatment is to use drugs to stop the growth of cancer cells either by killing the cells or by stopping them from dividing.
:*[[Chemotherapy]]: Chemotherapy is the use of drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.


==Where to find medical care for squamous cell carcinoma?==
==Where to find medical care for Squamous cell carcinoma?==


[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|squamous cell carcinoma}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating squamous cell carcinoma]
[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|squamous cell carcinoma}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating squamous cell carcinoma]


==Prevention of squamous cell carcinoma==
==Prevention of Squamous cell carcinoma==
The best way to lower the risk of squamous cell carcinoma is to avoid too much exposure to the sun and other sources of UV light. Regular self check is also important.
The most effective way to lower the risk of squamous cell carcinoma is to avoid exposure to the sun and other sources of UV light. Regular self checks of the skin are also important.


:*Sun protection practices: Slip on a shirt, slop on sunscream, slap on a wide-brimmed hat, stay in the shade, wear sunglasses.  
:*Sun protection techniques: Slip on a shirt, slop on sunscream, slap on a wide-brimmed hat, stay in the shade, wear sunglasses.  


:*Avoid other sources of UV light: Aavoidance of tanning beds and sun lamps.  
:*Avoid other sources of UV light: Avoidance of tanning beds and sun lamps.  


:*Check for abnormal moles and have them removed: Regular self-examinations for your moles and go to see your dermatologist.
:*Check for abnormal moles and have them removed: Regular self-examination of moles and other skin lesions, and an evaluation by your dermatologist.


==What to expect (Outook/Prognosis)?==
==What to expect (Outook/Prognosis)?==
The prognosis of squamous cell carcinoma depends on the following:
The prognosis of squamous cell carcinoma depends on the following:


:*The stage of squamous cell carcinoma: Whether cancer is found in the layer of skin only, or has spread to the lymph nodes, or to distant places in the body.  
:*The stage of squamous cell carcinoma: Whether cancer is found in the skin only, or whether is has invaded the layer below the skin and has spread to the lymph nodes, or to other distant places in the body.  


:*The location and the size of the tumor  
:*The location and the size of the tumor.


:*The patient’s general health
:*The patient’s general health.


==Possible Complications==
==Possible Complications==
*Local spread of the tumor
*Local spread of the tumor.
*Spread to other locations, including the internal organs
*Spread to other locations, including the internal organs.


==Sources==
==Sources==
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http://www.nlm.nih.gov/medlineplus/ency/article/000829.htm
http://www.nlm.nih.gov/medlineplus/ency/article/000829.htm


{{SIB}}
{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Patient information]]
[[Category:Patient information]]
[[Category:Oncology]]
[[Category:Oncology patient information]]
[[Category:Oncology patient information]]
[[Category:Dermatology]]
[[Category:Dermatology]]
[[Category:Dermatology patient information]]
[[Category:Dermatology patient information]]
[[Category:Mature chapter]]
[[Category:Mature chapter]]
[[Category:Disease state]]
[[Category:Disease]]
[[Category:Grammar]]

Latest revision as of 19:38, 28 August 2015

For the WikiDoc page for this topic, click here

Squamous cell carcinoma

Overview

What are the symptoms?

What are the causes?

Who is at highest risk?

Diagnosis

When to seek urgent medical care?

Treatment options

Where to find medical care for Squamous cell carcinoma?

Prevention

What to expect (Outlook/Prognosis)?

Possible complications

Squamous cell carcinoma On the Web

Ongoing Trials at Clinical Trials.gov

Images of Squamous cell carcinoma

Videos on Squamous cell carcinoma

FDA on Squamous cell carcinoma

CDC on Squamous cell carcinoma

Squamous cell carcinoma in the news

Blogs on Squamous cell carcinoma

Directions to Hospitals Treating Squamous cell carcinoma

Risk calculators and risk factors for Squamous cell carcinoma

Editor-in-Chief: C. Michael Gibson, M.S.,M.D. [1] Phone:617-632-7753; Associate Editor(s)-In-Chief: Jinhui Wu, M.D.

Overview

The skin is the largest organ in the body, and covers and protects the body against germs, and prevents the loss of fluids. Squamous cell carcinoma is cancer that originates in the upper part of the skin called the epidermis. Signs of squamous cell carcinoma include rough and flat red patches, scars, skin ulcers, or other lesions of the skin. Skin biopsy can confirm whether the lesion is malignant or not. Treatments include surgery and chemotherapy.

What are the symptoms of Squamous cell carcinoma?

General appearance is a rough, flat reddish patch, but special attention needs to be given to the following:

  • Any new growth
  • A mark or bump that is increasing in size
  • A sore or ulcer that doesn't heal within three months

Many skin problems can cause lesions that are similar in appearance to squamous cell carcinoma. A dermatologist will need to assess the lesion to confirm the exact nature of it. Any person with suspicious skin markings and changes should seek help from a dermatologist immediately to ensure that it is diagnosed and treated as early as possible. Conditions with symptoms similar to sqaumous cell carcinoma are:

Who is at the highest risk?

Clinical data suggests that the development of squamous cell carcinoma is related to several factors.

  • Sunlight(solar UV radiation): Excessive exposure to sunlight is thought to be the largest risk factor for developing squamous cell carcinoma.
  • Fair skin: Data show that caucasian persons and persons with fair skin are at higher risk for skin cancer than darker skinned persons.
  • Genetic factors: Some persons are genetically more at risk to develop skin cancer, and may have a history of skin cancer in their family.
  • Immunosuppressive factors: Persons who have been treated with immunosuppressive medications such as transplant patients, have an increased risk of developing squamous cell carcinoma.
  • Xeroderma pigmentosum (XP): Patients with XP are at higher risk of squamous cell carcinoma because thay cannot repair the damage caused by sunlight.
  • Chemical exposure: Work exposure to large amounts of arsenic, tar, coal, or paraffin increases the risk of squamous cell carcinoma.
  • Age: Epidemiological data suggests that the risk of squamous cell carcinoma increases with age.
  • Gender: Men are at greater risk of developing squamous cell carcinoma than women.

When to seek urgent medical care?

See your dermatologist if you get any new or rapidly growing lesions on the skin.

Treatment options

Regular self-examinations are key to the early detection of squamous cell carcinoma. A dermatologist will need to evaluate any skin lesions. He may suggest you several tests such as:

  • Biopsy: A visual examination of the skin and mucous membranes may prompt the dermatologist to perform a biopsy if malignancy is suspected. This is the most important step in the diagnosis of skin cancer.

Patients with squamous cell carcinoma have several treatment options, for which the selection of treatment depends on the stage of the tumor. The options include surgery, radiation therapy, chemotherapy, or a combination of these. Before treatment starts, ask your health care team about possible side effects of treatment and how treatment may impact your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effects vary from person and person, and may change from one treatment session to the next.

  • Surgery: Surgery as an option will depend on the size of the tumor, and the extent of spread to other organs.
  • Radiation therapy: If the tumor is very large, or if it is in an area that is difficult to access through surgery, radiation may be used as the main treatment. This treatment is to kill cancer cells or keep them from growing by using high-energy x-rays or other types of rays.
  • Chemotherapy: Chemotherapy is the use of drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.

Where to find medical care for Squamous cell carcinoma?

Directions to Hospitals Treating squamous cell carcinoma

Prevention of Squamous cell carcinoma

The most effective way to lower the risk of squamous cell carcinoma is to avoid exposure to the sun and other sources of UV light. Regular self checks of the skin are also important.

  • Sun protection techniques: Slip on a shirt, slop on sunscream, slap on a wide-brimmed hat, stay in the shade, wear sunglasses.
  • Avoid other sources of UV light: Avoidance of tanning beds and sun lamps.
  • Check for abnormal moles and have them removed: Regular self-examination of moles and other skin lesions, and an evaluation by your dermatologist.

What to expect (Outook/Prognosis)?

The prognosis of squamous cell carcinoma depends on the following:

  • The stage of squamous cell carcinoma: Whether cancer is found in the skin only, or whether is has invaded the layer below the skin and has spread to the lymph nodes, or to other distant places in the body.
  • The location and the size of the tumor.
  • The patient’s general health.

Possible Complications

  • Local spread of the tumor.
  • Spread to other locations, including the internal organs.

Sources

http://www.cancer.org/docroot/CRI/CRI_2_1x.asp?rnav=criov&dt=51

http://www.nlm.nih.gov/medlineplus/ency/article/000829.htm

Template:WH Template:WS