Noncompaction cardiomyopathy histology: Difference between revisions
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==Overview== | ==Overview== | ||
There is no pathognomonic finding on biopsy, although the majority of studies indicate that fibrosis is frequently present. | There is no pathognomonic finding on biopsy, although the majority of studies indicate that fibrosis is frequently present<ref>Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.</ref><ref>Conraads V, Paelinck B, Vorlat A, et al. Isolated non-compaction of the left ventricle: a rare indication for transplantation. J Heart Lung Transplant. 2001; 20: 904–907.</ref><ref>Daimon Y, Watanabe S, Takeda S, et al. Two-layered appearance of noncompaction of the ventricular myocardium on magnetic resonance imaging.</ref>. | ||
==Histologic Differences Between Isolated Noncompaction Cardiomyopathy and that Associated with Congenital Heart Disease== | ==Histologic Differences Between Isolated Noncompaction Cardiomyopathy and that Associated with Congenital Heart Disease== | ||
Among patients with isolated noncompaction, the deep intertrabecular recesses communicate with only the left ventricular cavity. In contrast, among patients with noncompaction associated with other congenital heart diseases, | Among patients with isolated noncompaction, the deep intertrabecular recesses communicate with only the left ventricular cavity. In contrast, among patients with noncompaction associated with other congenital heart diseases, the deep intertrabecular recesses communicate with both the left ventricular cavity and the coronary circulation<ref>Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.</ref>. | ||
==Findings on Biopsy== | ==Findings on Biopsy== | ||
Latest revision as of 14:01, 6 August 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
There is no pathognomonic finding on biopsy, although the majority of studies indicate that fibrosis is frequently present[1][2][3].
Histologic Differences Between Isolated Noncompaction Cardiomyopathy and that Associated with Congenital Heart Disease
Among patients with isolated noncompaction, the deep intertrabecular recesses communicate with only the left ventricular cavity. In contrast, among patients with noncompaction associated with other congenital heart diseases, the deep intertrabecular recesses communicate with both the left ventricular cavity and the coronary circulation[4].
Findings on Biopsy
- Interstitial fibrosis was observed in 5/5 patients with isolated noncompaction cardiomyopathy who underwent right ventricular biopsy[5]
- Endomyocardial thickening and subendocardial fibroelastosis was observed in 3/5 patients who underwent right ventricular biopsy
- Myocyte necrosis has been observed in areas of trabeculation [6][7].
References
- ↑ Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.
- ↑ Conraads V, Paelinck B, Vorlat A, et al. Isolated non-compaction of the left ventricle: a rare indication for transplantation. J Heart Lung Transplant. 2001; 20: 904–907.
- ↑ Daimon Y, Watanabe S, Takeda S, et al. Two-layered appearance of noncompaction of the ventricular myocardium on magnetic resonance imaging.
- ↑ Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.
- ↑ Hamamichi Y, Ichida F, Hashimoto I, et al. Isolated noncompaction of the ventricular myocardium: ultrafast computer tomography and magnetic resonance imaging. Int J Cardiovasc Imaging. 2001; 17: 305–314.
- ↑ Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.
- ↑ Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.