Atrial septal defect causes: Difference between revisions

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{{Atrial septal defect}}
#REDIRECT [[Atrial septal defect risk factors]]
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [[mailto:psingh@perfuse.org]]; {{CZ}}; '''Assistant Editor(s)-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [[mailto:kfeeney@perfuse.org]]
 
==Overview==
As is common with most congenital heart conditions, the exact cause of atrial septal defect is not known. Research suggests a potential link between genetic conditions such as [[Down syndrome]] and the development of an atrial septal defect. Other potential causes include exposure to environmental contaminants such as [[rubella]] as well as [[alcohol]] consumption.
 
==Causes==
 
* The cause of atrial septal defect is not known.  There does appear to be a genetic component to the disease as it often occurs in patients with [[Down syndrome]].  [[Atrial septal defect]]s are often associated with other malformations. There is a well described association with primum or secundum ASDs with [[Down syndrome]]. Other associated lesions include:
**[[total anomalous pulmonary venous return | partially anomalous pulmonary venous return]]
**[[pulmonary valve stenosis]]
**[[mitral stenosis]] or [[mitral valve prolapse]]
**[[ventricular septal defects]]
**[[coarctation of the aorta]]
As a parent, if you or a sibling of a child have a [[congenital heart defect]], then you should consider [[genetic counseling]].
 
* There are a small group of [[atrial septal defect|ASDs]] that may have a familial occurrence <ref name="pmid9610535">{{cite journal| author=Benson DW, Sharkey A, Fatkin D, Lang P, Basson CT, McDonough B et al.| title=Reduced penetrance, variable expressivity, and genetic heterogeneity of familial atrial septal defects. | journal=Circulation | year= 1998 | volume= 97 | issue= 20 | pages= 2043-8 | pmid=9610535 | doi= | pmc= | url= }} </ref>.
 
* If the mother contracts [[rubella]] (german measles) during pregnancy, this can increase the risk of [[congenital heart disease]].  In one study, exposure to [[alcohol]] during pregnancy doubled the risk of an [[atrial septal defect]]<ref name="pmid1397217">{{cite journal| author=Tikkanen J, Heinonen OP| title=Risk factors for atrial septal defect. | journal=Eur J Epidemiol | year= 1992 | volume= 8 | issue= 4 | pages= 509-15 | pmid=1397217 | doi= | pmc= | url= }} </ref>.
 
==References==
{{reflist|2}}
 
[[Category:Cardiology]]
[[Category:Congenital heart disease]]
[[Category:Pediatrics]]
[[Category:Mature chapter]]
 
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{{WS}}

Latest revision as of 14:23, 2 September 2011