Aprindine: Difference between revisions

	WikiDoc Resources for Aprindine
Articles
Most recent articles on Aprindine Most cited articles on Aprindine Review articles on Aprindine Articles on Aprindine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Aprindine Images of Aprindine Photos of Aprindine Podcasts & MP3s on Aprindine Videos on Aprindine
Evidence Based Medicine
Cochrane Collaboration on Aprindine Bandolier on Aprindine TRIP on Aprindine
Clinical Trials
Ongoing Trials on Aprindine at Clinical Trials.gov Trial results on Aprindine Clinical Trials on Aprindine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Aprindine NICE Guidance on Aprindine NHS PRODIGY Guidance FDA on Aprindine CDC on Aprindine
Books
Books on Aprindine
News
Aprindine in the news Be alerted to news on Aprindine News trends on Aprindine
Commentary
Blogs on Aprindine
Definitions
Definitions of Aprindine
Patient Resources / Community
Patient resources on Aprindine Discussion groups on Aprindine Patient Handouts on Aprindine Directions to Hospitals Treating Aprindine Risk calculators and risk factors for Aprindine
Healthcare Provider Resources
Symptoms of Aprindine Causes & Risk Factors for Aprindine Diagnostic studies for Aprindine Treatment of Aprindine
Continuing Medical Education (CME)
CME Programs on Aprindine
International
Aprindine en Espanol Aprindine en Francais
Business
Aprindine in the Marketplace Patents on Aprindine
Experimental / Informatics
List of terms related to Aprindine

Aprindine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C01BB04 (WHO) ;
Identifiers
	IUPAC name {3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine;
CAS Number	37640-71-4;
PubChem CID	2218;
DrugBank	DB01429 ;
ChemSpider	2132 ;
UNII	5Y48085P9Q;
KEGG	D02969 ;
ChEMBL	ChEMBL1213033 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H30N2
Molar mass	322.487 g/mol
3D model (JSmol)	Interactive image;
	SMILES c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3;
	InChI InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 ; Key:NZLBHDRPUJLHCE-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Latest revision as of 22:10, 23 July 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Aprindine is a Class 1b antiarrhythmic agent.^[1]

In one study, it delayed atrial fibrillation more than digoxin did.^[2]

It has shown effectiveness when given orally.^[3]

References

↑ Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" (^{[dead link]}). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.
↑ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

Template:Antiarrhythmic agents

[pmid1660104-1] Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.

[pmid12074271-2] Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" (^{[dead link]}). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.

[pmid603737-3] Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-{{drugbox |
+{{Drugbox
-| IUPAC_name = ''N''<nowiki>'</nowiki>-(2,3-dihydro-1''H''-inden-2-yl)-''N'',''N''-diethyl-''N''<nowiki>'</nowiki>-<br>phenyl-propane-1,3-diamine
+| verifiedrevid = 443395414
+| IUPAC_name = {3-[2,3-dihydro-1''H''-inden-2-yl(phenyl)amino]propyl}diethylamine
 | image = Aprindine_svg.png
+<!--Clinical data-->
+| tradename =
+| Drugs.com = {{drugs.com|international|aprindine}}
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| legal_UK = <!-- GSL         / P       / POM / CD -->
+| legal_US = <!-- OTC                   / Rx-only  -->
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CASNo_Ref = {{cascite|correct|CAS}}
 | CAS_number = 37640-71-4
 | ATC_prefix = C01
 | ATC_suffix = BB04
 | PubChem = 2218
-| DrugBank =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| C = 22 | H = 30 | N = 2
+| DrugBank = DB01429
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 2132
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 5Y48085P9Q
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D02969
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 1213033
+<!--Chemical data-->
+| C=22 | H=30 | N=2
 | molecular_weight = 322.487 g/mol
-| bioavailability =
+| smiles = c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3
-| protein_bound =
+| InChI = 1/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
-| metabolism =
+| InChIKey = NZLBHDRPUJLHCE-UHFFFAOYAO
-| elimination_half-life =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| excretion =
+| StdInChI = 1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
-| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_US =  <!-- A / B            / C / D / X -->
+| StdInChIKey = NZLBHDRPUJLHCE-UHFFFAOYSA-N
-| pregnancy_category =
-| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
-| legal_UK =      <!-- GSL         / P       / POM / CD -->
-| legal_US =      <!-- OTC                   / Rx-only  -->
-| legal_status =
-| routes_of_administration =
 }}
 __NOTOC__
+{{SI}}
 {{CMG}}
-{{Editor Join}}
+==Overview==
+'''Aprindine''' is a Class 1b [[antiarrhythmic agent]].<ref name="pmid1660104">{{cite journal |author=Sato R, Hisatome I, Tanaka Y, ''et al.'' |title=Aprindine blocks the sodium current in guinea-pig ventricular myocytes |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=344 |issue=3 |pages=331–6 |date=September 1991 |pmid=1660104 |doi= 10.1007/bf00183008|url=}}</ref>
+In one study, it delayed [[atrial fibrillation]] more than [[digoxin]] did.<ref name="pmid12074271">{{cite journal |author=Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H |title=Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation |journal=Circ. J. |volume=66 |issue=6 |pages=553–6 |date=June 2002 |pmid=12074271 |doi= 10.1253/circj.66.553|url=http://joi.jlc.jst.go.jp/JST.JSTAGE/circj/66.553?from=PubMed |format={{dead link|date=May 2010}}}}</ref>
+It has shown effectiveness when given orally.<ref name="pmid603737">{{cite journal |author=Reid PR, Greene HL, Varghese PJ |title=Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome |journal=Br Heart J |volume=39 |issue=12 |pages=1353–60 |date=December 1977 |pmid=603737 |pmc=483421 |doi= 10.1136/hrt.39.12.1353|url=http://heart.bmj.com/cgi/pmidlookup?view=long&pmid=603737}}</ref>
-==Overview==
+==References==
-'''Aprindine''' is a Class 1b [[antiarrhythmic agent]].
+{{reflist|2}}
 {{Antiarrhythmic agents}}
 [[Category:Antiarrhythmic agents]]
-[[Category:Drugs]]
+[[Category:Cardiovascular Drugs]]
-{{WikiDoc Help Menu}}
+[[Category:Drug]]
-{{WikiDoc Sources}}

Aprindine: Difference between revisions

Latest revision as of 22:10, 23 July 2014

Overview

References

Navigation menu