Molsidomine: Difference between revisions
m (Protected "Molsidomine": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))) |
No edit summary |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
{{chembox | |||
| Verifiedfields = changed | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = D46583G77X | |||
| verifiedrevid = 446670426 | |||
|ImageFile=Molsidomine.png | |||
|ImageSize=200px | |||
|IUPACName=1-Ethoxy-''N''-(3-morpholino-5-oxadiazol-3-iumyl)methanimidate | |||
|OtherNames= | |||
|Section1={{Chembox Identifiers | |||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | |||
| ChemSpiderID = 4090 | |||
| InChI = 1/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3 | |||
| InChIKey = XLFWDASMENKTKL-UHFFFAOYAC | |||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChI = 1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3 | |||
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChIKey = XLFWDASMENKTKL-UHFFFAOYSA-N | |||
| CASNo_Ref = {{cascite|correct|??}} | |||
| CASNo=25717-80-0 | |||
| PubChem=5353788 | |||
| ChEMBL_Ref = {{ebicite|changed|EBI}} | |||
| ChEMBL = 1256353 | |||
| KEGG_Ref = {{keggcite|correct|kegg}} | |||
| KEGG = D01320 | |||
| SMILES = [O-]C(OCC)=Nc2on[n+](N1CCOCC1)c2 | |||
| ATCCode_prefix = C01 | |||
| ATCCode_suffix = DX12 | |||
}} | |||
|Section2={{Chembox Properties | |||
| Formula=C<sub>9</sub>H<sub>14</sub>N<sub>4</sub>O<sub>4</sub> | |||
| MolarMass=242.23 g/mol | |||
| Appearance= | |||
| Density= | |||
| MeltingPt= | |||
| BoilingPt= | |||
| Solubility= | |||
}} | |||
|Section3={{Chembox Hazards | |||
| MainHazards= | |||
| FlashPt= | |||
| Autoignition= | |||
}} | |||
}} | |||
__NOTOC__ | |||
{{SI}} | {{SI}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
'''Molsidomine''' is an orally active, long acting [[vasodilator|vasodilating]] [[drug]]. Molsidomine is [[drug metabolism|metabolized]] in the [[liver]] to the [[active metabolite]] [[SIN-1]]. SIN-1 is an unstable compound that releases [[nitric oxide]] upon decay as the actual vasodilating compound. | '''Molsidomine''' is an orally active, long acting [[vasodilator|vasodilating]] [[drug]]. Molsidomine is [[drug metabolism|metabolized]] in the [[liver]] to the [[active metabolite]] [[SIN-1]]. SIN-1 is an unstable compound that releases [[nitric oxide]] upon decay as the actual vasodilating compound. | ||
| Line 12: | Line 54: | ||
Molsidomine as well as SIN-1 are [[sydnone imine]]s, a class of [[mesoionic]] [[heterocyclic compound|heterocyclic]] [[aromatic]] [[chemical compound]]s. | Molsidomine as well as SIN-1 are [[sydnone imine]]s, a class of [[mesoionic]] [[heterocyclic compound|heterocyclic]] [[aromatic]] [[chemical compound]]s. | ||
== See | ==References== | ||
{{reflist|2}} | |||
== See Also == | |||
* [[Nitric oxide]] | * [[Nitric oxide]] | ||
* [[Vasodilator]] | * [[Vasodilator]] | ||
{{Vasodilators used in cardiac diseases}} | {{Vasodilators used in cardiac diseases}} | ||
[[Category:Cardiovascular Drugs]] | |||
[[Category:Drug]] | |||
[[Category:Vasodilators]] | [[Category:Vasodilators]] | ||
Latest revision as of 21:32, 24 July 2014
| |
| Names | |
|---|---|
| IUPAC name
1-Ethoxy-N-(3-morpholino-5-oxadiazol-3-iumyl)methanimidate
| |
| Identifiers | |
3D model (JSmol)
|
|
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). |
| KEGG | |
PubChem CID
|
|
| |
| |
| Properties | |
| C9H14N4O4 | |
| Molar mass | 242.23 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is  ?)
| |
| Infobox references | |
|
WikiDoc Resources for Molsidomine |
|
Articles |
|---|
|
Most recent articles on Molsidomine Most cited articles on Molsidomine |
|
Media |
|
Powerpoint slides on Molsidomine |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Molsidomine at Clinical Trials.gov Clinical Trials on Molsidomine at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Molsidomine
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Molsidomine Discussion groups on Molsidomine Patient Handouts on Molsidomine Directions to Hospitals Treating Molsidomine Risk calculators and risk factors for Molsidomine
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Molsidomine |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite SIN-1. SIN-1 is an unstable compound that releases nitric oxide upon decay as the actual vasodilating compound.
Chemistry
Molsidomine as well as SIN-1 are sydnone imines, a class of mesoionic heterocyclic aromatic chemical compounds.
References
See Also
- Pages with script errors
- Pages using duplicate arguments in template calls
- Articles without UNII source
- Chemical articles with unknown parameter in Chembox
- Articles with changed EBI identifier
- ECHA InfoCard ID from Wikidata
- Articles containing unverified chemical infoboxes
- Chembox image size set
- Cardiovascular Drugs
- Drug
- Vasodilators