Muscarinic antagonist: Difference between revisions
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==Overview== | ==Overview== | ||
A '''muscarinic receptor antagonist''' is an agent that reduces the activity of the [[muscarinic acetylcholine receptor]]. Most of them are synthetic, but [[scopolamine]] [[atropine]] are belladonna alkaloids, and are naturally extracted. | A '''muscarinic receptor antagonist''' is an agent that reduces the activity of the [[muscarinic acetylcholine receptor]]. Most of them are synthetic, but [[scopolamine]] [[atropine]] are belladonna alkaloids, and are naturally extracted. | ||
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==References== | ==References== | ||
{{reflist}} | {{reflist|2}} | ||
==External links== | ==External links== | ||
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{{Mydriatics and cycloplegics}} | {{Mydriatics and cycloplegics}} | ||
{{Receptor agonists and antagonists}} | {{Receptor agonists and antagonists}} | ||
[[Category:Muscarinic antagonists| ]] | [[Category:Muscarinic antagonists| ]] | ||
Latest revision as of 19:42, 4 September 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A muscarinic receptor antagonist is an agent that reduces the activity of the muscarinic acetylcholine receptor. Most of them are synthetic, but scopolamine atropine are belladonna alkaloids, and are naturally extracted.
Important[1] muscarinic agonists include atropine, hyoscine, ipratropium, tropicamide, cyclopentolate and pirenzepine.
Comparison table
| Substance | Trade names | Mechanism[2] | Clinical use[2] | Adverse effects[2] |
|---|---|---|---|---|
| Atropine (D/L-Hyoscyamine) | non-selective antagonism, CNS stimulation |
|
||
| Scopolamine (L-Hyoscine) | non-selective antagonism, CNS depression |
|
| |
| Ipratropium | non-selective antagonism, without any mucociliary excretion inhibition. |
|
||
| Tropicamide | short acting non-selective antagonism, CNS depression |
|
| |
| Pirenzepine | M1 receptor-selective antagonist
|
|
(fewer than non-selective ones) | |
| Diphenhydramine | Benadryl | |||
| Dimenhydrinate | Dramamine | |||
| dicyclomine | ||||
| flavoxate | ||||
| oxybutynin | ||||
| tiotropium | Spiriva | |||
| cyclopentolate | short acting non-selective antagonism, CNS depression |
|
| |
| atropine methonitrate | non-selective antagonism, blocks transmission in ganglia |
|
| |
| trihexyphenidyl | Artane | |||
| tolterodine | Detrusitol | |||
| solifenacin | Vesicare | |||
| darifenacin | Enablex | |||
| benztropine | Cogentin |
See also
References
- ↑ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 147
- ↑ 2.0 2.1 2.2 Unless else specified in table boxes, then ref is: Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 147
External links
- http://cvpharmacology.com/antiarrhy/atropine.htm
- Muscarinic+antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)
Template:Drugs for functional gastrointestinal disorders
Template:Mydriatics and cycloplegics Template:Receptor agonists and antagonists