Bromazine: Difference between revisions

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Media
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Evidence Based Medicine
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Clinical Trials
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Bromazine
Clinical data
MedlinePlus	a682065
Routes of; administration	Oral
ATC code	R06AA01 (WHO) ;
Pharmacokinetic data
Bioavailability	High
Protein binding	96%
Metabolism	Mostly hepatic (CYP-mediated), also renal
Elimination half-life	1 to 4 hours
Identifiers
	IUPAC name 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine;
CAS Number	1808-12-4 1808-12-4;
PubChem CID	2444;
DrugBank	DB01237 ;
ChemSpider	2350 ;
UNII	202J683U97;
ChEBI	CHEBI:59177 ;
ChEMBL	ChEMBL1201245 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C17H20BrNO
Molar mass	334.251 g/mol
3D model (JSmol)	Interactive image;
	SMILES Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2;
	InChI InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 ; Key:NUNIWXHYABYXKF-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 19:36, 6 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bromazine (trade names Ambrodyl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic. It is a halogenated form of diphenhydramine and in many respects is somewhat stronger than the parent compound. The other three halogenated diphenhydramine derivatives are used in research and chlorodiphenhydramine is also marketed with iododiphenhydramine being a much less common pharmaceutical.

References

@@ Line 1: / Line 1: @@
 {{Drugbox
-| IUPAC_name        = 2-[(4-bromophenyl)-phenylmethoxy]-''N'',''N''-dimethylethanamine
+| Verifiedfields = changed
-| image             = Bromazine.svg
+| verifiedrevid = 459983265
-| CAS_number        = 118-23-0
+| IUPAC_name = 2-[(4-bromophenyl)-phenylmethoxy]-''N'',''N''-dimethylethanamine
-| CAS_supplemental  = {{CAS|1808-12-4}} ([[hydrochloride]])
+| image = Bromazine.svg
-| ATC_prefix        = R06
-| ATC_suffix        = AA01
+<!--Clinical data-->
-| PubChem           = 2444
+| tradename =
-| DrugBank          = APRD00710
+| MedlinePlus = a682065
-| C=17|H=20|Br=1|N=1|O=1
+| routes_of_administration = Oral
-| molecular_weight  = 334.251 g/mol
-| bioavailability   = High
+<!--Pharmacokinetic data-->
-| protein_bound     = 96%
+| bioavailability = High
-| metabolism        = Mostly [[liver|hepatic]] ([[cytochrome P450|CYP]]-mediated), also [[kidney|renal]]
+| protein_bound = 96%
+| metabolism = Mostly [[liver|hepatic]] ([[cytochrome P450|CYP]]-mediated), also [[kidney|renal]]
 | elimination_half-life = 1 to 4 hours
-| excretion         =
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+<!--Identifiers-->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| CASNo_Ref = {{cascite|correct|CAS}}
-| pregnancy_category=
+| CAS_number_Ref = {{cascite|correct|??}}
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| CAS_number = 1808-12-4
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| CAS_supplemental = {{CAS|1808-12-4}}
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| ATC_prefix = R06
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+| ATC_suffix = AA01
-| legal_status      =
+| PubChem = 2444
-| routes_of_administration = Oral
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+  | DrugBank = DB01237
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 2350
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 202J683U97
+| ChEBI_Ref = {{ebicite|correct|EBI}}
+| ChEBI = 59177
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 1201245
+<!--Chemical data-->
+| C=17 | H=20 | Br=1 | N=1 | O=1
+| molecular_weight = 334.251 g/mol
+| smiles = Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2
+| InChI = 1/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3
+| InChIKey = NUNIWXHYABYXKF-UHFFFAOYAG
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = NUNIWXHYABYXKF-UHFFFAOYSA-N
 }}
-'''Bromazine''' ([[International Nonproprietary Name|INN]], also known as '''bromodiphenhydramine''') is an [[antihistamine]]. It is a [[bromine|brominated]] derivative of [[diphenhydramine]].
+__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Bromazine''' (trade names '''Ambrodyl''', '''Ambrodil''' and others), also known as '''bromodiphenhydramine''', is an [[antihistamine]] and [[anticholinergic]]. It is a halogenated form of [[diphenhydramine]] and in many respects is somewhat stronger than the parent compound.  The other three halogenated diphenhydramine derivatives are used in research and [[chlorodiphenhydramine]] is also marketed with [[iododiphenhydramine]] being a much less common pharmaceutical.
+== References ==
+{{Reflist|2}}
-{{pharmacology-stub}}
 {{Antihistamines}}
 [[Category:H1 receptor antagonists]]
-{{WikiDoc Help Menu}}
+[[Category:Organobromides]]
+[[Category:Ethers]]
+[[Category:Amines]]
+[[Category:Drug]]

v t e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Clinical data

MedlinePlus	a682065
Routes of administration	Oral
ATC code	R06AA01 (WHO)
Pharmacokinetic data
Bioavailability	High
Protein binding	96%
Metabolism	Mostly hepatic (CYP-mediated), also renal
Elimination half-life	1 to 4 hours
Identifiers
IUPAC name 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
CAS Number	1808-12-4^Y 1808-12-4
PubChem CID	2444
DrugBank	DB01237^Y
ChemSpider	2350^Y
UNII	202J683U97
ChEBI	CHEBI:59177^Y
ChEMBL	ChEMBL1201245^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₇H₂₀BrNO
Molar mass	334.251 g/mol
3D model (JSmol)	Interactive image
SMILES Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2
InChI InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3^Y Key:NUNIWXHYABYXKF-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Bromazine: Difference between revisions

Latest revision as of 19:36, 6 April 2015

Overview

References

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