Alamethicin: Difference between revisions
m Protected "Alamethicin": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)) |
m Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +) |
||
| Line 1: | Line 1: | ||
{{SI}} | {{SI}} | ||
'''Alamethicin''' is a [[peptide]] [[antibiotic]], produced by the fungus ''[[Trichoderma viride]]''. It contains the non-[[proteinogenic]] [[amino acid]] [[2-Aminoisobutyric acid|2-aminoisobutyric acid]] (Aib), which strongly induces [[helix|helical]] peptide structures. The peptide sequence is: | '''Alamethicin''' is a [[peptide]] [[antibiotic]], produced by the fungus ''[[Trichoderma viride]]''. It contains the non-[[proteinogenic]] [[amino acid]] [[2-Aminoisobutyric acid|2-aminoisobutyric acid]] (Aib), which strongly induces [[helix|helical]] peptide structures. The peptide sequence is: | ||
| Line 22: | Line 22: | ||
[[Category:Antimicrobial peptides]] | [[Category:Antimicrobial peptides]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 20:49, 8 August 2012
|
WikiDoc Resources for Alamethicin |
|
Articles |
|---|
|
Most recent articles on Alamethicin Most cited articles on Alamethicin |
|
Media |
|
Powerpoint slides on Alamethicin |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Alamethicin at Clinical Trials.gov Clinical Trials on Alamethicin at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Alamethicin
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Alamethicin Discussion groups on Alamethicin Patient Handouts on Alamethicin Directions to Hospitals Treating Alamethicin Risk calculators and risk factors for Alamethicin
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Alamethicin |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. It contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. The peptide sequence is:
Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl
(Ac = acetyl, Phl = phenylalaninol)
- Molecular Formula: C92H150N22O25
- CAS number: 27061-78-5
- Appearance: Off white solid
- UV spectrum maxima: 265, 257
- Melting point: 255°C-270°C
- Solubility information: DMSO, Methanol, Ethanol. Not soluble in water
In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules.
data copied from Fermentek Alamethicin product page