Ampicillin sulbactam: Difference between revisions

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{{Drugbox
#REDIRECT [[Ampicillin-Sulbactam]]
| type              = combo
| component1        = Ampicillin
| class1            = [[Penicillin]] [[antibiotic]]
| component2        = Sulbactam
| class2            = [[Beta-lactamase inhibitor]]
| CAS_number        =
| ATC_prefix        = J01
| ATC_suffix        = CR01
| PubChem          = 656676
| DrugBank          =
| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| pregnancy_category= 
| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA          =  <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK          =  <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US          =  <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status      =
| routes_of_administration =
}}
{{SI}}
{{EH}}
 
'''Ampicillin/sulbactam''' is a combination of the common [[penicillin]]-derived [[antibiotic]] [[ampicillin]] and [[sulbactam]], an [[Enzyme inhibitor|inhibitor]] of [[bacteria]]l [[beta-lactamase]]. Two different forms of the drug exist. The first, developed in [[1987]] and marketed in the United States under the tradename '''Unasyn''', is an [[intravenous]] antibiotic. The second, an oral form called [[sultamicillin]], is marketed under the trade name '''Ampictam''' outside of the United States. Ampicillin/sulbactam is used to treat [[infection]]s caused by bacteria resistant to [[beta-lactam antibiotic]]s. Sulbactam blocks the [[enzyme]] which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.
 
{| class="wikitable" style="text-align:center"
| [[Image:Ampicillin-2D-skeletal.png|200px]] || [[Image:Sulbactam.svg|100px]] || [[Image:Sultamicillin schematic.svg|220px]]
|-
| [[Skeletal formula]] of [[ampicillin]] || Skeletal formula of [[sulbactam]] || Skeletal formula of [[sultamicillin]], highlighting ampicillin in blue and sulbactam in orange
|}
 
Ampicillin/sulbactam is also used when the cause of an infection is not known ([[empiric therapy]]). [[peritonitis|Intra-abdominal infections]], skin infections, [[pneumonia]], and [[gynecology|gynecologic infections]]. It is active against a wide range of bacterial groups, including ''[[Staphylococcus aureus]]'', ''[[Enterobacteriaceae]]'', and [[anaerobic bacteria]]. Importantly, it is not active against ''[[Pseudomonas aeruginosa]]'' and should not be used alone when infection with this organism is suspected or known.
 
{{PenicillinAntiBiotics}}
[[Category: Beta-lactam antibiotics]]
 
[[Category:Combination antibiotics]]
{{SIB}}
{{WikiDoc Help Menu}}
{{WS}}

Latest revision as of 19:05, 4 April 2015