Candicidin: Difference between revisions

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Candicidin
Clinical data
ATC code	G01AA04 (WHO) ;
Identifiers
	IUPAC name 33-[(3-Amino-3,6-dideoxy-D-mannopyranosyl)oxy]-17-[6-(4-aminophenyl)-4-hydroxy-1,3-dimethyl-6-oxohexyl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid;
CAS Number	1403-17-4 ;
PubChem CID	441142;
DrugBank	DB01152 ;
ChemSpider	10128184 ;
UNII	48N2IYJ202;
ChEMBL	ChEMBL1200647 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C59H84N2O18
Molar mass	1109,32 g/mol
3D model (JSmol)	Interactive image;
	SMILES Nc1ccc(cc1)C(=O)CC(O)C(C)CC(C)C3OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC4(O)CC(O)C(C(=O)O)C(CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C=CC=CC=CC=CC=CC=CC=CC3C)O4;
	InChI InChI=1S/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-46(77-58-55(72)53(61)54(71)38(4)76-58)31-50-52(57(73)74)49(69)34-59(75,79-50)33-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)30-51(70)78-56(35)37(3)26-36(2)47(67)32-48(68)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-47,49-50,52-56,58,64-67,69,71-72,75H,17,19-20,26-34,60-61H2,1-4H3,(H,73,74)/b6-5-,9-7-,10-8-,13-11-,14-12-,18-15-,21-16-/t35?,36?,37?,38-,43?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58?,59?/m1/s1 ; Key:YKSVGLFNJPQDJE-WDANKXQLSA-N ;
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VisualWikitext

Latest revision as of 13:39, 10 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Candicidin is an antifungal compound obtained from Streptomyces griseus. It is active against some fungi including Candida albicans. Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis.^[1]

This bioactive compound was named candicidin, because of its high activity on Candida albicans.^[2]

References

↑ "Product information Candicidin" (pdf). Toku-E. 2012-01-11. Retrieved 2012-06-11.
↑ Selman A. Waksman, Hubert A. Lechevalier & Carl P. Schaffner: Candicidin and other Polyenic Antifungal Antibiotics, 1965, 33, 219-226

[1] "Product information Candicidin" (pdf). Toku-E. 2012-01-11. Retrieved 2012-06-11.

[2] Selman A. Waksman, Hubert A. Lechevalier & Carl P. Schaffner: Candicidin and other Polyenic Antifungal Antibiotics, 1965, 33, 219-226

[1]

[2]

@@ Line 1: / Line 1: @@
 {{Drugbox
-| IUPAC_name        = 33-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
+| Verifiedfields = changed
-| image             = Candicidin.png
+| Watchedfields = changed
-| CAS_number        = 1403-17-4
+| verifiedrevid = 460122980
-| ATC_prefix        = G01
+| IUPAC_name = 33-[(3-Amino-3,6-dideoxy-<small>D</small>-mannopyranosyl)oxy]-17-[6-(4-aminophenyl)-4-hydroxy-1,3-dimethyl-6-oxohexyl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
-| ATC_suffix        = AA04
+| image = Candicidin.png
-| PubChem           = 441142
-| DrugBank          = APRD00843
+<!--Clinical data-->
-| C=59|H=84|N=2|O=18
+| tradename =
-| molecular_weight  = 875.9947 g/mol
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| bioavailability   =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| protein_bound     =
+| pregnancy_category =
-| metabolism        =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| elimination_half-life =
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| excretion         =
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_status =
-| pregnancy_category=
+| routes_of_administration =
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+<!--Pharmacokinetic data-->
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| bioavailability =
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+| protein_bound =
-| legal_status      =
+| metabolism =
-| routes_of_administration =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 1403-17-4
+| ATC_prefix = G01
+| ATC_suffix = AA04
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-46(77-58-55(72)53(61)54(71)38(4)76-58)31-50-52(57(73)74)49(69)34-59(75,79-50)33-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)30-51(70)78-56(35)37(3)26-36(2)47(67)32-48(68)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-47,49-50,52-56,58,64-67,69,71-72,75H,17,19-20,26-34,60-61H2,1-4H3,(H,73,74)/b6-5-,9-7-,10-8-,13-11-,14-12-,18-15-,21-16-/t35?,36?,37?,38-,43?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58?,59?/m1/s1
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = YKSVGLFNJPQDJE-WDANKXQLSA-N
+| PubChem = 441142
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+ | DrugBank = DB01152
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 10128184
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 48N2IYJ202
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 1200647
+<!--Chemical data-->
+| C=59 | H=84 | N=2 | O=18
+| molecular_weight = 1109,32 g/mol
+| smiles = Nc1ccc(cc1)C(=O)CC(O)C(C)CC(C)C3OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC4(O)CC(O)C(C(=O)O)C(CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C=CC=CC=CC=CC=CC=CC=CC3C)O4
 }}
+              __NOTOC__
 {{SI}}
-{{EH}}
+{{CMG}}
+==Overview==
+'''Candicidin''' is an [[Antifungal medication|antifungal]] compound obtained from ''[[Streptomyces]] griseus''.  It is active against some fungi including ''[[Candida albicans]]''. Candicidin is administered intravaginally in the treatment of vulvovaginal [[candidiasis]].<ref>{{ cite web | title = Product information Candicidin | url = http://www.toku-e.com/Upload/Products/PDS/20120604006556.pdf | format = pdf | publisher = Toku-E | date = 2012-01-11 | accessdate = 2012-06-11 }}</ref>
-'''Candicidin''' is an [[antibiotic]].
+This [[Bioactive compounds|bioactive compound]] was named candicidin, because of its high activity on '' Candida albicans''.<ref>Selman A. Waksman, Hubert A. Lechevalier & Carl P. Schaffner: ''Candicidin and other Polyenic Antifungal Antibiotics'', 1965, 33, 219-226</ref>
+== References ==
+{{reflist|2}}
 {{Gynecological anti-infectives and antiseptics}}
-[[Category:Macrolide antibiotics]]
+[[Category:Drug]]
-{{SIB}}
+[[Category:Antifungals]]
-{{WH}}
-{{WS}}

v t e Gynecological anti-infectives and antiseptics (G01)
Antibiotics	polyene antimycotic (Nystatin, Natamycin, Amphotericin B) - Candicidin - Chloramphenicol - Hachimycin - Oxytetracycline - Carfecillin - Mepartricin - Clindamycin - Pentamycin
Arsenic compounds	Acetarsol
Quinoline derivatives	Diiodohydroxyquinoline - Clioquinol - Chlorquinaldol - Dequalinium - Broxyquinoline - Oxyquinoline
Organic acids	Lactic acid - Acetic acid - Ascorbic acid
Sulfonamides	Sulfatolamide
Imidazole derivatives	Metronidazole - Clotrimazole - Miconazole - Econazole - Ornidazole - Isoconazole - Tioconazole - Ketoconazole - Fenticonazole - Azanidazole - Propenidazole - Butoconazole - Omoconazole - Oxiconazole - Flutrimazole
Triazole derivatives	Terconazole
Other	Clodantoin - Inosine - Policresulen - Nifuratel - Furazolidone - Methylrosaniline - Povidone-iodine - Ciclopirox - Protiofate - Lactobacillus fermentum - Copper usnate

Clinical data

ATC code	G01AA04 (WHO)
Identifiers
IUPAC name 33-[(3-Amino-3,6-dideoxy-D-mannopyranosyl)oxy]-17-[6-(4-aminophenyl)-4-hydroxy-1,3-dimethyl-6-oxohexyl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
CAS Number	1403-17-4^Y
PubChem CID	441142
DrugBank	DB01152^Y
ChemSpider	10128184^Y
UNII	48N2IYJ202
ChEMBL	ChEMBL1200647^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₅₉H₈₄N₂O₁₈
Molar mass	1109,32 g/mol
3D model (JSmol)	Interactive image
SMILES Nc1ccc(cc1)C(=O)CC(O)C(C)CC(C)C3OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC4(O)CC(O)C(C(=O)O)C(CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C=CC=CC=CC=CC=CC=CC=CC3C)O4
InChI InChI=1S/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-46(77-58-55(72)53(61)54(71)38(4)76-58)31-50-52(57(73)74)49(69)34-59(75,79-50)33-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)30-51(70)78-56(35)37(3)26-36(2)47(67)32-48(68)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-47,49-50,52-56,58,64-67,69,71-72,75H,17,19-20,26-34,60-61H2,1-4H3,(H,73,74)/b6-5-,9-7-,10-8-,13-11-,14-12-,18-15-,21-16-/t35?,36?,37?,38-,43?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58?,59?/m1/s1^Y Key:YKSVGLFNJPQDJE-WDANKXQLSA-N^Y
^NY (what is this?) (verify)

Candicidin: Difference between revisions

Latest revision as of 13:39, 10 April 2015

Overview

References

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