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| {{drugbox
| | #REDIRECT [[Podofilox]] |
| | IUPAC_name = 5,8,8a,9-Tetrahydro-9-hydroxy-5- (3,4,5-trimethoxylphenyl) furo [3',4':6,7] naphtho [2,3,d]-1,3-dioxol-6(5aH)-one
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| | image = Podophyllotoxin.png
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| | CAS_number = 518-28-5
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| | ATC_prefix = D06
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| | ATC_suffix = BB04
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| | ATC_supplemental =
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| | PubChem = 10607
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| | DrugBank = APRD01189
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| | C=22 | H=22 | O=8
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| | molecular_weight = 414.405 g/mol
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| | bioavailability =
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| | protein_bound =
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| | metabolism =
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| | elimination_half-life = 1.0 to 4.5 hours.
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| | pregnancy_category =
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| | legal_status =
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| | routes_of_administration =
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| }}
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| '''Podophyllotoxin''', otherwise known as '''podofilox''' is a non-[[alkaloid]] [[toxin]] in the [[lignan]] family present at concentrations of 0.3 to 1.0% by mass in the [[rhizome]] of [[Podophyllum peltatum|American Mayapple]] [[Podophyllum peltatum]]. Another common source of podophyllotoxin are the rhizomes of Podophyllum hexandrum Royle ([[Berberidaceae]]).
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| It is synthetised biologically from two molecules of [[coniferyl alcohol]] by phenolic oxidative coupling and a series of [[oxidation]]s, [[Redox|reduction]]s and [[methylation]]s
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| The melting point of Podophyllotoxin is 183.3 - 184.0 °C.
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| Podophyllotoxin is the pharmacological base for the important anti-cancer drug [[Etoposide]].
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| It is also used as a [[gel]] or [[solution]] to treat [[genital warts]].
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| ==References==
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| *{{cite journal|
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| | author =Canel, C; Moraes, RM; Dayan, FE; Ferreira, D
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| | title = Molecules of Interest: Podophyllotoxin
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| | journal = Phytochemistry
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| | year = 2000
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| | volume =54
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| | issue = 2
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| | pages = 115-120}}
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| *{{cite journal|
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| | author =J. L. Hartwell, A. W. Schrecker
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| | title = Components of Podophyllin. V. The Constitution of Podophyllotoxin
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| | journal = [[Journal of the American Chemical Society]]
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| | year = 1951
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| | volume =73
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| | issue = 6
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| | pages = 2909 - 2916
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| | doi = 10.1021/ja01150a143}}
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| {{Antibiotics and chemotherapeutics for dermatological use}}
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| {{Antivirals}}
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| [[Category:Antivirals]]
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| [[nl:Podofyllotoxine]]
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| [[pl:Podofilotoksyna]]
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