Dimetotiazine: Difference between revisions

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Dimetotiazine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: <! -- A / B1 / B2 / B3 / C / D / X --> ; US: <! -- A / B / C / D / X-- > ; ;
Routes of; administration	Oral
ATC code	N02CX05 (WHO) ;
Legal status
Legal status	AU: <! -- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> ; CA: <! -- Schedule I, II, III, IV, V, VI, VII, VIII-- > ; UK: <! -- GSL, P, POM, CD, or Class A, B, C-- > ; US: <! -- OTC / Rx-only / Schedule I, II, III, IV, V-- > ; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide;
CAS Number	7456-24-8 ;
PubChem CID	3089;
ChemSpider	2979 ;
UNII	1FTA475ZDB;
KEGG	D07854 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C19H25N3O2S2
Molar mass	391.55 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C;
	InChI InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3 ; Key:VWNWVCJGUMZDIU-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 16:49, 14 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

For patient information, click here.

Overview

Dimetotiazine (INN) is a phenothiazine. It is a serotonin antagonist and histamine antagonist.^[1]

Dimetotiazine is also known as Dimétotiazine, Dimetotiazine Mesilate and Fonazine Mesylate.

References

↑ Shimazawa M, Hara H, Watano T, Sukamoto T (August 1995). "Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats". Br. J. Pharmacol. 115 (8): 1359–68. PMC 1908864. PMID 8564192.

Template:Antimigraine preparations

[pmid8564192-1] Shimazawa M, Hara H, Watano T, Sukamoto T (August 1995). "Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats". Br. J. Pharmacol. 115 (8): 1359–68. PMC 1908864. PMID 8564192.

[1]

@@ Line 1: / Line 1: @@
 {{Drugbox
-| IUPAC_name        = 10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide
+| Verifiedfields = changed
-| image             = Dimetotiazine.png
+| verifiedrevid = 443778442
-| CAS_number        = 7456-24-8
+| IUPAC_name = 10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide
-| CAS_supplemental  =
+| image = Dimetotiazine.png
-| ATC_prefix        =
+<!--Clinical data-->
-| ATC_suffix        =
+| tradename =
-| ATC_supplemental  =
+| Drugs.com = {{drugs.com|international|dimetotiazine}}
-| PubChem           = 3089
+| pregnancy_AU =<! -- A / B1 / B2 / B3 / C / D / X -->
-| DrugBank          =
+| pregnancy_US =<! -- A / B            / C / D / X-- >
-| chemical_formula  =
+| pregnancy_category =
+| legal_AU =<! -- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
+| legal_CA =<! -- Schedule I, II, III, IV, V, VI, VII, VIII-- >
+| legal_UK =<! -- GSL, P, POM, CD, or Class A, B, C-- >
+| legal_US =<! -- OTC / Rx-only / Schedule I, II, III, IV, V-- >
+| legal_status = Rx-only
+| routes_of_administration = Oral
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 7456-24-8
+| ATC_prefix = N02
+| ATC_suffix = CX05
+| ATC_supplemental =
+| PubChem = 3089
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 1FTA475ZDB
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07854
+|  ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
+| ChemSpiderID = 2979
+|  InChI = 1/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
+|  InChIKey = VWNWVCJGUMZDIU-UHFFFAOYAN
+|  StdInChI_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChI = 1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
+|  StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChIKey = VWNWVCJGUMZDIU-UHFFFAOYSA-N
+<!--Chemical data-->
+| chemical_formula =
 | C=19 | H=25 | N=3 | O=2 | S=2
-| molecular_weight  = 391.55 g/mol
+| molecular_weight = 391.55 g/mol
-| smiles            = CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C
+| smiles = CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C
-| bioavailability   =
-| protein_bound     =
-| metabolism        =
-| elimination_half-life =
-| excretion         =
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
-| pregnancy_category=
-| legal_AU =  <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| legal_CA =  <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
-| legal_UK =  <!-- GSL, P, POM, CD, or Class A, B, C -->
-| legal_US =  <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
-| legal_status      = Rx-only
-| routes_of_administration = Oral
 }}
+__NOTOC__
+{{SI}}
 {{CMG}}
+==Overview==
+'''''For patient information, click [[Oxetoron (patient information)|here]]'''''.
+==Overview==
+'''Dimetotiazine''' ([[International Nonproprietary Name|INN]]) is a [[phenothiazine]]. It is a [[serotonin antagonist]] and [[histamine antagonist]].<ref name="pmid8564192">{{cite journal |author=Shimazawa M, Hara H, Watano T, Sukamoto T |title=Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats |journal=Br. J. Pharmacol. |volume=115 |issue=8 |pages=1359–68 |date=August 1995 |pmid=8564192 |pmc=1908864 |doi= |url=}}</ref>
-{{EH}}
+Dimetotiazine is also known as Dimétotiazine, Dimetotiazine Mesilate and Fonazine Mesylate.
-'''Dimetotiazine''' ([[International Nonproprietary Name|INN]]) is a phenothiazine.
+==Category==
-{{Antimigraine preparations}}
+Antimigraine Drugs
-[[Category:Phenothiazines]]
+==References==
-{{WH}}
+{{Reflist|2}}
-{{WS}}
+{{Antimigraine preparations}}
+[[Category:Phenothiazines]]
+[[Category:Antimigraine drugs]]
+[[Category:Drugs]]

Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	AU: <! -- A / B1 / B2 / B3 / C / D / X --> US: <! -- A / B / C / D / X-- >
Routes of administration	Oral
ATC code	N02CX05 (WHO)
Legal status
Legal status	AU: <! -- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> CA: <! -- Schedule I, II, III, IV, V, VI, VII, VIII-- > UK: <! -- GSL, P, POM, CD, or Class A, B, C-- > US: <! -- OTC / Rx-only / Schedule I, II, III, IV, V-- > In general: ℞ (Prescription only)
Identifiers
IUPAC name 10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide
CAS Number	7456-24-8^Y
PubChem CID	3089
ChemSpider	2979^N
UNII	1FTA475ZDB
KEGG	D07854^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₉H₂₅N₃O₂S₂
Molar mass	391.55 g/mol
3D model (JSmol)	Interactive image
SMILES CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C
InChI InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3^N Key:VWNWVCJGUMZDIU-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Dimetotiazine: Difference between revisions

Latest revision as of 16:49, 14 April 2015

Overview

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References

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