Promazine: Difference between revisions

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Promazine
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a600010
ATC code	N05AA03 (WHO) ;
Pharmacokinetic data
Protein binding	94%
Identifiers
	IUPAC name N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine;
CAS Number	58-40-2 ;
PubChem CID	4926;
DrugBank	DB00420 ;
ChemSpider	4757 ;
UNII	O9M39HTM5W;
ChEBI	CHEBI:8459 ;
ChEMBL	ChEMBL564 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C17H20N2S
Molar mass	284.42 g/mol
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCCN1c2ccccc2Sc3c1cccc3;
	InChI InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3 ; Key:ZGUGWUXLJSTTMA-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Latest revision as of 15:09, 9 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Promazine (Sparine) is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia, it is still prescribed, alongside newer agents such as olanzapine and quetiapine. It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon either.

Promazine is not approved for human use in the United States. It is available in the US for veterinary use under the names Promazine and Tranquazine.

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name = N,N-dimethyl-3-(10H-phenothiazin-10-yl) propan-1-amine
+| verifiedrevid = 464215585
-| image = Promazine.svg
+| IUPAC_name = N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
-| image2= Promazine3d.png
+| image =Promazine.png
 | width = 160
+| image2 =Promazine3d.png
+<!--Clinical data-->
+| tradename =
+| Drugs.com = {{drugs.com|CONS|promazine}}
+| MedlinePlus = a600010
+| pregnancy_category =
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound = 94%
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CASNo_Ref = {{cascite|correct|CAS}}
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 58-40-2
 | ATC_prefix = N05
 | ATC_suffix = AA03
 | ATC_supplemental =
 | PubChem = 4926
-| DrugBank = APRD00358
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| C=17 | H=20 | N=2 | S=1
+ | DrugBank = DB00420
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 4757
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = O9M39HTM5W
+| ChEBI_Ref = {{ebicite|correct|EBI}}
+| ChEBI = 8459
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 564
+<!--Chemical data-->
+| C=17 | H=20 | N=2 | S=1
 | molecular_weight = 284.42 g/mol
-| bioavailability =
+| smiles = CN(C)CCCN1c2ccccc2Sc3c1cccc3
-| protein_bound = 94%
+| InChI = 1/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
-| metabolism =
+| InChIKey = ZGUGWUXLJSTTMA-UHFFFAOYAX
-| elimination_half-life =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| excretion =
+| StdInChI = 1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
-| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_US = <!-- A / B / C / D / X -->
+| StdInChIKey = ZGUGWUXLJSTTMA-UHFFFAOYSA-N
-| pregnancy_category =
-| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
-| legal_UK = <!-- GSL / P / POM / CD -->
-| legal_US = <!-- OTC / Rx-only -->
-| legal_status =
-| routes_of_administration =
 }}
+__Notoc__
+{{SI}}
+{{CMG}}
+==Overview==
-{{SI}}
+'''Promazine''' ('''Sparine''') is a medication that belongs to the [[phenothiazine]] class of [[antipsychotics]]. An older medication used to treat [[schizophrenia]], it is still prescribed, alongside newer agents such as [[olanzapine]] and [[quetiapine]]. It has predominantly [[anticholinergic]] side effects, though [[extrapyramidal symptoms|extrapyramidal]] side effects are not uncommon either.
-{{EH}}
-'''Promazine''' (marketed as Sparine) is a medication that belongs to the [[phenothiazine]] class of [[antipsychotics]]. An older medication used to treat [[schizophrenia]], its use has largely been replaced by newer agents such as [[olanzapine]] and [[quetiapine]].
+Promazine is not approved for human use in the United States.   It is available in the US for veterinary use under the names Promazine and Tranquazine.
-It has predominantly [[anticholinergic]] side effects, though [[extrapyramidal]] side effects are not uncommon either.
+==See also==
+*[[Chlorpromazine]]
+*[[Triflupromazine]]
+*[[Prochlorperazine]]
+*[[Trifluoperazine]]
+*[[Fluphenazine]]
+*[[Thioridazine]]
+*[[Mesoridazine]]
 {{Antipsychotics}}
+[[Category:Drug]]
-{{SIB}}
 [[Category:Phenothiazines]]
-[[pl:Promazyna]]
-[[ru:Промазин]]
-{{WH}}
-{{WS}}

v t e Antipsychotics (neuroleptics) (N05A)
Typical	Benzamides: Levosulpiride • Nemonapride • Sulpiride • Sultopride • Tiapride • Veralipride; Butyrophenones: Azaperone • Benperidol • Bromperidol • Droperidol • Fluanisone • Haloperidol • Lenperone • Moperone • Pipamperone • Spiperone • Timiperone • Trifluperidol; Diphenylbutylpiperidines: Clopimozide • Fluspirilene • Penfluridol • Pimozide; Phenothiazines: Acepromazine • Acetophenazine • Butaperazine • Carphenazine • Chloracizine • Chlorproethazine • Chlorpromazine • Cyamemazine • Dixyrazine • Fluacizine • Fluphenazine • Levomepromazine/Methotrimeprazine • Mesoridazine • Perazine • Periciazine • Perphenazine • Piperacetazine • Pipotiazine • Prochlorperazine • Promazine • Promethazine • Propiomazine • Sulforidazine • Thiethylperazine • Thiopropazate • Thioproperazine • Thioridazine • Trifluoperazine • Triflupromazine; Thioxanthenes: Chlorprothixene • Clopenthixol • Flupentixol • Thiothixene • Zuclopenthixol; Tricyclics: Amoxapine • Butaclamol • Fluotracen • Loxapine • Metitepine/Methiothepin • Octoclothiepin • Trimipramine; Others: Prothipendyl
Atypical	Benzamides: Amisulpride • Remoxipride; Butyrophenones: Cinuperone • Setoperone; Benzo(iso)oxazole piperidines: Iloperidone • Ocaperidone • Paliperidone • Risperidone; Benzo(iso)thiazole piperazines: Lurasidone • Perospirone • Revospirone • Tiospirone • Ziprasidone; Diphenylbutylpiperazines: Amperozide; Phenylpiperazines: Aripiprazole • Bifeprunox • Elopiprazole • Umespirone; Tricyclics: Asenapine • Carpipramine • Clocapramine • Clotiapine • Clozapine • Fluperlapine • Gevotroline • Metitepine/Methiothepin • Mosapramine • NDMC • Olanzapine • Piquindone • Quetiapine • Tenilapine • Zotepine; Others: Blonanserin • Cariprazine • Molindone • Pimavanserin • Roxindole • Sarizotan • Sertindole • Spiramide
Others	Azacyclonol • Cannabidiol • D-Cycloserine • Lithium • Mifepristone • Oxypertine • Reserpine • Rimcazole • Secretin • Talnetant • Tetrabenazine • Vabicaserin
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III Template:Psychology navs

Promazine: Difference between revisions

Latest revision as of 15:09, 9 April 2015

Overview

See also

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