Bivalirudin mechanism of action: Difference between revisions

Latest revision as of 00:23, 22 July 2014

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+#REDIRECT [[Bivalirudin#Pharmacology]]
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-==Overview==
-==Mechanism of action==
-) Specific and reversible direct thrombin inhibitor
-) Binds to the catalytic and anionic sites of both circulating and clot-bound thrombin.
-) Catalytic binding site occupation functionally inhibits coagulant effects by preventing thrombin-mediated cleavage of fibrinogen to fibrin monomers, and activation of factors V, VIII, and XIII.
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