Idiopathic thrombocytopenic purpura (patient information): Difference between revisions
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'''For the WikiDoc page for this topic, click [[Idiopathic thrombocytopenic purpura|here]]''' | '''For the WikiDoc page for this topic, click [[Idiopathic thrombocytopenic purpura|here]]''' | ||
{{ | {{ITP (patient information)}} | ||
'''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto: | '''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; '''Associate Editor-In-Chief:''' [[Lakshmi Gopalakrishnan]], M.B.B.S. | ||
==Overview== | ==Overview== | ||
Idiopathic thrombocytopenic purpura is a | Idiopathic thrombocytopenic purpura is a [[bleeding disorder]] in which the immune system destroys [[platelet]]s, which are necessary for normal blood clotting. People with the disease have too few platelets in the blood. | ||
ITP is sometimes called | ITP is sometimes called immune thrombocytopenic purpura. | ||
==What are the symptoms of Idiopathic thrombocytopenic purpura?== | ==What are the symptoms of Idiopathic thrombocytopenic purpura?== | ||
*Abnormally heavy menstruation | *Abnormally heavy menstruation | ||
*Bleeding into the skin causes a characteristic skin rash that looks like pinpoint red spots ( | *Bleeding into the skin causes a characteristic skin rash that looks like pinpoint red spots ([[petechial rash]]) | ||
*Easy bruising | *Easy bruising | ||
*Nosebleed or bleeding in the mouth | *Nosebleed or bleeding in the mouth | ||
==What causes Idiopathic thrombocytopenic purpura?== | ==What causes Idiopathic thrombocytopenic purpura?== | ||
*ITP occurs when certain | *ITP occurs when certain [[immune system]] cells produce [[antibodies]] against [[platelet]]s. Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels. | ||
*The antibodies attach to the platelets. The spleen destroys the platelets that carry the antibodies. | *The antibodies attach to the platelets. The [[spleen]] destroys the platelets that carry the antibodies. | ||
*In children, the disease sometimes follows a viral infection. In adults, it is more often a chronic (long-term) disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder. | *In children, the disease sometimes follows a [[viral infection]]. In adults, it is more often a chronic (long-term) disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder. | ||
*ITP affects women more frequently than men, and is more common in children than adults. The disease affects boys and girls equally. | *ITP affects women more frequently than men, and is more common in children than adults. The disease affects boys and girls equally. | ||
==Diagnosis== | ==Diagnosis== | ||
* | *Laboratory tests will be done to see how well your blood clots and to check your platelet count. | ||
:*A complete blood count (CBC) shows a low number of platelets. | :*A [[complete blood count]] (CBC) shows a low number of platelets. | ||
:*Blood clotting tests (PTT and PT) are normal. | :*Blood clotting tests ([[PTT]] and PT) are normal. | ||
:*Bleeding time is prolonged. | :*Bleeding time is prolonged. | ||
:*Platelet associated antibodies may be detected. | :*Platelet associated antibodies may be detected. | ||
*A | *A bone marrow aspiration or biopsy appears normal or may show a greater than normal number of cells called [[megakaryocyte]]s. These cells are an early form of platelets. | ||
==When to seek urgent medical care?== | |||
Go to the emergency room or call the local emergency number (such as 911) if severe bleeding occurs, or if other new symptoms develop. | |||
==Treatment options== | ==Treatment options== | ||
*In children, the disease usually goes away without treatment. Some children, however, may need treatment. | *In children, the disease usually goes away without treatment. Some children, however, may need treatment. | ||
*Adults are usually started on an anti-inflammatory steroid medicine called | *Adults are usually started on an anti-inflammatory steroid medicine called [[prednisone]]. In some cases, surgery to remove the [[spleen]] ([[splenectomy]]) is recommended. This will increase the platelet count in about half of all patients. However, other drug treatments are usually recommended instead. | ||
*If the disease | *If the disease does not get better with prednisone, other treatments may include: | ||
:*A medicine called [[danazol]] (Danocrine) taken by mouth | :*A medicine called [[danazol]] (Danocrine) taken by mouth | ||
:*Injections of high-dose gamma globulin (an immune factor) | :*Injections of high-dose [[gamma globulin]] (an immune factor) | ||
:*Drugs that suppress the immune system | :*Drugs that suppress the immune system | ||
:*Filtering antibodies out of the blood stream | :*Filtering antibodies out of the blood stream | ||
:* | :*Anti-RhD therapy for people with certain blood types | ||
*People with ITP | *People with ITP should not take [[aspirin]], [[ibuprofen]], or [[warfarin]] because these drugs interfere with platelet function or blood clotting, and bleeding may occur. | ||
==Where to find medical care for Idiopathic thrombocytopenic purpura?== | ==Where to find medical care for Idiopathic thrombocytopenic purpura?== | ||
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[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|Idiopathic thrombocytopenic purpura}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating Idiopathic thrombocytopenic purpura] | [http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|Idiopathic thrombocytopenic purpura}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating Idiopathic thrombocytopenic purpura] | ||
==Prevention== | ==Prevention of Idiopathic thrombocytopenic purpura== | ||
The causes and risk factors are unknown, except in children when it may be related to a viral infection. Prevention methods are unknown. | The causes and risk factors are unknown, except in children when it may be related to a viral infection. Prevention methods are unknown. | ||
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==Possible complications== | ==Possible complications== | ||
Sudden and severe loss of blood from the digestive tract may occur. Bleeding into the brain may also occur. | |||
==Source== | ==Source== | ||
http://www.nlm.nih.gov/medlineplus/ency/article/000535.htm | http://www.nlm.nih.gov/medlineplus/ency/article/000535.htm | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Patient information]] | |||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
[[Category:Blood disorders]] | |||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
Latest revision as of 15:12, 13 March 2013
For the WikiDoc page for this topic, click here
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Idiopathic thrombocytopenic purpura |
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Where to find medical care for Idiopathic thrombocytopenic purpura? |
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Idiopathic thrombocytopenic purpura On the Web |
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Directions to Hospitals Treating Idiopathic thrombocytopenic purpura |
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Risk calculators and risk factors for Idiopathic thrombocytopenic purpura |
Editor-in-Chief: C. Michael Gibson, M.S.,M.D. [1] Phone:617-632-7753; Associate Editor-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S.
Overview
Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. People with the disease have too few platelets in the blood.
ITP is sometimes called immune thrombocytopenic purpura.
What are the symptoms of Idiopathic thrombocytopenic purpura?
- Abnormally heavy menstruation
- Bleeding into the skin causes a characteristic skin rash that looks like pinpoint red spots (petechial rash)
- Easy bruising
- Nosebleed or bleeding in the mouth
What causes Idiopathic thrombocytopenic purpura?
- ITP occurs when certain immune system cells produce antibodies against platelets. Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels.
- The antibodies attach to the platelets. The spleen destroys the platelets that carry the antibodies.
- In children, the disease sometimes follows a viral infection. In adults, it is more often a chronic (long-term) disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder.
- ITP affects women more frequently than men, and is more common in children than adults. The disease affects boys and girls equally.
Diagnosis
- Laboratory tests will be done to see how well your blood clots and to check your platelet count.
- A complete blood count (CBC) shows a low number of platelets.
- Blood clotting tests (PTT and PT) are normal.
- Bleeding time is prolonged.
- Platelet associated antibodies may be detected.
- A bone marrow aspiration or biopsy appears normal or may show a greater than normal number of cells called megakaryocytes. These cells are an early form of platelets.
When to seek urgent medical care?
Go to the emergency room or call the local emergency number (such as 911) if severe bleeding occurs, or if other new symptoms develop.
Treatment options
- In children, the disease usually goes away without treatment. Some children, however, may need treatment.
- Adults are usually started on an anti-inflammatory steroid medicine called prednisone. In some cases, surgery to remove the spleen (splenectomy) is recommended. This will increase the platelet count in about half of all patients. However, other drug treatments are usually recommended instead.
- If the disease does not get better with prednisone, other treatments may include:
- A medicine called danazol (Danocrine) taken by mouth
- Injections of high-dose gamma globulin (an immune factor)
- Drugs that suppress the immune system
- Filtering antibodies out of the blood stream
- Anti-RhD therapy for people with certain blood types
- People with ITP should not take aspirin, ibuprofen, or warfarin because these drugs interfere with platelet function or blood clotting, and bleeding may occur.
Where to find medical care for Idiopathic thrombocytopenic purpura?
Directions to Hospitals Treating Idiopathic thrombocytopenic purpura
Prevention of Idiopathic thrombocytopenic purpura
The causes and risk factors are unknown, except in children when it may be related to a viral infection. Prevention methods are unknown.
What to expect (Outlook/Prognosis)?
With treatment, the chance of remission (a symptom-free period) is good. Rarely, ITP may become a long-term condition in adults and reappear, even after a symptom-free period.
Possible complications
Sudden and severe loss of blood from the digestive tract may occur. Bleeding into the brain may also occur.