Glucocorticoid resistance: Difference between revisions

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VisualWikitext

Latest revision as of 20:34, 19 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess

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Overview

Patients can be both resistant and hypersensitive to glucocorticoids.

In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be

Generalized or tissue-specific
Transient or permanent
Partial or complete
Compensated or noncompensated.

The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D. Template:WH Template:WS

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-'''Quick Start:''' ''You don't need to be Editor-In-Chief to add or edit content. You can begin to add to or edit text on this wiki doc page by clicking on the edit button above and to the left on this same page. Type in the text you want to add. Once you are done, click the save changes button at the bottom.
+__NOTOC__
+{{CMG}}
+{{SI}}
-'''Apply to be Editor-In-Chief for this topic:''' There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [mailto:mgibson@perfuse.org] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
+{{SK}} Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess
+Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.
 == Overview ==
-Patients can be both resistant and hypersensitive to glucocorticoids.
+Patients can be both [[resistant]] and [[hypersensitive]] to [[glucocorticoids]].
-In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be
+In glucocorticoid resistance, the [[target tissue]] is unable to respond to glucocorticoids. The lack of responsiveness can be
 #Generalized or tissue-specific
 #Transient or permanent
@@ Line 13: / Line 16: @@
 The presence of complete glucocorticoid resistance is fatal.  Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.
-'''''Related Key Words and Synonyms:'''''
-cortisol resistance, glucocorticoid insensitivity, steroid hormone resistance, glucocorticoid receptor, steroid hormone insensitivity, overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations, elevations in circulating cortisol, mineralocorticoid excess, androgen excess
-== Epidemiology and Demographics ==
-== Risk Factors ==
-== Screening ==
-== Pathophysiology & Etiology==
-== Molecular Biology ==
-== Genetics ==
-== Natural History ==
-== Diagnosis ==
-=== Differential Diagnosis ===
-=== History and Symptoms ===
-=== Physical Examination ===
-==== Appearance of the Patient ====
-====Vital Signs====
-====Skin====
-==== Eyes ====
-==== Ear Nose and Throat ====
-==== Heart ====
-==== Lungs ====
-==== Abdomen ====
-==== Extremities ====
-==== Neurologic ====
-==== Other ====
-=== Laboratory Findings ===
-==== Electrolyte and Biomarker Studies ====
-==== Electrocardiogram ====
-==== Chest X Ray ====
-==== MRI and CT ====
-==== Echocardiography or Ultrasound ====
-==== Other Imaging Findings ====
-=== Other Diagnostic Studies ===
-== Risk Stratification and Prognosis==
-== Treatment ==
-=== Pharmacotherapy ===
-==== Acute Pharmacotherapies ====
-==== Chronic Pharmacotherapies ====
-=== Surgery and Device Based Therapy ===
-==== Indications for Surgery ====
-==== Pre-Operative Assessment ====
-==== Post-Operative Management ====
-==== Transplantation ====
-=== Primary Prevention ===
-=== Secondary Prevention ===
-=== Cost-Effectiveness of Therapy ===
-=== Future or Investigational Therapies ===
-=="The Way I Like To Do It ..." Tips and Tricks From Clinicians Around The World==
-===Suggested Revisions to the Current Guidelines===
-==References==
-<biblio>
-</biblio>
 == Acknowledgements ==
 The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.
+{{WH}}
-Initial content for this page in some instances came from [http://www.wikipedia.org Wikipedia]
+{{WS}}
-'''List of contributors:'''
-== Suggested Reading and Key General References ==
-== Suggested Links and Web Resources ==
-== For Patients ==
-----
-{{WikiDoc Sources}}
 [[Category:Disease]]
 [[Category:Endocrinology]]
+[[Category:Needs content]]

Glucocorticoid resistance: Difference between revisions

Latest revision as of 20:34, 19 September 2012

Overview

Acknowledgements

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