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'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
__NOTOC__
{{DiseaseDisorder infobox |
  Name        = Thyroid cancer |
  Image      = folladen.jpg |
  Caption    = This follicular adenoma of the thyroid is shown in a right lobectomy specimen, sectioned vertically and viewed from the posterior aspect to show a 2.7 cm tumor distending the lower pole. Courtesy of  Ed Uthman, MD |
  ICD10      = C73 |
  ICD9        = {{ICD9|193}} |
}}
 
{{CMG}}
{{MJM}}
{{Thyroid cancer}}
{{Thyroid cancer}}
{{Editor Help}}
{{CMG}}; {{AE}} {{MJM}}; {{Ammu}}{{SMP}}{{Sahar}}
 
==Overview==
==[[Thyroid cancer overview|Overview]]==
Thyroid cancer refers to any of four kinds of [[tumor]]s of the [[thyroid]] gland which include [[Papillary thyroid cancer|papillary]], [[Follicular thyroid cancer|follicular]], [[Medullary thyroid cancer|medullary]] and [[Anaplastic thyroid cancer|anaplastic tumors]]. [[Papillary thyroid cancer|Papillary]] and [[Follicular thyroid cancer|follicular]] tumors are the most common and are usually [[benign tumor|benign]]. [[Papillary thyroid cancer|Papillary]] and [[Follicular thyroid cancer|follicular]] tumors have a slow growth and may recur, but are generally not fatal in patients under 45 years of age. [[Medullary thyroid cancer|Medullary]] and [[Anaplastic thyroid cancer|anaplastic tumors]] are [[cancer|malignant]].  [[Medullary]] tumors have a good prognosis if the are restricted to the thyroid gland and a poorer prognosis if [[metastasis]] occurs. [[Anaplastic thyroid cancer|Anaplastic tumors]] are fast-growing and respond poorly to therapy.
 
[[Thyroid nodule|Thyroid nodules]] are diagnosed by [[ultrasound]] guided [[fine needle aspiration]] or frequently by [[thyroidectomy]] (surgical removal and subsequent [[Histology|histological]] examination). As the thyroid cancer can uptake [[iodine]], [[radioactive iodine]] is commonly used for the treatment of thyroid carcinomas. However, radioactive iodine therapy is accompanied by [[thyroxine]] therapy to ensure [[TSH]] suppression.
==[[Thyroid cancer historical perspective|Historical Perspective]]==
 
==[[Thyroid cancer pathophysiology|Pathophysiology]]==
 
==[[Thyroid cancer epidemiology and demographics|Epidemiology & Demographics]]==
 
==[[Thyroid cancer risk factors|Risk Factors]]==
 
==[[Thyroid cancer screening|Screening]]==
 
==[[Thyroid cancer causes|Causes]]==
 
==[[Thyroid cancer differential diagnosis|Differentiating Thyroid cancer]]==
 
==[[Thyroid cancer natural history|Complications & Prognosis]]==
 
==Diagnosis==
[[Thyroid cancer history and symptoms|History and Symptoms]] | [[Thyroid cancer physical examination|Physical Examination]] | [[Thyroid cancer staging|Staging]] | [[Thyroid cancer laboratory tests|Laboratory tests]] | [[Thyroid cancer electrocardiogram|Electrocardiogram]]  | [[Thyroid cancer x ray|X Rays]] | [[Thyroid cancer CT|CT]] | [[Thyroid cancer MRI|MRI]] [[Thyroid cancer echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Thyroid cancer other imaging findings|Other images]] | [[Thyroid cancer other diagnostic studies|Alternative diagnostics]]
 
==Treatment==
[[Thyroid cancer medical therapy|Medical therapy]] | [[Thyroid cancer surgery|Surgical options]] | [[Thyroid cancer primary prevention|Primary prevention]]  | [[Thyroid cancer secondary prevention|Secondary prevention]] | [[Thyroid cancer cost-effectiveness of therapy|Financial costs]] | [[Thyroid cancer future or investigational therapies|Future therapies]]
 
 
==Diagnosis==
After a [[nodule]] is found during a physical examination, a referral to an [[endocrinologist]], or a thyroidologist is the best approach. Most commonly an [[ultrasound]] is performed to confirm the presence of a nodule, and assess the status of the whole gland. Measurement of [[thyroid stimulating hormone]] and anti-thyroid antibodies will help decide if there is a functional thyroid disease such as [[Hashimoto's thyroiditis]] present, a known cause of a benign nodular goiter. The most cost-effective, sensitive and accurate test to determine whether the nodule is malignant is the ''fine needle biopsy'' (FNB). FNB or ultrasound-guided FNA usually yields sufficient thyroid cells to assess the risk of malignancy, although in some cases, the suspected nodule may need to be removed surgically for pathological examination. Rarely, a biopsy is done using a large cutting needle, so that the a piece of nodule capsule can be obtained. Blood or imaging tests may be done prior to or in lieu of a biopsy. The possibility of a nodule which secretes thyroid hormone (which is less likely to be cancer) or hypothyroidism is investigated by measuring [[thyroid stimulating hormone]] (TSH), and the thyroid hormones [[thyroxine]] (T4) and [[triiodothyronine]] (T3). Tests for serum thyroid [[antibodies|autoantibodies]] are sometimes done as these may indicate [[autoimmune]] thyroid disease (which can mimic nodular disease). The blood assays may be accompanied by [[Medical ultrasonography|ultrasound]] imaging of the nodule to determine the position, size and texture, and to assess whether the nodule may be [[cyst|cystic]] (fluid filled). Also suspicious findings in a nodule are hypoechoic, irregular borders, microcalcifications, or very high levels of blood flow within the nodule. Less suspicious findings in benign nodules include, hyperechoic, comet tail artifacts from [[colloid]], no blood flow in the nodule and a halo, or smooth border. Some clinicians will also request [[technetium]] (Tc) or radioactive [[iodine]] (I) [[scintigraphy|imaging]] of the thyroid. An I<sup>123</sup> scan showing a hot nodule, accompanied by a lower than normal TSH, is strong evidence that the nodule is not cancerous.
 
==Classification==
==Classification==
Thyroid cancers can be classified according to their pathological characteristics. The following variants can be distinguished (distribution over various subtypes may show regional variation):
Thyroid cancers can be classified according to their pathological characteristics. The following variants can be distinguished (distribution over various subtypes may show regional variation):
* [[Papillary]] thyroid cancer (75%, incl. mixed papillary/follicular)
* [[Papillary thyroid cancer]] (75%, including mixed papillary/follicular)
* [[Thyroid follicle|Follicular]] thyroid cancer (16%)
* [[Follicular thyroid cancer]] (16%)
* [[Medullary]] thyroid cancer (5-7%)
* [[Medullary thyroid cancer]] (5-7%)
* [[Anaplastic]] thyroid cancer (3%)
* [[Anaplastic thyroid cancer]] (3%)
* [[Lymphoma]] (1%)
* [[Primary thyroid lymphoma|Lymphoma]] (1%)
* [[Squamous cell carcinoma]], [[sarcoma]] (0.5 - 2%)


===Follicular thyroid cancer===
[[Image:Follicular adenoma of the thyroid.jpg|thumb|left|Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).]]
This occurs more commonly in women of over 50 years old. [[Thyroglobulin]] (Tg) can be used as a [[tumor marker]] for well-differentiated follicular thyroid cancer.


It is not possible to distinguish between follicular adenoma and carcinoma on cytological grounds. If fine needle aspiration cytology (FNAC) suggests follicular neoplasm, thyroid lobectomy should be performed to establish the [[Histopathology|histopathological]] diagnosis. Follicular carcinoma tends to metastasize to lung and bone via the bloodstream, while papillary thyroid carcinoma commonly metastasizes to cervical lymph nodes.
{| align="center"
|-
|
{{Familytree/start}}
{{Familytree| | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01= Thyroid carcinoma}}
{{Familytree|boxstyle=text-align: left;| | |,|-|-|-|v|-|-|-|v|-|-|-|^|-|-|-|v|-|-|-|v|-|-|-|.| | | | | | | | | | | | | |}}
{{Familytree|boxstyle=text-align: left;| | B01 | | B02 | | B03 | | | | | | B04 | | B05 | | B06 | | | | | | | | | | | | | | | | |B01=[[Papillary thyroid cancer]]|B02=[[Follicular thyroid cancer]]|B03=[[Medullary thyroid cancer]]|B04= [[Anaplastic thyroid cancer]]|B05=[[Primary thyroid lymphoma|Lymphoma]]|B06= [[Miscellaneous]]}}
{{Familytree|boxstyle=text-align: left;| | |!| | | |!| | | | | | | | | | | |!| | | | | | | |!| | | | | | | | | | | |}}
{{Familytree|boxstyle=text-align: left;| | C01 | | C02 | | | | | | | | | | C03 | | | | | | C04 | | | | | | | | | | | | | | | | |C01=
•Follicular variant<br>
•Tall cell<br>
•Diffuse sclerosing<br>
•Encapsulated<br>
•Columnar<br>


====Surgical Treatment====
|C02=
*''Unilateral hemithyroidectomy'' (removal of one entire lobe of the thyroid) is uncommon due to the aggressive nature of this form of thyroid cancer.
•Minimally invasive<br>
*''Total thyroidectomy'' is almost automatic with this diagnosis. This is invariably followed by [[radioiodine]] treatment at levels from 50 to 200 millicuries following two weeks of a low iodine diet (LID). Occasionally treatment must be repeated if annual scans indicate remaining cancerous tissue. Some physicians favor administering the maximum safe dose (calculated based on a number of factors), while others favor administering smaller doses, which may still be effective in ablating all thyroid tissue. I-131 is used for ablation of the thyroid tissue.
•Overtly invasive<br>
* Some studies have shown that thyroglobulin (Tg) testing combined with neck [[ultrasound]] is more productive in finding disease recurrence than full- or [[Full-body scan|whole-body scans]] (WBS) using radioactive iodine. However, current protocol (in the USA) suggests a small number of clean annual WBS are required before relying on Tg testing plus neck ultrasound. When needed, whole body scans consist of withdrawal from thyroxine medication and/or injection of recombinant human Thyroid Stimulating Hormone (TSH). In both cases, a low iodine diet regimen must also be followed to optimize the takeup of the radioactive iodine dose. Low dose radioiodine of a few millicuries is administered. Full body [[nuclear medicine]] scan follows using a [[gamma camera]]. Scan doses of radioactive iodine may be [[Iodine-131|I<sup>131</sup>]] or [[Iodine-123|I<sup>123</sup>]].
* Recombinant human TSH, commercial name Thyrogen, is produced in cell culture from genetically engineered hamster cells.


====Hurthle cell variant====
|C03=  
[[Hurthle cell]] thyroid cancer is a variant of follicular cell carcinoma. Hurthle cell forms are more likely than follicular carcinomas to be bilateral and multifocal and to  metastasize to lymph nodes. Like follicular carcinoma, unilateral hemithyroidectomy is performed for non-invasive disease, and total thyroidectomy for invasive disease
•Small cell<br>
•Giant cell<br>
|C04=
•Sarcoma<br>
•Lymphoma<br>
•Squamous cell carcinoma<br>
•Mucoepidermoid carcinoma<br>
•Plasma cell tumors<br>
•Direct extension<br>
•Kidney<br>
•Melanoma<br>
•Colon<br>
}}
{{Familytree/end}}
|}
==Causes==
* For more information on [[papillary thyroid cancer]] [[causes]], [[Papillary thyroid cancer causes|click here]].
* For more information on [[follicular thyroid cancer]] [[causes]], [[Follicular thyroid cancer causes|click here]].
* For more information on [[medullary thyroid cancer]] [[causes]], [[Medullary thyroid cancer causes|click here]].
* For more information on [[anaplastic thyroid cancer]] [[causes]], [[Anaplastic thyroid cancer causes|click here]].
* For more information on [[primary thyroid lymphoma]] [[causes]], [[Primary thyroid lymphoma|click here]].


===Medullary thyroid cancer (MTC)===
==Differential diagnosis==
This form of thyroid carcinoma originates from the ''[[parafollicular cells]]'' (C cells), which produce the hormone [[calcitonin]]. While the increased serum concentration of calcitonin is not harmful, it is useful as a marker which can be tested in [[blood test|blood]]. A second marker, [[carcinoembryonic antigen]] (CEA), also produced by medullary thyroid carcinoma, is released into the blood and it is useful as a [[serum]] or [[blood]] [[tumor marker]]. In general measurement of serum CEA is less sensitive than serum calcitonin for detecting the presence of a tumor, but has less minute to minute variability and is therefore useful as an indicator of tumor mass.
Thyroid cancers should be [[Differential diagnosis|differentiated]] from one another and from various other [[diseases]]:
{| border="3"
|+
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Disease Name}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Age of Onset}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Gender Preponderance}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Signs/Symptoms}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Imaging Feature(s)}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Macroscopic Feature(s)}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Microscopic Feature(s)}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Laboratory Findings(s)}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Other Feature(s)}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF| Microscopic Appearance}}
|-
! style="padding: 5px 5px; background: #DCDCDC; " align="left" |Papillary Thyroid Cancer<ref name="FaginMitsiades2008">{{cite journal|last1=Fagin|first1=James A.|last2=Mitsiades|first2=Nicholas|title=Molecular pathology of thyroid cancer: diagnostic and clinical implications|journal=Best Practice & Research Clinical Endocrinology & Metabolism|volume=22|issue=6|year=2008|pages=955–969|issn=1521690X|doi=10.1016/j.beem.2008.09.017}}</ref><ref name="Schlumberger1998">{{cite journal|last1=Schlumberger|first1=Martin Jean|title=Papillary and Follicular Thyroid Carcinoma|journal=New England Journal of Medicine|volume=338|issue=5|year=1998|pages=297–306|issn=0028-4793|doi=10.1056/NEJM199801293380506}}</ref><ref name="pmid20001718">{{cite journal |vauthors=Sipos JA |title=Advances in ultrasound for the diagnosis and management of thyroid cancer |journal=Thyroid |volume=19 |issue=12 |pages=1363–72 |date=December 2009 |pmid=20001718 |doi=10.1089/thy.2009.1608 |url=}}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More common in the middle aged (30 - 50 years of age)
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More commonly affects women
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Asymptomatic]] [[thyroid]] [[mass]] or [[nodule]]
*Compressive [[symptoms]], such as:
*[[Dysphagia|Difficulty swallowing]]/[[Dyspnea|breathing]]
*Persistent [[cough]]
*[[Stridor]]
*[[Vocal cord|Vocal chord]] [[paralysis]]
*Rapid enlarging [[mass]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* On [[ultrasound]]
** [[Solitary]] [[mass]] with an irregular outline
** Located in the sub-capsular region
** High [[vascularity]]


The prognosis of MTC is poorer than that of follicular and papillary thyroid cancer when it has metastasized (spread) beyond the thyroid gland. Approximately 25% the cancer develops in families. When MTC occurs by itself it is termed familial MTC; when it coexists with tumors of the parathyroid gland and medullary component of the adrenal glands ([[pheochromocytoma]]) it is called multiple endocrine neoplasia type 2 ([[MEN2]]).
*[[Imaging]] features are not characteristic of this [[cancer]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Solitary]] hypoechogenic [[nodule]] with [[Lobule|lobulated]] margin which may extend into adjacent [[tissues]]
*[[Calcification]] may be present or not
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Empty-appearing [[nuclei]] with central clearing (Orphan Annie eye)
*[[Psammoma body|Psammoma bodies]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Thyroid function test|Thyroid function tests]] can be normal
*Serum [[thyroglobulin]] can be used as a [[tumor marker]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* History of [[radiation]] to the [[head]] and [[neck]]
*[[BRAF]] and/or [[RET gene|RET]] [[mutation]] may be present
*The most common type of thyroid cancer
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[Image:Thyroid papillary carcinoma histopathology (3).jpg|thumb|none|200px|Source:Wikimedia commons ]]
|-
! style="padding: 5px 5px; background: #DCDCDC; " align="left" |Follicular Thyroid Cancer<ref name="Schlumberger1998">{{cite journal|last1=Schlumberger|first1=Martin Jean|title=Papillary and Follicular Thyroid Carcinoma|journal=New England Journal of Medicine|volume=338|issue=5|year=1998|pages=297–306|issn=0028-4793|doi=10.1056/NEJM199801293380506}}</ref><ref name="pmid20001718">{{cite journal |vauthors=Sipos JA |title=Advances in ultrasound for the diagnosis and management of thyroid cancer |journal=Thyroid |volume=19 |issue=12 |pages=1363–72 |date=December 2009 |pmid=20001718 |doi=10.1089/thy.2009.1608 |url=}}</ref><ref name="pmid2019455">{{cite journal |vauthors=Pettersson B, Adami HO, Wilander E, Coleman MP |title=Trends in thyroid cancer incidence in Sweden, 1958-1981, by histopathologic type |journal=Int. J. Cancer |volume=48 |issue=1 |pages=28–33 |date=April 1991 |pmid=2019455 |doi=10.1002/ijc.2910480106 |url=}}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Peak [[incidence]] at 40 - 60 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More commonly affects women
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Asymptomatic]] [[thyroid]] [[mass]] or [[nodule]]
*Compressive [[symptoms]], such as:
*[[Difficulty swallowing]]/[[Dyspnea|breathing]]
*Persistent [[cough]]
*[[Stridor]]
*[[Vocal cord|Vocal chord]] [[paralysis]]
*Rapid enlarging [[mass]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* On [[ultrasound]]:
**Solid hypoechoic [[nodule]] with a peripheral halo indicating [[fibrous capsule]]
**Irregular margin
*[[Imaging]] features are not characteristic of this [[cancer]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Single encapsulated [[nodule]]
* Thick and irregular [[capsule]]
* Can be [[cystic]] or [[hemorrhage|hemorrhagic]] in appearance
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Invades [[thyroid]] [[capsule]] and [[vasculature]]
* Uniform [[Follicle|follicles]] <br />
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Thyroid function test|Thyroid function tests]] can be normal
* Serum [[thyroglobulin]] can be used as a [[tumor marker]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[RASA3|RAS]] [[mutation]] may be present
*[[PAX8]]-[[PPAR|PPARγ]]  [[Translocation|translocations]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[Image:Metastatic follicular thyroid carcinoma - Case 264.jpg|thumb|none|200px|Source:Wikimedia common ]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="left" |Medullary Thyroid Cancer<ref name="pmid6690009">{{cite journal |vauthors=Busnardo B, Girelli ME, Simioni N, Nacamulli D, Busetto E |title=Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma |journal=Cancer |volume=53 |issue=2 |pages=278–85 |date=January 1984 |pmid=6690009 |doi=10.1002/1097-0142(19840115)53:2<278::aid-cncr2820530216>3.0.co;2-z |url=}}</ref><ref name="pmid10699905">{{cite journal |vauthors=Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH |title=Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems |journal=Cancer |volume=88 |issue=5 |pages=1139–48 |date=March 2000 |pmid=10699905 |doi=10.1002/(sici)1097-0142(20000301)88:5<1139::aid-cncr26>3.0.co;2-z |url=}}</ref><ref name="HofstraLandsvater1994">{{cite journal|last1=Hofstra|first1=Robert M. W.|last2=Landsvater|first2=Rudy M.|last3=Ceccherini|first3=Isabella|last4=Stulp|first4=Rein P.|last5=Stelwagen|first5=Tineke|last6=Luo|first6=Yin|last7=Pasini|first7=Barbara|last8=Hoppener|first8=Jo W. M.|last9=van Amstel|first9=Hans Kristian Ploos|last10=Romeo|first10=Giovanni|last11=Lips|first11=Cornells J. M.|last12=Buys|first12=Charles H. C. M.|title=A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma|journal=Nature|volume=367|issue=6461|year=1994|pages=375–376|issn=0028-0836|doi=10.1038/367375a0}}</ref><ref name="pmid20001718">{{cite journal |vauthors=Sipos JA |title=Advances in ultrasound for the diagnosis and management of thyroid cancer |journal=Thyroid |volume=19 |issue=12 |pages=1363–72 |date=December 2009 |pmid=20001718 |doi=10.1089/thy.2009.1608 |url=}}</ref>


====The genetics of medullary thyroid cancer====
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*[[Incidence]] increases with age
* More common in the 3rd to 4th decades of life
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Both genders are affected equally
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Solitary]] [[thyroid nodule]]
* Mostly affects upper [[Lobe (anatomy)|lobe]] of [[thyroid gland]]
* Possible [[systemic]] [[symptoms]] due to [[Hormone|hormonal]] [[secretion]] by the [[tumor]]
*[[Cervical]] [[lymphadenopathy]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*On [[ultrasound]]:
**[[Solitary]] hypoechoic [[nodule]] with or without [[calcification]]
*[[Imaging]] features are not characteristic of this [[cancer]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Single non-encapsulated mass
* Gray-tan color
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Sheets of [[cells]] in an [[amyloid]] [[stroma]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Secretion|Secretes]] [[calcitonin]]
*Normal [[thyroid function test|thyroid function tests]]
*[[Carcinoembryonic antigen]] ([[CEA]]) may be used as a [[tumor marker]]
*Rarely negative for [[calcitonin]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Can be part of [[MEN syndromes|MEN 2A]] and [[Multiple endocrine neoplasia type 2|2B syndrome]]
* Can be associated with [[RET gene|RET]] [[mutation]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[File:Thyroid MedullaryCarcinoma SpindleCell LP PA.JPG|thumb|none|200px|Source:Wikimedia common ]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="left" |Anaplastic Thyroid Cancer<ref name="pmid21772843">{{cite journal |vauthors=Nagaiah G, Hossain A, Mooney CJ, Parmentier J, Remick SC |title=Anaplastic thyroid cancer: a review of epidemiology, pathogenesis, and treatment |journal=J Oncol |volume=2011 |issue= |pages=542358 |date=2011 |pmid=21772843 |pmc=3136148 |doi=10.1155/2011/542358 |url=}}</ref><ref name="pmid2794956">{{cite journal |vauthors=Chang TC, Liaw KY, Kuo SH, Chang CC, Chen FW |title=Anaplastic thyroid carcinoma: review of 24 cases, with emphasis on cytodiagnosis and leukocytosis |journal=Taiwan Yi Xue Hui Za Zhi |volume=88 |issue=6 |pages=551–6 |date=June 1989 |pmid=2794956 |doi= |url=}}</ref><ref name="pmid1695118">{{cite journal |vauthors=Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H, Samaan NA |title=Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases |journal=Cancer |volume=66 |issue=2 |pages=321–30 |date=July 1990 |pmid=1695118 |doi=10.1002/1097-0142(19900715)66:2<321::aid-cncr2820660221>3.0.co;2-a |url=}}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More common among older individuals
*[[Mean]] age at [[diagnosis]] is 65 years
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More commonly affects women
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Rapidly enlarging [[thyroid]] [[mass]]
* May manifest with compressive [[symptoms]]
*Can present with [[signs]]/[[symptoms]] of [[metastasis]]
*Constitutional [[symptoms]] may be present
*Hard [[Nodule (medicine)|nodular]] [[goiter]] without [[tenderness]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* On [[ultrasound]]:
** Solid hypoechoic [[nodule]] with a peripheral halo indicating [[fibrous capsule]]


Mutations (DNA changes) in the [[RET proto-oncogene]], located on chromosome 10, lead to the [[gene expression|expression]] of a mutated [[receptor tyrosine kinase]] protein, termed RET. RET is involved in the regulation of cell growth and development and its mutation is responsible for nearly all cases of hereditary or familial medullary thyroid carcinoma. Its mutation may also be responsible for the development of [[hyperparathyroidism]] and [[pheochromocytoma]]. Hereditary medullary thyroid cancer is inherited as an autosomal dominant trait, meaning that each child of an affected parent has a 50/50 probability of inheriting the mutant [[RET proto-oncogene]] from the affected parent. DNA analysis makes it possible to identify children who carry the mutant gene; surgical removal of the thyroid in children who carry the mutant gene is curative if the entire thyroid gland is removed at an early age, before there is spread of the tumor. The parathyroid tumors and pheochromocytomas are removed when they cause clinical symptomatology. Hereditary medullary thyroid carcinoma or multiple endocrine neoplasia (MEN2) accounts for approximately 25% of all medullary thyroid carcinomas.
** Irregular margin
*[[Imaging]] features are not characteristic of this [[cancer]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Solid [[tumor]] with areas of [[necrosis]] and [[hemorrhage]]
*[[Infiltration (medical)|Infiltrative]] pattern
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Undifferentiated, devastatingly aggressive variant of [[Papillary thyroid cancer|papillary]]/[[follicular thyroid cancer]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Normal [[thyroid function test|thyroid function tests]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Poor [[prognosis]]
* May be associated with [[TP53]] [[mutation]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[File:Anaplastic thyroid carcinoma low mag.jpg|thumb|none|200px|Source:Wikimedia common ]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="left" |Follicular Adenoma<ref name="MathurOlson2014">{{cite journal|last1=Mathur|first1=Aarti|last2=Olson|first2=Matthew T.|last3=Zeiger|first3=Martha A.|title=Follicular Lesions of the Thyroid|journal=Surgical Clinics of North America|volume=94|issue=3|year=2014|pages=499–513|issn=00396109|doi=10.1016/j.suc.2014.02.005}}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More commonly affects individuals older than 50 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More commonly affects women
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Asymptomatic]] or [[symptoms]] of [[hyperthyroidism]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Solitary [[nodule]] which may show echogenicity or not
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Solitary, spherical, and encapsulated [[lesion]]
* Well demarcated from the surrounding [[parenchyma]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Uniform  [[Follicle|follicles]]
* Absence of capsular or [[vascular]] invasion
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Functional [[adenoma]]:
** Elevated T3, T4
** Decreased TSH
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* May be considered functional or hot
* May be considered non-functional or cold
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[File:Follicular adenoma -- intermed mag.jpg|thumb|none|200px|Source:Wikimedia common ]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="left" |Multinodular Goiter<ref name="pmid8197088">{{cite journal |vauthors=Bronshteĭn ME, Makarov AD, Artemova AM, Bazarova EN, Kozlov GI |title=[Morphology of the thyroid tissue in multinodular euthyroid goiter] |language=Russian |journal=Probl Endokrinol (Mosk) |volume=40 |issue=2 |pages=36–9 |date=1994 |pmid=8197088 |doi= |url=}}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Commonly affects individuals older than 60 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More commonly affects women
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Thyroid]] enlargement
*[[Signs]]/[[symptoms]] of [[Hypothyroidism|hypo]]/[[hyperthyroidism]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Multiple [[nodules]] with different echogenicity
*[[Calcification]] may be present
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Multiple [[Thyroid nodule|thyroid nodules]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Variable sized [[Follicle|follicles]]
* Some may show [[papillary]] [[Projection areas|projections]] without [[nuclear]] characteristics of [[papillary thyroid cancer]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Classification|Classified]] as toxic and non-toxic
**'''Toxic:''' [[Hyperthyroidism]]
**'''Non-toxic:''' Normal [[thyroid function test|thyroid function tests]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
*[[Benign]] [[condition]]
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[File:ThyroidnodularSatturwar08.jpg|thumb|none|200px|Source:pathology outline, case courtesy of Dr. Swati Satturwar]]
|-
! style="padding: 5px 5px; background: #DCDCDC; " align="left" |Thyroid Lymphoma<ref name="pmid8838117">{{cite journal |vauthors=Pedersen RK, Pedersen NT |title=Primary non-Hodgkin's lymphoma of the thyroid gland: a population based study |journal=Histopathology |volume=28 |issue=1 |pages=25–32 |date=January 1996 |pmid=8838117 |doi= |url=}}</ref>
<ref name="pmid3141260">{{cite journal |vauthors=Hyjek E, Isaacson PG |title=Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis |journal=Hum. Pathol. |volume=19 |issue=11 |pages=1315–26 |date=November 1988 |pmid=3141260 |doi=10.1016/s0046-8177(88)80287-9 |url=}}</ref><ref name="pmid3759532">{{cite journal |vauthors=Tupchong L, Hughes F, Harmer CL |title=Primary lymphoma of the thyroid: clinical features, prognostic factors, and results of treatment |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=12 |issue=10 |pages=1813–21 |date=October 1986 |pmid=3759532 |doi=10.1016/0360-3016(86)90324-x |url=}}</ref><ref name="pmid17042683">{{cite journal |vauthors=Ota H, Ito Y, Matsuzuka F, Kuma S, Fukata S, Morita S, Kobayashi K, Nakamura Y, Kakudo K, Amino N, Miyauchi A |title=Usefulness of ultrasonography for diagnosis of malignant lymphoma of the thyroid |journal=Thyroid |volume=16 |issue=10 |pages=983–7 |date=October 2006 |pmid=17042683 |doi=10.1089/thy.2006.16.983 |url=}}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Affects [[Adult|adults]] or elderly
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* More common among women
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
* Rapidly enlarging mass/[[nodule]] of [[thyroid]]
* Compressive [[symptoms]] may be present
* [[B symptoms|Constitiutional symptoms]] can be present in 10%
*[[Physical examination|P/E]]:Firm, hard [[thyroid]]
* Fixed to the nearby structures
* Immobile even during swallowing
* [[Cervical]] or [[supraclavicular]] [[lymphadenopathy]] may be present


Seventy-five percent of medullary thyroid carcinoma occurs in individuals without an identifiable family history and is assigned the term "sporadic". Individuals who develop sporadic medullary thyroid carcinoma tend to be older and have more extensive disease at the time of initial presentation than those with a family history  (screening is likely to be initiated at an early age in the hereditary form). Approximately 25% of sporadic medullary thyroid carcinomas have a somatic mutation (one that occurs within a single "parafollicular" cell) of the [[RET proto-oncogene]]. This mutation is presumed to be the initiating event, although there could be other as yet unidentified causes.
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 
* On [[ultrasound]]:
====Clinical features of medullary thyroid carcinoma====
**Hypoechogenic appearance
 
**Difficult to distinguish from [[Chronic (medical)|chronic]] [[thyroiditis]]
The major clinical symptom of medullary thyroid carcinoma is [[diarrhea]]; occasionally a patient will have [[flushing]] episodes. Both occur particularly with [[liver]] [[metastasis]]. Occasionally, diarrhea or flushing will be the initial presenting complaint. The flushing that occurs in medullary thyroid carcinoma is indistinguishable from that associated with [[carcinoid]] syndrome. The presumed cause of flushing and diarrhea is the excessive production of [[calcitonin]] gene products ([[calcitonin]] or [[calcitonin gene-related peptide]]) and differs from the causation of flushing and diarrhea in [[carcinoid]] syndrome. Sites of spread of medullary thyroid carcinoma include local [[lymph nodes]] in the [[neck]], [[lymph nodes]] in the central portion of the [[chest]] ([[mediastinum]]), [[liver]], [[lung]], and [[bone]]. Spread to other sites such as skin or brain occurs but is uncommon.
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 
* [[Thyroid nodule]]/mass
=====Adjuvant therapy for medullary thyroid cancer=====
*Fixed to adjacent [[tissue]]
Unlike differentiated thyroid carcinoma, there is no role for radioiodine treatment in medullary-type disease. External beam radiotherapy should be considered for patients at high risk of regional recurrence, even after optimum surgical treatment. Brierley et al., conducted a retrospective study of the treatment given to patients with microscopic residual disease, extraglandular invasion, or lymph-node metastases and found the locoregional relapse-free rate at 10 years was 86%, compared with 52% for those patients who did not receive [[adjuvant]] therapy. Typically, 40 Gy is given in 20 fractions to the cervical, supraclavicular, and upper mediastinal lymph nodes for 4 weeks, with subsequent booster doses of 10 Gy in five fractions to the thyroid bed, especially in the setting of gross residual disease.
*Firm texture
 
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
After a long period during which surgery and radiation therapy formed the major treatments for medullary thyroid carcinoma, clinical trials of several new tyrosine kinase inhibitors [http://www.thyroidtrials.org] are now being studied. Preliminary results show clear evidence of response of a small percentage of patients, providing hope for future advances.
* It is of [[B cell]] lineage in the majority of cases
 
* Dffuse, large [[B-cell lymphoma|B-cell lymphomas]] is the most common subtype
====Medullary Thyroid Carcinoma Prognostic Indicators====
* [[Marginal zone lymphoma]] is the second most common type
The prognostic value of measuring [[calcitonin]] and [[carcinoembryonic antigen]] (CEA) concentrations in the blood has been recently studied in a retrospective study of 65 MTC patients; see Barbet, ''et al''.  The post-surgical times ranged from 2.9 years to 29.5 years; all 65 patients continued to have abnormal calcitonin levels after total thyroidectomy and bilateral lymph node dissection.  The prognosis of surviving MTC appears to be correlated with the rate at which a patient's postoperative calcitonin concentration doubles, rather than the pre- or postoperative absolute calcitonin level.
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 
* No specific test
The result of the 65 patient study can be summarized with respect to the calcitonin doubling time (CDT):
* Some [[Patient|patients]] may have [[hypothyroidism]]
 
*[[Patient|Patients]] can also have [[antibody|antibodies]] against [[thyroid peroxidase]] or [[thyroglobulin]]
'''CDT < 6 months:'''  3 patients out of 12 (25%) survived 5 years.  1 patient out of 12 (8%) survived 10 years. All died within 6 months to 13.3 years.
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |
 
* Preexisting [[Chronic (medical)|chronic]] [[Hashimoto's thyroiditis|autoimmune (Hashimoto's) thyroiditis]] is a known [[risk factor]] for this [[condition]]
'''CDT between 6 months and 2 years:'''  11 patients out of 12 (92%) survived 5 years.  3 patients out of 8 (37%) survived 10 years.  4 patients out of 12 (25%) survived to the end of the study.
| style="padding: 5px 5px; background: #F5F5F5;" align="left" |[[File:Thyroid lymphoma large cell type fine needle aspiration biop.jpeg|thumb|none|200px|Source:pathology outline, case courtesy of Dr. Mark R. Wick]]
 
|}
'''CDT > 2 years:''' 41 patients out of 41 (100%) were alive at the end of the study.  These included 1 patient whose calcitonin was stable, and 11 patients who had decreasing calcitonin levels.
 
The 65 patients had a median age of 51 (range was 6 to 75), with 24 age 45 years or younger and 41 older than 45 years.  The gender representation was 31 males and 34 females.  All patients shared the following characteristics: 1) had total thyroidectomy and lymph node dissection; 2) had non-zero calcitonin levels after surgery; 3) had at least 4 serum calcitonin measurements after surgery; 4) had a status that could be confirmed at the conclusion of the study.
 
The same study noted that calcitonin doubling time is a statistically better predictor of MTC survival, compared with CEA.
 
===Anaplastic thyroid cancer===
This form of thyroid cancer has a very poor prognosis (near 100% mortality) due to its aggressive behavior and resistance to cancer treatments. It rapidly invades surrounding tissues (such as the [[vertebrate trachea|trachea]]). The presence of regional lymphadenopathy in older patients in whom FNA reveals characteristic vesicular appearance of the nuclei would support a diagnosis of anaplastic carcinoma.
 
====Treatment====
Unlike its differentiated counterparts, anaplastic thyroid cancer is highly unlikely to be curable either by surgery or by any other treatment modality, and is in fact usually unresectable due to its high propensity for invading surrounding tissues. Palliative treatment consists of [[radiation therapy]] usually combined with [[chemotherapy]]. However, with today's technology, new drugs, such as Bortezomib and TNF-Related Apoptosis Induced Ligand (TRAIL), are being introduced and trialed in clinical labs. Recent studies in Italy, have shown positive results against ATC, but more tests, outside the lab, are needed to confirm this, before it can be used in Chemotherapy. There has been some case studies where patients with aggressive Thyroid Cancer have survived outside the mean expected survival time. But the best treatment recommended at this stage is early detection and complete surgery, followed by Chemotherapy alongside Radiotherapy, for any chance of survival of ATC.
 
=====Post-operative radiotherapy for differentiated thyroid carcinoma: when and how much=====
The role of [[external beam radiotherapy]] (EBRT) in thyroid cancer remains controversial and there is no level I evidence to recommend it. No published randomised controlled trials have examined the addition of EBRT to standard treatment, namely surgery, [[radioactive iodine]] and medical suppression of thyroid stimulating hormones.
 
Imbalances in age, sex, completeness of surgical excision, histological type and stage, between patients receiving and not receiving EBRT, confound retrospective studies. Variability also exists between treatment and non-treatment groups in the use of radio-iodine and post-treatment [[thyroid stimulating hormone]] (TSH) suppression and treatment techniques between and within retrospective studies.
 
Farahati et al. and Philips et al. have reported statistically significant advantages for post operative EBRT, however, in both studies many confounding factors have been reported. For example, patients receiving EBRT were more likely to have node-positive disease, extracapsular extension and incomplete macroscopic excision. The differences in patient groups among these studies, and the difficulties with confounding factors, make evidence-based recommendations for the use of EBRT difficult to formulate. Tsang et al. have suggested a role for EBRT in patients with papillary cancer, with microscopic residual disease based on sub-group analysis showing a statistically significant advantage in terms of cause-specific survival (100% vs 95%; P=0.038) and local recurrence (93% vs 78%; P=0.01). Farahati et al. recommend the use of EBRT in node-positive patients over 40 years of age with papillary histology on the basis of an increase in time to local or distant failure (P=0.0009). Other indications for EBRT include high-grade tumours that do not concentrate iodine and tumours with gross local invasion where there is a high suspicion of microscopic or macroscopic residual disease.
 
The use of EBRT is controversial for those patients with microscopic residual disease. All reports on the use of EBRT have been retrospective, with varying criteria for patient selection, resulting in contradictory conclusions. Several studies have described either no or deleterious effects for EBRT, but many others have described benefit. In a study from Toronto, Brierley et al. found superior local control and improved survival in patients who received EBRT for microscopic residual disease (10-year local relapse-free rate 93% compared with 83% for patients not receiving EBRT, P = 0.01; and cause-specific survival 99% compared with 93%; P = 0.04).
“Total thyroidectomy with adjuvant 131I, followed by TSH suppression is considered standard therapy for differentiated thyroid carcinoma”. In the absence of randomised data, there is credible evidence from retrospective studies (Level II-III) to recommend EBRT in addition to standard therapy in high-risk patients.
 
The apparent difference in outcomes related to the dose of radiotherapy is subject to the confounding factors in all retrospective studies of EBRT as outlined above. However, there are few published data that define the dose to be used. In one retrospective study, 114 patients with macroscopically resected, well-differentiated thyroid cancer were treated with EBRT and an ‘adequate’ total dose was defined as >45 Gy. Patients receiving an ‘adequate’ dose had a significantly improved local regional relapse-free survival (P<0.001). However, only three of the 114 patients in this study also received radio-iodine, and therefore the role of EBRT in addition to standard management was not examined. A total dose of 50–60 Gy was used in the two studies, which showed a reduction in local failure where EBRT was used in addition to radio-iodine (Farahatti et al., and Phillip et al.). Others have treated patients with gross residual disease with 50 Gy in 20 fractions or its equivalent and 40 Gy in 15 fractions or its equivalent in the presence of microscopic residual disease. If the decision is made to treat a large volume, including the cervical nodes for instance, or if there is extracapsular extension and local invasion of cervical nodes, fractionation is changed to 2 Gy fractions. Currently, recommended doses are 50 to 60 Gy in 25 to 30 fractions over 5 to 6 weeks.
 
To treat the thyroid bed, a clinical target volume from the hyoid to suprasternal notch is determined. A simple technique is to use two antero-lateral oblique wedged fields, or direct [[electron beam]]s. When using oblique fields the posterior border is placed to exclude the spinal cord. If it is determined that the clinical target volume should include the cervical and superior mediastinal lymph nodes, as well as the thyroid bed, a two-phase technique is commonly used. The initial volume (phase I) includes the regional lymph nodes from the mastoid tip to the carina, including the thyroid bed. The phase I volume may consist of parallel opposing antero-posterior/postero-anterior fields to 40–46 Gy. The phase II volume should include the tissues considered at highest risk of relapse, aiming to boost the high-risk area to a total dose of 14 Gy (cumulative total dose of 60 Gy). For the boost to the thyroid bed alone, several techniques can used, such as, a direct anterior electron beam, antero-lateral oblique wedge fields, or a lateral pair of angled-down oblique fields, achieved with a couch rotation of 10–20 degrees, aiming inferiorly to avoid the shoulders, off the spinal cord. Since the thyroid bed target volume is wrapped around many critical structures in the neck and it is often necessary to include regional lymph nodes, treatment planning of this difficult volume is ideal for conformal radiotherapy, or intensity-modulated radiation therapy. A conformal plan may be used either to treat the thyroid bed alone or to include the cervical nodes.
 
Recommended indications for the use of EBRT are:
 
# High Grade tumors that do not concentrate radio-iodine.
# Recommendations for EBRT after 131I therapy include high-risk patients defined as; older (>45 years) with potential microscopic residual disease, after resection of gross extrathyroid extension (i.e. UICC 6th edition category T4a or T4b but not T3), or multiple lymph-node involvement.
# Bulky tumors with superior mediastinal / retro-sternal extension.
# Gross evidence of local invasion at surgery and presumed to have significant macro or microscopic residual disease, particularly if there is residual tumour that fails to concentrate 131I and is apparent only by raised [[thyroglobulin]].
# For locally advanced tumors which are inoperable for a variety of lesions it can be used for palliation along with TSH suppression.
# For recurrent disease in the neck which is not amenable to radio-iodine therapy or further surgery.
# For palliation of recurrent disease or metastatic disease in bone, cerebrum, spine and other areas.
 
=====Adjuvant therapy for anaplastic thyroid cancer=====
Treatment of anaplastic-type carcinoma is generally palliative in its intent for a disease that is rarely cured and almost always fatal. The median survival from diagnosis ranges from 3 to 7 months, with worse prognosis associated with large tumours, distant metastases, acute obstructive symptoms, and leucocytosis. Death is attributable to upper airway obstruction and suffocation in half of patients, and to a combination of complications of local and distant disease, or therapy, or both in the remainder. In the absence of extracervical or unresectable disease, surgical excision should be followed by adjuvant radiotherapy. In the 18–24% of patients whose tumour seems both confined to the neck and grossly resectable, complete surgical resection followed by adjuvant radiotherapy and chemotherapy could yield a 75–80% survival at 2 years.
 
There are a number of clinical trials for anaplastic thyroid carcinoma[http://www.thyroidtrials.org] underway or being planned.


==References==
==References==
*{{cite journal
{{Reflist|2}}
| author=Bennedbæk F.N.; Perrild H.; Hegedüs L.
| title=Diagnosis and treatment of the solitary thyroid nodule. Results of a European survey
| journal=Clinical Endocrinology
| year=1999
| volume=50
| issue=3
| pages=357–363}}
*{{cite journal
| author=Carlo Ravetto, Luigia Colombo, Massimo E. Dottorini
| title=Usefulness of fine-needle aspiration in the diagnosis of thyroid carcinoma
| journal=Cancer Cytopathology
| year=2000
| volume=90
| issue=6
| pages=357–363}}
*{{cite journal
| author=Jacques Barbet, Loïc Campion, Françoise Kraeber-Bodéré, Jean-François Chatal, and the GTE Study Group
| title=Prognostic Impact of Serum Calcitonin and Carcinoembryonic Antigen Doubling-Times in Patients with Medullary Thyroid Carcinoma
| journal=The Journal of Clinical Endocrinology & Metabolism
| year=2005
| volume=90
| issue=11
| pages=6077-6084}}


== See also ==
[[Category:Endocrinology]]
[[Category:Oncology]]


*Chernobyl disaster ([[radioactive contamination]] is a cause of thyroid cancer)


==External links==
* [http://www.bidmc.org/YourHealth/ConditionsAZ.aspx?ChunkID=11507 Beth Israel Deaconess Medical Center: Thyroid cancer]
* {{dmoz|/Health/Conditions_and_Diseases/Cancer/Endocrine/Thyroid/|Thyroid cancer}}
* [http://www.thyroidtrials.org Thyroid Cancer Clinical Trials Page] of the American Thyroid Association
* [http://www.nucmedinfo.com/Pages/thyroid.html Nuclear Medicine Information =– Thyroid Diseases]
* [http://www.cancer.gov/cancertopics/types/thyroid Thyroid Cancer]- National Cancer Institute
* [http://www.thyca.org] - Thyroid Cancer Survivors' Association


{{Tumors}}
{{WH}}
{{SIB}}
{{WS}}
[[bs:Rak štitne žlijezde]]
[[de:Schilddrüsenkrebs]]
[[es:Cáncer tiroideo]]
[[fr:Cancer de la thyroïde]]
[[hr:Rak štitnjače]]
[[it:Tumore della tiroide]]
[[he:סרטן בלוטת התריס]]
[[nl:Schildklierkanker]]
[[ja:甲状腺癌]]
[[no:Skjoldkjertelkreft]]
[[pt:Tumor da tiróide]]
[[simple:Thyroid cancer]]
[[fi:Kilpirauhassyöpä]]
[[sv:Sköldkörtelcancer]]
[[vi:Ung thư tuyến giáp]]
[[tr:Tiroid kanseri]]
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Latest revision as of 15:19, 26 September 2019

Thyroid Cancer Main Page

Patient Information

Overview

Classification

Papillary Thyroid Cancer
Follicular Thyroid Cancer
Medullary Thyroid Cancer
Anaplastic Thyroid Cancer
Thyroid Lymphoma

Causes

Differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Michael Maddaleni, B.S.; Ammu Susheela, M.D. [2]Seyedmahdi Pahlavani, M.D. [3] Sahar Memar Montazerin, M.D.[4]

Overview

Thyroid cancer refers to any of four kinds of tumors of the thyroid gland which include papillary, follicular, medullary and anaplastic tumors. Papillary and follicular tumors are the most common and are usually benign. Papillary and follicular tumors have a slow growth and may recur, but are generally not fatal in patients under 45 years of age. Medullary and anaplastic tumors are malignant. Medullary tumors have a good prognosis if the are restricted to the thyroid gland and a poorer prognosis if metastasis occurs. Anaplastic tumors are fast-growing and respond poorly to therapy. Thyroid nodules are diagnosed by ultrasound guided fine needle aspiration or frequently by thyroidectomy (surgical removal and subsequent histological examination). As the thyroid cancer can uptake iodine, radioactive iodine is commonly used for the treatment of thyroid carcinomas. However, radioactive iodine therapy is accompanied by thyroxine therapy to ensure TSH suppression.

Classification

Thyroid cancers can be classified according to their pathological characteristics. The following variants can be distinguished (distribution over various subtypes may show regional variation):


 
 
 
 
 
 
 
 
 
 
 
 
 
Thyroid carcinoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Papillary thyroid cancer
 
Follicular thyroid cancer
 
Medullary thyroid cancer
 
 
 
 
 
Anaplastic thyroid cancer
 
Lymphoma
 
Miscellaneous
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
•Follicular variant

•Tall cell
•Diffuse sclerosing
•Encapsulated

•Columnar
 
•Minimally invasive
•Overtly invasive
 
 
 
 
 
 
 
 
 
•Small cell
•Giant cell
 
 
 
 
 
•Sarcoma

•Lymphoma
•Squamous cell carcinoma
•Mucoepidermoid carcinoma
•Plasma cell tumors
•Direct extension
•Kidney
•Melanoma

•Colon
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Causes

Differential diagnosis

Thyroid cancers should be differentiated from one another and from various other diseases:

Disease Name Age of Onset Gender Preponderance Signs/Symptoms Imaging Feature(s) Macroscopic Feature(s) Microscopic Feature(s) Laboratory Findings(s) Other Feature(s) Microscopic Appearance
Papillary Thyroid Cancer[1][2][3]
  • More common in the middle aged (30 - 50 years of age)
  • More commonly affects women
Source:Wikimedia commons
Follicular Thyroid Cancer[2][3][4]
  • More commonly affects women
Source:Wikimedia common
Medullary Thyroid Cancer[5][6][7][3]
  • Incidence increases with age
  • More common in the 3rd to 4th decades of life
  • Both genders are affected equally
  • Single non-encapsulated mass
  • Gray-tan color
Source:Wikimedia common
Anaplastic Thyroid Cancer[8][9][10]
  • More common among older individuals
  • Mean age at diagnosis is 65 years
  • More commonly affects women
    • Irregular margin
  • Imaging features are not characteristic of this cancer
Source:Wikimedia common
Follicular Adenoma[11]
  • More commonly affects individuals older than 50 years of age
  • More commonly affects women
  • Solitary nodule which may show echogenicity or not
  • Solitary, spherical, and encapsulated lesion
  • Well demarcated from the surrounding parenchyma
  • Functional adenoma:
    • Elevated T3, T4
    • Decreased TSH
  • May be considered functional or hot
  • May be considered non-functional or cold
Source:Wikimedia common
Multinodular Goiter[12]
  • Commonly affects individuals older than 60 years of age
  • More commonly affects women
Source:pathology outline, case courtesy of Dr. Swati Satturwar
Thyroid Lymphoma[13]

[14][15][16]

  • More common among women
Source:pathology outline, case courtesy of Dr. Mark R. Wick

References

  1. ↑ Fagin, James A.; Mitsiades, Nicholas (2008). "Molecular pathology of thyroid cancer: diagnostic and clinical implications". Best Practice & Research Clinical Endocrinology & Metabolism. 22 (6): 955–969. doi:10.1016/j.beem.2008.09.017. ISSN 1521-690X.
  2. ↑ 2.0 2.1 Schlumberger, Martin Jean (1998). "Papillary and Follicular Thyroid Carcinoma". New England Journal of Medicine. 338 (5): 297–306. doi:10.1056/NEJM199801293380506. ISSN 0028-4793.
  3. ↑ 3.0 3.1 3.2 Sipos JA (December 2009). "Advances in ultrasound for the diagnosis and management of thyroid cancer". Thyroid. 19 (12): 1363–72. doi:10.1089/thy.2009.1608. PMID 20001718.
  4. ↑ Pettersson B, Adami HO, Wilander E, Coleman MP (April 1991). "Trends in thyroid cancer incidence in Sweden, 1958-1981, by histopathologic type". Int. J. Cancer. 48 (1): 28–33. doi:10.1002/ijc.2910480106. PMID 2019455.
  5. ↑ Busnardo B, Girelli ME, Simioni N, Nacamulli D, Busetto E (January 1984). "Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma". Cancer. 53 (2): 278–85. doi:10.1002/1097-0142(19840115)53:2<278::aid-cncr2820530216>3.0.co;2-z. PMID 6690009.
  6. ↑ Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH (March 2000). "Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems". Cancer. 88 (5): 1139–48. doi:10.1002/(sici)1097-0142(20000301)88:5<1139::aid-cncr26>3.0.co;2-z. PMID 10699905.
  7. ↑ Hofstra, Robert M. W.; Landsvater, Rudy M.; Ceccherini, Isabella; Stulp, Rein P.; Stelwagen, Tineke; Luo, Yin; Pasini, Barbara; Hoppener, Jo W. M.; van Amstel, Hans Kristian Ploos; Romeo, Giovanni; Lips, Cornells J. M.; Buys, Charles H. C. M. (1994). "A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma". Nature. 367 (6461): 375–376. doi:10.1038/367375a0. ISSN 0028-0836.
  8. ↑ Nagaiah G, Hossain A, Mooney CJ, Parmentier J, Remick SC (2011). "Anaplastic thyroid cancer: a review of epidemiology, pathogenesis, and treatment". J Oncol. 2011: 542358. doi:10.1155/2011/542358. PMC 3136148. PMID 21772843.
  9. ↑ Chang TC, Liaw KY, Kuo SH, Chang CC, Chen FW (June 1989). "Anaplastic thyroid carcinoma: review of 24 cases, with emphasis on cytodiagnosis and leukocytosis". Taiwan Yi Xue Hui Za Zhi. 88 (6): 551–6. PMID 2794956.
  10. ↑ Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H, Samaan NA (July 1990). "Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases". Cancer. 66 (2): 321–30. doi:10.1002/1097-0142(19900715)66:2<321::aid-cncr2820660221>3.0.co;2-a. PMID 1695118.
  11. ↑ Mathur, Aarti; Olson, Matthew T.; Zeiger, Martha A. (2014). "Follicular Lesions of the Thyroid". Surgical Clinics of North America. 94 (3): 499–513. doi:10.1016/j.suc.2014.02.005. ISSN 0039-6109.
  12. ↑ Bronshteĭn ME, Makarov AD, Artemova AM, Bazarova EN, Kozlov GI (1994). "[Morphology of the thyroid tissue in multinodular euthyroid goiter]". Probl Endokrinol (Mosk) (in Russian). 40 (2): 36–9. PMID 8197088.
  13. ↑ Pedersen RK, Pedersen NT (January 1996). "Primary non-Hodgkin's lymphoma of the thyroid gland: a population based study". Histopathology. 28 (1): 25–32. PMID 8838117.
  14. ↑ Hyjek E, Isaacson PG (November 1988). "Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis". Hum. Pathol. 19 (11): 1315–26. doi:10.1016/s0046-8177(88)80287-9. PMID 3141260.
  15. ↑ Tupchong L, Hughes F, Harmer CL (October 1986). "Primary lymphoma of the thyroid: clinical features, prognostic factors, and results of treatment". Int. J. Radiat. Oncol. Biol. Phys. 12 (10): 1813–21. doi:10.1016/0360-3016(86)90324-x. PMID 3759532.
  16. ↑ Ota H, Ito Y, Matsuzuka F, Kuma S, Fukata S, Morita S, Kobayashi K, Nakamura Y, Kakudo K, Amino N, Miyauchi A (October 2006). "Usefulness of ultrasonography for diagnosis of malignant lymphoma of the thyroid". Thyroid. 16 (10): 983–7. doi:10.1089/thy.2006.16.983. PMID 17042683.


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