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| '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' | | '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' |
| {{Infobox_Disease
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| | Name = {{PAGENAME}}
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| | DiseasesDB = 13693
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| {{Vaginal cancer}} | | {{Vaginal cancer}} |
| {{CMG}} | | {{CMG}}; {{AE}} {{SC}} {{sali}} |
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| | {{SK}} Primary vaginal carcinoma, primary vaginal cancer, vaginal carcinoma |
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| ==[[Vaginal cancer overview|Overview]]== | | ==[[Vaginal cancer overview|Overview]]== |
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| ==[[Vaginal cancer historical perspective|Historical Perspective]]== | | ==[[Vaginal cancer historical perspective|Historical Perspective]]== |
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| | ==[[Vaginal cancer classification|Classification]]== |
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| ==[[Vaginal cancer pathophysiology|Pathophysiology]]== | | ==[[Vaginal cancer pathophysiology|Pathophysiology]]== |
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| ==[[Vaginal cancer epidemiology and demographics|Epidemiology & Demographics]]==
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| ==[[Vaginal cancer risk factors|Risk Factors]]==
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| ==[[Vaginal cancer screening|Screening]]==
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| ==[[Vaginal cancer causes|Causes]]== | | ==[[Vaginal cancer causes|Causes]]== |
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| ==[[Vaginal cancer differential diagnosis|Differentiating Vaginal cancer]]== | | ==[[Vaginal cancer differential diagnosis|Differentiating Vaginal cancer from other Diseases]]== |
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| ==[[Vaginal cancer natural history|Complications & Prognosis]]== | | ==[[Vaginal cancer epidemiology and demographics|Epidemiology and Demographics]]== |
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| ==Diagnosis== | | ==[[Vaginal cancer risk factors|Risk Factors]]== |
| [[Vaginal cancer history and symptoms|History and Symptoms]] | [[Vaginal cancer physical examination|Physical Examination]] | [[Vaginal cancer staging|Staging]] | [[Vaginal cancer laboratory tests|Laboratory tests]] | [[Vaginal cancer electrocardiogram|Electrocardiogram]] | [[Vaginal cancer x ray|X Rays]] | [[Vaginal cancer CT|CT]] | [[Vaginal cancer MRI|MRI]] [[Vaginal cancer echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Vaginal cancer other imaging findings|Other images]] | [[Vaginal cancer other diagnostic studies|Alternative diagnostics]] | |
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| ==Treatment== | | ==[[Vaginal cancer screening|Screening]]== |
| [[Vaginal cancer medical therapy|Medical therapy]] | [[Vaginal cancer surgery|Surgical options]] | [[Vaginal cancer primary prevention|Primary prevention]] | [[Vaginal cancer secondary prevention|Secondary prevention]] | [[Vaginal cancer cost-effectiveness of therapy|Financial costs]] | [[Vaginal cancer future or investigational therapies|Future therapies]] | |
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| | ==[[Vaginal cancer natural history|Natural History, Complications and Prognosis]]== |
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| ==Diagnosis== | | ==Diagnosis== |
| | | [[Vaginal cancer history and symptoms|History and Symptoms]] | [[Vaginal cancer physical examination|Physical Examination]] | [[Vaginal cancer staging|Staging]] | [[Vaginal cancer laboratory findings|Laboratory Findings]] | [[Vaginal cancer x ray|X Ray]] | [[Vaginal cancer CT|CT]] | [[Vaginal cancer MRI|MRI]] | [[Vaginal cancer ultrasound|Ultrasound]] | [[Vaginal cancer other imaging findings|Other Imaging Findings]] | [[Vaginal cancer other diagnostic studies|Other Diagnostic Studies]] |
| Several tests are used to diagnose vaginal cancer, including:
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| * [[Physical exam]] and history
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| * [[Pelvic exam]]
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| * [[Pap smear]]
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| * [[Biopsy]]
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| * [[Colposcopy]]
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| ==Recurrent Vaginal Cancer==
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| Recurrent vaginal cancer is cancer that has recurred (come back) after it has been treated. The cancer may come back in the vagina or in other parts of the body.
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| ==Treatment== | | ==Treatment== |
| | [[Vaginal cancer medical therapy|Medical therapy]] | [[Vaginal cancer surgery|Surgery]] | [[Vaginal cancer primary prevention|Primary Prevention]] | [[Vaginal cancer secondary prevention|Secondary Prevention]] | [[Vaginal cancer cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Vaginal cancer future or investigational therapies|Future or Investigational Therapies]] |
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| Therapeutic alternatives depend on stage; surgery or radiation therapy is highly effective in early stages, while radiation therapy is the primary treatment of more advanced stages. Chemotherapy has not been shown to be curative for advanced vaginal cancer, and there are no standard drug regimens.
| | ==Case Studies== |
| | | [[Vaginal cancer case study one|Case #1]] |
| ===Stage 0 Vaginal Cancer===
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| ====Squamous Cell Carcinoma In Situ====
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| This disease is usually multifocal and commonly occurs at the vaginal vault. Because vaginal intraepithelial neoplasia (VAIN) is associated with other genital neoplasias, the cervix (when present) and vulva should be carefully examined. The treatments listed below produce equivalent cure rates. The selection of treatment depends on patient factors and local expertise (e.g., anatomical distortion of the vaginal vault [related to wall closure at the time of hysterectomy] requires excision for technical reasons to exclude the possibility of invasion by buried disease). Lesions with hyperkeratosis respond better to excision or laser vaporization than to fluorouracil.
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| =====Standard treatment options:=====
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| * Wide local excision with or without skin grafting.
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| * Partial or total vaginectomy with skin grafting for multifocal or extensive disease.
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| * Intravaginal chemotherapy with 5% fluorouracil cream. Instillation of 1.5 g weekly for 10 weeks has been found to be as effective as more frequent use.
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| * Laser therapy.
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| * Intracavitary radiation therapy delivering 60 Gy to 70 Gy to the mucosa. The entire vaginal mucosa should be treated.
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| ===Stage I Vaginal Cancer===
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| ====Squamous Cell Carcinoma====
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| The treatments listed below produce equivalent cure rates. The selection of treatment depends on patient factors and local expertise.
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| =====Standard treatment options for superficial lesions less than 0.5 cm thick:=====
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| * Intracavitary radiation therapy. In most instances, 60 Gy to 70 Gy prescribed to 0.5 cm is delivered to the tumor for 5 to 7 days (external-beam radiation therapy [EBRT] is required for bulky lesions). For lesions of the lower third of the vagina, elective radiation therapy of 45 Gy to 50 Gy is given to pelvic and/or inguinal lymph nodes.
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| * Surgery. Wide local excision or total vaginectomy with vaginal reconstruction, especially in lesions of the upper vagina. In cases with close or positive surgical margins, adjuvant radiation therapy should be considered.
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| =====Standard treatment options for lesions greater than 0.5 cm thick:=====
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| * Surgery. In lesions of the upper third of the vagina, radical vaginectomy and pelvic lymphadenectomy should be performed. Construction of a neovagina may be performed if feasible and if desired by the patient. In lesions of the lower third, inguinal lymphadenectomy should be performed. In cases with close or positive surgical margins, adjuvant radiation therapy should be considered.
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| * Radiation therapy. Combination of interstitial (single-plane implant) and intracavitary therapy to a dose of at least 75 Gy to the primary tumor. In addition to brachytherapy, EBRT is advocated for poorly differentiated or infiltrating tumors that may have a higher probability of lymph node metastasis. For lesions of the lower third of the vagina, elective radiation therapy of 45 Gy to 50 Gy is given to the pelvic and/or inguinal lymph nodes.
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| ====Adenocarcinoma====
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| =====Standard treatment options:=====
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| * Surgery. Because the tumor spreads subepithelially, total radical vaginectomy and hysterectomy with lymph node dissection are indicated. The deep pelvic nodes are dissected if the lesion invades the upper vagina, and the inguinal nodes are removed if the lesion originates in the lower vagina. Construction of a neovagina may be performed if feasible and if desired by the patient. In cases with close or positive surgical margins, adjuvant radiation therapy should be considered.
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| * Intracavitary and interstitial radiation as previously described for squamous cell cancer. For lesions of the lower third of the vagina, elective radiation therapy of 45 Gy to 50 Gy is given to the pelvic and/or inguinal lymph nodes.
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| * Combined local therapy in selected cases, which may include wide local excision, lymph node sampling, and interstitial therapy.
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| ===Stage II Vaginal Cancer===
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| ====Squamous Cell Carcinoma====
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| Radiation therapy is the standard treatment for patients with stage II vaginal carcinoma.
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| =====Standard treatment options:=====
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| * Combination of brachytherapy and external-beam radiation therapy (EBRT) to deliver a combined dose of 70 Gy to 80 Gy to the primary tumor volume. For lesions of the lower third of the vagina, elective radiation therapy of 45 Gy to 50 Gy is given to the pelvic and/or inguinal lymph nodes.
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| * Radical surgery (radical vaginectomy or pelvic exenteration) with or without radiation therapy.
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| ====Adenocarcinoma====
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| =====Standard treatment options:=====
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| * Combination of brachytherapy and EBRT to deliver a combined dose of 70 Gy to 80 Gy to the primary tumor. For lesions of the lower third of the vagina, elective radiation therapy of 45 Gy to 50 Gy is given to the pelvic and/or inguinal lymph nodes.
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| * Radical surgery (radical vaginectomy or pelvic exenteration) with or without radiation therapy.
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| ===Stage III Vaginal Cancer===
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| ====Squamous Cell Carcinoma====
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| =====Standard treatment options:=====
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| * Combination of interstitial, intracavitary, and external-beam radiation therapy (EBRT). EBRT for a period of 5 to 6 weeks (including pelvic nodes) followed by an interstitial and/or intracavitary implant for a total tumor dose of 75 Gy to 80 Gy and a dose to the lateral pelvic wall of 55 Gy to 60 Gy.
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| * Rarely, surgery may be combined with the above.
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| ====Adenocarcinoma====
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| =====Standard treatment options:=====
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| * Combination of interstitial, intracavitary, and EBRT as described for squamous cell cancer.
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| * Rarely, surgery may be combined with the above.
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| ===Stage IVA Vaginal Cancer===
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| ====Squamous Cell Carcinoma====
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| =====Standard treatment options:=====
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| * Combination of interstitial, intracavitary, and external-beam radiation therapy (EBRT).
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| * Rarely, surgery may be combined with the above.
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| ====Adenocarcinoma====
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| =====Standard treatment options:=====
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| * Combination of interstitial, intracavitary, and EBRT.
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| * Rarely, surgery may be combined with the above.
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| ===Stage IVB Vaginal Cancer===
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| ====Squamous Cell Carcinoma====
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| Patients should be considered candidates for one of the ongoing clinical trials to improve therapeutic results. Standard treatment is inadequate.
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| =====Standard treatment options:=====
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| * Radiation (for palliation of symptoms) with or without chemotherapy.
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| ====Adenocarcinoma====
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| Patients should be considered candidates for one of the ongoing clinical trials to improve therapeutic results.
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| =====Standard treatment options:=====
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| * Radiation (for palliation of symptoms) with or without chemotherapy.
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| === Recurrent Vaginal Cancer ===
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| Recurrence carries a grave prognosis. In a large series only five of fifty patients with recurrence were salvaged by surgery or radiation therapy. All five of these salvaged patients originally presented with stage I or II disease and failed in the central pelvis. Most recurrences are in the first 2 years after treatment. In centrally recurrent vaginal cancers, some patients may be candidates for pelvic exenteration or radiation therapy. Neither cisplatin nor mitoxantrone has significant activity in recurrent or advanced squamous cell cancer. There is no standard chemotherapy.
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| ==Prognosis== | | ==Related Chapters== |
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| Prognosis depends primarily on the stage of disease, but survival is reduced in patients who are greater than 60 years of age, are symptomatic at the time of diagnosis, have lesions of the middle and lower third of the vagina, or have poorly differentiated tumors. In addition, the length of vaginal wall involvement has been found to be significantly correlated to survival and stage of disease in squamous cell carcinoma patients
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| ==See also==
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| *[[Cervical cancer]] | | *[[Cervical cancer]] |
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| ==References==
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| * [http://www.cancer.gov/cancertopics/types/vaginal National Cancer Institute: Vaginal Cancer (public domain)]
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| * Stenchever: Comprehensive Gynecology, 4th ed., Copyright © 2001 Mosby, Inc.
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| [[Category:Gynecology]] | | [[Category:Gynecology]] |
| [[Category:Oncology]] | | [[Category:Oncology]] |
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