Pheochromocytoma other diagnostic studies: Difference between revisions

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(Created page with "{{Pheochromocytoma}} {{CMG}} ==Overview== A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a neuroendocrine tumor of the [[Adrenal medulla|medulla...")
 
 
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{{Pheochromocytoma}}
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==Overview==
==Overview==
 
[[Clonidine#Clonidine suppression test|Clonidine suppression test]] may be used in the diagnosis of pheochromocytoma.
A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a [[neuroendocrine tumor]] of the [[Adrenal medulla|medulla]] of the [[adrenal gland]]s (originating in the [[chromaffin cell]]s) or extra-adrenal chromaffin tissue which failed to involute after birth,<ref>{{cite book |author=Boulpaep, Emile L.; Boron, Walter F. |title=Medical physiology: a cellular and molecular approach |publisher=Saunders |location=Philadelphia |year=2003 |pages=1065 |isbn=0-7216-3256-4 |oclc= |doi=}}</ref> which secretes excessive amounts of [[catecholamine]]s, usually [[epinephrine]] and [[norepinephrine]].
==Other Diagnostic Studies==
Extra-adrenal [[paragangliomas]] (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the [[ganglion|ganglia]] of the [[sympathetic nervous system]] and are named based upon the primary anatomical site of origin.
Other diagnostic studies for [[pheochromocytoma]] include:
*[[Clonidine#Clonidine suppression test|Clonidine suppression test]], which demonstrates: <ref name="pmid26335433">{{cite journal| author=Goupil R, Fountoulakis S, Gordon RD, Stowasser M| title=Urinary clonidine suppression testing for the diagnosis of pheochromocytoma. | journal=J Hypertens | year= 2015 | volume= 33 | issue= 11 | pages= 2286-93 | pmid=26335433 | doi=10.1097/HJH.0000000000000705 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26335433  }}</ref>
**Lack of a response to clonidine (no reduction in [[catecholamine]] levels after test)
*[[Clonidine]] is a centrally-acting [[Alpha-2 receptor|alpha-2 agonist]] which mimics [[catecholamines]] in the [[brain]] and reduces the activity of the [[sympathetic nerves]] controlling the [[adrenal medulla]].
*Healthy [[adrenal medulla]] will respond to the [[clonidine]] suppression test by reducing [[catecholamine]] production.


==References==
==References==
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[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Oncology]]
[[de:Phäochromozytom]]
[[es:Feocromocitoma]]
[[fr:Phéochromocytome]]
[[it:Feocromocitoma]]
[[he:פאוכרומוציטומה]]
[[nl:Feochromocytoom]]
[[ja:褐色細胞腫]]
[[pl:Guz chromochłonny nadnerczy]]
[[sv:Feokromocytom]]
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Latest revision as of 22:04, 28 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2] Mohammed Abdelwahed M.D[3]

Overview

Clonidine suppression test may be used in the diagnosis of pheochromocytoma.

Other Diagnostic Studies

Other diagnostic studies for pheochromocytoma include:

References

  1. Goupil R, Fountoulakis S, Gordon RD, Stowasser M (2015). "Urinary clonidine suppression testing for the diagnosis of pheochromocytoma". J Hypertens. 33 (11): 2286–93. doi:10.1097/HJH.0000000000000705. PMID 26335433.