Primary central nervous system lymphoma history and symptoms: Difference between revisions

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{{Primary central nervous system lymphoma}}
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==Overview==
==Overview==
'''Primary CNS lymphoma''' is a [[brain tumor|primary intracranial tumor]] usually present in those with severe immunosuppression --- commonly in those with [[AIDS]] --- and represents around 20% of all cases of lymphomas in HIV infection (other types being [[Burkitt's lymphoma]] and immunoblastic lymphoma). Primary CNS lymphoma (PCNSL) is highly associated with [[Epstein-Barr virus]] infection (> 90%) in immunodeficient patients<ref>Fine HA, Mayer RJ. Primary central nervous system lymphoma. ''Ann Intern Med'' 1993; 119(11):1093-1104</ref> (such as those with AIDS and those iatrogenically immunosupressed) and does not have predilections for any age group. Mean [[CD4]]+ count at time of diagnosis is ~50/uL. Because of the severity of immunosuppression at the time of diagnosis, it is to no surprise that prognosis is usually poor. In immunocompetent patients (that is, patients that do not have AIDS or some other immunodeficiency) there is rarely an association with EBV infection or other infectious DNAs. In the immunocompetent population, PCNSL typically affects older patients in their 50's and 60's. Importantly, the incidence of PCNSL in the immunocompetent population has been reported to have increased more than 10-fold from 2.5 cases to 30 cases per 10 million population<ref>Eby NL, Grufferman S, Flannelly CM, Schold SC, Jr., Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. ''Cancer'' 1988;62(11):2461-2465</ref><ref>Corn BW, Marcus SM, Topham A, Hauck W, Curran WJ, Jr. Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000? ''Cancer'' 1997;79(12):2409-2413</ref>.  The cause for the increase in incidence of this disease in the immunocompetent population is unknown.
Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.Primary central nervous system lymphoma is multifocal.  Symptoms of primary nervous system lymphoma include [[headache]], [[nausea]], [[vomiting]], [[Dysphagia|difficulty swallowing]], [[vision loss|monocular vision loss]], [[Muscle weakness|Muscle weakness or paralysis]], [[memory loss]], [[hypoesthesia|facial hypoesthesia]], [[seizures]], [[fever]], [[night sweats]], and [[weight loss]].
 
==Symptoms==
*Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.<ref name="signsandsymptomsofprimarycnslymphoma1">Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016</ref>
*Primary central nervous system lymphoma is multifocal (tumors in different parts of the [[brain]]).
*[[Symptom|Symptoms]] of primary nervous system lymphoma include:<ref name="signsandsymptomsofprimarycnslymphoma1">Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016</ref><ref name="signsandsymptomsprimarycnslymphomawiki1">Signs and symptoms of primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016</ref><ref name="Ferreri2011">{{cite journal|last1=Ferreri|first1=A. J. M.|title=How I treat primary CNS lymphoma|journal=Blood|volume=118|issue=3|year=2011|pages=510–522|issn=0006-4971|doi=10.1182/blood-2011-03-321349}}</ref>
:*[[Headache]]
:*[[Nausea]]
:*[[Vomiting]]
:*[[Dysphagia|Difficulty swallowing]]
:*[[Diplopia|Double vision]]
:*[[vision loss|Monocular vision loss]]
:*[[Vertigo]]
:*[[Muscle weakness|Muscle weakness or paralysis]]
:*[[aphasia|Trouble speaking]]
:*[[Memory loss]]
:*[[Confusion]]
:*[[Lethargy]]
:*[[dementia|Progressive dementia]] or [[stupor]] in patients with a nonfocal neurologic exam and minimal abnormalities on MRI (more common in [[AIDS]] patients)
:*[[hypoesthesia|Facial hypoesthesia]]
:*[[Seizures]] (uncommon)
:*[[Fever]]
:*[[Night sweats]]
:*[[Weight loss]]


==References==
==References==
<references/>
{{Reflist|2}}
 
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Latest revision as of 17:10, 20 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.Primary central nervous system lymphoma is multifocal. Symptoms of primary nervous system lymphoma include headache, nausea, vomiting, difficulty swallowing, monocular vision loss, Muscle weakness or paralysis, memory loss, facial hypoesthesia, seizures, fever, night sweats, and weight loss.

Symptoms

  • Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.[1]
  • Primary central nervous system lymphoma is multifocal (tumors in different parts of the brain).
  • Symptoms of primary nervous system lymphoma include:[1][2][3]

References

  1. ↑ 1.0 1.1 Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016
  2. ↑ Signs and symptoms of primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016
  3. ↑ Ferreri, A. J. M. (2011). "How I treat primary CNS lymphoma". Blood. 118 (3): 510–522. doi:10.1182/blood-2011-03-321349. ISSN 0006-4971.

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