Myelodysplastic syndrome laboratory findings: Difference between revisions
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{{Myelodysplastic syndrome}} | {{Myelodysplastic syndrome}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{NM}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal [[complete blood count]], [[peripheral blood smear]], cytogenetic analysis, and [[immunohistochemistry]].<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref><ref name=Macrocytosis>Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015</ref><ref name=Basophilic>Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015</ref><ref name=Howell>Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015</ref><ref name=Pseudopelger>Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015</ref><ref name=Librepathology2>Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref><ref name="Haase2008">{{cite journal|last1=Haase|first1=Detlef|title=Cytogenetic features in myelodysplastic syndromes|journal=Annals of Hematology|volume=87|issue=7|year=2008|pages=515–526|issn=0939-5555|doi=10.1007/s00277-008-0483-y}}</ref><ref name="TricotWolf-Peeters1984">{{cite journal|last1=Tricot|first1=G.|last2=Wolf-Peeters|first2=C. De|last3=Hendrickx|first3=B.|last4=Verwilghen|first4=R. L.|title=Bone marrow histology in myelodysplastic syndromes.|journal=British Journal of Haematology|volume=57|issue=3|year=1984|pages=423–430|issn=0007-1048|doi=10.1111/j.1365-2141.1984.tb02916.x}}</ref> | |||
==Laboratory Findings== | |||
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal [[complete blood count]], [[peripheral blood smear]], cytogenetic analysis, [[immunohistochemistry]], and [[bone marrow biopsy]].<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref> | |||
===Complete Blood Count=== | |||
On [[complete blood count]], characteristic findings of myelodysplastic syndrome include:<ref name=cancergov5>Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015</ref> | |||
*[[Anemia]] | |||
*[[Thrombocytopenia]] | |||
*[[Leukopenia]] | |||
*[[Neutropenia]] | |||
===Peripheral Blood Smear=== | |||
On [[peripheral blood smear]], characteristic findings of myelodysplastic syndrome include:<ref name=Macrocytosis>Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015</ref><ref name=Basophilic>Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015</ref><ref name=Howell>Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015</ref><ref name=Pseudopelger>Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015</ref> | |||
*Macro-ovalocytes | |||
*Basophilic stippling | |||
*[[Howell-Jolly body]] | |||
*Acquired or pseudo-Pelger-Huët anomaly | |||
===Cytogenetic Analysis=== | |||
On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:<ref name=Librepathology2>Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref><ref name="Haase2008">{{cite journal|last1=Haase|first1=Detlef|title=Cytogenetic features in myelodysplastic syndromes|journal=Annals of Hematology|volume=87|issue=7|year=2008|pages=515–526|issn=0939-5555|doi=10.1007/s00277-008-0483-y}}</ref> | |||
*Deletions within the long arm of chromosome 5 | |||
*Deletions within the short arm of chromosome 17 | |||
*Monosomy 7 | |||
*Monosomy 8 | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Neurology]] | |||
[[Category:Neurosurgery]] | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, and immunohistochemistry.[1][2][3][4][5][6][7][8]
Laboratory Findings
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]
Complete Blood Count
On complete blood count, characteristic findings of myelodysplastic syndrome include:[1]
Peripheral Blood Smear
On peripheral blood smear, characteristic findings of myelodysplastic syndrome include:[2][3][4][5]
- Macro-ovalocytes
- Basophilic stippling
- Howell-Jolly body
- Acquired or pseudo-Pelger-Huët anomaly
Cytogenetic Analysis
On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:[6][7]
- Deletions within the long arm of chromosome 5
- Deletions within the short arm of chromosome 17
- Monosomy 7
- Monosomy 8
References
- ↑ 1.0 1.1 1.2 Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015
- ↑ 2.0 2.1 Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015
- ↑ 3.0 3.1 Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015
- ↑ 4.0 4.1 Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015
- ↑ 5.0 5.1 Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015
- ↑ 6.0 6.1 Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ 7.0 7.1 Haase, Detlef (2008). "Cytogenetic features in myelodysplastic syndromes". Annals of Hematology. 87 (7): 515–526. doi:10.1007/s00277-008-0483-y. ISSN 0939-5555.
- ↑ Tricot, G.; Wolf-Peeters, C. De; Hendrickx, B.; Verwilghen, R. L. (1984). "Bone marrow histology in myelodysplastic syndromes". British Journal of Haematology. 57 (3): 423–430. doi:10.1111/j.1365-2141.1984.tb02916.x. ISSN 0007-1048.