Rat-bite fever medical therapy: Difference between revisions

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Latest revision as of 18:52, 18 September 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Responds to penicillin antibiotics. In cases allergic to penicillin, erythromycin or tetracyclines can be used for respectively streptobacillary or spirillary infections.

Treatment

Antimicrobial therapy

Streptobacillus moniliformis treatment^[1]

1. Migratory arthropathy and arthritis

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

2. Diarrhea, (especially kids) liver or spleen abscess

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

3. Undifferentiated fever

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

4. Endocarditis, myocarditis, pericarditis (cardiac)

Preferred regimen: Penicillin 20 MU/day IV divided q4h. Optimal duration recommendation for infective endocarditis is 4 weeks.
Alternative regimen: Cephalosporins-Ceftriaxone OR Clindamycin OR Erythromycin OR Chloramphenicol AND Streptomycin.

5. Meningitis, brain abscess

Preferred regimen: Penicillin 20 MU/day IV divided q4h.
Alternative regimen: Cephalosporins-Ceftriaxone OR Clindamycin OR Erythromycin OR Chloramphenicol AND Streptomycin.

6. Anemia

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

7. Pneumonia

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

8. Amnionitis (pregnancy)

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

9. Renal abscess

Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

References

↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

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[1] Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

[1]

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+__NOTOC__
 {{Rat-bite fever}}
 {{CMG}}
+Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
 ==Overview==
+Responds to [[penicillin]] [[antibiotics]]. In cases allergic to [[penicillin]], [[erythromycin]] or [[tetracyclines]] can be used for respectively [[streptobacillary]] or spirillary infections.
 ==Treatment==
-Responds to [[penicillin]] antibiotics or where allergic to this [[erythromycin]] or [[tetracyclines]] for repectively streptobacillary or spirillary infections.
+===Antimicrobial therapy===
+:* Streptobacillus moniliformis treatment<ref>{{cite book | last = Bartlett | first = John | title = Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases | publisher = Jones and Bartlett Learning | location = Burlington, MA | year = 2012 | isbn = 978-1449625580 }}</ref>
+::* 1. '''Migratory arthropathy and arthritis'''
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
+::* 2. '''Diarrhea, (especially kids) liver or spleen abscess'''
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
+::* 3. '''Undifferentiated fever'''
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
+::* 4. '''Endocarditis, myocarditis, pericarditis (cardiac)'''
+:::* Preferred regimen: [[Penicillin]] 20 MU/day IV divided q4h. Optimal duration recommendation for infective endocarditis is 4 weeks.
+:::* Alternative regimen: [[Cephalosporins]]-[[Ceftriaxone]] {{or}} [[Clindamycin]] {{or}} [[Erythromycin]] {{or}} [[Chloramphenicol]] {{and}} [[Streptomycin]].
+::* 5. '''Meningitis, brain abscess'''
+:::* Preferred regimen: [[Penicillin]] 20 MU/day IV divided q4h.
+:::* Alternative regimen: [[Cephalosporins]]-[[Ceftriaxone]] {{or}} [[Clindamycin]] {{or}} [[Erythromycin]] {{or}} [[Chloramphenicol]] {{and}} [[Streptomycin]].
+::* 6. '''Anemia'''
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
+::* 7. ''' Pneumonia'''
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
+::* 8. '''Amnionitis''' (pregnancy)
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
+::* 9. '''Renal abscess'''
+:::* Preferred regimen (uncomplicated disease): [[Penicillin G]] 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral [[Amoxicillin]] {{or}} Penicillin Vk complete 14 days.
 ==References==
 {{Reflist|2}}
+{{WH}}
+{{WS}}
+[[Category:Needs content]]
+[[Category:Disease]]
+[[Category:Bacterial diseases]]
+[[Category:Infectious Disease Project]]