Pre-operative assessment: Difference between revisions

	Pre-operative clearance
Overview
Perioperative risk of death
Preoperative patient questionnaire
Preoperative laboratory testing
Approach to preoperative cardiac risk assessment
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Latest revision as of 04:16, 16 September 2022

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Mohammed A. Sbeih, M.D. [2]; Kashish Goel,M.D.

Please click here for Preoperative Cardiac Risk Assessment
For a printable checklist for pre-operative cardiac work up click here

Overview

The goal of the preoperative clearance (Preoperative medical assessment) is to assess the patient's general medical condition in order to identify any unrecognized co-morbid diseases and optimize the patient's state for the procedure. The preoperative medical assessment helps the doctors to decide if the patient is suitable for the proposed surgery according to the patient's risk category, also it helps them to identify the factors that may reduce the patient's risk for complications and provide the best possible recommendations for the post-operative care. Preoperative clearance usually starts by identifying the type of surgery to be performed and the risk category of the patient who needs this surgery.

Perioperative risk of death

Patients can be divided into different risk categories based on the basis of their preoperative medical assessment. This helps the doctors to decide if the patient is suitable for the proposed surgery or procedure, and identify the factors that may reduce the patient risk. There are many factors that may influence the risk of perioperative complications, including death.

Anesthesia

Although the modern anesthesia is safe, the risk of surgical complications varies according to the type of anesthesia (general or regional).

The patient's factors and surgical factors are more important risk predictors for post operative complications.

The American society of anesthesiologists (ASA) classification is a predictor of perioperative mortality. It also predicts cardiac and pulmonary morbidity.

ASA classification


Class	Systemic disturbance	Mortality rate
1	Healthy patient with no disease outside of the surgical process	<0.03%
2	Mild-to-moderate systemic disease caused by the surgical condition or by other pathologic processes	0.2%
3	Severe disease process which limits activity but is not incapacitating	1.2%
4	Severe incapacitating disease process that is a constant threat to life	8%
5	Moribund patient not expected to survive 24 hours with or without an operation	34%
E	Suffix to indicate an emergency surgery for any class	Increased

Type of surgery

Perioperative risk of complications varies according to the type of surgery.

Patient age

Some studies showed that the risk of surgery increases with advancing age.^[1] ^[2]

Emergency procedures

In emergency procedures the risk of complications may increases two to four times, or even more than that in elderly patients.

Pulmonary factors

There are several pulmonary factors that may increase the risk of complications in surgical patients, these may include:

Cigarete smoking.^[3]
Respiratory diseases.
Abnormal chest x-ray or phisical examination findings.
Thoracic or upper abdominal surgery.
Morbid obesity.
Age over 60.

Cardiac factors

There are several cardiac factors that may increase the risk of complications in surgical patients, these may include:

History of prosthetic valves.
History of rheumatic fever.
Congestive heart failure.
Arrhithmia.

Preoperative patient questionnaire

In general, the overall risk of surgery is extremely low in healthy individuals.

History

The patient should be asked about his age. Some studies found a small increased risk of surgery with advanced age of the patient. The mortality rate for most surgical procedures increases linearly with age due to increasing numbers of comorbidities with advancing age.

The patient should be asked if he had a history of:

Heart diseases,irregular heart beat, murmurs or rheumatic fever as a child.
Pulmonary diseases, such as asthma, bronchitis, or emphysema.
Chest pain, angina, or chest tightness.
Hypertension or hypotension.
Shortness of breath, cough.
Liver diseases, jaundice or hepatitis.
Gastrointestinal problems or indigestion.
Diabetes.
Thyroid problems.
Kidney problems.
Weakness or numbness in the extremities.
Seizures or blackouts.
Bleeding disorders.
Blood clotting abnormality.
Arthritis or joint pain.

The patient should be asked about:

Any allergies for food or medication.
A list of any medications he is currently taking, including over-the-counter medications and steroidal compounds. Nonsteroidal anti-inflammatory drugs are associated with :an increased risk of perioperative bleeding.
Any other medical conditions in the past.
Any previous surgeries or anesthesia.
pregnancy state.
Any problems with a previous surgery due to anesthesia.

The patient should be asked when did he last eat or drink on the day of surgery.
The patient should be asked about his height and weight. Studies showed that obesity is not a risk factor for most adverse postoperative outcomes, with the exception of :deep venous thrombosis and pulmonary embolism. However, some cardiac surgery studies have shown higher complication rates for obese patients, such as prolonged hospital stay, wound infections and prolonged mechanical ventilation ^[4] ^[5].
The patient should be asked about his exercise capacity, patients with unlimited exercise tolerance generally have a low risk of postoperative complications. Those patients :can walk two blocks on level ground without symptoms,
The patient should be asked if he smokes cigarettes, how many packs per day and for how many years.^[3]
The patient should be asked if he drinks alcohol. There is increased risk for postoperative complications in patients who misuse alcohol on a regular basis.^[6]
The patient should be asked about his family history.

Preoperative laboratory testing

The American society of anesthesiologists recommends against routine preoperative laboratory testing in the absence of clinical indications ^[7]. In specific circumstances, selective testing may be appropriate, such as in patients with underlying diseases or risk factors that would increase their risk for surgical complications. Also in specific high risk surgical procedures, these tests should be done. If there is no significant change in the clinical condition of the patient, it may be safe to use test results that were performed within the past four months. These tests include:

1. Complete blood count (CBC): Anemia maybe presents in asymptomatic patients and it is common following major surgery. Postoperative mortality maybe predicted by the preoperative hemoglobin level ^[8]. CBC test should be done for:

Patients 65 years of age or older.
Patients who are undergoing major surgery.
Young patients who undergoing major surgery with the expectation to result in significant blood loss.
Patients with a history that suggests anemia.

2. Renal function test (RFT): Serum creatinine concentration should be ordered for patients over the age of 50 undergoing intermediate or high risk surgeries, also it should be ordered if hypotension is likely, or when nephrotoxic medications will be used. Mild to moderate renal impairment is usually asymptomatic. Dosage adjustment of some medications may be needed if the patient has renal insufficiency.

3. Electrolytes: It is not recommended to be done routinely if the patient does not have a history of electrolytes abnormality.

4. Blood glucose: Diabetes increases the operative risk in patients undergoing vascular surgery or coronary artery bypass grafting ^[9]^[10]. Routine measurement of blood glucose is not recommended for healthy patients before the surgery, since some studies showed that unexpected abnormal blood glucose results do not often influence perioperative management ^[1]^[11].

5. Liver function tests (LFT): It is not recommended to do this test routinely unless the patient has a history of liver disease ^[12].

6. Hemostasis tests: It is not recommended to do prothrombin time (PT) or Partial thromboplastin time (PTT) blood tests routinely unless the patient has bleeding disorder or an unusual bleeding tendency ^[12]. Some doctors have suggested to test all patients who undergoing intermediate to high risk surgeries. This avoids the chance that clinicians may forget to ask the patients about their bleeding history. The bleeding time is not useful in assessing the risk of perioperative hemorrhage ^[12]^[13].

7. Urinalysis: It is usually done to detect any urinary tract infection which has the potential to cause wound infection after the surgery ^[14], especially with prosthetic surgery. If the test is positive, the patient should be treated with antibiotics and proceed with surgery without delay. Some studies showed that there is no reduction in the risk of postoperative wound infection if the patient treated with antibiotics before the surgery, and so, it is not indicated to test for Urinary tract infection before the surgery for every patient ^[15]^[16].

8. Pregnancy testing: Pregnant women may need specific perioperative management, this includes specific anesthetic teqniques. An elective surgery may be cancelled or postponed in pregnant women. The American society of anesthesiologists recommends that clinicians consider pregnancy testing for all woman of childbearing age ^[7]. Many institutions require pregnancy testing for all reproductive age women before surgery.

9. Electrocardiogram (EKG): This should be done to detect any recent myocardial infarction (MI) which known to be associated with increased surgical morbidity and mortality ^[1], also it may be important as a baseline to be compared with the one postoperatively. In general, EKG alone may be a poor indicator of postoperative cardiac complications. The 2007 American college of cardiology/American heart association (ACC/AHA) Guidelines on perioperative cardiovascular evaluation states that ECG is not useful in asymptomatic patients undergoing low risk procedures ^[17]. Also, the European Society of Cardiology 2009 preoperative guidelines do not recommend ECG in patients without risk factors ^[18]. According to the 2007 ACC/AHA guidelines the 12-lead ECG are recommended for the following patients:

Patients who are scheduled to undergo vascular surgery and have at least one of the following clinical risk factors:

It is less strongly recommended to perform an ECG for patients scheduled to undergo vascular surgery with no clinical risk factors.

Patients who are scheduled to undergo intermediate-risk surgery with known cardiovascular disease, peripheral artery disease, or cerebrovascular disease.It is less strongly recommended to perform an ECG for patients scheduled to undergo intermediate-risk surgery with at least one clinical risk factor.

10. Chest radiograph (Chest x-ray): Its not recommended to do this test routinely before the operations in healthy patients, many studies showed that an abnormal chest x-ray findings may occur frequently, especially in elderly persons ^[19]. According to the American College of Physicians (ACP), if there is a suspicion of cardiopulmonary disease from the patient's history or physical examination, then this test should be done, also in those older than 50 years of age who are undergoing abdominal aortic aneurysm surgery or upper abdominal/thoracic surgery ^[20]. The American heart association (AHA) recommends preoperative chest x-ray for patients with morbid obesity (BMI ≥40 kg/m2)^[21].

11. Pulmonary function test (PFT): This test only recommended for patients who have dyspnea or other abnormal respiratory clinical findings such as decreased breath sounds, prolonged expiratory phase, rales, rhonchi, or wheezes ^[22].

Thromboembolism prophylaxis

Orthopedic surgery

For knee of hip arthroplasty

The CRISTAL trial found more benefit (mainly from reducing distal DVTs) from Enoxaparin than aspirin (aspirin 100 mg daily or enoxaparin 40 mg daily for 35 days after hip replacement and 14 days after knee replacement)^[23].

However shorter therapy,After an initial 5 days of rivaroxaban, 9 days of aspirin or rivaroxaban may similarly reduce thromboembolism according to the EPCAT II trial^[24].

For knee arthroscopy

Evidence from trials conflicts:
- Low molecular weight heparin did not prevent thromboembolism in the POT-KAST trial trial published in 2017^[25]. There was no routine imaging for outcomes in this study. Average age of patients was 56. The patients were not routinely imaged for thromboembolism.
  - In comparing their negative results to the two positive studies below, the POT-KAST authors noted "...in both trials, all the participants underwent ultrasonographic screening for venous thromboembolism, at which time questions were asked about possible signs and symptoms. This clearly does not reflect the method for identification of symptomatic venous thromboembolism that is used in general clinical practice and has therefore led to overestimation of the incidences."
- Rivaroxaban once-daily rivaroxaban (10 mg) for .seven days may be better than placebo at preventing thromboembolism in the ERIKA trial published in 2016^[26]. Average age of patients was 46. All patients received colour-coded Doppler ultrasonography (CCDU) after seven days.
- Low molecular weight heparin did prevent thromboembolism as compared to compression stockings in a trial published in 2008^[27]. In this trial, "All patients had bilateral, whole-leg, color-coded Doppler ultrasonography at the end of prophylaxis (8 or 15 days)."
For systematic reviews:
- The Cochrane Collaboration concludes "There is moderate- to low-certainty evidence of no benefit from the use of LMWH, aspirin or rivaroxaban in reducing this small risk of PE or symptomatic DVT. There is very low-certainty evidence that LMWH use may reduce the risk of asymptomatic DVT when compared to no treatment but it is uncertain how this directly relates to incidence of DVT or PE in healthy patients"^[28]

External links

http://www.askdrwiki.com/mediawiki/index.php?title=Preoperative_Clearance

http://www.asahq.org/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2146059/

http://circ.ahajournals.org/content/116/17/e418.full.pdf+html

References

↑ ^1.0 ^1.1 ^1.2 Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B; et al. (1977). "Multifactorial index of cardiac risk in noncardiac surgical procedures". N Engl J Med. 297 (16): 845–50. doi:10.1056/NEJM197710202971601. PMID 904659.
↑ Linn BS, Linn MW, Wallen N (1982). "Evaluation of results of surgical procedures in the elderly". Ann Surg. 195 (1): 90–6. PMC 1352408. PMID 7055387.
↑ ^3.0 ^3.1 Jones R, Nyawo B, Jamieson S, Clark S (2011). "Current smoking predicts increased operative mortality and morbidity after cardiac surgery in the elderly". Interact Cardiovasc Thorac Surg. 12 (3): 449–53. doi:10.1510/icvts.2010.239863. PMID 21097455.
↑ Yap CH, Zimmet A, Mohajeri M, Yii M (2007). "Effect of obesity on early morbidity and mortality following cardiac surgery". Heart Lung Circ. 16 (1): 31–6. doi:10.1016/j.hlc.2006.09.007. PMID 17161973.
↑ Kuduvalli M, Grayson AD, Oo AY, Fabri BM, Rashid A (2002). "Risk of morbidity and in-hospital mortality in obese patients undergoing coronary artery bypass surgery". Eur J Cardiothorac Surg. 22 (5): 787–93. PMID 12414047.
↑ Tønnesen H, Nielsen PR, Lauritzen JB, Møller AM (2009). "Smoking and alcohol intervention before surgery: evidence for best practice". Br J Anaesth. 102 (3): 297–306. doi:10.1093/bja/aen401. PMID 19218371.
↑ ^7.0 ^7.1 American Society of Anesthesiologists Task Force on Preanesthesia Evaluation (2002). "Practice advisory for preanesthesia evaluation: a report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation". Anesthesiology. 96 (2): 485–96. PMID 11818784.
↑ Mathew A, Devereaux PJ, O'Hare A, Tonelli M, Thiessen-Philbrook H, Nevis IF; et al. (2008). "Chronic kidney disease and postoperative mortality: a systematic review and meta-analysis". Kidney Int. 73 (9): 1069–81. doi:10.1038/ki.2008.29. PMID 18288098.
↑ Eagle KA, Coley CM, Newell JB, Brewster DC, Darling RC, Strauss HW; et al. (1989). "Combining clinical and thallium data optimizes preoperative assessment of cardiac risk before major vascular surgery". Ann Intern Med. 110 (11): 859–66. PMID 2655519.
↑ Higgins TL, Estafanous FG, Loop FD, Beck GJ, Blum JM, Paranandi L (1992). "Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score". JAMA. 267 (17): 2344–8. PMID 1564774.
↑ Velanovich V (1991). "The value of routine preoperative laboratory testing in predicting postoperative complications: a multivariate analysis". Surgery. 109 (3 Pt 1): 236–43. PMID 2000554.
↑ ^12.0 ^12.1 ^12.2 Smetana GW, Macpherson DS (2003). "The case against routine preoperative laboratory testing". Med Clin North Am. 87 (1): 7–40. PMID 12575882.
↑ Peterson P, Hayes TE, Arkin CF, Bovill EG, Fairweather RB, Rock WA; et al. (1998). "The preoperative bleeding time test lacks clinical benefit: College of American Pathologists' and American Society of Clinical Pathologists' position article". Arch Surg. 133 (2): 134–9. PMID 9484723.
↑ Koulouvaris P, Sculco P, Finerty E, Sculco T, Sharrock NE (2009). "Relationship between perioperative urinary tract infection and deep infection after joint arthroplasty". Clin Orthop Relat Res. 467 (7): 1859–67. doi:10.1007/s11999-008-0614-8. PMC 2690738. PMID 19009324.
↑ Lawrence VA, Kroenke K (1988). "The unproven utility of preoperative urinalysis. Clinical use". Arch Intern Med. 148 (6): 1370–3. PMID 3377621.
↑ Ollivere BJ, Ellahee N, Logan K, Miller-Jones JC, Allen PW (2009). "Asymptomatic urinary tract colonisation predisposes to superficial wound infection in elective orthopaedic surgery". Int Orthop. 33 (3): 847–50. doi:10.1007/s00264-008-0573-4. PMC 2903079. PMID 18521600.
↑ Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE; et al. (2009). "2009 ACCF/AHA focused update on perioperative beta blockade incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American college of cardiology foundation/American heart association task force on practice guidelines". Circulation. 120 (21): e169–276. doi:10.1161/CIRCULATIONAHA.109.192690. PMID 19884473.
↑ Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery. European Society of Cardiology (ESC). Poldermans D, Bax JJ, Boersma E, De Hert S; et al. (2009). "Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery". Eur Heart J. 30 (22): 2769–812. doi:10.1093/eurheartj/ehp337. PMID 19713421.
↑ García-Miguel FJ, Serrano-Aguilar PG, López-Bastida J (2003). "Preoperative assessment". Lancet. 362 (9397): 1749–57. PMID 14643127.
↑ Smetana GW, Lawrence VA, Cornell JE, American College of Physicians (2006). "Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians". Ann Intern Med. 144 (8): 581–95. PMID 16618956. Review in: ACP J Club. 2006 Sep-Oct;145(2):37
↑ Poirier P, Alpert MA, Fleisher LA, Thompson PD, Sugerman HJ, Burke LE; et al. (2009). "Cardiovascular evaluation and management of severely obese patients undergoing surgery: a science advisory from the American Heart Association". Circulation. 120 (1): 86–95. doi:10.1161/CIRCULATIONAHA.109.192575. PMID 19528335.
↑ Lawrence VA, Dhanda R, Hilsenbeck SG, Page CP (1996). "Risk of pulmonary complications after elective abdominal surgery". Chest. 110 (3): 744–50. PMID 8797421.
↑ CRISTAL Study Group. Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R; et al. (2022). "Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial". JAMA. 328 (8): 719–727. doi:10.1001/jama.2022.13416. PMC 9399863 Check |pmc= value (help). PMID 35997730 Check |pmid= value (help).
↑ Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M; et al. (2018). "Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty". N Engl J Med. 378 (8): 699–707. doi:10.1056/NEJMoa1712746. PMID 29466159.
↑ van Adrichem RA, Nemeth B, Algra A, le Cessie S, Rosendaal FR, Schipper IB; et al. (2017). "Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting". N Engl J Med. 376 (6): 515–525. doi:10.1056/NEJMoa1613303. PMID 27959702.
↑ Camporese G, Bernardi E, Noventa F, Bosco M, Monteleone G, Santoro L; et al. (2016). "Efficacy of Rivaroxaban for thromboprophylaxis after Knee Arthroscopy (ERIKA). A phase II, multicentre, double-blind, placebo-controlled randomised study". Thromb Haemost. 116 (2): 349–55. doi:10.1160/TH16-02-0118. PMID 27075710.
↑ Camporese G, Bernardi E, Prandoni P, Noventa F, Verlato F, Simioni P; et al. (2008). "Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy: a randomized trial". Ann Intern Med. 149 (2): 73–82. doi:10.7326/0003-4819-149-2-200807150-00003. PMID 18626046. Review in: ACP J Club. 2008 Dec 16;149(6):10
↑ Perrotta C, Chahla J, Badariotti G, Ramos J (2020). "Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy". Cochrane Database Syst Rev. 5: CD005259. doi:10.1002/14651858.CD005259.pub4. PMC 7202465 Check |pmc= value (help). PMID 32374919 Check |pmid= value (help).

Template:WikiDoc Sources

[pmid904659-1] 1.0 ^1.1 ^1.2 Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B; et al. (1977). "Multifactorial index of cardiac risk in noncardiac surgical procedures". N Engl J Med. 297 (16): 845–50. doi:10.1056/NEJM197710202971601. PMID 904659.

[pmid7055387-2] Linn BS, Linn MW, Wallen N (1982). "Evaluation of results of surgical procedures in the elderly". Ann Surg. 195 (1): 90–6. PMC 1352408. PMID 7055387.

[pmid21097455-3] 3.0 ^3.1 Jones R, Nyawo B, Jamieson S, Clark S (2011). "Current smoking predicts increased operative mortality and morbidity after cardiac surgery in the elderly". Interact Cardiovasc Thorac Surg. 12 (3): 449–53. doi:10.1510/icvts.2010.239863. PMID 21097455.

[pmid17161973-4] Yap CH, Zimmet A, Mohajeri M, Yii M (2007). "Effect of obesity on early morbidity and mortality following cardiac surgery". Heart Lung Circ. 16 (1): 31–6. doi:10.1016/j.hlc.2006.09.007. PMID 17161973.

[pmid12414047-5] Kuduvalli M, Grayson AD, Oo AY, Fabri BM, Rashid A (2002). "Risk of morbidity and in-hospital mortality in obese patients undergoing coronary artery bypass surgery". Eur J Cardiothorac Surg. 22 (5): 787–93. PMID 12414047.

[pmid19218371-6] Tønnesen H, Nielsen PR, Lauritzen JB, Møller AM (2009). "Smoking and alcohol intervention before surgery: evidence for best practice". Br J Anaesth. 102 (3): 297–306. doi:10.1093/bja/aen401. PMID 19218371.

[pmid11818784-7] 7.0 ^7.1 American Society of Anesthesiologists Task Force on Preanesthesia Evaluation (2002). "Practice advisory for preanesthesia evaluation: a report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation". Anesthesiology. 96 (2): 485–96. PMID 11818784.

[pmid18288098-8] Mathew A, Devereaux PJ, O'Hare A, Tonelli M, Thiessen-Philbrook H, Nevis IF; et al. (2008). "Chronic kidney disease and postoperative mortality: a systematic review and meta-analysis". Kidney Int. 73 (9): 1069–81. doi:10.1038/ki.2008.29. PMID 18288098.

[pmid2655519-9] Eagle KA, Coley CM, Newell JB, Brewster DC, Darling RC, Strauss HW; et al. (1989). "Combining clinical and thallium data optimizes preoperative assessment of cardiac risk before major vascular surgery". Ann Intern Med. 110 (11): 859–66. PMID 2655519.

[pmid1564774-10] Higgins TL, Estafanous FG, Loop FD, Beck GJ, Blum JM, Paranandi L (1992). "Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score". JAMA. 267 (17): 2344–8. PMID 1564774.

[pmid2000554-11] Velanovich V (1991). "The value of routine preoperative laboratory testing in predicting postoperative complications: a multivariate analysis". Surgery. 109 (3 Pt 1): 236–43. PMID 2000554.

[pmid12575882-12] 12.0 ^12.1 ^12.2 Smetana GW, Macpherson DS (2003). "The case against routine preoperative laboratory testing". Med Clin North Am. 87 (1): 7–40. PMID 12575882.

[pmid9484723-13] Peterson P, Hayes TE, Arkin CF, Bovill EG, Fairweather RB, Rock WA; et al. (1998). "The preoperative bleeding time test lacks clinical benefit: College of American Pathologists' and American Society of Clinical Pathologists' position article". Arch Surg. 133 (2): 134–9. PMID 9484723.

[pmid19009324-14] Koulouvaris P, Sculco P, Finerty E, Sculco T, Sharrock NE (2009). "Relationship between perioperative urinary tract infection and deep infection after joint arthroplasty". Clin Orthop Relat Res. 467 (7): 1859–67. doi:10.1007/s11999-008-0614-8. PMC 2690738. PMID 19009324.

[pmid3377621-15] Lawrence VA, Kroenke K (1988). "The unproven utility of preoperative urinalysis. Clinical use". Arch Intern Med. 148 (6): 1370–3. PMID 3377621.

[pmid18521600-16] Ollivere BJ, Ellahee N, Logan K, Miller-Jones JC, Allen PW (2009). "Asymptomatic urinary tract colonisation predisposes to superficial wound infection in elective orthopaedic surgery". Int Orthop. 33 (3): 847–50. doi:10.1007/s00264-008-0573-4. PMC 2903079. PMID 18521600.

[pmid19884473-17] Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE; et al. (2009). "2009 ACCF/AHA focused update on perioperative beta blockade incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American college of cardiology foundation/American heart association task force on practice guidelines". Circulation. 120 (21): e169–276. doi:10.1161/CIRCULATIONAHA.109.192690. PMID 19884473.

[pmid19713421-18] Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery. European Society of Cardiology (ESC). Poldermans D, Bax JJ, Boersma E, De Hert S; et al. (2009). "Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery". Eur Heart J. 30 (22): 2769–812. doi:10.1093/eurheartj/ehp337. PMID 19713421.

[pmid14643127-19] García-Miguel FJ, Serrano-Aguilar PG, López-Bastida J (2003). "Preoperative assessment". Lancet. 362 (9397): 1749–57. PMID 14643127.

[pmid16618956-20] Smetana GW, Lawrence VA, Cornell JE, American College of Physicians (2006). "Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians". Ann Intern Med. 144 (8): 581–95. PMID 16618956. Review in: ACP J Club. 2006 Sep-Oct;145(2):37

[pmid19528335-21] Poirier P, Alpert MA, Fleisher LA, Thompson PD, Sugerman HJ, Burke LE; et al. (2009). "Cardiovascular evaluation and management of severely obese patients undergoing surgery: a science advisory from the American Heart Association". Circulation. 120 (1): 86–95. doi:10.1161/CIRCULATIONAHA.109.192575. PMID 19528335.

[pmid8797421-22] Lawrence VA, Dhanda R, Hilsenbeck SG, Page CP (1996). "Risk of pulmonary complications after elective abdominal surgery". Chest. 110 (3): 744–50. PMID 8797421.

[pmid35997730-23] CRISTAL Study Group. Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R; et al. (2022). "Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial". JAMA. 328 (8): 719–727. doi:10.1001/jama.2022.13416. PMC 9399863 Check |pmc= value (help). PMID 35997730 Check |pmid= value (help).

[pmid29466159-24] Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M; et al. (2018). "Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty". N Engl J Med. 378 (8): 699–707. doi:10.1056/NEJMoa1712746. PMID 29466159.

[pmid27959702-25] van Adrichem RA, Nemeth B, Algra A, le Cessie S, Rosendaal FR, Schipper IB; et al. (2017). "Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting". N Engl J Med. 376 (6): 515–525. doi:10.1056/NEJMoa1613303. PMID 27959702.

[pmid27075710-26] Camporese G, Bernardi E, Noventa F, Bosco M, Monteleone G, Santoro L; et al. (2016). "Efficacy of Rivaroxaban for thromboprophylaxis after Knee Arthroscopy (ERIKA). A phase II, multicentre, double-blind, placebo-controlled randomised study". Thromb Haemost. 116 (2): 349–55. doi:10.1160/TH16-02-0118. PMID 27075710.

[pmid18626046-27] Camporese G, Bernardi E, Prandoni P, Noventa F, Verlato F, Simioni P; et al. (2008). "Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy: a randomized trial". Ann Intern Med. 149 (2): 73–82. doi:10.7326/0003-4819-149-2-200807150-00003. PMID 18626046. Review in: ACP J Club. 2008 Dec 16;149(6):10

[pmid32374919-28] Perrotta C, Chahla J, Badariotti G, Ramos J (2020). "Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy". Cochrane Database Syst Rev. 5: CD005259. doi:10.1002/14651858.CD005259.pub4. PMC 7202465 Check |pmc= value (help). PMID 32374919 Check |pmid= value (help).

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@@ Line 1: / Line 1: @@
 {{Pre-operative clearance}}
-{{CMG}}; '''Associate Editor-In-Chief:''' [[User: Mohammed Sbeih|Mohammed A. Sbeih, M.D.]] [mailto:msbeih@perfuse.org]
+{{CMG}}; '''Associate Editor-In-Chief:''' [[User: Mohammed Sbeih|Mohammed A. Sbeih, M.D.]] [mailto:msbeih@wikidoc.org]; [[User:Kashish Goel|Kashish Goel,M.D.]]
+'''Please click here for [[Preoperative cardiac risk assessment|Preoperative Cardiac Risk Assessment]]'''<br>
+'''For a printable checklist for pre-operative cardiac work up [[Preoperative cardiac clearance checklist|click here]]'''
 ==Overview==
@@ Line 133: / Line 136: @@
 '''10. Chest radiograph (Chest x-ray)''': Its not recommended to do this test routinely before the operations in healthy patients, many studies showed that an abnormal chest x-ray findings may occur frequently, especially in elderly persons <ref name="pmid14643127">{{cite journal| author=García-Miguel FJ, Serrano-Aguilar PG, López-Bastida J| title=Preoperative assessment. | journal=Lancet | year= 2003 | volume= 362 | issue= 9397 | pages= 1749-57 | pmid=14643127 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14643127  }} </ref>. According to the American College of Physicians (ACP), if there is a suspicion of cardiopulmonary disease from the patient's history or physical examination, then this test should be done, also in those older than 50 years of age who are undergoing [[abdominal aortic aneurysm]] surgery or upper abdominal/thoracic surgery <ref name="pmid16618956">{{cite journal| author=Smetana GW, Lawrence VA, Cornell JE, American College of Physicians| title=Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians. | journal=Ann Intern Med | year= 2006 | volume= 144 | issue= 8 | pages= 581-95 | pmid=16618956 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16618956  }}  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16944857 Review in: ACP J Club. 2006 Sep-Oct;145(2):37] </ref>.
-The [[American heart association]] (AHA) recommends preoperative chest x.ray for patients with morbid obesity (BMI ≥40 kg/m2)<ref name="pmid19528335">{{cite journal| author=Poirier P, Alpert MA, Fleisher LA, Thompson PD, Sugerman HJ, Burke LE et al.| title=Cardiovascular evaluation and management of severely obese patients undergoing surgery: a science advisory from the American Heart Association. | journal=Circulation | year= 2009 | volume= 120 | issue= 1 | pages= 86-95 | pmid=19528335 | doi=10.1161/CIRCULATIONAHA.109.192575 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19528335  }} </ref>.
+The [[American heart association]] (AHA) recommends preoperative chest x-ray for patients with morbid obesity (BMI ≥40 kg/m2)<ref name="pmid19528335">{{cite journal| author=Poirier P, Alpert MA, Fleisher LA, Thompson PD, Sugerman HJ, Burke LE et al.| title=Cardiovascular evaluation and management of severely obese patients undergoing surgery: a science advisory from the American Heart Association. | journal=Circulation | year= 2009 | volume= 120 | issue= 1 | pages= 86-95 | pmid=19528335 | doi=10.1161/CIRCULATIONAHA.109.192575 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19528335  }} </ref>.
 '''11. [[Pulmonary function test]] (PFT)''': This test only recommended for patients who have dyspnea or other abnormal respiratory clinical findings such as decreased breath sounds, prolonged expiratory phase, rales, rhonchi, or wheezes <ref name="pmid8797421">{{cite journal| author=Lawrence VA, Dhanda R, Hilsenbeck SG, Page CP| title=Risk of pulmonary complications after elective abdominal surgery. | journal=Chest | year= 1996 | volume= 110 | issue= 3 | pages= 744-50 | pmid=8797421 | doi= | pmc= | url= }} </ref>.
-==ACC / AHA recommendations for perioperative cardiac assessment==
+==Thromboembolism prophylaxis==
-This table below contains the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery<ref name="pmid17901357">{{cite journal| author=Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof E, Fleischmann KE et al.| title=ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. | journal=Circulation | year= 2007 | volume= 116 | issue= 17 | pages= e418-99 | pmid=17901357 | doi=10.1161/CIRCULATIONAHA.107.185699 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17901357  }} </ref>.
-{{cquote|
-'''Class I'''
-#Patients who have a need for emergency noncardiac surgery should proceed to the operating room and continue perioperative surveillance and postoperative risk :stratification and risk factor management. ''(Level of Evidence: C)''
-#Patients with active cardiac conditions* should be evaluated and treated per ACC/AHA guidelines and, if appropriate, consider proceeding to the operating room. ''(Level of Evidence: B)''
-#Patients undergoing low risk surgery are recommended to proceed to planned surgery.† ''(Level of Evidence: B)''
-#Patients with poor (less than 4 METs) or unknown functional capacity and no clinical risk factors  should proceed with planned surgery.† ''(Level of Evidence: B)''
-'''Class IIa'''
-#It is probably recommended that patients with functional capacity greater than or equal to 4 METs without symptoms‡ proceed to planned surgery.§ ''(Level of Evidence: B)''
-#It is probably recommended that patients with poor (less than 4 METs) or unknown functional capacity and 3 or more clinical risk factors  who are scheduled for vascular surgery consider testing if it will change management.¶ ''(Level of Evidence: B)''
-#It is probably recommended that patients with poor (less than 4 METs) or unknown functional capacity and 3 or more clinical risk factors  who are scheduled for intermediate risk surgery proceed with planned surgery with heart rate control.¶ ''(Level of Evidence: B)''
-#It is probably recommended that patients with poor (less than 4 METs) or unknown functional capacity and 1 or 2 clinical risk factors  who are scheduled for vascular or intermediate risk surgery proceed with planned surgery with heart rate control.¶ ''(Level of Evidence: B)''
-'''Class IIb'''
-#Noninvasive testing might be considered if it will change management for patients with poor (less than 4 METs) or unknown functional capacity and 3 or more clinical risk factors  who are scheduled for intermediate risk surgery. ''(Level of Evidence: B)''
-#Noninvasive testing might be considered if it will change management for patients with poor (less than 4 METs) or unknown functional capacity and 1 or 2 clinical risk factors  who are scheduled for vascular or intermediate risk surgery. ''(Level of Evidence: B)''
-----
-§Noninvasive testing may be considered before surgery in specific
-patients with risk factors if it will change management.
-Clinical risk factors include ischemic heart disease, compensated or
-prior heart failure, diabetes mellitus, renal insufficiency, and cerebrovascular disease.
-¶Consider perioperative beta blockade (see Table 12) for populations
-in which this has been shown to reduce cardiac morbidity/mortality.}}
-==Stepwise approach to preoperative cardiac assessment==
-[[Image:Preoperative_Evaluation.jpg|1000px]]
-Adapted from Fleisher et al. Circulation. 2009 Nov 24;120(21):e169-276<ref name="pmid19884473">{{cite journal |author=Fleisher LA, Beckman JA, Brown KA, ''et al.'' |title=2009 ACCF/AHA focused update on perioperative beta blockade incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American college of cardiology foundation/American heart association task force on practice guidelines |journal=Circulation |volume=120 |issue=21 |pages=e169–276 |year=2009 |month=November |pmid=19884473 |doi=10.1161/CIRCULATIONAHA.109.192690 |url=}}</ref>
-§,∧ Noninvasive testing is not useful for patients with no clinical risk factors undergoing intermediate-risk or low-risk noncardiac surgery (AHA guidelines Class III, Level of Evidence: C).
-===Active Cardiac conditions===
-'''1.  Unstable coronary syndromes'''
-* Unstable or severe angina (Canadian Cardiovascular Society class III or IV): May include “stable” angina in patients who are unusually sedentary.
-* Recent MI: Greater than 7 days, but less than or equal to 1 month (within 30 days)
-'''2. Decompensated HF'''
-* NYHA functional class IV
-* Worsening or new-onset heart failure
-'''3. Significant arrhythmias'''
-* High-grade atrioventricular block
-* Mobitz II atrioventricular block
-* Third-degree atrioventricular heart block
-* Symptomatic ventricular arrhythmias
-* Supraventricular arrhythmias (including atrial fibrillation) with uncontrolled ventricular rate (HR greater than 100 bpm at rest)
-* Symptomatic bradycardia
-* Newly recognized ventricular tachycardia
-'''4. Severe valvular disease'''
-* Severe aortic stenosis (mean pressure gradient >40 mm Hg, aortic valve area <1.0 cm2, or symptomatic)
-* Symptomatic mitral stenosis (progressive dyspnea on exertion, exertional presyncope, or heart failure)
-==Estimated energy requirements for various activities==
-The '''metabolic equivalent of task (MET)''', or simply '''metabolic equivalent''', is a physiological concept expressing the energy cost of physical activities<ref>Physical activity can be defined as “bodily movement produced by the contraction of skeletal muscle that increases energy expenditure above the basal level”</ref> as multiples of resting [[metabolic rate]] (RMR) and is defined as the ratio of metabolic rate (and therefore the rate of energy consumption) during a specific physical activity to a reference rate of metabolic rate at rest, set by convention to 3.5 ml O2·kg-1·min-1 or equivalently 1 kcal·kg-1· h-1 or 4.184 kJ·kg-1· h-1. By convention 1 MET is considered as the resting metabolic rate obtained during quiet sitting<ref>Ainsworth et al., 1993 </ref><ref> Ainsworth et al., 2000. </ref> . MET values of physical activities range from 0.9 (sleeping) to 18 (running at 17.5 km/h or a 5:31 mile pace).
-'''Calculating the weekly energy expended in recreational-time physical activity using METs (Metabolic equivalent task) <ref>Adapted from Compendium of Physical Activities. Ainsworth, BE et al. Medicine and Science in Sports and Exercise. Vol 25, Pg 713 (1993) and Vol 32, S498 (2000).</ref>'''.
-{| class="wikitable" border="1"
-|-
-! Physical Activity
-! MET
-|-
-! Light Intensity Activities
-! < 3
-|-
-| sleeping
-| 0.9
-|-
-| watching television
-| 1.0
-|-
-| writing, desk work, typing
-| 1.8
-|-
-| walking, 1.7 mph (2.7&nbsp;km/h), level ground, strolling, very slow
-| 2.3
-|-
-| walking, 2.5 mph (4 km/h)
-| 2.9
-|-
-|-
-! Moderate Intensity Activities
-! 3 to 6
-|-
-| bicycling, stationary, 50 watts, very light effort
-| 3.0
-|-
-| walking 3.0 mph (4.8 km/h)
-| 3.3
-|-
-| calisthenics, home exercise, light or moderate effort, general
-| 3.5
-|-
-| walking 3.4 mph (5.5 km/h)
-| 3.6
-|-
-| bicycling, <10 mph (16&nbsp;km/h), leisure, to work or for pleasure
-| 4.0
-|-
-| bicycling, stationary, 100 watts, light effort
-| 5.5
-|-
-! Vigorous Intensity Activities
-! > 6
-|-
-| jogging, general
-| 7.0
-|-
-| calisthenics (e.g. pushups, situps, pullups,jumping jacks), heavy, vigorous effort
-| 8.0
-|-
-| running jogging, in place
-| 8.0
-|-
-| rope jumping
-| 10.0
-|}
-==Cardiac risk stratification for noncardiac surgical procedures==
+===Orthopedic surgery===
-====High (Reported cardiac risk often greater than 5%)====
+For knee of hip [[arthroplasty]]
-*Emergent major operations, particularly in the elderly.
+* The CRISTAL trial found more benefit (mainly from reducing distal DVTs) from Enoxaparin than aspirin (aspirin 100 mg daily or enoxaparin 40 mg daily for 35 days after hip replacement and 14 days after knee replacement)<ref name="pmid35997730">{{cite journal| author=CRISTAL Study Group. Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R | display-authors=etal| title=Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial. | journal=JAMA | year= 2022 | volume= 328 | issue= 8 | pages= 719-727 | pmid=35997730 | doi=10.1001/jama.2022.13416 | pmc=9399863 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35997730  }} </ref>.
-*Aortic and other major vascular surgery.
-*Peripheral vascular surgery.
-*Anticipated prolonged surgical procedures associated with large fluid shifts and/or blood loss.
-====Intermediate (Reported cardiac risk generally less than 5%)====
-*[[Carotid endarterectomy]].
-*Head and neck surgery.
-*Intraperitoneal and intrathoracic surgery.
-*Orthopedic surgery.
-*Prostate surgery.
-====Low (Reported cardiac risk generally less than 1%)====
+* However shorter therapy,''After an initial 5 days of [[rivaroxaban]]'', 9 days of aspirin or [[rivaroxaban]] may similarly reduce [[thromboembolism]] according to the EPCAT II trial<ref name="pmid29466159">{{cite journal| author=Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M | display-authors=etal| title=Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty. | journal=N Engl J Med | year= 2018 | volume= 378 | issue= 8 | pages= 699-707 | pmid=29466159 | doi=10.1056/NEJMoa1712746 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29466159  }} </ref>.
-*Endoscopic procedures.
-*Superficial procedure.
-*Cataract surgery.
-*Breast surgery.
+For knee [[arthroscopy]]
+* Evidence from trials conflicts:
+** [[Low molecular weight heparin]] did not prevent [[thromboembolism]] in the  POT-KAST trial trial published in 2017<ref name="pmid27959702">{{cite journal| author=van Adrichem RA, Nemeth B, Algra A, le Cessie S, Rosendaal FR, Schipper IB | display-authors=etal| title=Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting. | journal=N Engl J Med | year= 2017 | volume= 376 | issue= 6 | pages= 515-525 | pmid=27959702 | doi=10.1056/NEJMoa1613303 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27959702  }} </ref>. There was no routine imaging for outcomes in this study. Average age of patients was 56. The patients were not routinely imaged for [[thromboembolism]].
+*** In comparing their negative results to the two positive studies below, the POT-KAST authors noted "...in both trials, all the participants underwent ultrasonographic screening for venous thromboembolism, at which time questions were asked about possible signs and symptoms. This clearly does not reflect the method for identification of symptomatic venous thromboembolism that is used in general clinical practice and has therefore led to overestimation of the incidences."
+** [[Rivaroxaban]] once-daily rivaroxaban (10 mg) for .seven days may be better than placebo at preventing [[thromboembolism]] in the ERIKA trial published in 2016<ref name="pmid27075710">{{cite journal| author=Camporese G, Bernardi E, Noventa F, Bosco M, Monteleone G, Santoro L | display-authors=etal| title=Efficacy of Rivaroxaban for thromboprophylaxis after Knee Arthroscopy (ERIKA). A phase II, multicentre, double-blind, placebo-controlled randomised study. | journal=Thromb Haemost | year= 2016 | volume= 116 | issue= 2 | pages= 349-55 | pmid=27075710 | doi=10.1160/TH16-02-0118 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27075710  }} </ref>. Average age of patients was 46. All patients received colour-coded Doppler ultrasonography (CCDU) after seven days.
+** [[Low molecular weight heparin]] ''did'' prevent [[thromboembolism]] as compared to [[compression stockings]] in a trial published in 2008<ref name="pmid18626046">{{cite journal| author=Camporese G, Bernardi E, Prandoni P, Noventa F, Verlato F, Simioni P | display-authors=etal| title=Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy: a randomized trial. | journal=Ann Intern Med | year= 2008 | volume= 149 | issue= 2 | pages= 73-82 | pmid=18626046 | doi=10.7326/0003-4819-149-2-200807150-00003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18626046  }}  [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=&cmd=prlinks&id=19071876 Review in: ACP J Club. 2008 Dec 16;149(6):10] </ref>. In this trial, "All patients had bilateral, whole-leg, color-coded Doppler ultrasonography at the end of prophylaxis (8 or 15 days)."
+* For [[systematic review]]s:
+** The [[Cochrane Collaboration]] concludes "There is moderate- to low-certainty evidence of no benefit from the use of LMWH, aspirin or rivaroxaban in reducing this small risk of PE or symptomatic DVT. There is very low-certainty evidence that LMWH use may reduce the risk of asymptomatic DVT when compared to no treatment but it is uncertain how this directly relates to incidence of DVT or PE in healthy patients"<ref name="pmid32374919">{{cite journal| author=Perrotta C, Chahla J, Badariotti G, Ramos J| title=Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy. | journal=Cochrane Database Syst Rev | year= 2020 | volume= 5 | issue=  | pages= CD005259 | pmid=32374919 | doi=10.1002/14651858.CD005259.pub4 | pmc=7202465 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32374919  }} </ref>
 ==External links==
@@ Line 290: / Line 168: @@
 ==References==
 {{reflist|2}}
 [[Category:Cardiology]]