Squamous cell carcinoma of the skin risk factors: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(16 intermediate revisions by 7 users not shown)
Line 1: Line 1:
__NOTOC__
{{Squamous cell carcinoma}}
{{Squamous cell carcinoma}}
{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@perfuse.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:rgudetti@perfuse.org]
{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@wikidoc.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:ravitheja.g@gmail.com]


== Overview ==
== Overview ==
The risk factors for the [[Squamous cell carcinoma]] (SCC) include prolonged sunlight exposure, UV radiation, smoking, drugs etc
The [[risk factors]] for the [[Squamous cell carcinoma]] (SCC) include prolonged sunlight exposure, [[UV radiation]], [[smoking]], [[drugs]] etc.


== Common Risk Factors ==
== Risk Factors ==


Common risk factors for the development of the disease inlcude:
=== Common Risk Factors ===


* Chronic sun exposure.
Common [[risk factors]] inlcude:<ref name="pmid22881582">{{cite journal| author=de Vries E, Trakatelli M, Kalabalikis D, Ferrandiz L, Ruiz-de-Casas A, Moreno-Ramirez D et al.| title=Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study. | journal=Br J Dermatol | year= 2012 | volume= 167 Suppl 2 | issue=  | pages= 1-13 | pmid=22881582 | doi=10.1111/j.1365-2133.2012.11081.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22881582  }}</ref>


* Fair skin
* [[UV light]] exposure<ref name="pmid11684448">{{cite journal| author=de Gruijl FR, van Kranen HJ, Mullenders LH| title=UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. | journal=J Photochem Photobiol B | year= 2001 | volume= 63 | issue= 1-3 | pages= 19-27 | pmid=11684448 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11684448  }}</ref>
**[[UV light]] damages [[DNA]], initiating a series of changes can result in [[malignant]] transformation
* Having [[skin]] that [[burns]] easily and does not tan or tans poorly
* Light-colored [[hair]]
* Older [[age]]
* [[Smoking]]


* Elderly age (>45 yrs)
=== Less Common Risk factors ===


* Male sex
* Northern European ancestry
* Exposure to [[PUVA therapy|PUVA phototherapy]]
* [[Immunosuppressive therapy|Immunosuppressive treatment]]<ref name="pmid10025742">{{cite journal| author=Jensen P, Hansen S, Møller B, Leivestad T, Pfeffer P, Geiran O et al.| title=Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 2 Pt 1 | pages= 177-86 | pmid=10025742 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10025742  }}</ref>
* Exposure to [[ionizing radiation]] and other industrial [[carcinogens]]<ref name="pmid15704092">{{cite journal| author=Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH et al.| title=Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists. | journal=Int J Cancer | year= 2005 | volume= 115 | issue= 5 | pages= 828-34 | pmid=15704092 | doi=10.1002/ijc.20939 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15704092  }}</ref>
* [[Inflammation|Chronic inflammation]]<ref name="pmid12843850">{{cite journal| author=Jellouli-Elloumi A, Kochbati L, Dhraief S, Ben Romdhane K, Maalej M| title=[Cancers arising from burn scars: 62 cases]. | journal=Ann Dermatol Venereol | year= 2003 | volume= 130 | issue= 4 | pages= 413-6 | pmid=12843850 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12843850  }}</ref>
* Rare [[Inherited disorder|inherited disorders]]
**[[Xeroderma pigmentosum]]<ref name="pmid10447254">{{cite journal| author=Cleaver JE, Thompson LH, Richardson AS, States JC| title=A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. | journal=Hum Mutat | year= 1999 | volume= 14 | issue= 1 | pages= 9-22 | pmid=10447254 | doi=10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10447254  }}</ref>
** [[Epidermolysis bullosa]]<ref name="pmid19026465">{{cite journal| author=Fine JD, Johnson LB, Weiner M, Li KP, Suchindran C| title=Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986-2006. | journal=J Am Acad Dermatol | year= 2009 | volume= 60 | issue= 2 | pages= 203-11 | pmid=19026465 | doi=10.1016/j.jaad.2008.09.035 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19026465  }}</ref>
** [[Albinism]]<ref name="pmid2766562">{{cite journal| author=Kromberg JG, Castle D, Zwane EM, Jenkins T| title=Albinism and skin cancer in Southern Africa. | journal=Clin Genet | year= 1989 | volume= 36 | issue= 1 | pages= 43-52 | pmid=2766562 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2766562  }}</ref>
** [[Epidermodysplasia verruciformis]]
** [[Fanconi's anemia]]
* [[Arsenic|Arsenic exposure]]
* [[Genetic]] alterations<ref name="pmid15468170">{{cite journal| author=Tsai KY, Tsao H| title=The genetics of skin cancer. | journal=Am J Med Genet C Semin Med Genet | year= 2004 | volume= 131C | issue= 1 | pages= 82-92 | pmid=15468170 | doi=10.1002/ajmg.c.30037 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15468170  }}</ref>
* [[Family history]]<ref name="pmid23257063">{{cite journal| author=Kharazmi E, Fallah M, Sundquist K, Hemminki K| title=Familial risk of early and late onset cancer: nationwide prospective cohort study. | journal=BMJ | year= 2012 | volume= 345 | issue=  | pages= e8076 | pmid=23257063 | doi=10.1136/bmj.e8076 | pmc=3527651 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23257063  }}</ref>
* Drugs
**[[BRAF (gene)|BRAF inhibitors]]
** [[Voriconazole]]<ref name="pmid19896749">{{cite journal| author=Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS et al.| title=Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. | journal=J Am Acad Dermatol | year= 2010 | volume= 62 | issue= 1 | pages= 31-7 | pmid=19896749 | doi=10.1016/j.jaad.2009.09.033 | pmc=2815347 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19896749  }}</ref>
** Other photosensitizing [[drugs]] like [[ibuprofen]] and [[isotretinoin]]<ref name="pmid23344461">{{cite journal| author=Robinson SN, Zens MS, Perry AE, Spencer SK, Duell EJ, Karagas MR| title=Photosensitizing agents and the risk of non-melanoma skin cancer: a population-based case-control study. | journal=J Invest Dermatol | year= 2013 | volume= 133 | issue= 8 | pages= 1950-5 | pmid=23344461 | doi=10.1038/jid.2013.33 | pmc=3655101 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23344461  }}</ref>


* Smoking
'''<u>Skin</u>'''
== Less Common Risk factors ==


* Personal History of a skin cancer previously
* Significant [[sun exposure]]
* [[Benign]] lesions like [[Chalazion]]
* Chronic [[ulcers]].


* [[Xeroderma Pigmentosa]]
'''<u>Tongue and Esophagus</u>'''
* Drugs that cause photo-sensitivity like [[ibuprofen]], [[isotretinoin]] etc.,
 
* Immuno suppression in post-transplantation patients
* [[Tobacco]] [[chewing]]/[[Tobacco smoking|smoking]]
* Skin inflammation or injury.
* [[Alcohol, Drug Abuse, and Mental Health Services Block Grant|Alcohol Abuse]]
* Poor [[dental]] hygiene
 
'''<u>Nasopharynx</u>'''
 
Persons who have [[SCC]] of this region seldom have any [[risk factors]]. It most of the times caused by [[EBV infection]].
 
'''<u>Lungs</u>'''
 
* Therapeutic radiation ([[PUVA therapy|PUVA]] for [[Psoriasis|psoriasis)]]
* [[Tobacco smoking]]
 
'''<u>Penis</u>'''
 
* Pre-[[malignant]] [[lesions]] ([[Bowen's disease]], [[Condyloma]] , [[Warts]])
* Smoking and [[tobacco]] chewing


==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[Category:Disease]]
[[Category:Dermatology]]
[[Category:Dermatology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Oncology]]
[[Category:Otolaryngology]]
[[Category:Otolaryngology]]
[[Category:Mature chapter]]
[[Category:Grammar]]
[[de:Plattenepithelkarzinom]]
[[he:קרצינומת תאי קשקש]]
[[nl:Plaveiselcelcarcinoom]]
[[pl:Rak kolczystokomórkowy skóry]]
[[tr:Skuamöz hücreli karsinoma]]


{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}

Latest revision as of 21:45, 12 September 2019

Squamous cell carcinoma of the skin Microchapters

Home

Patient Info

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Squamous cell carcinoma of the skin from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT Scan

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Squamous cell carcinoma of the skin risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Squamous cell carcinoma of the skin risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Squamous cell carcinoma of the skin risk factors

CDC on Squamous cell carcinoma of the skin risk factors

Squamous cell carcinoma of the skin risk factors in the news

Blogs on Squamous cell carcinoma of the skin risk factors

Directions to Hospitals Treating Squamous cell carcinoma of the skin

Risk calculators and risk factors for Squamous cell carcinoma of the skin risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

The risk factors for the Squamous cell carcinoma (SCC) include prolonged sunlight exposure, UV radiation, smoking, drugs etc.

Risk Factors

Common Risk Factors

Common risk factors inlcude:[1]

Less Common Risk factors

Skin

Tongue and Esophagus

Nasopharynx

Persons who have SCC of this region seldom have any risk factors. It most of the times caused by EBV infection.

Lungs

Penis

References

  1. ↑ de Vries E, Trakatelli M, Kalabalikis D, Ferrandiz L, Ruiz-de-Casas A, Moreno-Ramirez D; et al. (2012). "Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study". Br J Dermatol. 167 Suppl 2: 1–13. doi:10.1111/j.1365-2133.2012.11081.x. PMID 22881582.
  2. ↑ de Gruijl FR, van Kranen HJ, Mullenders LH (2001). "UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer". J Photochem Photobiol B. 63 (1–3): 19–27. PMID 11684448.
  3. ↑ Jensen P, Hansen S, Møller B, Leivestad T, Pfeffer P, Geiran O; et al. (1999). "Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens". J Am Acad Dermatol. 40 (2 Pt 1): 177–86. PMID 10025742.
  4. ↑ Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH; et al. (2005). "Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologists". Int J Cancer. 115 (5): 828–34. doi:10.1002/ijc.20939. PMID 15704092.
  5. ↑ Jellouli-Elloumi A, Kochbati L, Dhraief S, Ben Romdhane K, Maalej M (2003). "[Cancers arising from burn scars: 62 cases]". Ann Dermatol Venereol. 130 (4): 413–6. PMID 12843850.
  6. ↑ Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy". Hum Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
  7. ↑ Fine JD, Johnson LB, Weiner M, Li KP, Suchindran C (2009). "Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986-2006". J Am Acad Dermatol. 60 (2): 203–11. doi:10.1016/j.jaad.2008.09.035. PMID 19026465.
  8. ↑ Kromberg JG, Castle D, Zwane EM, Jenkins T (1989). "Albinism and skin cancer in Southern Africa". Clin Genet. 36 (1): 43–52. PMID 2766562.
  9. ↑ Tsai KY, Tsao H (2004). "The genetics of skin cancer". Am J Med Genet C Semin Med Genet. 131C (1): 82–92. doi:10.1002/ajmg.c.30037. PMID 15468170.
  10. ↑ Kharazmi E, Fallah M, Sundquist K, Hemminki K (2012). "Familial risk of early and late onset cancer: nationwide prospective cohort study". BMJ. 345: e8076. doi:10.1136/bmj.e8076. PMC 3527651. PMID 23257063.
  11. ↑ Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS; et al. (2010). "Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole". J Am Acad Dermatol. 62 (1): 31–7. doi:10.1016/j.jaad.2009.09.033. PMC 2815347. PMID 19896749.
  12. ↑ Robinson SN, Zens MS, Perry AE, Spencer SK, Duell EJ, Karagas MR (2013). "Photosensitizing agents and the risk of non-melanoma skin cancer: a population-based case-control study". J Invest Dermatol. 133 (8): 1950–5. doi:10.1038/jid.2013.33. PMC 3655101. PMID 23344461.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Squamous_cell_carcinoma_of_the_skin_risk_factors&oldid=1581636"