|
|
| (16 intermediate revisions by one other user not shown) |
| Line 1: |
Line 1: |
| {{SI}}
| | #REDIRECT [[Lorcaserin Hydrochloride Hemihydrate]] |
| {{CMG}}
| |
| ==Overview==
| |
| Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has [[serotonergic]] properties and acts as an [[anorectic]]. On 27 June 2012, the [[Food and Drug Administration|FDA]] officially approved lorcaserin for use in the treatment of [[obesity]] for adults with a [[BMI]] equal to or greater than 30 or adults with a BMI of 27 or greater who "have at least one weight-related health condition, such as high [[blood pressure]], [[type 2 diabetes]], or high [[cholesterol]]".
| |
| ==Mechanism of action==
| |
| Lorcaserin is a selective [[5-HT2C receptor|5-HT<sub>2C</sub> receptor]] [[agonist]] and ''in vitro'' testing of the drug showed reasonable selectivity for 5-HT<sub>2C</sub> over other related targets.
| |
| | |
| 5-HT<sub>2C</sub> receptors are located almost exclusively in the brain, and can also be found in the [[choroid plexus]], [[Cerebral cortex|cortex]], [[hippocampus]], [[cerebellum]], [[amygdala]], [[thalamus]], and [[hypothalamus]].
| |
| | |
| The activation of 5-HT<sub>2C</sub> receptors in the hypothalamus is supposed to activate [[proopiomelanocortin]] (POMC) production and consequently promote weight loss through [[satiety]]. This hypothesis is supported by clinical trials and other studies.
| |
| ==Side effects==
| |
| Lorcaserin was approximately as tolerable as placebo in Phase III, with 7% of participants in both the lorcaserin drug and placebo arms dropping out due to side effects. | |
| | |
| ==References==
| |
| {{Reflist|2}}
| |
| | |
| [[Category:Antiobesity drugs]]
| |
| [[Category:Serotonin receptor agonists]]
| |
| [[Category:Organochlorides]]
| |
| [[Category:Benzazepines]]
| |
| | |
| {{WH}}
| |
| {{WS}}
| |