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| __NOTOC__
| | #REDIRECT [[Paget-Schroetter disease]] |
| {{Infobox disease
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| | Name = Paget-Schrotter disease
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| | Image = Gray576.png
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| | Caption = Anterior view of right upper limb and thorax
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| | DiseasesDB = 34349
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| | ICD10 = {{ICD10|I|82|8|i|80}}
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| | ICD9 = {{ICD9|453.8}}
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| | ICDO =
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| | OMIM =
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| | MedlinePlus =
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| | eMedicineSubj = med
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| | eMedicineTopic = 2772
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| | MeshID =
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| }}
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| {{SI}}
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| {{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]]
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| {{SK}} Paget-von Schrotter disease; effort-induced thrombosis.
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| ==Overview==
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| '''Paget-Schroetter disease''' is a form of upper extremity [[deep vein thrombosis]] (DVT), a medical condition in which [[blood clot]]s form in the deep [[vein]]s of the [[arm]]s. These DVTs typically occur in the [[axillary vein|axillary]] or [[subclavian vein]]s.
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| ==Historical Perspective==
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| The condition is named after two men. [[James Paget]]<ref name=WhoNam>{{WhoNamedIt|synd|1924|Paget-von Schrötter disease}}</ref> first proposed the idea of venous thrombosis causing upper extremity pain and swelling,<ref name=Paget>{{cite journal |author=Paget J |title=On gouty and some other forms of phlebitis |journal=St. Bartholomew's Hospital Reports |volume=2 |issue= |pages=82–92 |year=1866}}</ref> and [[Leopold von Schrötter]] later linked the clinical syndrome to thrombosis of the axillary and subclavian veins.<ref name=vonSch>L. von Schrötter. Erkrankungen der Gefässe. Nothnagel’s Handbuch der speciellen Pathologie und Therapie, 1901. Volume XV, II. Theil, II. Hälfte: Erkrankungen der Venen. Wien, Hölder, 1899: 533–535.</ref> Paget-Schroetter syndrome was described once for a [[viola]] player who suddenly increased practice time 10-fold, creating enough repetitive pressure against the brachiocephalic and external jugular veins to cause thrombosis.<ref>{{cite journal |last1=Reina |first1=Nick J. |last2=Honet |first2=Joseph C. |last3=Brown |first3=William |last4=Beitman |first4=Max |last5=Chodoroff |first5=Gary |title=Paget-Schroetter syndrome in a viola player |journal=Medical Problems of Performing Artists |volume=3 |number=1 |pages=24 |year=1988}}</ref>
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| ==Epidemiology and Demographics==
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| The condition is relatively rare.<ref>{{cite journal | last = Hughes | first = ES | title = Venous obstruction in the upper extremity; Paget-Schroetter's syndrome; a review of 320 cases | journal = Surg Gynecol Obstet | year = 1949 | page = 89 | issue = 2 | pmid=18108679 | volume = 88 | pages = 89–127}}</ref>
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| ==Natural history, Complications and Prognosis==
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| These DVTs rarely cause fatal [[pulmonary embolism]].
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| ==Diagnosis==
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| ===History and symptoms===
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| It usually presents in young and otherwise healthy patients, and also occurs more often in males than females.
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| The syndrome also became known as "effort-induced thrombosis" in the 1960s,<ref>{{cite journal | author = Drapanas, T; Curran, WL | title = Thrombectomy in the treatment of "effort" thrombosis of the axillary and subclavian veins | journal = Journal of Trauma | year = 1966 | page = 107 |issue = 6}}</ref> as it has been reported to occur after vigorous activity,<ref>{{cite journal | title = Current perspective of venous thrombosis in the upper extremity | author = Flinterman LE; Van Der Meer FJ; Rosendaal FR; Doggen CJ | journal = Journal of Thrombosis and Haemostasis | year = 2008 | month = Aug | volume = 6 | pages = 1262–6 | pmid = 18485082 | issue = 8 | doi = 10.1111/j.1538-7836.2008.03017.x}}</ref> though it can also occur spontaneously.
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| It may develop as a sequela of [[thoracic outlet syndrome]].
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| Symptoms may include
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| *Sudden onset of pain
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| *Warmth, redness, blueness and swelling in the arm.
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| ==Treatment==
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| The traditional treatment for thrombosis is the same as for a lower extremity DVT, and involves [[anticoagulation]] with [[heparin]] (generally [[low molecular weight heparin]]) with a transition to [[warfarin]].
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| Alternative treatment is thrombolytic therapy to open up the vein followed by first-rib resection during the same hospital admission and not waiting for a repeat episode.
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| ==See also==
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| * [[Thoracic outlet syndrome]], a possible cause of blood clots in arms
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| ==References==
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| {{Reflist|2}}
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| {{WH}}
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| {{WS}}
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| ==External links==
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| * [http://rad.usuhs.mil/medpix/medpix.html?mode=single&comebackto=mode%3Dcat_browse&recnum=4200 Overview] at [[Uniformed Services University of the Health Sciences]]
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| [[Category:Vascular diseases]]
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| [[Category:Diseases of veins, lymphatic vessels and lymph nodes]]
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| [[Category:Disease]]
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