Papular purpuric gloves and socks syndrome: Difference between revisions
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==Causes== | ==Causes== | ||
* An association with [[parvovirus B19]] has been described.<ref name="pmid18808380">{{cite journal |author=Fölster-Holst R, Kreth HW|title=Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems |journal=J Dtsch Dermatol Ges |volume=7|issue=5 |pages=414–9 |year=2009 |month=May |pmid=18808380 |doi=10.1111/j.1610-0387.2008.06869.x }}</ref> | * An association with [[parvovirus B19]] has been described.<ref name="pmid18808380">{{cite journal |author=Fölster-Holst | ||
R, Kreth HW|title=Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems |journal=J | |||
Dtsch Dermatol Ges |volume=7|issue=5 |pages=414–9 |year=2009 |month=May |pmid=18808380 |doi=10.1111/j.1610- | |||
0387.2008.06869.x }}</ref> | |||
* The syndrome has also been associated with several viruses such as [[HHV]]6, [[measles]] and [[coxsackie]] B6 | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
* PPGSS occurs primarily in teenagers and young adults. | * PPGSS occurs primarily in teenagers and young adults. | ||
==Natural History, Complications and Prognosis== | |||
* [[Rash]] and [[fever]] completely resolved in less than 3 days. | |||
* The disease has a short course and a benign prognosis. | |||
==Diagnosis== | ==Diagnosis== | ||
| Line 23: | Line 34: | ||
====Extremities==== | ====Extremities==== | ||
* [[Edema]] | * [[Edema]] | ||
* [[Erythema]] of the hands and feet, <ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi=|accessdate=}}</ref> | * [[Erythema]] of the hands and feet, <ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et | ||
al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= | |||
|isbn=0-7216-2921-0 |oclc= |doi=|accessdate=}}</ref> | |||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
* Positive serology for [[Parvovirus B19]]. | * All laboratory tests are normal. | ||
* Positive serology for [[Parvovirus B19]]. IgM is positive but not IgG.<ref name="pmid19129008">{{cite journal | | |||
author=Parez N, Dehée A, Michel Y, Veinberg F, Garbarg-Chenon A |title=Papular-purpuric gloves and socks syndrome | |||
associated with B19V infection in a 6-year-old child |journal=J. Clin. Virol. |volume=44 |issue=2 |pages=167–9 |year=2009 | |||
|month=February |pmid=19129008 |doi=10.1016/j.jcv.2008.11.013 |url=}}</ref> | |||
* Viral DNA test to detect the [[virus]]. | |||
== References == | == References == | ||
Latest revision as of 17:55, 1 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Synonyms and keywords: PPGSS
Overview
Papular purpuric gloves and socks syndrome (PPGSS) is an uncommon cutaneous condition with a typical purpuric exanthem limited to hands and feet.
Causes
- An association with parvovirus B19 has been described.[1]
- The syndrome has also been associated with several viruses such as HHV6, measles and coxsackie B6
Epidemiology and Demographics
- PPGSS occurs primarily in teenagers and young adults.
Natural History, Complications and Prognosis
- Rash and fever completely resolved in less than 3 days.
- The disease has a short course and a benign prognosis.
Diagnosis
Symptoms
PPGSS is characterized by
Physical Examination
Extremities
Laboratory Findings
- All laboratory tests are normal.
- Positive serology for Parvovirus B19. IgM is positive but not IgG.[3]
- Viral DNA test to detect the virus.
References
- ↑ Fölster-Holst
R, Kreth HW (2009). "Viral exanthems in childhood--infectious (direct) exanthems. Part 2: Other viral exanthems". J Dtsch Dermatol Ges. 7 (5): 414–9. doi:[//doi.org/10.1111%2Fj.1610-%0A%0A0387.2008.06869.x 10.1111/j.1610-
0387.2008.06869.x] Check
|doi=value (help). PMID 18808380. Unknown parameter|month=ignored (help); line feed character in|author=at position 15 (help); line feed character in|journal=at position 3 (help); line feed character in|doi=at position 16 (help) - ↑ James, William D.; Berger, Timothy G.; et
al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. line feed character in
|author=at position 43 (help) - ↑ Parez N, Dehée A, Michel Y, Veinberg F, Garbarg-Chenon A (2009). "Papular-purpuric gloves and socks syndrome
associated with B19V infection in a 6-year-old child". J. Clin. Virol. 44 (2): 167–9. doi:10.1016/j.jcv.2008.11.013. PMID 19129008. Unknown parameter
|month=ignored (help); line feed character in|title=at position 44 (help)