Acetarsol: Difference between revisions

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Acetarsol
Names
	Preferred IUPAC name Acetarsone[citation needed]
	Systematic IUPAC name (3-Acetamido-4-hydroxyphenyl)arsonic acid
	Other names 3-Acetamido-4-hydroxyphenylarsonic acid[citation needed]
Identifiers
CAS Number	97-44-9 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL1330792 ;
ChemSpider	1908 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D07110 ;
MeSH	Acetarsol
PubChem CID	1985;
UNII	806529YU1N ;
	InChI InChI=1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15) Key: ODFJOVXVLFUVNQ-UHFFFAOYSA-N ; InChI=1/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15) Key: ODFJOVXVLFUVNQ-UHFFFAOYAX;
	SMILES CC(=O)Nc1cc(ccc1O)[As](O)(O)=O; CC(=O)NC1=CC(=CC=C1O)[As](O)(O)=O;
Properties
Chemical formula	C; 8AsNH; 10O; 5
Molar mass	275.0903 g mol−1
Hazards
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

VisualWikitext

Latest revision as of 17:09, 18 August 2015

Template:Chembox ECNumber Template:Chembox E number Template:Chembox UNNumber Template:Chembox GHSPictograms Template:Chembox GHSSignalWord Template:Chembox HPhrases Template:Chembox PPhrases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acetarsol is an anti-infective.^[2] It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol (fourneau is the French word for stove).^[3]^[4]

It has been given in suppositories.^[5]

References

↑ "acetarsol - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information.
↑ Chen MY, Smith NA, Fox EF, Bingham JS, Barlow D (April 1999). "Acetarsol pessaries in the treatment of metronidazole resistant Trichomonas vaginalis". Int J STD AIDS. 10 (4): 277–80. doi:10.1258/0956462991913943. PMID 12035784.
↑ Éric Fouassier, Ces poisons qui guérissent, oct. 1996, p. 5.
↑ Traité de chimie organique, sous la direction de Victor Grignard, Paul Baud, vol. 22, Masson, 1959, p. 1127-1130.
↑ Gionchetti P, Rizzello F, Morselli C, Campieri M (October 2004). "Review article: problematic proctitis and distal colitis". Aliment. Pharmacol. Ther. 20 Suppl 4: 93–6. doi:10.1111/j.1365-2036.2004.02049.x. PMID 15352902.

Template:Antidiarrheals, intestinal anti-inflammatory/anti-infective agents Template:Agents against leishmaniasis and trypanosomiasis

[1] "acetarsol - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information.

[pmid12035784-2] Chen MY, Smith NA, Fox EF, Bingham JS, Barlow D (April 1999). "Acetarsol pessaries in the treatment of metronidazole resistant Trichomonas vaginalis". Int J STD AIDS. 10 (4): 277–80. doi:10.1258/0956462991913943. PMID 12035784.

[3] Éric Fouassier, Ces poisons qui guérissent, oct. 1996, p. 5.

[4] Traité de chimie organique, sous la direction de Victor Grignard, Paul Baud, vol. 22, Masson, 1959, p. 1127-1130.

[pmid15352902-5] Gionchetti P, Rizzello F, Morselli C, Campieri M (October 2004). "Review article: problematic proctitis and distal colitis". Aliment. Pharmacol. Ther. 20 Suppl 4: 93–6. doi:10.1111/j.1365-2036.2004.02049.x. PMID 15352902.

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-{{Drugbox
+{{Chembox
-| IUPAC_name        = (3-Acetamido-4-hydroxyphenyl)arsonic acid
+| Verifiedfields = changed
-| image             = Acetarsol.png
+| verifiedrevid = 477238724
-| CAS_number        = 97-44-9
+| ImageFile = Acetarsol.png
-| ATC_prefix        = A07
+| ImageFile_Ref = {{chemboximage|correct|??}}
-| ATC_suffix        = AX02
+| ImageSize = 150px
-| PubChem           = 1985
+| ImageName = Kekulé, skeletal formula of acetarsol
-| DrugBank          =
+| PIN = Acetarsone{{Citation needed|date = June 2011}}
-| chemical_formula  = C<sub>8</sub>H<sub>10</sub>AsNO<sub>5</sub>
+| SystematicName = (3-Acetamido-4-hydroxyphenyl)arsonic acid<ref>{{Cite web|url = http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1985|title = acetarsol - PubChem Public Chemical Database|work = The PubChem Project|location = USA|publisher = National Center for Biotechnology Information}}</ref>
-| molecular_weight  = 275.0903 g/mol
+| OtherNames = 3-Acetamido-4-hydroxyphenylarsonic acid{{Citation needed|date = June 2011}}
-| bioavailability   =
+| Section1 = {{Chembox Identifiers
-| protein_bound     =
+|  CASNo_Ref = {{cascite|changed|??}}
-| metabolism        =
+| CASNo = 97-44-9
-| elimination_half-life =
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
-| excretion         =
+| ChEMBL = 1330792
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+|  PubChem = 1985
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+|  PubChem_Ref = {{Pubchemcite|correct|pubchem}}
-| pregnancy_category=
+|  ChemSpiderID = 1908
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+|  UNII = 806529YU1N
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+|  UNII_Ref = {{fdacite|correct|FDA}}
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+|  EINECS = 202-582-3
-| legal_status      =
+|  UNNumber = 3465
-| routes_of_administration =
+|  KEGG_Ref = {{keggcite|correct|kegg}}
+|  KEGG = D07110
+|  MeSHName = Acetarsol
+|  ATCCode_prefix = A07
+|  ATCCode_suffix = AX02
+|  ATC_Supplemental = {{ATC|G01|AB01}}, {{ATC|P01|CD02}}, {{ATC|P51|AD05}}
+|  SMILES = CC(=O)Nc1cc(ccc1O)[As](O)(O)=O
+|  SMILES1 = CC(=O)NC1=CC(=CC=C1O)[As](O)(O)=O
+|  StdInChI = 1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15)
+|  StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+|  InChI = 1/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15)
+|  StdInChIKey = ODFJOVXVLFUVNQ-UHFFFAOYSA-N
+|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+|  InChIKey = ODFJOVXVLFUVNQ-UHFFFAOYAX}}
+| Section2 = {{Chembox Properties
+|  Formula = {{Chem|C|8|AsNH|10|O|5}}
+|  MolarMass = 275.0903 g mol<sup>−1</sup>
+|  ExactMass = 274.977493852 g mol<sup>−1</sup>
 }}
+| Section3 = {{Chembox Hazards
+|  GHSPictograms = {{GHS skull and crossbones}} {{GHS environment}}
+|  GHSSignalWord = Danger
+|  HPhrases = {{H-phrases|301|331|410}}
+|  PPhrases = {{P-phrases|261|273|301+310|311|501}}
+|  EUClass = {{Hazchem T}} {{Hazchem N}}
+|  RPhrases = {{R23/25}}, {{R50/53}}
+|  SPhrases = {{S20/21}}, {{S28}}, {{S45}}, {{S60}}, {{S61}}
+}}
+}}                     __NOTOC__
+{{SI}}
+{{CMG}}
-'''Acetarsol''' is an anti-infective.
+==Overview==
+'''Acetarsol''' is an anti-infective.<ref name="pmid12035784">{{cite journal |author=Chen MY, Smith NA, Fox EF, Bingham JS, Barlow D |title=Acetarsol pessaries in the treatment of metronidazole resistant Trichomonas vaginalis |journal=Int J STD AIDS |volume=10 |issue=4 |pages=277–80 |date=April 1999 |pmid=12035784 |doi= 10.1258/0956462991913943|url=http://ijsa.rsmjournals.com/cgi/pmidlookup?view=long&pmid=12035784}}</ref>
+It was first discovered in 1921 at [[Pasteur Institute]] by Ernest Fourneau, and sold under the brand name '''Stovarsol''' (''fourneau'' is the French word for stove).<ref>[http://www.ordre.pharmacien.fr/upload/Syntheses/161.pdf Éric Fouassier, ''Ces poisons qui guérissent'', oct. 1996, p. 5.]</ref><ref>''Traité de chimie organique'', sous la direction de Victor Grignard, Paul Baud, vol. 22, Masson, 1959, p. 1127-1130.</ref>
+It has been given in [[suppositories]].<ref name="pmid15352902">{{cite journal |author=Gionchetti P, Rizzello F, Morselli C, Campieri M |title=Review article: problematic proctitis and distal colitis |journal=Aliment. Pharmacol. Ther. |volume=20 Suppl 4 |issue= |pages=93–6 |date=October 2004 |pmid=15352902 |doi=10.1111/j.1365-2036.2004.02049.x |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2004&volume=20&issue=&spage=93}}</ref>
-{{pharma-stub}}
+==References==
+{{Reflist|2}}
 {{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}}
+{{Agents against leishmaniasis and trypanosomiasis}}
-[[Category:Arsenic compounds]]
+[[Category:Antiprotozoal agents]]
+[[Category:Acetanilides]]
-{{WikiDoc Help Menu}}
+[[Category:Drug]]
-{{WS}}
+[[Category:Phenols]]

Names

Preferred IUPAC name Acetarsone^{[citation needed]}
Systematic IUPAC name (3-Acetamido-4-hydroxyphenyl)arsonic acid^[1]
Other names 3-Acetamido-4-hydroxyphenylarsonic acid^{[citation needed]}
Identifiers
CAS Number	97-44-9^N
3D model (JSmol)	Interactive image Interactive image
ChEMBL	ChEMBL1330792^N
ChemSpider	1908^Y
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D07110^Y
MeSH	Acetarsol
PubChem CID	1985
UNII	806529YU1N^Y
InChI InChI=1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15)^Y Key: ODFJOVXVLFUVNQ-UHFFFAOYSA-N^Y InChI=1/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15) Key: ODFJOVXVLFUVNQ-UHFFFAOYAX
SMILES CC(=O)Nc1cc(ccc1O)[As](O)(O)=O CC(=O)NC1=CC(=CC=C1O)[As](O)(O)=O
Properties
Chemical formula	C ₈AsNH ₁₀O ₅
Molar mass	275.0903 g mol⁻¹
Hazards
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Acetarsol: Difference between revisions

Latest revision as of 17:09, 18 August 2015

Overview

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