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| {{drugbox | | | {{Details0|Betamethasone sodium phosphate (injection)}} |
| | image=Betamethasone.png
| | {{Details0|Betamethasone dipropionate (topical)}} |
| | IUPAC_name = 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-<br />trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-<br />dodecahydrocyclopenta[a]phenanthren-3-one
| | {{Details0|Betamethasone valerate (aerosol)}} |
| | CAS_number = 378-44-9
| | {{Details0|Betamethasone valerate (topical)}} |
| | ATC_prefix= A07
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| | ATC_suffix= EA04
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| | ATC_supplemental = {{ATC|C05|AA05}} {{ATC|D07|AC01}} {{ATC|D07|XC01}} {{ATC|H02|AB01}} {{ATC|R01|AD06}} {{ATC|R03|BA04}} {{ATC|S01|BA06}} {{ATC|S01|CB04}} {{ATC|S02|BA07}} {{ATC|S03|BA03}}
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| | PubChem= 9782
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| | DrugBank= APRD00513
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| | C=22 | H=29 | F=1 | O=5
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| | molecular_weight = 392.461
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| | bioavailability = ?
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| | metabolism = [[hepatic]] [[CYP3A4]]
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| | elimination_half-life = 5.6 hours
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| | excretion = ?
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = C
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| | pregnancy_category =
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| | legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
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| | legal_UK = <!-- GSL / P / POM / CD -->
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| | legal_US = <!-- OTC / Rx-only -->
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| | legal_status = Rx-only
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| | routes_of_administration = oral or topical
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| }} | |
| {{CMG}} | |
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| '''Betamethasone''' is a moderate-potent [[glucocorticoid]] [[steroid]] with [[anti-inflammatory]] and [[immunosuppressant|immunosuppressive]] abilities, used especially where water retention is undesirable. It is applied as a [[topical]] cream, ointment, foam, lotion or gel to treat [[pruritus|itching]] (e.g. from [[eczema]]).
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| It is available as a number of [[ester]]s: [[propionate|Dipropionate]] (branded as Diprosone®, Diprolene® and others), Sodium Phosphate and [[Valerate]] (branded as Betnovate®, Celestone® and others).
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| Betamethasone sodium phosphate is sometimes prescribed as an [[intramuscular injection]] (I.M) for itching from various ailments including allergic reactions to [[poison ivy]] and similar plants. | |
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| == Indications ==
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| Betamethasone is a [[corticosteroid]] used to stimulate fetal lung maturation, and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.
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| It is also used as a topical cream to relieve skin irritation.
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| 0.05% Betamethasone cream appears effective in treating [[phimosis]] in boys, and often averts the need for [[circumcision]].
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| Betamethasone sodium phosphate is used orally and via [[injection]] with the same indications as other [[steroids]].
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| == Fetal risk ==
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| As it crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as [[hypoglycemia]] and [[Neutrophil leucocytosis|leucocytosis]] in newborns exposed [[in utero]].
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| ==Notes==
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| <References/>
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| == External links ==
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| * {{cite web | title=Betamethasone | url=http://www.safefetus.com/DrugDetail.asp?DrugId=709&TradeName=Betaval&TradeId=775 | publisher=safefetus.com}}
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| * {{cite web | title=Betamethasone | url=http://www.musc.edu/pharmacyservices/Drugs/B/Betamethasone.htm | work=Pharmacy Services | publisher=Medical University of South Carolina}}
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| {{Corticosteroids}}
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| {{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}}
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| {{Vasoprotectives}}
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| {{Corticosteroids for systemic use}}
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| {{Nasal preparations}}
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| {{Otologicals}}
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| [[Category:Steroids]]
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| [[Category:Organofluorides]]
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| <br>
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| [[de:Betamethason]]
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| [[fr:Bétaméthasone]]
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| [[hu:Betametazon]]
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| [[ru:Бетаметазон]]
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