CYP20A1: Difference between revisions

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{{protein
{{Infobox_gene}}
|Name=cytochrome P450, family 20, subfamily A, polypeptide 1
|caption=
|image=
|width=
|HGNCid=20576
|Symbol=CYP20A1
|AltSymbols=
|EntrezGene=57404
|OMIM=
|RefSeq=NM_020674
|UniProt= Q6UW02
|PDB=
|ECnumber=
|Chromosome=2
|Arm=q
|Band=33
|LocusSupplementaryData=
}}
{{SI}}


'''CYP20A1'''  ('''cy'''tochrome '''P'''450, family '''20''', subfamily '''A''', polypeptide '''1''') is a [[protein]] which in humans is encoded by the ''CYP20A1'' [[gene]].<ref name="pmid12975309">{{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Res. | volume = 13 | issue = 10 | pages = 2265–70 |date=October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 | url = | issn = }}</ref>


'''CYP20A1'''  ('''cy'''tochrome '''P'''450, family '''20''', subfamily '''A''', polypeptide '''1''') is a [[protein]] which in humans is encoded by the ''CYP20A1'' [[gene]].<ref name="pmid12975309">{{cite journal | author = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Res. | volume = 13 | issue = 10 | pages = 2265–70 | year = 2003 | month = October | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 | url = | issn = }}</ref>
This gene encodes a member of the [[cytochrome P450]] superfamily of enzymes. The cytochrome P450 proteins are [[monooxygenase]]s that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved [[heme]] binding site. It also lacks the conserved I-helix motif [[AGXT|AGX(D,E)T]], suggesting that its substrate may carry its own oxygen.<ref name="entrez">{{cite web | title = Entrez Gene: CY20A1 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57404 | accessdate = }}</ref>
 
This gene encodes a member of the [[cytochrome P450]] superfamily of enzymes. The cytochrome P450 proteins are [[monooxygenase]]s that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved [[heme]] binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.<ref name="entrez">{{cite web | title = Entrez Gene: CY20A1 | url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57404 | accessdate = }}</ref>


==References==
==References==
{{Reflist}}
{{Reflist}}
==External links==
* {{UCSC gene info|CYP20A1}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899  |pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Jiang JH, Jia WH, Qin HD |title=[Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue] |journal=Ai Zheng |volume=23 |issue= 6 |pages= 672–7 |year= 2004 |pmid= 15191668 |doi=  |display-authors=etal}}
*{{cite journal  |vauthors=Werck-Reichhart D, Feyereisen R |title=Cytochromes P450: a success story. |journal=Genome Biol. |volume=1 |issue= 6 |pages= REVIEWS3003 |year= 2000 |pmid= 11178272 |doi= 10.1186/gb-2000-1-6-reviews3003 |pmc=138896  }}
*{{cite journal  |vauthors=Ross CJ, Katzov-Eckert H, Dubé MP |title=Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. |journal=Nat. Genet. |volume=41 |issue= 12 |pages= 1345–9 |year= 2009 |pmid= 19898482 |doi= 10.1038/ng.478 |display-authors=etal}}
*{{cite journal  |vauthors=Nelson DR, Zeldin DC, Hoffman SM |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001  |display-authors=etal}}
*{{cite journal  |vauthors=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1998 |pmid= 9890157 |doi= 10.1080/004982598238868 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{genetics-stub}}
{{Cytochrome P450}}
{{Cytochrome P450}}


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{{WS}}
{{gene-2-stub}}

Latest revision as of 19:22, 5 July 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.[2]

References

  1. ↑ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  2. ↑ "Entrez Gene: CY20A1".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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