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| __NOTOC__
| | #REDIRECT [[Diazoxide#Pharmacology]] |
| {{drugbox
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| | IUPAC_name = 7-chloro-3-methyl-4''H''-1,2,4-benzothiadiazine 1,1-dioxide
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| | image = Diazoxide_svg.png
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| | CAS_number = 364-98-7
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| | ATC_prefix = C02
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| | ATC_suffix = DA01
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| | ATC_supplemental = {{ATC|V03|AH01}}
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| | PubChem = 3019
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| | DrugBank = APRD00914
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| | C = 8 | H = 7 | Cl = 1 | N = 2 | O = 2 | S = 1
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| | molecular_weight = 230.672 g/mol
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| | bioavailability =
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| | protein_bound = 90%
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| | metabolism = [[Liver|Hepatic]] [[oxidation]] and [[sulfate]] conjugation
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| | elimination_half-life = 21-45 hours
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| | excretion = [[Kidney|Renal]]
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| | pregnancy_AU = C
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| | pregnancy_US = C
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| | legal_UK = POM
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| | legal_US = Rx-only
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| | routes_of_administration = Oral, [[Intravenous therapy|intravenous]]
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| }}
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| {{CMG}}
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| '''Diazoxide''' is a [[potassium channel]] activator, which causes local relaxation in [[smooth muscle]] by increasing membrane [[Semipermeable membrane|permeability]] to potassium [[ion]]s. This switches off voltage-gated [[calcium]] ion channels which inhibits the generation of an [[action potential]].
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| It is used as a [[vasodilator]] in the treatment of acute [[hypertension]], and also to decrease the secretion of [[insulin]] in disease states such as [[insulinoma]] (a tumor producing insulin).
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| {{Antihypertensives and diuretics}}
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| [[Category:Sulfonamides]]
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| [[Category:Vasodilators]]
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| [[Category:Drugs]]
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| {{WikiDoc Help Menu}}
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| {{WikiDoc Sources}}
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| [[de:Diazoxid]]
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| [[fr:Diazoxide]]
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| [[hr:Diazoksid]]
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