Formestane: Difference between revisions

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List of terms related to Formestane

Formestane
Clinical data
Synonyms	4-hydroxyandrost-4-ene-3,17-dione
AHFS/Drugs.com	International Drug Names
ATC code	L02BG02 (WHO) ;
Identifiers
	IUPAC name (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione;
CAS Number	566-48-3 ;
PubChem CID	11273;
ChemSpider	10799 ;
UNII	PUB9T8T355;
KEGG	D07260 ;
ChEBI	CHEBI:75172 ;
ChEMBL	ChEMBL132530 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C19H26O3
Molar mass	302.408 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C4C(/O)=C3/CC[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4;
	InChI InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1 ; Key:OSVMTWJCGUFAOD-KZQROQTASA-N ;
(what is this?) (verify)

VisualWikitext

Latest revision as of 14:37, 13 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Formestane (Lentaron) is a type I, steroidal aromatase inhibitor. It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot injection.

Formestane is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.

Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.

It is selective.

References

@@ Line 1: / Line 1: @@
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 437193284
+| IUPAC_name = (8''R'',9''S'',10''R'',13''S'',14''S'')-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1''H''-cyclopenta[''a'']phenanthrene-3,17-dione
+| image = Formestane1.png
+<!--Clinical data-->
+| tradename =
+| Drugs.com = {{drugs.com|international|formestane}}
+| pregnancy_category =
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| metabolism =
+| excretion =
-{{Drugbox|
+<!--Identifiers-->
-|IUPAC_name = (8''R'',9''S'',10''R'',13''S'',14''S'')-4-hydroxy-10,13-dimethyl-<br>2,6,7,8,9,11,12,14,15,16-decahydro-1''H''-<br>cyclopenta[a]phenanthrene-3,17-dione
+| CAS_number_Ref = {{cascite|correct|??}}
-| image= Formestane.png
+| CAS_number = 566-48-3
-| CAS_number=566-48-3
+| ATC_prefix = L02
-| ATC_prefix=L02
+| ATC_suffix = BG02
-| ATC_suffix=BG02
+| PubChem = 11273
-| ATC_supplemental=
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| PubChem=11273
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
-| DrugBank=
+| ChemSpiderID = 10799
-| C = 19 | H = 26 | O = 3
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = PUB9T8T355
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07260
+| ChEBI_Ref = {{ebicite|changed|EBI}}
+| ChEBI = 75172
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 132530
+<!--Chemical data-->
+| C=19 | H=26 | O=3
 | molecular_weight = 302.408 g/mol
-| bioavailability=
+| smiles = O=C4C(/O)=C3/CC[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4
-| metabolism =
+| InChI = 1/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
-| elimination_half-life=
+| InChIKey = OSVMTWJCGUFAOD-KZQROQTABI
-| excretion =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_category =
+| StdInChI = 1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
-| legal_status =
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| routes_of_administration=
+| StdInChIKey = OSVMTWJCGUFAOD-KZQROQTASA-N
+| synonyms = <small>4-hydroxyandrost-4-ene-3,17-dione</small>
 }}
-'''Formestane''' belongs to a class of drugs known as [[aromatase inhibitors]].  It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women.  It is available as an intramuscular depot injection (Lentaron).
+ __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Formestane''' ('''Lentaron''') is a type I, steroidal [[aromatase inhibitor]].  It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women.  It is available as an intramuscular depot injection.
-Formestane is often used to suppress [[estrogen]] production from [[anabolic steroids]] or [[prohormones]].
+Formestane is often used to suppress [[estrogen]] production from [[anabolic steroids]] or [[prohormones]].  It also acts as a prohormone to [[4-hydroxytestosterone]], an active steroid which displays weak [[androgenic]] activity in addition to acting as a mild aromatase inhibitor.
-Formestane has poor oral bioavailability and as such is no longer popular as many orally available aromatase inhibitors have been developed.
+Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.
-It is available as a supplement for bodybuilders in transdermal formulations.
+It is selective.
+==References==
+{{Reflist|2}}
-{{Sex hormones}}
 [[Category:Aromatase inhibitors]]
-[[Category:Endocrinology]]
+[[Category:Drug]]
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}

Formestane: Difference between revisions

Latest revision as of 14:37, 13 April 2015

Overview

References

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