Interleukin 28 receptor, alpha subunit: Difference between revisions

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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Interleukin 28 receptor, alpha (interferon, lambda receptor)
| HGNCid = 18584
| Symbol = IL28RA
| AltSymbols =; CRF2/12; IFNLR; IFNLR1; LICR2
| OMIM = 607404
| ECnumber = 
| Homologene = 52086
| MGIid = 2429859
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004907 |text = interleukin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0032002 |text = interleukin-28 receptor complex}}
| Process = {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0050691 |text = regulation of antiviral response by host}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 163702
    | Hs_Ensembl = ENSG00000185436
    | Hs_RefseqProtein = NP_734464
    | Hs_RefseqmRNA = NM_170743
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 24353234
    | Hs_GenLoc_end = 24387036
    | Hs_Uniprot = Q8IU57
    | Mm_EntrezGene = 242700
    | Mm_Ensembl = ENSMUSG00000062157
    | Mm_RefseqmRNA = NM_174851
    | Mm_RefseqProtein = NP_777276
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 134958600
    | Mm_GenLoc_end = 134980257
    | Mm_Uniprot = Q3URN4
  }}
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{{CMG}}
__NOTOC__
 
 
==Overview==
 
'''Interleukin 28 receptor, alpha subunit''' is a subunit for the [[interleukin-28 receptor]]. '''IL28RA''' is its human [[gene]].
'''Interleukin 28 receptor, alpha subunit''' is a subunit for the [[interleukin-28 receptor]]. '''IL28RA''' is its human [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=163702| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=163702| accessdate = }}</ref>
}}
}}


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{{refend}}
{{refend}}


 
{{gene-1-stub}}
{{Immune receptors}}
{{Immune receptors}}
{{Interleukin receptor modulators}}


[[Category:Cytokine receptors|1]]
[[Category:Type II cytokine receptors]]
[[Category:Type II cytokine receptors]]


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Latest revision as of 00:18, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]

References

  1. ↑ "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".


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