Methdilazine: Difference between revisions

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Evidence Based Medicine
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Clinical Trials
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List of terms related to Methdilazine

Methdilazine
Clinical data
AHFS/Drugs.com	Monograph
ATC code	R06AD04 (WHO) ;
Identifiers
	IUPAC name 10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine;
CAS Number	1982-37-2 ;
PubChem CID	14677;
DrugBank	DB00902 ;
ChemSpider	14009 ;
UNII	4Q13LY9Z8X;
KEGG	D04979 ;
ChEMBL	ChEMBL1200959 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C18H20N2S
Molar mass	296.431 g/mol
3D model (JSmol)	Interactive image;
	SMILES S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4;
	InChI InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 ; Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 16:20, 11 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

References

Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002. PMID 15782943.
Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83. PMID 9700532.
Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.

The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 462249764
 | IUPAC_name = 10-[(1-methylpyrrolidin-3-yl) methyl]- 10''H''-phenothiazine
+| image = Methdilazine.png
+<!--Clinical data-->
+| tradename =
+| Drugs.com = {{drugs.com|monograph|promethazine-hydrochloride}}
+| pregnancy_category =
+| legal_status =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CASNo_Ref = {{cascite|correct|CAS}}
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 1982-37-2
 | ATC_prefix = R06
 | ATC_suffix = AD04
-| ATC_supplemental =
 | PubChem = 14677
-| DrugBank = APRD00713
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| C=18 | H=20 | N=2 | S=1
+ | DrugBank = DB00902
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 14009
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 4Q13LY9Z8X
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D04979
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 1200959
+<!--Chemical data-->
+| C=18 | H=20 | N=2 | S=1
 | molecular_weight = 296.431 g/mol
-| bioavailability =
+| smiles = S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
-| protein_bound =
+| InChI = 1/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
-| metabolism =
+| InChIKey = HTMIBDQKFHUPSX-UHFFFAOYAR
-| elimination_half-life =
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| excretion =
+| StdInChI = 1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
-| pregnancy_US = <!-- A / B / C / D / X -->
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| pregnancy_category =
+| StdInChIKey = HTMIBDQKFHUPSX-UHFFFAOYSA-N
-| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
-| legal_UK = <!-- GSL / P / POM / CD -->
-| legal_US = <!-- OTC / Rx-only -->
-| legal_status =
 }}
+              __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Methdilazine''' ('''Dilosyn''', '''Tacaryl''') is a first-generation antihistamine with [[anticholinergic]] properties of the [[phenothiazine]] class.
-{{SI}}
+== See also ==
+* [[Phenothiazine]]
+== References ==
-==Overview==
+{{Reflist|2}}
-'''Methdilazine''' is an [[antihistamine]].
+* {{cite journal | author = Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S | title = Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine | journal = Microbiol Res | volume = 160 | issue = 1 | pages = 95–100 | year = 2005 | pmid = 15782943 | doi = 10.1016/j.micres.2004.10.002}}
+* {{cite journal | author = Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R | title = Altered membrane permeability as the basis of bactericidal action of methdilazine | journal = J Antimicrob Chemother | volume = 42 | issue = 1 | pages = 83–6 | year = 1998 | pmid = 9700532 | doi = 10.1093/jac/42.1.83}}
+* {{cite journal | author = Chattopadhyay D, Dastidar S, Chakrabarty A | title = Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents | journal = Arzneimittelforschung | volume = 38 | issue = 7 | pages = 869–72 | year = 1988 | pmid = 2905130}}
-==External links==
+The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.
-* {{cite journal | author = Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S | title = Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine | journal = Microbiol Res | volume = 160 | issue = 1 | pages = 95–100 | year = 2005 | id = PMID 15782943}}
-* {{cite journal | author = Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R | title = Altered membrane permeability as the basis of bactericidal action of methdilazine | journal = J Antimicrob Chemother | volume = 42 | issue = 1 | pages = 83–6 | year = 1998 | id = PMID 9700532}}
-* {{cite journal | author = Chattopadhyay D, Dastidar S, Chakrabarty A | title = Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents | journal = Arzneimittelforschung | volume = 38 | issue = 7 | pages = 869–72 | year = 1988 | id = PMID 2905130}}
 {{Antihistamines}}
-[[Category:Antihistamines]]
 [[Category:Phenothiazines]]
 [[Category:Pyrrolidines]]
+[[Category:H1 receptor antagonists]]
+[[Category:Drug]]
-{{WH}}
-{{WikiDoc Sources}}

v t e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Methdilazine: Difference between revisions

Latest revision as of 16:20, 11 April 2015

Overview

See also

References

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