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{{Infobox_Disease |
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{{Microscopic polyangiitis}}
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  ICD10          = {{ICD10|M|31|7|m|30}} |
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{{SI}}
{{CMG}}


'''Associate Editor-In-Chief:''' {{CZ}}
{{CMG}} ; {{AE}} {{VKG}}{{Vbe}}


{{SK}} MPA


==[[Microscopic polyangiitis overview|Overview]]==


==Overview==
==[[Microscopic polyangiitis historical perspective|Historical Perspective]]==


'''Microscopic polyangiitis (MPA) ''' is an ill-defined [[autoimmune disease]] characterized by pauci-immune, necrotizing, small-vessel [[vasculitis]] without clinical or pathological evidence of necrotizing granulomatous [[inflammation]]. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA.
==[[Microscopic polyangiitis classification|Classification]]==
 
==[[Microscopic polyangiitis pathophysiology|Pathophysiology]]==
 
==[[Microscopic polyangiitis causes|Causes]]==
 
==[[Microscopic polyangiitis differential diagnosis|Differentiating Any Disease from other Diseases]]==
 
==[[Microscopic polyangiitis epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Microscopic polyangiitis risk factors|Risk Factors]]==
 
==[[Microscopic polyangiitis screening|Screening]]==
 
==[[Microscopic polyangiitis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


==Diagnosis==
==Diagnosis==
Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (p-ANCA) directed against [MPO(a constituent of [[neutrophil]] granules), and [[protein]] and red blood cells in the [[urine]]. 
[[Microscopic polyangiitis history and symptoms|History and Symptoms]] | [[Microscopic polyangiitis physical examination|Physical Examination]] | [[Microscopic polyangiitis laboratory findings|Laboratory Findings]] | [[Microscopic polyangiitis electrocardiogram|Electrocardiogram]] | [[Microscopic polyangiitis chest x ray|Chest X Ray]] | [[Microscopic polyangiitis CT|CT]] | [[Microscopic polyangiitis MRI|MRI]] | [[Microscopic polyangiitis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Microscopic polyangiitis other imaging findings|Other Imaging Findings]] | [[Microscopic polyangiitis other diagnostic studies|Other Diagnostic Studies]]


The test for [[anti-glomerular basement membrane antibody]] (GBM), which is positive in [[Goodpasture's syndrome]], is negative.
==Treatment==
[[Microscopic polyangiitis medical therapy|Medical Therapy]] | [[Microscopic polyangiitis surgery|Surgery]] | [[Microscopic polyangiitis primary prevention|Primary Prevention]] | [[Microscopic polyangiitis secondary prevention|Secondary Prevention]] | [[Microscopic polyangiitis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Microscopic polyangiitis future or investigational therapies|Future or Investigational Therapies]]


==Cause==
==Case Studies==
This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by [[antibiotics]] and also by certain [[infection]]s, though, as with many autoimmune diseases, the causes remain to a large extent unknown.
[[Microscopic polyangiitis case study one|Case #1]]


==Treatment==
[[Category:Projects]]
The customary treatment involves long term dosage of [[prednisone]], alternated or combined with [[cytotoxic]] drugs, such as [[cyclophosphamide]] or [[azathioprine]]. [[Plasmapheresis]] may also be indicated in the acute setting to remove ANCA antibodies.
[[Category:Help]]


==See also==
{{WH}}
* [[ANCA-associated vasculitides]]
{{WS}}
*[[Polyarteritis nodosa]]


== External links ==
==References==
[http://vasculitis.med.jhu.edu/typesof/polyangiitis.html Overview from Johns Hopkins]
{{reflist|2}}


==Related Chapters==
* [[ANCA-associated vasculitides]]
* [[Polyarteritis nodosa]]


{{Diseases of the musculoskeletal system and connective tissue}}
{{Diseases of the musculoskeletal system and connective tissue}}


[[Category:Rheumatology]]
[[Category:Rheumatology]]

Latest revision as of 12:59, 23 July 2018

Microscopic polyangiitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Microscopic polyangiitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Radiation therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Microscopic polyangiitis On the Web

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Powerpoint slides

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American Roentgen Ray Society Images of Microscopic polyangiitis

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X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Microscopic polyangiitis

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Microscopic polyangiitis in the news

Blogs on Microscopic polyangiitis

Directions to Hospitals Treating Type chapter name here

Risk calculators and risk factors for Microscopic polyangiitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]Vindhya BellamKonda, M.B.B.S [3]

Synonyms and keywords: MPA

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Any Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Template:WH Template:WS

References

Related Chapters

Template:Diseases of the musculoskeletal system and connective tissue de:Mikroskopische Polyangiitis nl:Microscopische polyangiitis


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