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| {{CMG}}
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| ==Overview==
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| '''Erythema multiforme''' is a skin condition of unknown etiology, but some authors suggest that the disease is mediated by deposition of immune complex ( mostly IgM ) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an antecedent infection or drug exposure. It varies from a mild, self-limited rash (E. multiforme minor) to a severe, life-threatening form (E. multiforme major, or [[Stevens-Johnson syndrome]]) that also involves mucous membranes.
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| == Diagnosis ==
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| ===Common Causes===
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| The most common predisposing infection for E. multiforme is [[Herpes simplex]], but bacterial infections (commonly [[Mycoplasma]]) and fungal diseases are also implicated. E. multiforme may also be caused by drug reactions, most commonly [[sulfa drugs]], [[phenytoin]], [[barbiturates]], [[penicillin]], and [[allopurinol]], or a host of internal ailments.
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| === History and Symptoms ===
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| The skin form of E. multiforme, far more common than the severe form, usually presents with mildly itchy, pink-red blotches, symmetrically arranged and starting on the extremities. It often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7-10 days is the norm.
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| === Physical Examination ===
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| <div align="center">
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| <gallery heights="175" widths="175">
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| Image:erythema multiforme (HSV, target lesion).jpg|Erythema Multiforme (HSV, drug rxn, target lesion) Severe = Stevens-Johnson Syndrome<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages/photo#5089143178601475426</ref>
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| Image:Steven_Johnsons_Syndrome.jpg|Erythema Multiforme Major
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| Image:Erythema_multiforme.jpg|Erythema Multiforme reaction to an antibiotic
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| </gallery>
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| </div>
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| {{clr}}
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| ==References==
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| <references/>
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