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'''For patient information, click [[Polyarteritis nodosa (patient information)|here]]'''
'''For the heart in Polyarteritis Nodosa click[[The Heart in Polyarteritis Nodosa|  here]]'''
{{DiseaseDisorder infobox |
{{DiseaseDisorder infobox |
   Name          = Polyarteritis nodosa |
   Name          = Polyarteritis nodosa |
  ICD10          = {{ICD10|M|30|0|m|30}} |
  ICD9          = {{ICD9|446.0}} |
  ICDO          = |
   Image          = PAN Grade 6 atherosclerosis.jpg|
   Image          = PAN Grade 6 atherosclerosis.jpg|
   Caption        = Lung: Arteriosclerosis Grade 6: Micro med mag H&E; an excellent example of pulmonary polyarteritis nodosa. 4 yo male with primary pulmonary hypertension <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>|
   Caption        = Lung: Arteriosclerosis Grade 6: Micro med mag H&E; an excellent example of pulmonary polyarteritis nodosa. 4 yo male with primary pulmonary hypertension <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>|
  OMIM          = |
  OMIM_mult      = |
  MedlinePlus    = 001438 |
  DiseasesDB    = 10220 |
  MeshID        = D010488 |
}}
}}
{{Search infobox}}
{{Polyarteritis nodosa}}


{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}; [[User:Haritha|Haritha Machavarapu, M.B.B.S.]]
{{CMG}} {{APM}}; {{AE}}{{SSW}}{{OO}} {{CZ}}; [[User:Haritha|Haritha Machavarapu, M.B.B.S.]]


===[[The Heart in Polyarteritis Nodosa|For the heart in Polyarteritis Nodosa click here]]===
{{SK}} PAN; [[Adolph Kussmaul|Kussmaul]] disease; Kussmaul-Meier disease; periarteritis nodosa


==Overview==
==[[Polyarteritis nodosa overview|Overview]]==
'''Polyarteritis nodosa''' (or '''periarteritis nodosa''') is a vasculitis of medium-sized arteries, which become swollen and damaged from attack by rogue immune cells. Polyarteritis nodosa is also called '''[[Adolph Kussmaul|Kussmaul]] disease''' or '''Kussmaul-Meier disease'''.<ref>{{WhoNamedIt|synd|764}}</ref>


==Pathophysiology==
==[[Polyarteritis nodosa historical perspective|Historical Perspective]]==
Polyarteritis nodosa is a disease of unknown cause that affects arteries, the blood vessels that carry oxygenated blood to organs and tissues. It occurs when certain immune cells attack the affected arteries.Inflammation starts in the vessel intima and results in fibrinoid necrosis by destroying the internal and external elastic lamina. Aneurysms and thrombi may develop at the site of lesions. One hypothesis is that this condition is caused by antibodies against HBV, via a [[Hypersensitivity#Type_3_-_immune_complex | type IIII hypersensitivity reaction]].


==Epidemiology and Demographics==
==[[Polyarteritis nodosa classification|Classification]]==
The condition affects adults more frequently than children. It damages the tissues supplied by the affected arteries because they don't receive enough oxygen and nourishment without a proper blood supply.  Polyarteritis nodosa is more common in people with [[hepatitis]] B infection.


==Natural History, Prognosis, and Complications==
==[[Polyarteritis nodosa pathophysiology|Pathophysiology]]==
Therapy results in remissions or cures in 90% of cases.  Untreated, the disease is fatal in most cases.  The most serious associated conditions generally involve the kidneys and gastrointestinal tract. Without treatment, the outlook is poor.


Complications include the following:
==[[Polyarteritis nodosa causes|Causes]]==
* [[Stroke]]
* [[Kidney failure]]
* [[myocardial infarction|Heart attack]]
* Intestinal [[necrosis]] and perforation
==Diagnosis==
===Symptoms===
* [[Fatigue (physical)|Fatigue]]
* [[Weakness]]
* [[Fever]]
* [[Abdominal pain]]
* [[Decreased appetite]]
* Unintentional [[weight loss]]
* [[Muscle aches]]
* [[Joint aches]]


In this disease, symptoms result from damage to affected organs, often the skin, heart, kidneys, and nervous system.
==[[Differentiating Polyarteritis nodosa from other diseases|Differentiating Polyarteritis nodosa from other Diseases]]==


Generalized symptoms include [[fever]], [[fatigue]], [[weakness]], [[loss of appetite]], and [[weight loss]]. Muscle and joint aches are common. The skin may show rashes, swelling, ulcers, and lumps.
==[[Polyarteritis nodosa epidemiology and demographics|Epidemiology and Demographics]]==


Nerve involvement may cause sensory changes with [[numbness]], pain, burning, and [[weakness]]. Central nervous system involvement may cause [[strokes]] or [[seizures]]. Kidney involvement can produce varying degrees of [[renal failure]].
==[[Polyarteritis nodosa risk factors|Risk Factors]]==


Involvement of the arteries of the heart may cause a [[heart attack]], [[heart failure]], and inflammation of the sac around the heart ([[pericarditis]]).
==[[Polyarteritis nodosa screening|Screening]]==


===Laboratory Studies===
==[[Polyarteritis nodosa natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis:


* [[Complete blood count|CBC]] (may demonstrate an elevated white blood count)
== Diagnosis ==
* [[Erythrocyte sedimentation rate|ESR]] (often elevated)
* Perinuclear pattern of [[antineutrophil cytoplasmic antibodies]] ([[p-ANCA]]) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as [[microscopic polyangiitis]] or leukocytoclastic angiitis.
* Tissue biopsy (reveals inflammation in small arteries, called [[arteritis]])
* Elevated [[c reactive protein]]


===Diagnostic Criteria===
[[Polyarteritis nodosa diagnostic criteria|Diagnostic Criteria]] | [[Polyarteritis nodosa history and symptoms| History and Symptoms]] | [[Polyarteritis nodosa physical examination | Physical Examination]] | [[Polyarteritis nodosa laboratory findings | Laboratory Findings]] | [[Polyarteritis nodosa electrocardiography | Electrocardiography]] | [[Polyarteritis nodosa chest x ray | Chest X Ray]] | [[Polyarteritis nodosa CT|CT]] | [[Polyarteritis nodosa MRI|MRI]]  | [[Polyarteritis nodosa other diagnostic studies|Other Diagnostic Studies]] | [[Polyarteritis nodosa other imaging findings|Other Imaging Findings]]
A patient is said to have polyarteritis nodosa if he or she has 3 of the 10 following signs:


#Weight loss ≥4 kg.
==Treatment==
#Livedo reticularis (a mottled purplish skin discoloration over the extremities or torso).
[[Polyarteritis nodosa medical therapy|Medical Therapy]] | [[Polyarteritis nodosa surgery|Surgery]] | [[Polyarteritis nodosa primary prevention|Primary Prevention]] | [[Polyarteritis nodosa secondary prevention|Secondary Prevention]] |[[Polyarteritis nodosa cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | |[[Polyarteritis nodosa future or investigational therapies|Future or Investigational Therapies]]
#Testicular pain or tenderness. (occasionally, a site biopsied for diagnosis).
#Muscle pain, weakness, or leg tenderness.
#Nerve disease (either single or multiple).
#Diastolic blood pressure greater than 90mmHg (high blood pressure).
#Elevated kidney blood tests (BUN greater than 40 mg/dl or creatinine greater than 1.5 mg/dl).
#Hepatitis B virus tests positive (for surface antigen or antibody).
#Arteriogram (angiogram) showing the arteries that are dilated (aneurysms) or constricted by the blood vessel inflammation.
#Biopsy of tissue showing the arteritis (typically inflamed arteries).<ref>Shiel, Jr., William C, http://www.medicinenet.com/polyarteritis_nodosa/article.htm</ref>


==Diagnostic x-ray images==
==Case Studies==
[http://www.peir.net Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
[[Polyarteritis nodosa case study one|Case #1]]


<div align="left">
<gallery heights="150" widths="160">
Image:Polyarteritis nodosa mesenteric artery arteriogram.jpg|Polyarteritis nodosa mesenteric artery arteriogram
Image:Polyarteritis nodosa liver arteriogram.jpg|Polyarteritis nodosa liver arteriogram
</gallery>
</div>


<div align="left">
[[Category:Rheumatology]]
<gallery heights="150" widths="160">
[[Category:Nephrology]]
Image:Polyarteritis nodosa kidney arteriogram.jpg|Polyarteritis nodosa kidney arteriogram
Image:Polyarteritis nodosa kidney arteriogram 2.jpg|Polyarteritis nodosa kidney arteriogram
</gallery>
</div>


==Treatment==
Treatment involves medications to suppress the immune system, including [[prednisone]] and [[cyclophosphamide]].


==References==
{{reflist|2}}
[[Category:Diseases involving the fasciae]]
[[Category:Rheumatology]]


[[de:Polyarteriitis nodosa]]
[[nl:Polyarteritis nodosa]]
[[ja:結節性多発動脈炎]]
[[pl:Guzkowe zapalenie tętnic]]
[[sv:Polyarteritis nodosa]]
[[zh:結節性多動脈炎]]
[[tr:Poliarteritis nodoza]]


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Latest revision as of 04:24, 22 May 2018

For patient information, click here

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[3]Olufunmilola Olubukola M.D.[4] Cafer Zorkun, M.D., Ph.D. [5]; Haritha Machavarapu, M.B.B.S.

Synonyms and keywords: PAN; Kussmaul disease; Kussmaul-Meier disease; periarteritis nodosa

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Polyarteritis nodosa from other Diseases

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