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| {{CMG}}
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| {{Drug allergy}}
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| ==Overview==
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| Erythema multiforme is a skin condition of unknown etiology, but some authors suggest that the disease is mediated by deposition of immune complex (mostly [[IgM]]) in the superficial [[microvasculature]] of the skin and oral [[mucous membrane]]. It can occur due to [[drug exposure]],as well in association with some types of infections. It varies from a mild, self-limited [[rash]] (E. multiforme minor) to a severe, life-threatening form (E. multiforme major, or [[Stevens-Johnson syndrome]]) that also involves mucous membranes.
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| ===Common Causes===
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| E. multiforme may also be caused by drug reactions, most commonly [[sulfa drugs]], [[phenytoin]], [[barbiturates]], [[penicillin]], and [[allopurinol]], or a host of internal ailments. The most common predisposing infection for E. multiforme is [[Herpes simplex]], but bacterial infections (commonly [[Mycoplasma]]) and fungal diseases are also implicated.
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| == Diagnosis ==
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| === History and Symptoms ===
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| The skin form of E. multiforme, far more common than the severe form, usually presents with mildly itchy, pink-red blotches, symmetrically arranged and starting on the extremities. It often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7-10 days is the norm. [[Image:Erythema_multiforme_target_lesions.jpeg|left|Erythema multiforme target lesions]]
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| ===Laboratory Findings===
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| Laboratory findings are non-specific and can include an elevated erythrocyte sedimentation rate ([[ESR]]), elevated white blood cell count ([[WBC]]), and elevated liver enzymes.
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