Peptic ulcer causes: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
m (Bot: Removing from Primary care)
 
(61 intermediate revisions by 16 users not shown)
Line 1: Line 1:
{{Peptic ulcer}}{{CMG}}
__NOTOC__
{{Peptic ulcer}}
{{CMG}} ;{{AE}} {{MKK}}
 
==Overview==
==Overview==
Common causes of [[peptic ulcer]] disease include ''[[Helicobacter pylori]]'' infection and [[NSAID]] use.  Less common causes of [[peptic ulcer]] disease include [[Crohn's disease]], [[Zollinger-Ellison syndrome]], [[Cushing's Ulcer|Cushing]] and [[Curling ulcers]], [[Carcinoid tumors]], and [[carcinoid syndrome]].
==Causes==
'''Common Causes'''<ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref><ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref><ref name="pmid28150170">{{cite journal |vauthors=Dovjak P |title=[Duodenal ulcers, gastric ulcers and Helicobacter pylori] |language=German |journal=Z Gerontol Geriatr |volume=50 |issue=2 |pages=159–169 |year=2017 |pmid=28150170 |doi=10.1007/s00391-017-1190-x |url=}}</ref>
*[[Helicobacter pylori]]
*[[NSAID]]s 
'''Less common causes'''
*[[Hormonal]] or mediator-induced including secondary acid hypersecretory states
**[[Gastrinomas]]
** [[Mastocytosis|Systemic mastocytosis]]
** [[Carcinoid syndrome]]
** [[Myeloproliferative disease|Myeloproliferative disorder]] 
*Antral G-cell hyperfunction
*Post-surgical antral exclusion and post [[gastric]] bypass [[surgery]]
*Cancers and [[lymphoma|lymphomas]]
*Cameron [[ulcer]] ([[gastric]] [[ulcer]] where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]])
*True idiopathic [[ulcer]]
'''Rare causes of peptic ulcer disease'''
* [[Crohn's disease|Crohn’s disease]] of the [[stomach]] or [[duodenum]]
* [[Eosinophilic gastroduodenitis]]
* Systemic [[mastocytosis]]
* [[Radiation]] damage
* [[Viral infections]] (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in [[immunocompromised]] patients)
*Colonization of [[stomach]] with H heilmanii
* Severe [[systemic disease]]
'''Genetic causes'''<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377  }} </ref>
*Peptic ulcer disease caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]]) caused by a [[mutation]] in MEN [[gene]] present on [[chromosome]] 11q13
===Causes by Organ System===


==References==
{| style="width:80%; height:100px" border="1"
{{reflist|2}}
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" | '''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | [[Rosacea]],Chronic idiopathic [[urticaria]] ,[[Psoriasis|Psoriasis vulgaris]] ,[[Behçet's disease|Behcet's disease]] ,[[Alopecia areata]],[[Sweet's syndrome]] <ref name="pmid25045884">{{cite journal| author=Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E et al.| title=Helicobacter pylori infection and skin disorders. | journal=Hong Kong Med J | year= 2014 | volume= 20 | issue= 4 | pages= 317-24 | pmid=25045884 | doi=10.12809/hkmj134174 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25045884  }} </ref>
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" | [[Aceclofenac]], [[Acemetacin]], [[Alendronate]], [[Artemether and lumefantrin]], [[Aspirin]], [[Azapropazone]], [[Benoxaprofen]], [[Bisphosphonates]], [[Carbinoxamine]], [[Celecoxib]], [[Clopidogrel]], [[Dexamethasone]], [[Diclofenac]], [[Diflunisal]], [[Ethanol]], [[ethanolamine oleate]], [[Etidronic acid]], [[Etodolac]], [[Etoricoxib]], [[Febuxostat]], [[Fenbufen]], [[Fenoprofen]], [[Flurbiprofen]], [[Glucocorticoids]], [[Hydrocortisone]], [[Ibuprofen]], [[Indomethacin]], [[Ketoprofen]], [[Laxative abuse]], [[Mefenamic acid]], [[Meloxicam]], [[Mepenzolate bromide]], [[Methylprednisolone]], [[Nabumetone]], [[Naproxen]], [[Naproxen and esomeprazole magnesium]], [[Niacin]], [[Non steroidal anti-inflammatory drugs]], [[Oxcarbazepine]], [[Para-amino salicylic acid]], [[Pergolide]], [[Phenylbutazone]], [[Pramipexole]], [[Piroxicam]], [[Pramipexole]], [[Prednisolone]], [[Prednisone]], [[Rofecoxib]], [[Sertraline]], [[Sulindac]], [[Tacrolimus]], [[Tenoxicam]], [[Tiaprofenic acid]],  [[Tocilizumab]], [[Tolazoline]], [[Tolmetin]], [[Trimetrexate]]
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | [[Cushing syndrome]], [[Multiple endocrine neoplasia type 1]], [[Zollinger-Ellison syndrome]], [[Hyperparathyroidism|primary hyperparathyroidism]]
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | [[Crohn disease]], [[Cushing ulcers]], [[Dieulafoy's lesion]], [[Duodenal ulcer]], [[Eosinophilic gastroenteritis]], [[Gastric ulcer]], [[Oesophagitis]], [[Zollinger-Ellison syndrome]], [[Carcinoid tumours and carcinoid syndrome]], [[Stomach cancer]], [[Curling ulcers]]
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" | [[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN [[gene]] present on [[chromosome]] 11q 13
|-
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | [[Mastocytosis]], [[Polycythaemia rubra vera]], [[Primary thrombocythemia]]
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | [[Mechanical ventilation]]
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | [[Helicobacter pylori]]
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | [[Cushing ulcers]]
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
| bgcolor="Beige" | [[Hypercalcaemia]]
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | [[Carcinoid tumours and carcinoid syndrome]], [[Stomach cancer]], [[Zollinger-Ellison syndrome|Zollinger-Ellison syndrome ,]] [[gastrinomas]]
|-
|- bgcolor="LightSteelBlue"
| '''Opthalmologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
| bgcolor="Beige" | [[Aceclofenac]], [[Acemetacin]], [[Alendronate]], [[Aspirin]], [[Azapropazone]], [[Benoxaprofen]], [[Bisphosphonates]], [[Celecoxib]], [[Clopidogrel]], [[Diclofenac]], [[Diflunisal]], [[Ethanol]], [[Etodolac]], [[Etoricoxib]], [[Fenbufen]], [[Fenoprofen]], [[Flurbiprofen]], [[Glucocorticoids]], [[Ibuprofen]], [[Indomethacin]], [[Ketoprofen]], [[Laxative abuse]], [[Mefenamic acid]], [[Meloxicam]], [[Nabumetone]], [[Naproxen]], [[Non steroidal anti-inflammatory drugs]], [[Para-amino salicylic acid]], [[Phenylbutazone]], [[Piroxicam]], [[Prednisolone]], [[Rofecoxib]], [[Sulindac]], [[Tacrolimus]], [[Tenoxicam]], [[Tiaprofenic acid]], [[Tolazoline]], [[Trimetrexate]]
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | [[Curling ulcers]]
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | [[Sarcoidosis]]
|-
|- bgcolor="LightSteelBlue"
| '''Renal / Electrolyte'''
| bgcolor="Beige" | [[Hypercalcemia]]
|-
|- bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy'''
| bgcolor="Beige" | [[Fibromyalgia]]<ref name="pmid28384332" />
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | [[Burns]]
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | [[Alcohol]], [[Caffeine]], [[Smoking]]
|-
|}


{{Gastroenterology}}
===Causes in Alphabetical Order===


[[bs:Ulcerozne lezije želuca]]
{{MultiCol|80%}}
[[ca:Úlcera pèptica]]
*[[Aceclofenac]]
[[da:Mavesår]]
*[[Acemetacin]]
[[de:Magengeschwür]]
*[[Alcohol]]
[[el:Έλκος]]
*[[Alendronate]]
[[es:Úlcera péptica]]
*[[Artemether and lumefantrin]]
[[fr:Ulcère gastro-duodénal]]
*[[Aspirin]]
[[it:Ulcera peptica]]
*[[Azapropazone]]
[[nl:Maagzweer]]
*[[Benoxaprofen]]
[[ja:胃潰瘍]]
*[[Bisphosphonates]]
[[no:Magesår]]
*[[Burns]]
[[nn:Magesår]]
*[[Caffeine]]
[[pl:Choroba wrzodowa]]
*[[Carcinoid tumours and carcinoid syndrome]]
[[pt:Úlcera péptica]]
*[[Celecoxib]]
[[sq:Ulçera në stomak]]
*[[Clopidogrel]]
[[simple:Peptic ulcer]]
*[[Crohn disease]]
[[fi:Mahahaava]]
*[[Curling ulcers]]
[[sv:Magsår]]
*[[Cushing syndrome]]
[[zh:消化性溃疡]]
*[[Cushing ulcers]]
*[[Dexamethasone]]
*[[Diclofenac]]
*[[Dieulafoy's lesion]]
*[[Diflunisal]]
*[[Duodenal ulcer]]
*[[Eosinophilic gastroenteritis]]
*[[Ethanol]]
*[[Etodolac]]
*[[Etoricoxib]]
*[[Fenbufen]]
*[[Fenoprofen]]
*[[Flurbiprofen]]
*[[Gastric ulcer]]
*[[Glucocorticoids]]
*[[Helicobacter pylori]]
{{ColBreak}}
*[[Hypercalcaemia]]
*[[Ibuprofen]]
*[[Indomethacin]]
*[[Ketoprofen]]
*[[Laxative abuse]]
*[[Mastocytosis]]
*[[Mechanical ventilation]]
*[[Mefenamic acid]]
*[[Meloxicam]]
*[[Multiple endocrine neoplasia type 1]]
*[[Nabumetone]]
*[[Naproxen]]
*[[Niacin]]
*[[Non steroidal anti-inflammatory drugs]]
*[[Oesophagitis]]
*[[Para-amino salicylic acid]]
*[[Pergolide]]
*[[Phenylbutazone]]
*[[Piroxicam]]
*[[Polycythaemia rubra vera]]
*[[Prednisolone]]
*[[Primary thrombocythemia]]
*[[Rofecoxib]]
*[[Smoking]]
*[[Stomach cancer]]
*[[Sulindac]]
*[[Tacrolimus]]
*[[Tenoxicam]]
*[[Tiaprofenic acid]]
*[[Tolazoline]]
*[[Trimetrexate]]
*[[Zollinger-Ellison syndrome]]
{{EndMultiCol}}


==References==
{{reflist|2}}
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Gastroenterology]]

Latest revision as of 23:37, 29 July 2020

Peptic ulcer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Peptic Ulcer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Upper GI Endoscopy

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Endoscopic management
Surgical management

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

2017 ACG Guidelines for Peptic Ulcer Disease

Guidelines for the Indications to Test for, and to Treat, H. pylori Infection

Guidelines for First line Treatment Strategies of Peptic Ulcer Disease for Providers in North America

Guidlines for factors that predict the successful eradication when treating H. pylori infection

Guidelines to document H. pylori antimicrobial resistance in the North America

Guidelines for evaluation and testing of H. pylori antibiotic resistance

Guidelines for when to test for treatment success after H. pylori eradication therapy

Guidelines for penicillin allergy in patients with H. pylori infection

Guidelines for the salvage therapy

Peptic ulcer causes On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Peptic ulcer causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Peptic ulcer causes

CDC on Peptic ulcer causes

Peptic ulcer causes in the news

Blogs on Peptic ulcer causes

to Hospitals Treating Peptic ulcer

Risk calculators and risk factors for Peptic ulcer causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Common causes of peptic ulcer disease include Helicobacter pylori infection and NSAID use. Less common causes of peptic ulcer disease include Crohn's disease, Zollinger-Ellison syndrome, Cushing and Curling ulcers, Carcinoid tumors, and carcinoid syndrome.

Causes

Common Causes[1][2][3]

Less common causes

Rare causes of peptic ulcer disease

Genetic causes[4]

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome [5]
Drug Side Effect Aceclofenac, Acemetacin, Alendronate, Artemether and lumefantrin, Aspirin, Azapropazone, Benoxaprofen, Bisphosphonates, Carbinoxamine, Celecoxib, Clopidogrel, Dexamethasone, Diclofenac, Diflunisal, Ethanol, ethanolamine oleate, Etidronic acid, Etodolac, Etoricoxib, Febuxostat, Fenbufen, Fenoprofen, Flurbiprofen, Glucocorticoids, Hydrocortisone, Ibuprofen, Indomethacin, Ketoprofen, Laxative abuse, Mefenamic acid, Meloxicam, Mepenzolate bromide, Methylprednisolone, Nabumetone, Naproxen, Naproxen and esomeprazole magnesium, Niacin, Non steroidal anti-inflammatory drugs, Oxcarbazepine, Para-amino salicylic acid, Pergolide, Phenylbutazone, Pramipexole, Piroxicam, Pramipexole, Prednisolone, Prednisone, Rofecoxib, Sertraline, Sulindac, Tacrolimus, Tenoxicam, Tiaprofenic acid, Tocilizumab, Tolazoline, Tolmetin, Trimetrexate
Ear Nose Throat No underlying causes
Endocrine Cushing syndrome, Multiple endocrine neoplasia type 1, Zollinger-Ellison syndrome, primary hyperparathyroidism
Environmental No underlying causes
Gastroenterologic Crohn disease, Cushing ulcers, Dieulafoy's lesion, Duodenal ulcer, Eosinophilic gastroenteritis, Gastric ulcer, Oesophagitis, Zollinger-Ellison syndrome, Carcinoid tumours and carcinoid syndrome, Stomach cancer, Curling ulcers
Genetic Zollinger -Ellison syndrome associated with MEN TYPE 1 syndrome caused by mutation in MEN gene present on chromosome 11q 13
Hematologic Mastocytosis, Polycythaemia rubra vera, Primary thrombocythemia
Iatrogenic Mechanical ventilation
Infectious Disease Helicobacter pylori
Musculoskeletal / Ortho No underlying causes
Neurologic Cushing ulcers
Nutritional / Metabolic Hypercalcaemia
Obstetric/Gynecologic No underlying causes
Oncologic Carcinoid tumours and carcinoid syndrome, Stomach cancer, Zollinger-Ellison syndrome , gastrinomas
Opthalmologic No underlying causes
Overdose / Toxicity Aceclofenac, Acemetacin, Alendronate, Aspirin, Azapropazone, Benoxaprofen, Bisphosphonates, Celecoxib, Clopidogrel, Diclofenac, Diflunisal, Ethanol, Etodolac, Etoricoxib, Fenbufen, Fenoprofen, Flurbiprofen, Glucocorticoids, Ibuprofen, Indomethacin, Ketoprofen, Laxative abuse, Mefenamic acid, Meloxicam, Nabumetone, Naproxen, Non steroidal anti-inflammatory drugs, Para-amino salicylic acid, Phenylbutazone, Piroxicam, Prednisolone, Rofecoxib, Sulindac, Tacrolimus, Tenoxicam, Tiaprofenic acid, Tolazoline, Trimetrexate
Psychiatric Curling ulcers
Pulmonary Sarcoidosis
Renal / Electrolyte Hypercalcemia
Rheum / Immune / Allergy Fibromyalgia[6]
Sexual No underlying causes
Trauma Burns
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Alcohol, Caffeine, Smoking

Causes in Alphabetical Order


References

  1. ↑ Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
  2. ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
  3. ↑ Dovjak P (2017). "[Duodenal ulcers, gastric ulcers and Helicobacter pylori]". Z Gerontol Geriatr (in German). 50 (2): 159–169. doi:10.1007/s00391-017-1190-x. PMID 28150170.
  4. ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
  5. ↑ Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
  6. ↑

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Peptic_ulcer_causes&oldid=1641942"