Polyarteritis nodosa (patient information): Difference between revisions
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'''For the WikiDoc page on this topic, click [[Polyarteritis nodosa|here]]''' | |||
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Polyarteritis nodosa is a serious blood vessel disease in which small and medium-sized arteries become swollen and damaged. | Polyarteritis nodosa is a serious blood vessel disease in which small and medium-sized arteries become swollen and damaged. | ||
== | ==What are the symptoms of Polyarteritis nodosa?== | ||
Symptoms result from damage to affected organs, often the skin, heart, kidneys, and nervous system. | |||
Generalized symptoms include: | |||
* [[Abdominal pain]] | |||
* [[Decreased appetite]] | |||
* [[Fatigue]] | |||
* [[Fever]] | |||
* [[Joint aches]] | |||
* [[Muscle aches]] | |||
* [[Unintentional weight loss]] | |||
* [[Weakness]] | |||
Nerve involvement may cause sensory changes with numbness, pain, burning, and weakness. Central nervous system involvement may cause strokes or seizures. Kidney involvement can produce varying degrees of renal (kidney) failure. | |||
When heart arteries are involved, heart attack, heart failure, and inflammation of the sac around the heart (pericarditis) can occur. | |||
==What causes Polyarteritis nodosa== | |||
Polyarteritis nodosa is a disease of unknown cause that affects arteries, the blood vessels that carry oxygenated blood to organs and tissues. It occurs when certain immune cells attack the affected arteries. | |||
More adults than children get this disease. It damages the tissues supplied by the affected arteries because the tissues aren't receiving the oxygen and nourishment they need. | |||
People with active hepatitis B and C may develop this disease. | |||
==Who is at highest risk?== | |||
== | ==Diagnosis== | ||
There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is based on the physical examination and a few laboratory studies that help to confirm the diagnosis: | There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is based on the physical examination and a few laboratory studies that help to confirm the diagnosis: | ||
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* Immunoglobulins may be increased | * Immunoglobulins may be increased | ||
Treatment | ==When to seek urgent medical care?== | ||
Call your health care provider if you develop symptoms of this disorder. Early diagnosis and treatment may improve the chance of a good outcome. | |||
==Treatment options== | |||
Treatment involves medications to suppress the immune system, including prednisone and cyclophosphamide. | Treatment involves medications to suppress the immune system, including prednisone and cyclophosphamide. | ||
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For polyarteritis nodosa related to hepatitis, treatment may involve plasmapheresis and anti-viral medicines. | For polyarteritis nodosa related to hepatitis, treatment may involve plasmapheresis and anti-viral medicines. | ||
== Outlook | ==What to expect (Outlook/Prognosis)?== | ||
Current treatments using steroids and other drugs that suppress the immune system (such as cyclophosphamide) can improve symptoms and the chance of long-term survival. The most serious associated conditions generally involve the kidneys and gastrointestinal tract. Without treatment, the outlook is poor. | Current treatments using steroids and other drugs that suppress the immune system (such as cyclophosphamide) can improve symptoms and the chance of long-term survival. The most serious associated conditions generally involve the kidneys and gastrointestinal tract. Without treatment, the outlook is poor. | ||
== Possible Complications == | ==Possible Complications== | ||
* [http://www.nlm.nih.gov/medlineplus/ency/article/000195.htm Heart attack] | * [http://www.nlm.nih.gov/medlineplus/ency/article/000195.htm Heart attack] | ||
| Line 58: | Line 63: | ||
* [http://www.nlm.nih.gov/medlineplus/ency/article/000501.htm Kidney failure] | * [http://www.nlm.nih.gov/medlineplus/ency/article/000501.htm Kidney failure] | ||
* [http://www.nlm.nih.gov/medlineplus/ency/article/000726.htm Stroke] | * [http://www.nlm.nih.gov/medlineplus/ency/article/000726.htm Stroke] | ||
== Prevention == | == Prevention == | ||
| Line 67: | Line 68: | ||
There is no known prevention. However, early treatment can prevent some damage and symptoms. | There is no known prevention. However, early treatment can prevent some damage and symptoms. | ||
== | ==Sources== | ||
Sergent JS. Polyarteritis and related disorders. In: Harris ED Jr., Budd RC, Genovese MC, Firestein GS, Sargent JS, eds. ''Kelley's Textbook of Rheumatology''. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2008: chap 83. | Sergent JS. Polyarteritis and related disorders. In: Harris ED Jr., Budd RC, Genovese MC, Firestein GS, Sargent JS, eds. ''Kelley's Textbook of Rheumatology''. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2008: chap 83. | ||
Stone JH. The systemic vasculitides. In: Goldman L, Ausiello D, eds. ''Cecil Medicine''. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 291. | Stone JH. The systemic vasculitides. In: Goldman L, Ausiello D, eds. ''Cecil Medicine''. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 291. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 20:08, 29 June 2016
For the WikiDoc page on this topic, click here
|
Polyarteritis nodosa |
|
Polyarteritis nodosa On the Web |
|---|
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Polyarteritis nodosa is a serious blood vessel disease in which small and medium-sized arteries become swollen and damaged.
What are the symptoms of Polyarteritis nodosa?
Symptoms result from damage to affected organs, often the skin, heart, kidneys, and nervous system.
Generalized symptoms include:
- Abdominal pain
- Decreased appetite
- Fatigue
- Fever
- Joint aches
- Muscle aches
- Unintentional weight loss
- Weakness
Nerve involvement may cause sensory changes with numbness, pain, burning, and weakness. Central nervous system involvement may cause strokes or seizures. Kidney involvement can produce varying degrees of renal (kidney) failure.
When heart arteries are involved, heart attack, heart failure, and inflammation of the sac around the heart (pericarditis) can occur.
What causes Polyarteritis nodosa
Polyarteritis nodosa is a disease of unknown cause that affects arteries, the blood vessels that carry oxygenated blood to organs and tissues. It occurs when certain immune cells attack the affected arteries.
More adults than children get this disease. It damages the tissues supplied by the affected arteries because the tissues aren't receiving the oxygen and nourishment they need.
People with active hepatitis B and C may develop this disease.
Who is at highest risk?
Diagnosis
There are no specific lab tests for diagnosing polyarteritis nodosa. Diagnosis is based on the physical examination and a few laboratory studies that help to confirm the diagnosis:
- Arteriogram to see any changes in the smaller arteries
- CBC may show a higher than normal white blood count
- ESR or CRP is often higher than normal
- Tissue biopsy reveals inflammation in small arteries, called arteritis
- Immunoglobulins may be increased
When to seek urgent medical care?
Call your health care provider if you develop symptoms of this disorder. Early diagnosis and treatment may improve the chance of a good outcome.
Treatment options
Treatment involves medications to suppress the immune system, including prednisone and cyclophosphamide.
For polyarteritis nodosa related to hepatitis, treatment may involve plasmapheresis and anti-viral medicines.
What to expect (Outlook/Prognosis)?
Current treatments using steroids and other drugs that suppress the immune system (such as cyclophosphamide) can improve symptoms and the chance of long-term survival. The most serious associated conditions generally involve the kidneys and gastrointestinal tract. Without treatment, the outlook is poor.
Possible Complications
- Heart attack
- Intestinal necrosis and perforation
- Kidney failure
- Stroke
Prevention
There is no known prevention. However, early treatment can prevent some damage and symptoms.
Sources
Sergent JS. Polyarteritis and related disorders. In: Harris ED Jr., Budd RC, Genovese MC, Firestein GS, Sargent JS, eds. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2008: chap 83.
Stone JH. The systemic vasculitides. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 291.