Amyloidosis physical examination: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
 
(20 intermediate revisions by 9 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Amyloidosis}}
{{Amyloidosis}}
{{CMG}}
{{CMG}}; {{AE}} {{JH}}
 
== Overview ==
== Overview ==
Common findings in amyloidosis include waxy thickening, [[easy bruising]], [[purpura]], macroglossia, [[parotid gland]] and [[submandibular gland]] enlargement, [[edema]], [[numbness]] and [[paresthesia]].


==Physical Examination==
==Physical Examination==
===Vitals===
[[Physical examination]] of patients with amyloidosis is usually remarkable for waxy thickening, [[easy bruising]], [[purpura]], [[macroglossia]], [[parotid gland]] and [[submandibular gland]] enlargement, [[edema]], [[numbness]] and [[paresthesia]].<ref name="pmid267192344">{{cite journal |vauthors=Wechalekar AD, Gillmore JD, Hawkins PN |title=Systemic amyloidosis |journal=Lancet |volume=387 |issue=10038 |pages=2641–2654 |date=June 2016 |pmid=26719234 |doi=10.1016/S0140-6736(15)01274-X |url=}}</ref><ref name="pmid14660909">{{cite journal |vauthors=Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT |title=Amyloidosis of the upper aerodigestive tract |journal=Laryngoscope |volume=113 |issue=12 |pages=2095–101 |date=December 2003 |pmid=14660909 |doi=10.1097/00005537-200312000-00007 |url=}}</ref><ref name="pmid23239211">{{cite journal |vauthors=Shin SC, Robinson-Papp J |title=Amyloid neuropathies |journal=Mt. Sinai J. Med. |volume=79 |issue=6 |pages=733–48 |date=2012 |pmid=23239211 |pmc=3531896 |doi=10.1002/msj.21352 |url=}}</ref><br />
===Appearance of the Patient===
*Patients with amyloidosis usually appear normal.
===Vital signs===
* [[Hypertension]]
* [[Hypertension]]
* [[Tachycardia]]
* [[Tachycardia]]
===Skin===
*Waxy thickening
*Easy bruising (ecchymoses)
*Subcutaneous [[nodules]] or [[plaques]]
*[[Purpura]]
* [[Petechiae]]
* Brittle nails
*[[Edema]]
*Diffuse or patchy [[alopecia]]
*Nail dystrophy
*Brittle nails
===HEENT===
*[[Macroglossia]]
*[[Parotid gland]] enlargement
*[[Submandibular gland]] enlargement
*Peri-orbital [[purpura]]
* Raised [[intraocular pressure]] may be seen.
*Visual and hearing loss may be seen.
<gallery>
Image:Amyloidosis_01.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>
Image:Amyloidosis_02.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>
Image:Amyloidosis_03.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>
Image:Amyloidosis_04.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>
Image:Amyloidosis_05.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>
Image:Amyloidosis_06.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>
Image:Amyloidosis_07.jpeg|Amyloidosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://atlasdermatologico.com.br/disease.jsf?diseaseId=27>


===Skin===
</gallery>
* The most common skin findings are
** [[Petechiae]] (small red blood spots).
** [[Ecchymoses]] (small, flat blood spots that are round or irregular shape and bluish/purplish in colour)
** Waxy papular nodules can be seen around the eye lids, neck and also in the groin.
** Brittle nails.
** Edema due to [[heart failure]]
** Patches of [[hair loss]] can be seen.


===Head===
===Neck===
* [[Parotid gland]] enlargement
* Neck examination of patients with amyloidosis is usually normal.
* Submandibular gland enlargement


===Eye===
===Lungs===
* Raised intraocular pressure may be present.
*[[Hoarseness]]
*[[Stridor]]
*[[Dysphagia]]


===Throat===
===Heart===
* [[Enlarged tongue]]
*[[Arrhythmia]]


===Abdomen===
===Abdomen===
* [[Hepatomegaly]]
* [[Hepatomegaly]]
===Back===
* Back examination of patients with amyloidosis is usually normal.
===Genitourinary===
*[[Genitourinary]] examination of patients with amyloidosis is usually normal.
===Neuromuscular===
*[[Numbness]]
*[[Paresthesia]]
*Pain


===Extremities===
===Extremities===
*[[Edema]]
* [[Carpal tunnel syndrome]]
* [[Carpal tunnel syndrome]]
* [[Numbness]] of the fingers and toes
* [[Numbness]] of the fingers and toes
* [[Raynaud phenomenon]]
* [[Raynaud phenomenon]]
===Macular Amyloidosis===
<gallery widths="130px">
291.jpg | Macular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
292.jpg | Macular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
293.jpg | Macular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
294.jpg | Macular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
295.jpg | Macular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
</gallery>
===Nodular Amyloidosis===
<gallery widths="130px">
297.jpg | Nodular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
300.jpg | Nodular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
302.jpg | Nodular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
307.jpg | Nodular Amyloidosis <br> [http://www.atlasdermatologico.com.br <font size="-2">''Adapted from Dermatology Atlas''</font>]
</gallery>


== References ==
== References ==
{{reflist|2}}
{{reflist|2}}
[[Category:Disease]]
[[Category:Rheumatology]]
[[Category:Cardiology]]
[[Category:Endocrinology]]


{{WH}}
{{WH}}
{{WS}}
{{WS}}

Latest revision as of 21:19, 17 December 2019

Amyloidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

• Primary amyloidosis
• Secondary amyloidosis
• Familial amyloidosis
• Wild-type (senile) amyloidosis
• Cardiac amyloidosis
• Beta-2 microglobulin related amyloidosis
• Gelsolin related amyloidosis
• Lysozyme amyloid related amyloidosis
• Leucocyte cell-derived chemotaxin 2 related amyloidosis
• Fibrinogen A alpha-chain associated amyloidosis

Pathophysiology

Causes

Differentiating Amyloidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Amyloidosis physical examination On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Amyloidosis physical examination

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Amyloidosis physical examination

CDC on Amyloidosis physical examination

Amyloidosis physical examination in the news

Blogs on Amyloidosis physical examination

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Amyloidosis physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]

Overview

Common findings in amyloidosis include waxy thickening, easy bruising, purpura, macroglossia, parotid gland and submandibular gland enlargement, edema, numbness and paresthesia.

Physical Examination

Physical examination of patients with amyloidosis is usually remarkable for waxy thickening, easy bruising, purpura, macroglossia, parotid gland and submandibular gland enlargement, edema, numbness and paresthesia.[1][2][3]

Appearance of the Patient

  • Patients with amyloidosis usually appear normal.

Vital signs

Skin

HEENT


Neck

  • Neck examination of patients with amyloidosis is usually normal.

Lungs

Heart

Abdomen

Back

  • Back examination of patients with amyloidosis is usually normal.

Genitourinary

  • Genitourinary examination of patients with amyloidosis is usually normal.

Neuromuscular

Extremities

Macular Amyloidosis

Nodular Amyloidosis

References

  1. ↑ Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). "Systemic amyloidosis". Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.
  2. ↑ Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT (December 2003). "Amyloidosis of the upper aerodigestive tract". Laryngoscope. 113 (12): 2095–101. doi:10.1097/00005537-200312000-00007. PMID 14660909.
  3. ↑ Shin SC, Robinson-Papp J (2012). "Amyloid neuropathies". Mt. Sinai J. Med. 79 (6): 733–48. doi:10.1002/msj.21352. PMC 3531896. PMID 23239211.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Amyloidosis_physical_examination&oldid=1592062"