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{{Chronic lymphocytic leukemia}}
{{Chronic lymphocytic leukemia}}


{{CMG}}; {{AE}} {{RT}}
{{CMG}}; {{AE}} {{RT}}; {{Rim}}; {{HL}}


==Overview==
==Overview==
The age-adjusted [[incidence]] of chronic lymphocytic leukemia is 4.7 per 100,000 individuals in the United States. Chronic lymphocytic leukemia is a [[disease]] of the elderly and is rarely encountered in individuals under the age of 40 years. Most [[Patient|patients]] who are newly diagnosed with chronic lymphocytic leukemia are over the age 50 years. [[Male|Males]] are more commonly affected with chronic lymphocytic leukemia than [[Female|females]]. The number of deaths from chronic lymphocytic leukemia is 1.3 per 100,000 individuals in the United States.
==Epidemiology and Demographics==
===Prevalence===
* The [[prevalence]] of chronic lymphocytic leukemia ranges from a low of 10 to 50 cases per 100,000 individuals, with an average [[prevalence]] of 30 per 100,000 individuals.


==Epidemiology and demographics==
===Incidence===
===Incidence===
The [[incidence]] of CLL in developed countries is 4 per 100,000. It increases to more than 30 per 100,000 at age 80 yrs.
* The [[incidence]] of chronic lymphocytic leukemia in developed countries is 4 per 100,000 individuals. It increases to more than 30 per 100,000 individuals at the age of 80 years.<ref name="pmid18064533">{{cite journal |vauthors=Yamamoto JF, Goodman MT |title=Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002 |journal=Cancer Causes Control |volume=19 |issue=4 |pages=379–90 |date=May 2008 |pmid=18064533 |doi=10.1007/s10552-007-9097-2 |url=}}</ref>
 
* In 2011, the age-adjusted [[incidence]] of chronic lymphocytic leukemia was 4.82 per 100,000 individuals in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
===Prevalence===
The [[prevalence]] of CLL ranges from a low of 10 per 100,000 patients, to a high of 50 per 100,000 patients with an average prevalence of 30 per 100,000 patients.


===Age===
===Age===
[[CLL]] is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. Of note, subclinical "disease" can be identified in up to 7-8% of individuals over the age of 70. That is, small clones of B cells with the characteristic CLL phenotype can be identified in many healthy elderly persons. The clinical significance of these cells is unknown.
* Thereafter, the [[incidence]] of chronic lymphocytic leukemia increases with age.<ref name="pmid180645332">{{cite journal |vauthors=Yamamoto JF, Goodman MT |title=Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002 |journal=Cancer Causes Control |volume=19 |issue=4 |pages=379–90 |date=May 2008 |pmid=18064533 |doi=10.1007/s10552-007-9097-2 |url=}}</ref>
* Chronic lymphocytic leukemia is a [[disease]] of the elderly and is rarely encountered among individuals under the age of 40 years.  
* Most [[Patient|patients]] who are newly diagnosed with chronic lymphocytic leukemia are over the age 50.
* While the overall age-adjusted [[incidence]] of chronic lymphocytic leukemia in the United States is 4.4 per 100,000, the age-adjusted [[incidence]] of chronic lymphocytic leukemia by age category is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
:* 1.4 per 100,000 individuals among individuals '''younger''' than 65 years of age.
:* 25.2 per 100,000 individuals among individuals '''older''' than 65 years of age.


===Gender===
===Gender===
[[CLL]] is more common in men. Two thirds of the patients are men.
* [[Male|Males]] are more commonly affected with chronic lymphocytic leukemia than [[Female|females]]. (1.7:1)
* In the United States, the age-adjusted [[incidence]] of chronic lymphocytic leukemia by gender on 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref><ref name="pmid180645333">{{cite journal |vauthors=Yamamoto JF, Goodman MT |title=Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002 |journal=Cancer Causes Control |volume=19 |issue=4 |pages=379–90 |date=May 2008 |pmid=18064533 |doi=10.1007/s10552-007-9097-2 |url=}}</ref>
** 6.44 per 100,000 individuals among [[males]].
** 3.51 per 100,000 individuals among [[Female|females]].


===Race===
===Race===
[[CLL]] is common in the white race compared to the black race.
* Chronic lymphocytic leukemia usually affects individuals of the Caucasian [[race]]. African American individuals are slightly less likely to develop chronic lymphocytic leukemia.<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>
 
==Gallery==
 
[[Image:Chronic lymphocytic leukemia summary.png|thumb|none|500px|Chronic lymphocytic leukemia epidemiology summary<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]
 
[[Image:Chronic lymphocytic leukemia survival rate.png|thumb|none|500px|Chronic lymphocytic leukemia survival rate<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]
 
[[Image:Chronic lymphocytic leukemia mortality rate per age group.png|thumb|none|500px|Chronic lymphocytic leukemia mortality rate according to age group<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]
 
[[Image:Chronic lymphocytic leukemia mortality rate.png|thumb|none|500px|Chronic lymphocytic leukemia mortality rate according to gender and race<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]
 
[[Image:Chronic lymphocytic leukemia incidence rate per age group.png|thumb|none|500px|Chronic lymphocytic leukemia incidence rate according to age group<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]


==References==
[[Image:Chronic lymphocytic leukemia incidence rate.png|thumb|none|500px|Chronic lymphocytic leukemia incidence rate according to gender and race<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]
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{{Hematology}}
[[Image:Chronic lymphocytic leukemia compared to all cancers in the US.png|thumb|none|500px|Chronic lymphocytic leukemia incidence and mortality relative to all cancer cases in the United States<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]
{{Hematological malignancy histology}}


[[Image:Chronic lymphocytic leukemia incidence and mortality 1975-2011.png|thumb|none|500px|Chronic lymphocytic leukemia incidence and mortality between years 1975 and 2011<ref name="seer">SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015</ref>]]


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==References==
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Latest revision as of 11:27, 19 April 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Rim Halaby, M.D. [3]; Haytham Allaham, M.D. [4]

Overview

The age-adjusted incidence of chronic lymphocytic leukemia is 4.7 per 100,000 individuals in the United States. Chronic lymphocytic leukemia is a disease of the elderly and is rarely encountered in individuals under the age of 40 years. Most patients who are newly diagnosed with chronic lymphocytic leukemia are over the age 50 years. Males are more commonly affected with chronic lymphocytic leukemia than females. The number of deaths from chronic lymphocytic leukemia is 1.3 per 100,000 individuals in the United States.

Epidemiology and Demographics

Prevalence

  • The prevalence of chronic lymphocytic leukemia ranges from a low of 10 to 50 cases per 100,000 individuals, with an average prevalence of 30 per 100,000 individuals.

Incidence

  • The incidence of chronic lymphocytic leukemia in developed countries is 4 per 100,000 individuals. It increases to more than 30 per 100,000 individuals at the age of 80 years.[1]
  • In 2011, the age-adjusted incidence of chronic lymphocytic leukemia was 4.82 per 100,000 individuals in the United States.[2]

Age

  • Thereafter, the incidence of chronic lymphocytic leukemia increases with age.[3]
  • Chronic lymphocytic leukemia is a disease of the elderly and is rarely encountered among individuals under the age of 40 years.
  • Most patients who are newly diagnosed with chronic lymphocytic leukemia are over the age 50.
  • While the overall age-adjusted incidence of chronic lymphocytic leukemia in the United States is 4.4 per 100,000, the age-adjusted incidence of chronic lymphocytic leukemia by age category is:[2]
  • 1.4 per 100,000 individuals among individuals younger than 65 years of age.
  • 25.2 per 100,000 individuals among individuals older than 65 years of age.

Gender

  • Males are more commonly affected with chronic lymphocytic leukemia than females. (1.7:1)
  • In the United States, the age-adjusted incidence of chronic lymphocytic leukemia by gender on 2011 is:[2][4]
    • 6.44 per 100,000 individuals among males.
    • 3.51 per 100,000 individuals among females.

Race

  • Chronic lymphocytic leukemia usually affects individuals of the Caucasian race. African American individuals are slightly less likely to develop chronic lymphocytic leukemia.[5]

Gallery

Chronic lymphocytic leukemia epidemiology summary[5]
Chronic lymphocytic leukemia survival rate[5]
Chronic lymphocytic leukemia mortality rate according to age group[5]
Chronic lymphocytic leukemia mortality rate according to gender and race[5]
Chronic lymphocytic leukemia incidence rate according to age group[5]
Chronic lymphocytic leukemia incidence rate according to gender and race[5]
Chronic lymphocytic leukemia incidence and mortality relative to all cancer cases in the United States[5]
Chronic lymphocytic leukemia incidence and mortality between years 1975 and 2011[5]

References

  1. ↑ Yamamoto JF, Goodman MT (May 2008). "Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002". Cancer Causes Control. 19 (4): 379–90. doi:10.1007/s10552-007-9097-2. PMID 18064533.
  2. ↑ 2.0 2.1 2.2 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
  3. ↑ Yamamoto JF, Goodman MT (May 2008). "Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002". Cancer Causes Control. 19 (4): 379–90. doi:10.1007/s10552-007-9097-2. PMID 18064533.
  4. ↑ Yamamoto JF, Goodman MT (May 2008). "Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002". Cancer Causes Control. 19 (4): 379–90. doi:10.1007/s10552-007-9097-2. PMID 18064533.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015
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